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Epigenomes 2018, 2(2), 11; https://doi.org/10.3390/epigenomes2020011

Recent Advances in Chromatin Mechanisms Controlling Pancreatic Carcinogenesis

Department of Surgery and the Andrew L. Warshaw, MD, Institute for Pancreatic Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, 02114 MA, USA
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Received: 31 May 2018 / Revised: 14 June 2018 / Accepted: 15 June 2018 / Published: 20 June 2018
(This article belongs to the Special Issue Epigenetics of Pancreatic Cancer)
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Abstract

Pancreatic ductal adenocarcinoma has a heterogeneous genetic landscape, marked by frequent mutation of KRAS, CDKN2A, TP53, and SMAD4, resulting in poor responses to conventional therapeutic regimens. Over the past decade, increased understanding of the genetic underpinnings of this lethal cancer has yielded several different characterizations of pancreatic cancer subtypes. However, not all phenotypes and changes in pancreatic cancer can be explained by these findings. New insights on epigenetic modifications associated with pancreatic carcinogenesis have highlighted additional pathways, other than gene mutations, among which chromatin regulation plays a dominant role. Gene expression is highly regulated by subtle changes in chromatin configuration. The underlying mechanism is dominated by reversible post-translational histone modifications. In addition, there is growing evidence that different chromatin mechanisms interact with one another, contributing to the diversity of pancreatic carcinogenesis. This review highlights recent work characterizing chromatin regulatory mechanisms associated with pancreatic carcinogenesis as well as future directions of this emerging research. View Full-Text
Keywords: pancreatic cancer; epigenetics; chromatin remodeling; histone modification; HAT; HDAC; KDM; BET; SWI/SNF pancreatic cancer; epigenetics; chromatin remodeling; histone modification; HAT; HDAC; KDM; BET; SWI/SNF
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Hank, T.; Liss, A.S. Recent Advances in Chromatin Mechanisms Controlling Pancreatic Carcinogenesis. Epigenomes 2018, 2, 11.

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