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Hepatic Steatosis Assessment Using Quantitative Ultrasound Parametric Imaging Based on Backscatter Envelope Statistics
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Peer-Review Record

Effects of Hepatic Steatosis on Non-Invasive Liver Fibrosis Measurements Between Hepatitis B and Other Etiologies

Reviewer 1: Anonymous
Reviewer 2: Prakash Rai
Reviewer 3: Anonymous
Appl. Sci. 2019, 9(9), 1961; https://doi.org/10.3390/app9091961
Received: 3 April 2019 / Revised: 2 May 2019 / Accepted: 6 May 2019 / Published: 13 May 2019
(This article belongs to the Special Issue Ultrasound Technology for Clinical Diagnosis and Decisions Making)

Round 1

Reviewer 1 Report

Authors proposed very interesting approach for the effects of Hepatic Steatosis on non-invasive liver fibrosis and they used several approaches using TE and ARFI and showed good results.

Authors provided enough references to cover the previous research. Therefore, the manuscript can be accepted. 


1. Please may provide high quality of Figure 2. It is hard to see the labels inside the Figure 2.

2. Please may use same fonts for all Tables (Table 1 ~Table 4).

3. If possible, please provide  patient consent report or document (?) in the acknowledgement. For patient research, it needs to provide this document in the acknowledgement section.


Author Response

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Reviewer 2 Report

In this manuscript, Chen et. al. report on the the effects of fatty liver on the non-invasive methods used for measuring fibrosis especially comparing these effects on assessing fibrosis in patients with and without Hepatitis B.  Overall, the work is well done and the presentation is clear. Minor changes are needed prior to publishing this manuscript. These include: 

The introduction needs to be modified to provide a general reader of this journal adequate background to understand the manuscript. A general reader of applied sciences may not be as familiar with some of the technical terms mentioned in the introduction. 

Methods can cite previous work but all methods should be re-described briefly with details in the previous reports. 

The conclusions can also be expanded upon while keeping the typical audience for this journal in mind. Would these effects apply to other organs such as kidneys or the heart where steatosis may occur? Please comment.

Author Response

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Author Response File: Author Response.docx

Reviewer 3 Report

It's ready to publish.

Author Response

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Author Response File: Author Response.docx

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