Biodegradable Implantation Material: Mechanical Properties and Surface Corrosion Mechanism of Mg-1Ca-0.5Zr Alloy

: Mg alloy is suitable for biomedical implants as the mechanical properties of Mg are close to those of human bone. Ca is a major element in bone and Zr has a great grain reﬁnement e ﬀ ect. Hence, we developed Mg-1Ca-0.5Zr alloy (XK105) as a biodegradable biomaterial and investigated its mechanical properties and surface corrosion mechanism. The results showed that heat treatment made the secondary phase homogeneous. Tensile tests showed that the heat treatment increased ductility, and that the tensile stress results in the extrusion direction showed better ductility than that in the transverse direction because of the ﬁber texture and extrusion characteristics. Electrochemistry test results showed that XK105 after heat treatment had a lower corrosion rate than that before heat treatment and that of pure Mg. XK105 after heat treatment formed a calcium phosphate layer after immersion in simulated body ﬂuid; this layer protects Mg from corrosion. Surface roughening treatment increased corrosion because pits on the surface promoted pitting corrosion. This study developed Mg-1Ca-0.5Zr alloy as a biomedical implant material. The results can be used as a reference for the biomedical material industry. spectrometry (EDS) used elemental composition semi-quantitative analysis. This study used tensile tests to determine the tensile strength of the extruded proﬁles of XK105 and the mechanical properties after heat treatment. Three specimens of XK105-F were taken along the extrusion direction (ED) and the transverse direction (TD). After the samples were cut to an appropriate size, they were punched into a ﬁxed size using a punch press. A stretching test was conducted with an initial strain rate of 8.3 × 10 − 4 s − 1 at room temperature. We used SEM and EDS to investigate the stretch-breaking behavior. This study developed a biomedical implant material, Mg-1Ca-0.5Zr alloy. The results can be used as a reference for the biomedical material industry.


Introduction
Common biomedical implant materials include metals, polymers, and ceramics. Metal-based biomedical materials have better mechanical properties than those of polymers and ceramics [1] and are thus much more widely used in practical applications. Common metal-based biomedical materials such as stainless steel [2], Ti alloys [3], and Co-based alloys [4] have elastic moduli that are very different from that of human bone. This leads to a stress shielding effect, which makes new bone tissues lack stimulation during growth and leads to insufficient recovery of bone strength [5]. Another disadvantage of common metal-based biomedical materials is their non-degradability [6]; they must be removed in a second operation after the affected area has recovered.
In view of these issues, Mg alloys have been developed as next-generation biomedical materials [7]. Mg alloys have several advantages as biomaterials. Mg is an essential mineral nutrient, so it has good biosafety [8]. Mg alloys have biomechanical properties similar to those of human bone, which can avoid stress shielding effects and improve the strength of bone tissue after healing [9]. Mg is degradable in vivo, and when used for short-term implants, it does not need to be removed in a second operation [10]. The products produced by the degradation of Mg in vivo can be excreted through the kidney [11]. Mg alloy combines well with surrounding bone tissues after degradation and accelerates the formation of biological calcium phosphate [12]. Mg alloys can stimulate the differentiation and growth of osteoblasts and promote bone tissue production [13].

Material and Methods
Mg-1Ca-0.5Zr was produced in a smelting furnace. A 99.9 wt.% pure Mg block was placed in a stainless-steel bowl and heated to 700 • C until the Mg block had completely melted into a liquid state. Then, Mg-20Ca and Mg-33Zr blocks were placed into the molten Mg. After the alloy blocks had melted completely, the molten alloy was poured into a mold and allowed to cool in air to room temperature. For all casting, argon was used as a protective gas. The casting product, Mg-1Ca-0.5Zr alloy, is denoted as XK105 following the ASTM (American Society for Testing and Materials) naming convention. For experiments, we processed XK105 into an extruded sheet, denoted as XK105-F. To enhance the mechanical properties, XK105 was subjected to heat treatment at 400 • C for 8 h in an air furnace. To decrease the formation of the crystalline phase, the alloy was water-quenched after heat treatment. The heat-treated XK105 is denoted XK105-H.
For microstructural observation, epoxy was used to cold-mount and embed XK105-F and XK105-H. The samples were then polished using 1 and 0.3 µm aluminum oxide powder. After polishing, the samples were corroded using a solution of 4.2 g of picric acid, 10 mL of acetic acid, and 90 mL of ethanol. The microstructure was observed using light microscopy (LM) (ZEISS, Oberkochen, Germany) and scanning electron microscopy (SEM) (HITACHI, Tokyo, Japan). Energy-dispersive X-ray spectrometry (EDS) was used for elemental composition semi-quantitative analysis.
This study used tensile tests to determine the tensile strength of the extruded profiles of XK105 and the mechanical properties after heat treatment. Three specimens of XK105-F were taken along the extrusion direction (ED) and the transverse direction (TD). After the samples were cut to an appropriate size, they were punched into a fixed size using a punch press. A stretching test was conducted with an initial strain rate of 8.3 × 10 −4 s −1 at room temperature. We used SEM and EDS to investigate the stretch-breaking behavior.
An erosion wear test was conducted using XK105-F and XK105-H. A particle spray tester (Chun Yen Testing Machines Co., Taichung, Taiwan) was used for erosion wear and surface roughening. The environmental conditions in the erosion wear test were room temperature and a relative humidity of 50% to 70%. The erosion particles were Al 2 O 3 (average diameter: 150 µm) and SiO 2 (average diameter: 295 µm), and the erosion angle was 15 • to 90 • . The particle rate of erosion was 1.2 g/s, and the pressure was set to 3 kg/cm 2 (0.29 MPa). The average jet rate of Al 2 O 3 was calculated as 73 m/s, and that of SiO 2 was 66 m/s. Surface roughening treatment was conducted at erosion angles of 15 • , 45 • , and 90 • . After surface roughening, the samples were observed using LM and SEM.
A potentiodynamic polarization test was conducted using pure Mg, XK105-F, and XK105-H samples. In the test, a three-electrode system was used to obtain the polarization curve. The reference electrode was a saturated calomel electrode (SCE), the salt bridge was saturated KCl solution, and the auxiliary electrode was a platinum electrode. The specimens were embedded in epoxy resin and then carefully ground. The employed electrolyte was a revised simulated body fluid (R-SBF) solution [30], which has ion composition and concentration similar to those of human blood plasma. The scan rate in the polarization test was 1 mV/s, from −2.2 to −1.2 V, and a constant temperature of 37 • C was used. The polarization curve has a linear Tafel region around the corrosion potential. The corrosion current can be obtained from the anodization curves using the extrapolation method.
The immersion test was used to evaluate the corrosion rate. The corrosion rate was calculated as: where m 1 is the mass after immersion, m 0 is the mass before immersion, A is the total surface area of the sample, and T is the immersion time. The immersion solution was R-SBF. XK105-H and surfaceroughened XK105-H sampled were immersed in R-SBF for 1, 3, and 7 days at a constant temperature of 37 • C. Figure 1a,b respectively show metallographic images of XK105-F and XK105-H observed using LM. Crystal phases appear along ED for XK105-F. The crystal phases of XK105-H were not along ED. This indicates that heat treatment made the crystal phases dissolve into the matrix, homogenizing the material. The grains were subjected to dynamic recrystallization during extrusion, and thus isometric crystals formed. The calculated average grain sizes of XK105-F and XK105-H were 14.2 and 17.1 µm, respectively. The environmental conditions in the erosion wear test were room temperature and a relative humidity of 50% to 70%. The erosion particles were Al2O3 (average diameter: 150 μm) and SiO2 (average diameter: 295 μm), and the erosion angle was 15° to 90°. The particle rate of erosion was 1.2 g/s, and the pressure was set to 3 kg/cm 2 (0.29 MPa). The average jet rate of Al2O3 was calculated as 73 m/s, and that of SiO2 was 66 m/s. Surface roughening treatment was conducted at erosion angles of 15°, 45°, and 90°. After surface roughening, the samples were observed using LM and SEM. A potentiodynamic polarization test was conducted using pure Mg, XK105-F, and XK105-H samples. In the test, a three-electrode system was used to obtain the polarization curve. The reference electrode was a saturated calomel electrode (SCE), the salt bridge was saturated KCl solution, and the auxiliary electrode was a platinum electrode. The specimens were embedded in epoxy resin and then carefully ground. The employed electrolyte was a revised simulated body fluid (R-SBF) solution [30], which has ion composition and concentration similar to those of human blood plasma. The scan rate in the polarization test was 1 mV/s, from −2.2 to −1.2 V, and a constant temperature of 37 °C was used. The polarization curve has a linear Tafel region around the corrosion potential. The corrosion current can be obtained from the anodization curves using the extrapolation method.

Metallographic Analysis
The immersion test was used to evaluate the corrosion rate. The corrosion rate was calculated as: where m1 is the mass after immersion, m0 is the mass before immersion, A is the total surface area of the sample, and T is the immersion time. The immersion solution was R-SBF. XK105-H and surface-roughened XK105-H sampled were immersed in R-SBF for 1, 3, and 7 days at a constant temperature of 37 °C. Figure 1a,b respectively show metallographic images of XK105-F and XK105-H observed using LM. Crystal phases appear along ED for XK105-F. The crystal phases of XK105-H were not along ED. This indicates that heat treatment made the crystal phases dissolve into the matrix, homogenizing the material. The grains were subjected to dynamic recrystallization during extrusion, and thus isometric crystals formed. The calculated average grain sizes of XK105-F and XK105-H were 14.2 and 17.1 μm, respectively. SEM observation was conducted to verify the secondary phases of XK105. A Ca-rich crystal phase can be seen in Figure 2a; the phase was identified as Mg2Ca [31]. Most of the Mg2Ca phase was along ED. A Zr-rich phase can be seen in Figure 2b; the phase was identified as pure Zr particles which accumulated at grains [32].  SEM observation was conducted to verify the secondary phases of XK105. A Ca-rich crystal phase can be seen in Figure 2a; the phase was identified as Mg 2 Ca [31]. Most of the Mg 2 Ca phase was along ED. A Zr-rich phase can be seen in Figure 2b; the phase was identified as pure Zr particles which accumulated at grains [32].  Figure 3; Figure 4 respectively show the tensile stress-strain curve and tensile stress of XK105. The tensile stress of XK105-F along TD is about 220 MPa. According to reference [33], the tensile stress along TD of pure Mg was 173 MPa, and which of Mg-0.1Ca was 180 MPa. The tensile stress of human bone is about 150 MPa. XK105 thus has sufficient tensile strength to apply to stress load in the human body. The yield stress of XK105-F along TD was about 180 MPa, which of pure Mg was 103 MPa and which of Mg-0.1Ca was 92 MPa [33]. The results showed the adding Zr can improve the tensile strength effectively. Figure 5 shows the elongation of XK105. The elongation was about 4-8% and was caused by the addition of Ca [34]. Elongation increased after heat treatment because of the homogenization of textures and the solid solution of the secondary phases. Figure 6 shows the Young's modulus of XK105. The value is about 35-55 GPa; it increased after heat treatment because the Ca atoms dissolved into the matrix and changed the lattice. Although the Young's modulus of XK105 is much higher than that of human bone (3-20 GPa), it has greater similarity compared to other medical implant materials. The tensile strength along TD is higher than that along ED. The XRD pattern ( Figure 7) shows that the mean peak along ED was (101 1). This is due to the HCP crystals slipping along ED, which led to a small angle between the (0001) plane and ED. When the tensile strength transferred toward ED, the dislocations more easily slipped compared to that toward TD. Therefore, the elongation of XK105 along ED was higher but the tensile stress was lower compared to those along TD.  The tensile stress of XK105-F along TD is about 220 MPa. According to reference [33], the tensile stress along TD of pure Mg was 173 MPa, and which of Mg-0.1Ca was 180 MPa. The tensile stress of human bone is about 150 MPa. XK105 thus has sufficient tensile strength to apply to stress load in the human body. The yield stress of XK105-F along TD was about 180 MPa, which of pure Mg was 103 MPa and which of Mg-0.1Ca was 92 MPa [33]. The results showed the adding Zr can improve the tensile strength effectively. Figure 5 shows the elongation of XK105. The elongation was about 4-8% and was caused by the addition of Ca [34]. Elongation increased after heat treatment because of the homogenization of textures and the solid solution of the secondary phases. Figure 6 shows the Young's modulus of XK105. The value is about 35-55 GPa; it increased after heat treatment because the Ca atoms dissolved into the matrix and changed the lattice. Although the Young's modulus of XK105 is much higher than that of human bone (3-20 GPa), it has greater similarity compared to other medical implant materials. The tensile strength along TD is higher than that along ED. The XRD pattern ( Figure 7) shows that the mean peak along ED was (1011). This is due to the HCP crystals slipping along ED, which led to a small angle between the (0001) plane and ED. When the tensile strength transferred toward ED, the dislocations more easily slipped compared to that toward TD. Therefore, the elongation of XK105 along ED was higher but the tensile stress was lower compared to those along TD.

Tensile Properties and Fracture Morphology
higher than that along ED. The XRD pattern (Figure 7) shows that the mean peak along ED was (101 1). This is due to the HCP crystals slipping along ED, which led to a small angle between the (0001) plane and ED. When the tensile strength transferred toward ED, the dislocations more easily slipped compared to that toward TD. Therefore, the elongation of XK105 along ED was higher but the tensile stress was lower compared to those along TD.               Figure 8a,b shows the tensile fracture morphology of XK105-H on the ED plane. Dimples can be observed on the fracture surface. Mg2Ca, which did not dissolve into the matrix, appears inside the dimples. Figure 8c,d shows the tensile fracture morphology of XK105-H on the TD plane. Thin wall structures can be observed. These structures are cleavages of brittle failure.

Fracture Toughness
Medical implants easily deform when subjected to a stress impact. The fracture toughness of XK105 is thus an important property. Figure 9 shows the fracture toughness of XK105. The fracture

Fracture Toughness
Medical implants easily deform when subjected to a stress impact. The fracture toughness of XK105 is thus an important property. Figure 9 shows the fracture toughness of XK105. The fracture toughness was lower when the stress was applied toward TD. There is a non-plane strain of XK105, and it showed that the thickness of material was not thick enough to fracture as a plane strain. LM observations indicate that the fracture cracks had more bending along ED than TD, as shown in Figure 10a,c. The cracks thus required more energy to spread, so the toughness of the sample along ED was higher than that along TD. Figure 10b,d show the fracture surface of XK105-H. A smoother fracture surface, which resulted from brittle fracture on the TD plane, can be observed. Therefore, toughness on the TD plane was lower than that on the ED plane. Figure 11 shows the secondary surface morphology and fracture mechanism. The end of the crack on the ED plane has a branch morphology; the branching of that on the TD plane is not obvious. This was caused by the brittle secondary phase easily cracking when subjected to stress; the cracks spread along TD while tensile stress was applied along ED. The density of the secondary phase was thus lower on the crack-spreading path. Therefore, the cracks on the ED plane easily branched and had much longer spreading paths than those of cracks on the TD plane.
surface morphology and fracture mechanism. The end of the crack on the ED plane has a branch morphology; the branching of that on the TD plane is not obvious. This was caused by the brittle secondary phase easily cracking when subjected to stress; the cracks spread along TD while tensile stress was applied along ED. The density of the secondary phase was thus lower on the crack-spreading path. Therefore, the cracks on the ED plane easily branched and had much longer spreading paths than those of cracks on the TD plane.   morphology; the branching of that on the TD plane is not obvious. This was caused by the brittle secondary phase easily cracking when subjected to stress; the cracks spread along TD while tensile stress was applied along ED. The density of the secondary phase was thus lower on the crack-spreading path. Therefore, the cracks on the ED plane easily branched and had much longer spreading paths than those of cracks on the TD plane.    Figure 12 shows the relationship between erosion rate and erosion angle. For both Al2O3 or SiO2, the angle for the highest erosion rate changed from 45° to 30° after heat treatment. This shows that XK105 had lower hardness and higher ductility after heat treatment. The erosion rate obtained with Al2O3 particles was higher than that obtained with SiO2 due to the higher hardness of Al2O3.  Figure 13 shows the surface roughness after the erosion test. The roughness obtained with Al2O3 and SiO2 was similar. The highest and lowest roughness was obtained with erosion angles of 90° and 15°, respectively. The measurement of these erosion properties could be applied to later experiments to clarify the relationship between anti-corrosion ability and surface roughness. This will have a benefit of increasing the bioreactivity for medical applications.  Figure 12 shows the relationship between erosion rate and erosion angle. For both Al 2 O 3 or SiO 2 , the angle for the highest erosion rate changed from 45 • to 30 • after heat treatment. This shows that XK105 had lower hardness and higher ductility after heat treatment. The erosion rate obtained with Al 2 O 3 particles was higher than that obtained with SiO 2 due to the higher hardness of Al 2 O 3 .  Figure 12 shows the relationship between erosion rate and erosion angle. For both Al2O3 or SiO2, the angle for the highest erosion rate changed from 45° to 30° after heat treatment. This shows that XK105 had lower hardness and higher ductility after heat treatment. The erosion rate obtained with Al2O3 particles was higher than that obtained with SiO2 due to the higher hardness of Al2O3.  Figure 13 shows the surface roughness after the erosion test. The roughness obtained with Al2O3 and SiO2 was similar. The highest and lowest roughness was obtained with erosion angles of 90° and 15°, respectively. The measurement of these erosion properties could be applied to later experiments to clarify the relationship between anti-corrosion ability and surface roughness. This will have a benefit of increasing the bioreactivity for medical applications.  Figure 13 shows the surface roughness after the erosion test. The roughness obtained with Al 2 O 3 and SiO 2 was similar. The highest and lowest roughness was obtained with erosion angles of 90 • and 15 • , respectively. The measurement of these erosion properties could be applied to later experiments to clarify the relationship between anti-corrosion ability and surface roughness. This will have a benefit of increasing the bioreactivity for medical applications. Metals 2019, 9, x FOR PEER REVIEW 9 of 14 Figure 13. Surface roughness of XK105-H after erosion test.

Potentiodynamic Polarization Test
The potentiodynamic polarization test was used to analyze the corrosion rate of XK105 in simulated body fluid. Surface roughening treatment can effectively increase cell adhesion [35]. Therefore, in this study, surface roughen treatment using the particle erosion wear method was applied. The potentiodynamic polarization test was conducted to determine anti-corrosion ability. The electrochemical properties of XK105 calculated from the potentiodynamic polarization test results are shown in Table 1. The results show that heat treatment improved the anti-corrosion property of XK105, making it better than that of pure Mg. This was due to Mg2Ca being dissolved into the matrix during heat treatment, and the effect of galvanic corrosion becoming inactive, which reduced the corrosion current and potential. The potentiodynamic polarization curve is shown in Figure 14. The reduction rate of XK105-F is lower than that of pure Mg. XK105-H had the lowest reduction rate. The low reduction rate represents the low formation rate of H2, which is harmless to the human body. The curves of XK105-F and XK105-H show passivation at a corrosion potential of less than −1.5 V. Passivation was caused by the added Ca, which formed a stable passivation layer to restrain the corrosion compared to pure Mg [36].

Potentiodynamic Polarization Test
The potentiodynamic polarization test was used to analyze the corrosion rate of XK105 in simulated body fluid. Surface roughening treatment can effectively increase cell adhesion [35]. Therefore, in this study, surface roughen treatment using the particle erosion wear method was applied. The potentiodynamic polarization test was conducted to determine anti-corrosion ability. The electrochemical properties of XK105 calculated from the potentiodynamic polarization test results are shown in Table 1. The results show that heat treatment improved the anti-corrosion property of XK105, making it better than that of pure Mg. This was due to Mg 2 Ca being dissolved into the matrix during heat treatment, and the effect of galvanic corrosion becoming inactive, which reduced the corrosion current and potential. The potentiodynamic polarization curve is shown in Figure 14. The reduction rate of XK105-F is lower than that of pure Mg. XK105-H had the lowest reduction rate. The low reduction rate represents the low formation rate of H 2 , which is harmless to the human body. The curves of XK105-F and XK105-H show passivation at a corrosion potential of less than −1.5 V. Passivation was caused by the added Ca, which formed a stable passivation layer to restrain the corrosion compared to pure Mg [36].

Potentiodynamic Polarization Test
The potentiodynamic polarization test was used to analyze the corrosion rate of XK105 in simulated body fluid. Surface roughening treatment can effectively increase cell adhesion [35]. Therefore, in this study, surface roughen treatment using the particle erosion wear method was applied. The potentiodynamic polarization test was conducted to determine anti-corrosion ability. The electrochemical properties of XK105 calculated from the potentiodynamic polarization test results are shown in Table 1. The results show that heat treatment improved the anti-corrosion property of XK105, making it better than that of pure Mg. This was due to Mg2Ca being dissolved into the matrix during heat treatment, and the effect of galvanic corrosion becoming inactive, which reduced the corrosion current and potential. The potentiodynamic polarization curve is shown in Figure 14. The reduction rate of XK105-F is lower than that of pure Mg. XK105-H had the lowest reduction rate. The low reduction rate represents the low formation rate of H2, which is harmless to the human body. The curves of XK105-F and XK105-H show passivation at a corrosion potential of less than −1.5 V. Passivation was caused by the added Ca, which formed a stable passivation layer to restrain the corrosion compared to pure Mg [36].    For surface roughening, 90 • SiO 2 erosion created higher roughness. The electrochemical properties of surface-roughened XK105 are shown in Table 2. The corrosion current was higher after surface roughening treatment. The surface roughening increased the surface area of the material, increasing the corrosion rate [37]. The surface-roughened XK105 did not show passivation around −1.5 V in the potentiodynamic polarization curve because the rough surface made the passivation layer easily peel off after formation.

Immersion Test
To understand the surface corrosion mechanism and quantify the corrosion rate of materials, this study subjected XK105-H and surface-roughened XK105 to an immersion test. The results of the immersion test are shown in Figure 15. The corrosion rate after surface roughening treatment increased greatly, and the corrosion rate of XK105-H was lower than that of pure Mg. The corrosion rate of XK105-H after three days decreased and became stable. This was due to the formation of a surface passivation layer, which restrained the corrosion effect. The phenomenon in which the corrosion rate decreased after three days of surface-roughened XK105 was not obvious relatively, because it did not have a passivation layer. For surface roughening, 90° SiO2 erosion created higher roughness. The electrochemical properties of surface-roughened XK105 are shown in Table 2. The corrosion current was higher after surface roughening treatment. The surface roughening increased the surface area of the material, increasing the corrosion rate [37]. The surface-roughened XK105 did not show passivation around −1.5V in the potentiodynamic polarization curve because the rough surface made the passivation layer easily peel off after formation.

Immersion Test
To understand the surface corrosion mechanism and quantify the corrosion rate of materials, this study subjected XK105-H and surface-roughened XK105 to an immersion test. The results of the immersion test are shown in Figure 15. The corrosion rate after surface roughening treatment increased greatly, and the corrosion rate of XK105-H was lower than that of pure Mg. The corrosion rate of XK105-H after three days decreased and became stable. This was due to the formation of a surface passivation layer, which restrained the corrosion effect. The phenomenon in which the corrosion rate decreased after three days of surface-roughened XK105 was not obvious relatively, because it did not have a passivation layer.  Figure 16 shows the secondary surface of XK105-H and surface-roughened XK105 during the immersion test. XK105-H maintained the integrity of its macroscopic morphology, whereas the surface-roughened XK105 showed pitting corrosion after one day of immersion. The main corrosion mechanism of Mg alloy was pitting corrosion when immersed in R-SBF [30]. The surface roughening treatment created a lot of pits on the surface of the material. These pits promoted pitting corrosion, and thus weight loss due to corrosion was observed on the 7th day of immersion.  Figure 16 shows the secondary surface of XK105-H and surface-roughened XK105 during the immersion test. XK105-H maintained the integrity of its macroscopic morphology, whereas the surfaceroughened XK105 showed pitting corrosion after one day of immersion. The main corrosion mechanism of Mg alloy was pitting corrosion when immersed in R-SBF [30]. The surface roughening treatment created a lot of pits on the surface of the material. These pits promoted pitting corrosion, and thus weight loss due to corrosion was observed on the 7th day of immersion. In Figure 17a, a calcium phosphate layer can be observed on the XK105-H surface after immersion. This layer protected the material against corrosion. Calcium phosphate is the main component of human bone, so this layer could help heal the affected area [38]. In contrast, there was a thick cover layer on the surface of the surface-roughened XK105, as shown in Figure 17b. The cover compound was Mg hydroxide which does not have a healing effect. The formation of calcium phosphate requires a suitable hydroxide ion group to react with [39]. The degradation rate of surface-roughened XK105 was too fast for calcium phosphate to form; instead, Mg hydroxide formed.  In Figure 17a, a calcium phosphate layer can be observed on the XK105-H surface after immersion. This layer protected the material against corrosion. Calcium phosphate is the main component of human bone, so this layer could help heal the affected area [38]. In contrast, there was a thick cover layer on the surface of the surface-roughened XK105, as shown in Figure 17b. The cover compound was Mg hydroxide which does not have a healing effect. The formation of calcium phosphate requires a suitable hydroxide ion group to react with [39]. The degradation rate of surface-roughened XK105 was too fast for calcium phosphate to form; instead, Mg hydroxide formed. In Figure 17a, a calcium phosphate layer can be observed on the XK105-H surface after immersion. This layer protected the material against corrosion. Calcium phosphate is the main component of human bone, so this layer could help heal the affected area [38]. In contrast, there was a thick cover layer on the surface of the surface-roughened XK105, as shown in Figure 17b. The cover compound was Mg hydroxide which does not have a healing effect. The formation of calcium phosphate requires a suitable hydroxide ion group to react with [39]. The degradation rate of surface-roughened XK105 was too fast for calcium phosphate to form; instead, Mg hydroxide formed.  To summarize the above results, Mg-1Ca-0.5Zr biomedical alloy has a suitable degradation rate and good mechanical strength. The surface roughness can help control the degradation rate. Mg-1Ca-0.5Zr can thus be applied for biomedical implants. A summary is shown in Figure 18. To summarize the above results, Mg-1Ca-0.5Zr biomedical alloy has a suitable degradation rate and good mechanical strength. The surface roughness can help control the degradation rate. Mg-1Ca-0.5Zr can thus be applied for biomedical implants. A summary is shown in Figure 18.

Conclusions
(1) The brittle Mg2Ca phase of the XK105 solid dissolved into the matrix after heat treatment. This made the texture uniform and increased both elongation and fracture toughness. The Young's modulus of XK105 increased after heat treatment because of the solid solution of Ca atoms. (2) The TD plane of XK105 had higher strength but lower elongation than those of the ED plane because of the texture effects in which the grain slip was hard to start up on the ED plane. The fracture toughness along ED was better than that along TD because the crack-spreading direction was parallel to the arrangement direction of the secondary phase. (3) The heat treatment of XK105 reduced galvanic corrosion due to the solid solution, and further improved anti-corrosion ability. The surface-roughened XK105 had a larger surface area, which enhanced the corrosion reaction. (4) A calcium phosphate layer formed during corrosion on the XK105-H surface, significantly reducing the corrosion rate. The surface-roughened XK105 formed magnesium hydroxide instead because of its faster corrosion rate. The magnesium hydroxide did not provide a protective effect. (5) This study developed a biomedical implant material, Mg-1Ca-0.5Zr alloy. The results can be used as a reference for the biomedical material industry.