Heart Rate Variability and Electrocardiographic Parameters Predictive of Arrhythmias in Dogs with Stage IV Chronic Kidney Disease Undergoing Intermittent Haemodialysis
Abstract
:Simple Summary
Abstract
1. Introduction
2. Animals, Materials and Methods
2.1. Animals and Study Design
2.2. Conventional CKD Treatment
2.3. Intermittent Haemodialysis (IHD)
2.4. Clinical and Laboratory Evaluations
2.5. Electrocardiogram
2.6. Heart Rate Variability (HRV)
2.7. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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1st Session | 2nd Session | 3rd Session | |||||
---|---|---|---|---|---|---|---|
Arrhythmias | CT | IHD | CT | IHD | CT | IHD | |
ST | Before | n = 2 | n = 0 | n = 1 | n = 0 | n = 3 | n = 2 |
After | n = 2 | n = 0 | n = 2 | n = 2 | n = 33 | n = 2 | |
1st Degree AVB | Before | n = 1 | n = 1 | n = 1 | n = 1 | n = 1 | n = 1 |
After | n = 1 | n = 1 | n = 1 | n = 1 | n = 1 | n = 1 | |
Isolated APC | Before | n = 0 | n = 0 | n = 1 | n = 0 | n = 0 | n = 0 |
After | n = 0 | n = 0 | n = 0 | n = 1 | n = 0 | n = 0 | |
Sinus arrest | Before | n = 0 | n = 0 | n = 0 | n = 1 | n = 0 | n = 0 |
After | n = 0 | n = 1 | n = 0 | n = 3 | n = 0 | n = 0 | |
Paroxysmal AT | Before | n = 0 | n = 0 | n = 0 | n = 0 | n = 0 | n = 1 |
After | n = 0 | n = 0 | n = 0 | n = 2 | n = 0 | n = 1 | |
Sustained AT | Before | n = 0 | n = 0 | n = 0 | n = 0 | n = 0 | n = 0 |
After | n = 0 | n = 0 | n = 0 | n = 0 | n = 0 | n = 1 | |
Isolated VPC | Before | n = 0 | n = 1 | n = 0 | n = 0 | n = 0 | n = 1 |
After | n = 0 | n = 0 | n = 0 | n = 0 | n = 0 | n = 0 |
1st Session | 2nd Session | 3rd Session | |||||
---|---|---|---|---|---|---|---|
Parameters | CT | IHD | CT | IHD | CT | IHD | |
HR (bpm) | Before | 135.0 ± 33.69 | 119.0 ± 20.85 | 128.0 ± 24.51 | 120.0 ± 26.14 | 142.0 ± 30.34 | 133.0 ± 24.37 |
After | 129.0 ± 33.38 | 124.0 ± 24.30 | 128.0 ± 28.20 | 138.0 ± 31.65 | 141.0 ± 30.89 | 140.0 ± 36.83 | |
Pmax (s) | Before | 0.059 ± 0.005 | 0.059 ± 0.005 | 0.059 ± 0.007 | 0.058 ± 0.007 | 0.058 ± 0.007 | 0.059 ± 0.007 |
After | 0.06 ± 0.007 | 0.062 ± 0.007 | 0.058 ± 0.008 | 0.058 ± 0.008 | 0.06 ± 0.007 | 0.062 ± 0.007 | |
Pmin (s) | Before | 0.046 ± 0.006 | 0.044 ± 0.006 | 0.048 ± 0.006 | 0.042 ± 0.006 | 0.047 ± 0.007 | 0.043 ± 0.007 |
After | 0.05 ± 0.006 | 0.049 ± 0.006 | 0.046 ± 0.006 | 0.043 ± 0.006 | 0.049 ± 0.006 | 0.044 ± 0.006 | |
dP (s) | Before | 0.014 ± 0.009 | 0.014 ± 0.004 | 0.011 ± 0.006 | 0.015 ± 0.008 | 0.011 ± 0.006 a* | 0.016 ± 0.005 b* |
After | 0.01 ± 0.003 a* | 0.013 ± 0.004 b* | 0.012 ± 0.009 | 0.015 ± 0.005 | 0.011 ± 0.006 a* | 0.018 ± 0.007 b* | |
QTmax (s) | Before | 0.213 ± 0.021 | 0.224 ± 0.017 | 0.213 ± 0.018 | 0.21 ± 0.019 | 0.207 ± 0.024 | 0.2 ± 0.014 |
After | 0.212 ± 0.020 a** | 0.233 ± 0.018 b** | 0.214 ± 0.019 | 0.212 ± 0.021 | 0.212 ± 0.026 | 0.202 ± 0.019 | |
QTmin (s) | Before | 0.198 ± 0.020 | 0.208 ± 0.017 | 0.199 ± 0.021 | 0.191 ± 0.017 | 0.19 ± 0.024 | 0.182 ± 0.012 |
After | 0.194 ± 0.022 | 0.209 ± 0.019 | 0.196 ± 0.020 | 0.189 ± 0.025 | 0.195 ± 0.028 | 0.184 ± 0.020 | |
dQT (s) | Before | 0.015 ± 0.005 | 0.016 ± 0.005 | 0.014 ± 0.007 | 0.019 ± 0.007 | 0.017 ± 0.006 | 0.018 ± 0.008 |
After | 0.018 ± 0.013 a* | 0.024 ± 0.009 b* | 0.017 ± 0.008 | 0.02 ± 0.005 | 0.017 ± 0.008 | 0.017 ± 0.005 |
1st Session | 2nd Session | 3rd Session | |||||
---|---|---|---|---|---|---|---|
Parameters | CT | IHD | CT | IHD | CT | IHD | |
HR (bpm) | Before | 135.0 ± 37.5 | 120.7 ± 32.23 | 139.7 ± 33.25 | 133.3 ± 32.39 | 135.3 ± 22.63 | 132.5 ± 28.95 |
After | 140.0 ± 35.95 | 115.5 ± 34.25 | 136.0 ± 29.26 | 138.7 ± 37.30 | 137.9 ± 36.43 | 146.3 ± 28.26 | |
RR (ms) | Before | 470.2 ± 112.2 | 528.8 ± 141.7 | 452.1 ± 117.18 | 475.0 ± 124.78 | 453.3 ± 76.0 | 474.0 ± 119.94 |
After | 451.6 ± 108.24 | 567.1 ± 191.4 | 454.5 ± 78.72 | 466.6 ± 147.38 | 465.8 ± 137.15 | 422.4 ± 81.98 | |
RMSSD (ms) | Before | 42.81 ± 39.6 | 78.41 ± 65.31 | 22.86 ± 10.51 | 85.41 ± 65.82 | 25.46 ± 16.23 a* | 67.99 ± 41.06 b* |
After | 27.18 ± 16.32 a* | 119.7 ± 60.28 b* | 31.51 ± 14.80 | 85.51 ± 78.33 | 40.63 ± 24.77 | 42.14 ± 33.45 | |
SDNN (ms) | Before | 39.21 ± 34.78 | 57.61 ± 0.5 | 19.53 ± 9.64 | 65.71 ± 54.91 | 20.93 ± 14.21 a** | 66.52 ± 48.26 b** |
After | 22.83 ± 11.23 a* | 90.52 ± 76.98 b* | 30.52 ± 15.64 | 76.46 ± 53.42 | 29.38 ± 22.15 | 38.28 ± 31.85 | |
LF (n.u.) | Before | 30.3 ± 17.25 | 22.65 ± 15.48 | 35.68 ± 22.02 | 32.11 ± 26.44 | 31.2 ± 17.28 | 32.13 ± 20.12 |
After | 38.0 ± 18.75 b** | 22.64 ± 11.74 a** | 28.25 ± 13.52 | 35.75 ± 20.88 | 29.55 ± 16.59 | 32.64 ± 21.36 | |
HF (n.u.) | Before | 69.27 ± 17.21 | 76.99 ± 15.41 | 63.68 ± 21.6 | 67.46 ± 26.2 | 68.22 ± 17.14 | 67.51 ± 19.86 |
After | 63.33 ± 18.66 | 73.99 ± 21.26 | 71.33 ± 23.52 | 64.03 ± 20.94 | 69.73 ± 16.36 | 66.81 ± 21.09 | |
LF/HF | Before | 0.53 ± 0.49 | 0.35 ± 0.34 | 0.75 ± 0.65 | 0.76 ± 0.66 | 0.54 ± 0.41 | 0.6 ± 0.5 |
After | 1.12 ± 1.02 | 0.41 ± 0.40 | 0.6 ± 0.50 | 0.73 ± 0.63 | 0.48 ± 0.32 | 0.64 ± 0.57 |
1st Session | 2nd Session | 3rd Session | |||||
---|---|---|---|---|---|---|---|
Parameters | CT | IHD | CT | IHD | CT | IHD | |
K (mEq/L) | Before | 4.3 ± 0.74 b** | 2.42 ± 0.69 a** | 4.32 ± 0.5 b* | 2.52 ± 0.57 a* | 4.54 ± 0.38 b** | 2.8 ± 0.86 a** |
After | 4.27 ± 0.74 b** | 2.08 ± 0.42 a** | 4.46 ± 0.44 b** | 2.14 ± 0.4 a** | 4.42 ± 0.73 b** | 2.25 ± 0.47 a** | |
Na (mEq/L) | Before | 143.8 ± 2.34 a*** | 145.7 ± 5.0 b*** | 143.4 ± 1.07 a** | 146.3 ± 4.22 b** | 143.7 ± 1.82 a* | 145.4 ± 3.68 b* |
After | 143.9 ± 3.34 a*** | 146.0 ± 2.58 b*** | 143.8 ± 1.62 a*** | 146.2 ± 3.12 b*** | 143.6 ± 2.06 a* | 145.9 ± 2.55 b* | |
Mg (mg/dL) | Before | 2.94 ± 2.21 a* | 3.73 ± 0.61 b* | 1.81 ± 0.52 a*** | 3.57 ± 0.63 b*** | 1.85 ± 0.64 a*** | 4.46 ± 1.08 b*** |
After | 2.38 ± 1.99 a* | 3.04 ± 0.48 b* | 1.64 ± 0.45 a*** | 3.13 ± 0.36 b*** | 1.79 ± 0.70 a** | 3.69 ± 1.21 b** | |
iCa (mmol/L) | Before | 0.7 ± 0.15 | 0.79 ± 0.23 | 0.7 ± 0.15 | 0.82 ± 0.28 | 0.74 ± 0.15 | 0.83 ± 0.15 |
After | 0.73 ± 0.15 | 0.72 ± 0.15 | 0.7 ± 0.16 | 0.84 ± 0.17 | 0.62 ± 0.11 a** | 0.83 ± 0.15 b** | |
P (mg/dL) | Before | 13.91 ± 5.68 | 23.3 ± 22.6 | 12.32 ± 4.9 | 8.95 ± 3.66 | 13.9 ± 5.31 | 11.39 ± 3.44 |
After | 12.2 ± 3.34 b* | 9.28 ± 9.2 a* | 12.29 ± 5.14 b* | 5.84 ± 2.69 a* | 12.86 ± 5.12 b*** | 5.37 ± 1.38 a*** | |
Cr (mg/dL) | Before | 8.16 ± 3.17 | 8.07 ± 3.7 | 8.46 ± 3.16 | 6.97 ± 2.63 | 8.75 ± 3.65 | 7.13 ± 2.13 |
After | 7.9 ± 3.12 b** | 4.44 ± 1.66 a** | 7.82 ± 2.87 b** | 3.89 ± 1.86 a** | 8.07 ± 3.67 b** | 3.35 ± 1.79 a** | |
Urea (mg/dL) | Before | 260.0 ± 71.14 | 313.6 ± 127.78 | 259.2 ± 63.73 | 229.4 ± 108.68 | 264.0 ± 80.61 | 234.0 ± 76.04 |
After | 255.8 ± 73.15 | 191.0 ± 85.95 | 261.6 ± 77.45 b* | 126.0 ± 58.63 a* | 255.5 ± 69.15 b** | 112.5 ± 52.35 a** | |
HCO3 (mg/dL) | Before | 14.9 ± 1.69 | 16.89 ± 5.44 | 16.43 ± 2.92 | 18.84 ± 4.68 | 16.18 ± 2.15 | 17.97 ± 3.04 |
After | 16.34 ± 1.49 a*** | 21.62 ± 4.35 b*** | 17.03 ± 1.49 a*** | 23.74 ± 4.13 b*** | 16.36 ± 2.27 a** | 24.52 ± 4.55 b** | |
pH | Before | 7.29 ± 0.04 | 7.31 ± 0.1 | 7.32 ± 0.04 | 7.35 ± 0.7 | 7.3 ± 0.04 | 7.34 ± 0.062 |
After | 7.31 ± 0.04 a** | 7.39 ± 0.08 a** | 7.33 ± 0.04 a** | 7.42 ± 0.077 b** | 7.32 ± 0.04 a** | 7.4 ± 0.067 b** | |
SBP (mmHg) | Before | 175.0 ± 27.75 | 162.0 ± 35.53 | 165.0 ± 24.71 | 171.0 ± 25.82 | 154.0 ± 34.58 | 166.0 ± 24.04 |
After | 180 ± 29.0 | 155.0 ± 29.21 | 176.0 ± 25.0 | 158.0 ± 31.10 | 167.0 ± 31.66 | 161.0 ± 26.04 |
Parameters | Control | CT | IHD |
---|---|---|---|
HR (bpm) | 131.0 ± 26.38 | 141 ± 30.89 | 140.0 ± 36.83 |
P max (s) | 0.044 ± 0.005 a* | 0.06 ± 0.007 b* | 0.062 ± 0.007 b* |
P min (s) | 0.04 ± 0.005 a** | 0.049 ± 0.006 b** | 0.044 ± 0.006 |
dP (s) | 0.004 ± 0.001 a** | 0.011 ± 0.006 b** | 0.018 ± 0.007 b** |
QT max (s) | 0.192 ± 0.033 | 0.212 ± 0.026 | 0.202 ± 0.019 |
QT min (s) | 0.188 ± 0.033 | 0.195 ± 0.028 | 0.184 ± 0.020 |
dQT (s) | 0.004 ± 0.002 a** | 0.017 ± 0.008 b** | 0.017 ± 0.005 b** |
RR (ms) | 463.9 ± 94.4 | 465.8 ± 137.15 | 422.4 ± 81.98 |
RMSSD (ms) | 74.05 ± 52.86 | 40.63 ± 24.77 | 42.14 ± 33.45 |
SDNN (ms) | 58.22 ± 44.46 | 29.38 ± 22.15 | 38.28 ± 31.85 |
LF (nu) | 19.69 ± 14.49 | 29.55 ± 16.59 | 32.64 ± 21.36 |
HF (nu) | 79.52 ± 14.08 | 69.73 ± 16.36 | 66.81 ± 21.09 |
LF/HR | 0.28 ± 0.25 | 0.48 ± 0.32 | 0.64 ± 0.57 |
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Alfonso, A.; Le Sueur, A.N.V.; Geraldes, S.S.; Guimarães-Okamoto, P.T.C.; Tsunemi, M.H.; Santana, D.F.; Ribeiro, V.R.F.; Melchert, A.; Chiacchio, S.B.; Lourenço, M.L.G. Heart Rate Variability and Electrocardiographic Parameters Predictive of Arrhythmias in Dogs with Stage IV Chronic Kidney Disease Undergoing Intermittent Haemodialysis. Animals 2020, 10, 1829. https://doi.org/10.3390/ani10101829
Alfonso A, Le Sueur ANV, Geraldes SS, Guimarães-Okamoto PTC, Tsunemi MH, Santana DF, Ribeiro VRF, Melchert A, Chiacchio SB, Lourenço MLG. Heart Rate Variability and Electrocardiographic Parameters Predictive of Arrhythmias in Dogs with Stage IV Chronic Kidney Disease Undergoing Intermittent Haemodialysis. Animals. 2020; 10(10):1829. https://doi.org/10.3390/ani10101829
Chicago/Turabian StyleAlfonso, Angélica, André N. V. Le Sueur, Silvano S. Geraldes, Priscylla T. C. Guimarães-Okamoto, Miriam H. Tsunemi, Daniela F. Santana, Victor R. F. Ribeiro, Alessandra Melchert, Simone B. Chiacchio, and Maria Lucia G. Lourenço. 2020. "Heart Rate Variability and Electrocardiographic Parameters Predictive of Arrhythmias in Dogs with Stage IV Chronic Kidney Disease Undergoing Intermittent Haemodialysis" Animals 10, no. 10: 1829. https://doi.org/10.3390/ani10101829