A Split Ring Resonator-Based Metamaterial for Microwave Impedance Matching with Biological Tissue

A metamaterial lens based on a split ring resonator (SRR) array has been designed and optimized to improve the focusing and the penetration depth in human biological tissue of a microwave beam irradiated by a substrate integrated waveguide (SIW) cavity backed patch antenna. The impedance matching of the antenna loaded with human tissue is strongly improved. The simulations have been performed by using CST Microwave Studio®. A prototype of the device has been fabricated with the printed board circuits (PCB) process and has been characterized using a Network Analyzer and an antenna measurement system in anechoic chamber. A novel microwave applicator for hyperthermia therapy of skin cancer could be developed. The performances of the proposed applicator have been evaluated in terms of measured S11 scattering parameter modulus and simulated power loss density. The obtained results indicate that an SRR-based metamaterial is a promising solution for external microwave applicators to employ in dermatology.

Microwave applicators for hyperthermia treatment in medical field are suitable antennas irradiating into the tissue to be treated in order to produce a sufficient heating of the entire tumor volume without damages of the surrounding healthy tissue. Microwave applicators can be divided into external and internal applicators depending on their peculiar use. External microwave applicators for superficial cancer, have been investigated and described in literature [7][8][9][10][11][12][13]. They typically consist of a single radiating element or of an antenna array placed in contact with the skin surface. A water bolus is usually placed between the applicator and the body in order to improve the matching of the antenna and at same time maintain the temperature of the skin at normal human body level. Among the various types of antennas studied for the external applicators there are waveguide and horn antennas [8], phased array antennas [9], and patch antennas [10][11][12]. Different shapes-rectangular, circular, and horseshoe-have been considered for the radiating slot of microstrip antennas for microwave hyperthermia treatment of cancer [13].

Recall of Theory
In this section, the analytical model and physics of the split ring resonators is recalled since it has been employed in order to roughly obtain preliminary geometric parameters, before the actual design, which is numerically refined via CST Microwave Studio ® as described in Section 3.
The metamaterial based on SRR exhibits an effective magnetic permeability described by the Lorentz model approximation [31,32]: where ω = 2π f is the angular frequency; ω 0m is the resonant frequency; F is the fractional of the unit cell occupied by interior ring; γ is the damping factor due to metal losses. Starting from (1), a frequency range in which Re(µ reff ) is negative can be identified: where ω pm is the plasma magnetic frequency. Both ω pm and ω 0m are finely tunable by optimizing the geometry of the unit cell.
When an electromagnetic wave propagates orthogonally to the SRR plane, the SRR behavior can be approximatively described by an equivalent LC circuit, where the inductance and the capacitance are related to the currents induced in the metal rings and to the capacitive phenomena between the split terminations (capacitive gap), respectively [32]. If the dimension of unit cell is very small with respect to wavelength λ, the metamaterial layer exhibits an effective capacitance and an effective inductance at the macroscopic/average level, according to the effective medium theory, which leads to the calculation of an effective permeability [31].
Considering a single broadside coupled SRR with square form rings in the xy plane, the effective magnetic permeability is described by (3) [14]: where ∆ x and ∆ y are the dimensions of the SRR unit cell in xy plane; l x and l y are the lengths of the metallic ring in the x and y directions, respectively; R eff , C eff and L eff are the effective resistance, effective capacitance and effective inductance of the metamaterial, respectively. The effective capacitance is approximatively obtained from the formula for the capacitance per unit length of a strip line [33].
where K(k) and K (k) are elliptic integrals [34], w, s are the width and the split gap of the SRR; t is the distance between the two SRR in the z direction. The effective inductance is [33]: The effective resistance R eff includes the radiation resistance and the loss resistance [33]. In other words, the control of the effective magnetic permeability, by varying both the inductive and capacitive properties of metamaterial, via a proper SRR optimization, is the basic physics principle of the electromagnetic field focusing. A planar metamaterial lens based on SRR, formed by an array of the unit cell in the rings plane, exhibits an anisotropic negative permeability; if the wave propagates in the z direction, the permeability tensor is [14]: Appl. Sci. 2020, 10, 6740 4 of 14 When the antenna radiation frequency is within the range for which the permeability element µ reff (ω) < 0, the x-axis wave vector component is imaginary k x = ω √ ε y µ z , and therefore the component of the electromagnetic field parallel to SRRs plane is evanescent and the sideward radiation forbidden. Consequently, the main lobe of antenna radiation pattern will be improved while the side lobe is attenuated, and there is an overall improvement in terms of directivity and gain [15].
The metamaterial lens placed on the antenna, in addition to the electromagnetic field focusing properties, allowing the gain increasement, can be used as impedance matching layer. When the radiated electromagnetic waves propagate through media with different permittivity and permeability values an impedance mismatch occurs. The scheme of the normal wave propagation through the two layers sandwiched between two semi-infinite media is illustrated in Figure 1, where the SRR metamaterial layer is placed at distance t 2 from the biological layer to be matched. The metamaterial lens placed on the antenna, in addition to the electromagnetic field focusing properties, allowing the gain increasement, can be used as impedance matching layer. When the radiated electromagnetic waves propagate through media with different permittivity and permeability values an impedance mismatch occurs. The scheme of the normal wave propagation through the two layers sandwiched between two semi-infinite media is illustrated in Figure 1, where the SRR metamaterial layer is placed at distance from the biological layer to be matched. Figure 1. Scheme of the normal wave propagation through the two layers sandwiched between two semi-infinite media. The split ring resonator (SRR) metamaterial layer is placed to distance from the medium to be matched.
The metamaterial lens, if properly designed, can minimize the mismatch and maximize the energy transmission. With reference to Figure 1, the general form of wave matrices is given by (10).
where , and are the transmission coefficient, propagation constant and thickness of the layer , and is the reflection coefficient at the ( − 1) − layers interface. The total reflection coefficient of the multiple layers , given by (11), is zero for a 'perfect' impedance match. By considering (11), the total reflection coefficient is a function of frequency and can be minimized by appropriately planning the effective magnetic permeability of the metamaterial and by adjusting the distance from the medium to be matched.

Design
The considered microwave applicator, depicted in Figure 2, is an SIW cavity-backed patch antenna, designed and optimized for Ku-Band applications (10.7-12.7 GHz). It consists of a stack structure: a microstrip patch antenna coupled with a circular resonant cavity based on SIW technology. The substrate Rogers Duroid 5880 with low dielectric constant = 2.2 and low losses tan = 0.0009 has been considered for both layers. This antenna combines the attractive features of both SIW cavity-backed and patch antennas with truncated corners. The design has been performed by varying the size of the cavity, the hole diameters, the hole pitch, and the patch geometry. All the details pertaining to designs of this kind of antenna are reported in [22]; they are not reported for shortness. The two cuts on the sides of the rectangular patch were designed to provide a wider frequency band and a frequency downshift. This allows a more compact size. The metallized cavity further broadens the bandwidth and improves the gain of the antenna; furthermore, the SIW Figure 1. Scheme of the normal wave propagation through the two layers sandwiched between two semi-infinite media. The split ring resonator (SRR) metamaterial layer is placed to distance t 2 from the medium to be matched.
The metamaterial lens, if properly designed, can minimize the mismatch and maximize the energy transmission. With reference to Figure 1, the general form of wave matrices is given by (10).
T n e iγ n t n Γ n−1 e −iγ n t n Γ n−1 e iγ n t n e −iγ n t n E t 0 = a 11 a 12 a 21 a 22 E t 0 (10) where T n , γ n and t n are the transmission coefficient, propagation constant and thickness of the layer n, and Γ n−1 is the reflection coefficient at the (n − 1) − n layers interface. The total reflection coefficient of the multiple layers Γ in , given by (11), is zero for a 'perfect' impedance match. By considering (11), the total reflection coefficient is a function of frequency and can be minimized by appropriately planning the effective magnetic permeability of the metamaterial and by adjusting the distance from the medium to be matched.

Design
The considered microwave applicator, depicted in Figure 2, is an SIW cavity-backed patch antenna, designed and optimized for Ku-Band applications (10.7-12.7 GHz). It consists of a stack structure: a microstrip patch antenna coupled with a circular resonant cavity based on SIW technology. The substrate Rogers Duroid 5880 with low dielectric constant ε r = 2.2 and low losses tan δ = 0.0009 has been considered for both layers. This antenna combines the attractive features of both SIW cavity-backed and patch antennas with truncated corners. The design has been performed by varying the size of the cavity, the hole diameters, the hole pitch, and the patch geometry. All the details pertaining to designs of this kind of antenna are reported in [22]; they are not reported for shortness. The two cuts on the sides of the rectangular patch were designed to provide a wider frequency band and a frequency downshift. This allows a more compact size. The metallized cavity further broadens the bandwidth and improves the gain of the antenna; furthermore, the SIW technology offers the typical advantages of the standard PCB processes, such as easiness of fabrication, low cost, compact size and high integration with the planar circuits. Figure 3 shows the layout of an SIW cavity-backed patch antenna, the geometric parameters of which are listed in Table 1.
Appl. Sci. 2020, 10, x FOR PEER REVIEW 5 of 15 fabrication, low cost, compact size and high integration with the planar circuits. Figure 3 shows the layout of an SIW cavity-backed patch antenna, the geometric parameters of which are listed in Table  1.
The metamaterial theory reported in Section 2 has been applied to roughly identify the geometric parameters of the metamaterial operating at the Ku-Band applications. The analytical model for simple split ring resonators has been employed in order to obtain simple and preliminary line guides for the actual design, which is numerically performed via CST Microwave Studio ® . The employed dielectric substrate is Rogers RO4350B with dielectric constant = 3.48 and dissipation factor of tan = 0.004.   fabrication, low cost, compact size and high integration with the planar circuits. Figure 3 shows the layout of an SIW cavity-backed patch antenna, the geometric parameters of which are listed in Table  1.
The metamaterial theory reported in Section 2 has been applied to roughly identify the geometric parameters of the metamaterial operating at the Ku-Band applications. The analytical model for simple split ring resonators has been employed in order to obtain simple and preliminary line guides for the actual design, which is numerically performed via CST Microwave Studio ® . The employed dielectric substrate is Rogers RO4350B with dielectric constant = 3.48 and dissipation factor of tan = 0.004.    The metamaterial theory reported in Section 2 has been applied to roughly identify the geometric parameters of the metamaterial operating at the Ku-Band applications. The analytical model for simple split ring resonators has been employed in order to obtain simple and preliminary line guides for the actual design, which is numerically performed via CST Microwave Studio ® . The employed dielectric substrate is Rogers RO4350B with dielectric constant ε r = 3.48 and dissipation factor of tan δ = 0.004. The geometry of the SRR unit cell has been suitably modified and scaled with respect to the literature [14] in order to operate at the resonance frequency of the SIW microwave applicator. Moreover, with respect to [14], the unit cell of the proposed SRR presents a further double ring with splits placed on the opposite side and operates at a different frequency. A complementary configuration, i.e., a couples of coplanar rings written symmetrically with respect to the common center, has been considered to obtain a resonance frequency close to that of a single ring with the same dimensions, but with a larger magnetic moment due to higher current density. Since they are written on both sides of a dielectric substrate, they are broadside coupled. The analytical model of a single (not complementary) broadside coupled SRR satisfactorily approximates the complementary configuration when the couple of rings are very close each other. The metamaterial considered in this paper consists of an array of complementary broadside coupled split square-rings. The lattice of this inhomogeneous structure is shorter than the guided wavelength of antenna radiation, so the composite behaves as an effective homogeneous medium.
The design and optimization of the metamaterial lens has been numerically performed via CST Microwave Studio ® . After several simulations, in which the SRR geometry and cell size have been parametrically changed, the optimized geometric parameters are listed in Table 2. The optimized SRR metamaterial exhibits resonant frequency range overlapping the operating frequency range of the SIW cavity-backed patch antenna. Figure 4 shows the 3D view (a) and plan front view (b) of the unit cell of the SRR, respectively. The metamaterial lens used as superstrate of the SIW cavity-backed patch antenna is shown in Figure 5. The geometry of the SRR unit cell has been suitably modified and scaled with respect to the literature [14] in order to operate at the resonance frequency of the SIW microwave applicator. Moreover, with respect to [14], the unit cell of the proposed SRR presents a further double ring with splits placed on the opposite side and operates at a different frequency. A complementary configuration, i.e., a couples of coplanar rings written symmetrically with respect to the common center, has been considered to obtain a resonance frequency close to that of a single ring with the same dimensions, but with a larger magnetic moment due to higher current density. Since they are written on both sides of a dielectric substrate, they are broadside coupled. The analytical model of a single (not complementary) broadside coupled SRR satisfactorily approximates the complementary configuration when the couple of rings are very close each other. The metamaterial considered in this paper consists of an array of complementary broadside coupled split square-rings. The lattice of this inhomogeneous structure is shorter than the guided wavelength of antenna radiation, so the composite behaves as an effective homogeneous medium.
The design and optimization of the metamaterial lens has been numerically performed via CST Microwave Studio ® . After several simulations, in which the SRR geometry and cell size have been parametrically changed, the optimized geometric parameters are listed in Table 2. The optimized SRR metamaterial exhibits resonant frequency range overlapping the operating frequency range of the SIW cavity-backed patch antenna. Figure 4 shows the 3D view (a) and plan front view (b) of the unit cell of the SRR, respectively. The metamaterial lens used as superstrate of the SIW cavity-backed patch antenna is shown in Figure 5.
The parameter of the microwave applicator placed at distance from a model of human tissue is simulated to evaluate the lens metamaterial behavior as impedance matching layer. Figure  6 shows the sideview of the layout of SIW cavity-backed patch antenna covered by the metamaterial lens and at distance from the biological tissue. The biological tissue considered in the simulation is a slab of skin-fat-muscle, whose electromagnetic parameters at the = 11 GHz frequency are listed in Table 3 [35].    Length of the metamaterial lens in the direction 36.00 Length of the metamaterial lens in the direction  The S 11 parameter of the microwave applicator placed at distance D from a model of human tissue is simulated to evaluate the lens metamaterial behavior as impedance matching layer. Figure 6 shows the sideview of the layout of SIW cavity-backed patch antenna covered by the metamaterial lens and at distance D from the biological tissue. The biological tissue considered in the simulation is a slab of skin-fat-muscle, whose electromagnetic parameters at the f = 11 GHz frequency are listed in Table 3 [35]. The scattering parameter modulus | | of the SIW cavity-backed patch antenna with SRR superstrate has been simulated for different distances from the biological tissue, and the obtained results are compared in Figure 7a. It is apparent that the metamaterial placed at distance = 10 mm allows the best impedance matching with the biological tissue. It is worthwhile noting that even if Figure 7a shows a narrow dip at = 10.9 GHz, the overall operating bandwidth is typically defined at | | = −10 dB level. Therefore, a very large frequency range of about 2 GHz can be exploited.
By considering the strong change of scattering parameter modulus | | with respect to the distance , the following considerations can be inferred: (i) the distance change induces the radiation impedance transformation of the applicator; (ii) the distance could be optimized starting from the nominal value of = 10 mm, by considering the particular biological tissue; (iii) suitable mechanical spacers could be finely controlled, e.g., by ad-hoc dielectric screws to optimize the microwave radiation. Figure 7b illustrates the simulated scattering parameter modulus | | of the SIW cavity-backed patch antenna with SRR superstrate placed at distance = 10 mm from the human tissue (continuous line) and of the SIW cavity-backed patch antenna with SRR superstrate without tissue (dashed line). The reduction in the scattering parameter modulus | | can be observed over almost the entire frequency range, the metamaterial strongly improves the impedance matching.
The electric field distribution has been simulated in order to evaluate the ability of the proposed microwave applicator to focus the electromagnetic field into biological tissue. Simulated electric field  The scattering parameter modulus |S 11 | of the SIW cavity-backed patch antenna with SRR superstrate has been simulated for different distances from the biological tissue, and the obtained results are compared in Figure 7a. It is apparent that the metamaterial placed at distance D = 10 mm allows the best impedance matching with the biological tissue. It is worthwhile noting that even if Figure 7a shows a narrow dip at f = 10.9 GHz, the overall operating bandwidth is typically defined at |S 11 | = −10 dB level. Therefore, a very large frequency range of about 2 GHz can be exploited. observed over almost the entire frequency range, the metamaterial strongly improves the impedance matching.
The electric field distribution has been simulated in order to evaluate the ability of the proposed microwave applicator to focus the electromagnetic field into biological tissue. Simulated electric field 2D distribution in the plane at = 11 GHz is reported in Figure 8. By considering the strong change of scattering parameter modulus |S 11 | with respect to the distance D, the following considerations can be inferred: (i) the distance D change induces the radiation impedance transformation of the applicator; (ii) the distance D could be optimized starting from the nominal value of D = 10 mm, by considering the particular biological tissue; (iii) suitable mechanical spacers could be finely controlled, e.g., by ad-hoc dielectric screws to optimize the microwave radiation. Figure 7b illustrates the simulated scattering parameter modulus |S 11 | of the SIW cavity-backed patch antenna with SRR superstrate placed at distance D = 10 mm from the human tissue (continuous line) and of the SIW cavity-backed patch antenna with SRR superstrate without tissue (dashed line). The reduction in the scattering parameter modulus |S 11 | can be observed over almost the entire frequency range, the metamaterial strongly improves the impedance matching.
The electric field distribution has been simulated in order to evaluate the ability of the proposed microwave applicator to focus the electromagnetic field into biological tissue. Simulated electric field 2D distribution in the yz plane at f = 11 GHz is reported in Figure 8. The metamaterial lens produces a focusing improvement of the electromagnetic field into the skin model. In particular, in the case of SRR superstrate placed at distance = 10 mm from the human tissue, the electric field modulus better penetrates along -direction, in both the skin and fat layers, with respect to the case without SRR superstrate. Moreover, the region where the electric field modulus is close to | | = 300 Vm is more homogeneous in the presence of SRR superstrate ( Figure  8a). It is worth noting the nodal surfaces due to a stationary electromagnetic wave in absence of SRR metamaterial (Figure 8b). The metamaterial lens produces a focusing improvement of the electromagnetic field into the skin model. In particular, in the case of SRR superstrate placed at distance D = 10 mm from the human tissue, the electric field modulus better penetrates along z-direction, in both the skin and fat layers, with respect to the case without SRR superstrate. Moreover, the region where the electric field modulus is close to |E| = 300 Vm −1 is more homogeneous in the presence of SRR superstrate (Figure 8a). It is worth noting the nodal surfaces due to a stationary electromagnetic wave in absence of SRR metamaterial (Figure 8b).

Experimental
The antenna and metamaterial prototypes have been fabricated by employing the dielectric substrates Rogers Duroid 5880 with ε r = 2.2 and tan δ = 0.0009 and Rogers RO4350B with ε r = 3.48 and tan δ = 0.004, respectively, and by using a standard PCB process.
Top-views of the SIW cavity-backed antenna and the metamaterial lens are shown in Figure 9a, the four holes are fabricated to fixing with suitable screws the metamaterial lens to the SIW antenna and the nuts are screwed in order to the obtain the distance d = 6.9 mm, as shown in Figure 9b. The designed thickness of the metamaterial lens, t = 3.04 mm, is achieved by overlaying two layers of dielectric substrate each of thickness 1.52 mm. The scattering parameter S 11 of the device has been measured with the Agilent Technologies N5224A Network Analyzer.
The metamaterial lens produces a focusing improvement of the electromagnetic field into the skin model. In particular, in the case of SRR superstrate placed at distance = 10 mm from the human tissue, the electric field modulus better penetrates along -direction, in both the skin and fat layers, with respect to the case without SRR superstrate. Moreover, the region where the electric field modulus is close to | | = 300 Vm is more homogeneous in the presence of SRR superstrate ( Figure  8a). It is worth noting the nodal surfaces due to a stationary electromagnetic wave in absence of SRR metamaterial (Figure 8b).

Experimental
The antenna and metamaterial prototypes have been fabricated by employing the dielectric substrates Rogers Duroid 5880 with = 2.2 and tan = 0.0009 and Rogers RO4350B with = 3.48 and tan = 0.004, respectively, and by using a standard PCB process.
Top-views of the SIW cavity-backed antenna and the metamaterial lens are shown in Figure 9a, the four holes are fabricated to fixing with suitable screws the metamaterial lens to the SIW antenna and the nuts are screwed in order to the obtain the distance = 6.9 mm, as shown in Figure 9b. The designed thickness of the metamaterial lens, = 3.04 mm, is achieved by overlaying two layers of dielectric substrate each of thickness 1.52 mm. The scattering parameter of the device has been measured with the Agilent Technologies N5224A Network Analyzer.  In Figure 10, the scattering parameter modulus |S 11 | of the SIW antenna versus the frequency with metamaterial lens is illustrated, the measurement is performed with the device that irradiates in air (dashed line) and in the biological tissue of a hand (continuous line) placed at a distance close to D = 10 mm from the SRR superstrate. The comparison highlights a good impedance matching of the microwave applicator loaded with the biological tissue in the frequency range 10.4-11.5 GHz. A scattering parameter modulus |S 11 | minimum of −42 dB at the 10.6 GHz frequency has been measured. Moreover, the measured results are in good agreement with simulated one of Figure 7b, although we can observe a shift of the resonance frequency of few hundred of MHz, in fact a scattering parameter modulus |S 11 | minimum of −36.9 dB at the 10.9 GHz frequency has been simulated. The second resonance frequency at f = 12.7 GHz of the simulated results is less pronounced respect to the experimental results around at f = 12.3 GHz. These differences may be due to manufacturing tolerances and the possible air film between the two layers of the dielectric that constitute the metamaterial lens. Figure 11 shows the measured scattering parameter modulus |S 11 | of the SIW cavity-backed patch antenna, with (continuous line) and without (dashed line) the metamaterial superstrate that irradiates in the biological tissue. We can observe that the electromagnetic field of the antenna without the metamaterial lens is almost completely reflected from human tissue. We underline that the simulations of Figure 8 perfectly agree with the experimental results of Figures 10 and 11. In particular, in Figure 11, the measured scattering parameter modulus |S 11 | in the case of the antenna with SRR metamaterial and tissue (full curve) exhibits a strong dip close to the frequency f = 10.7 GHz. At the frequency f = 11 GHz, the impedance matching is good enough since the measured scattering parameter modulus is close to |S 11 | = −14 dB. In fact, Figure 8a shows a homogeneous propagation/distribution of the simulated electromagnetic field. Moreover, Figure 11 shows that the measured scattering parameter modulus in the case of antenna and tissue without SRR metamaterial (dashed curve) is close to |S 11 | = −4 dB. This implies an impedance mismatch, the presence of the stationary wave and a not homogeneous distribution of the simulated electromagnetic field with nodal regions. It is in perfect agreement with the simulation in Figure 8b. In other words, the SRR metamaterial provides an impedance matching and a consequent suppression of the reflected wave.     The SIW antenna covered by the metamaterial layer has been characterized with the antenna measurement system in anechoic chamber, StarLab SATIMO, shown in Figure 12. The measured gain of the antenna with and without the metamaterial is illustrated in Figure 13, we can observe that SRR superstrate produces an improvement of the gain in the frequency range over f = 11 GHz with an increasement of 4 dB at f = 12.2 GHz. Figure 11. Measured scattering parameter modulus | | versus frequency of SIW cavity-backed patch antenna with (continuous line) and without (dashed line) the metamaterial superstrate that irradiates in the biological tissue.    Even if the aim of the paper is the optimization of the impedance matching with the biological tissue, we performed the simulation of the SIW cavity-backed patch antenna covered by the metamaterial and loaded with a biological tissue, i.e., a slab of skin-fat-muscle, whose electromagnetic parameters at the f = 11 GHz frequency are reported in Table 3, in order to compare the proposed device with the literature. A comparison with other microwave applicators is complex, due to the large variety of parameters characterizing the investigations reported in literature, among which the kind of antenna, frequency, kind of metamaterial, applied microwave power and obtained performances characterized in terms of Heating Zone Dimension (HZD), SAR zone, maximum temperature at focusing depth, etc.
For the proposed applicator, the peak SAR averaged over the mass m = 1 g and over the mass m = 10 g, the 50% SAR zone, the 42 • C HZD, for an input power P = 1 W at f = 11 GHz frequency are evaluated, in the case of the microwave applicator placed at distance D = 10 mm from the skin surface of the human tissue. Table 4 shows that the obtained results are interesting if compared with those from the literature. The reduced HZD zone and high SAR peak evidence the strong focusing obtained via the designed SRR metamaterial. This paves the way for promising novel applications.

Conclusions
A metamaterial lens based on SRR has been designed to be employed as a lens to be put on an SIW cavity-backed patch antenna in order to improve the impedance matching of the antenna when loaded with human tissue and to enhance the focusing of the electromagnetic field into the biological tissue to be treated. A prototype has been fabricated employing the standard, low cost PCB technology and has been characterized by using a Network Analyzer. The simulated scattering parameter modulus of the antenna loaded with the biological tissue with and without metamaterial lens is |S 11 | = −37 dB and |S 11 | = −14 dB at the f = 11 GHz frequency, respectively. The measured minimum of the scattering parameter modulus |S 11 | = −42 dB has been measured at the f = 10.6 GHz frequency. The experimental results are in good agreement the simulations. The impedance matching improvement has been proved. The electromagnetic field distributions simulated have highlighted the focusing capability of the metamaterial lens. The antenna measurement in the anechoic chamber has confirmed that this kind of SRR lens can find actual application to focus the electromagnetic field of microwave applicators used in dermatology for the thermal therapy of skin cancer.