Subclinical Cognitive and Neuropsychiatric Correlates and Hippocampal Volume Features of Brain White Matter Hyperintensity in Healthy People

Spalletta, Gianfranco; Iorio, Mariangela; Vecchio, Daniela; Piras, Federica; Ciullo, Valentina; Banaj, Nerisa; Sensi, Stefano L.; Gianni, Walter; Assogna, Francesca; Caltagirone, Carlo; Piras, Fabrizio

doi:10.3390/jpm10040172

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Subclinical Cognitive and Neuropsychiatric Correlates and Hippocampal Volume Features of Brain White Matter Hyperintensity in Healthy People

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Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, 00179 Rome, Italy

Division of Neuropsychiatry, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA

Molecular Neurology Unit, Center of Advanced Studies and Technology (CAST), G. d’Annunzio University of Chieti-Pescara, 66100 Chieti, Italy

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Department of Psychology, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, Italy

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Department of Neuroscience, Imaging, and Clinical Sciences, University G. d’Annunzio of Chieti-Pescara, 66100 Chieti, Italy

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Institute for Mind Impairments and Neurological Disorders, University of California-Irvine, Irvine, CA 92697, USA

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II Division of Internal Medicine and Geriatrics, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, Italy

Authors to whom correspondence should be addressed.

J. Pers. Med. 2020, 10(4), 172; https://doi.org/10.3390/jpm10040172

Received: 31 August 2020 / Revised: 28 September 2020 / Accepted: 12 October 2020 / Published: 15 October 2020

(This article belongs to the Special Issue Personalized Medicine for Neurodegenerative Dementia)

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Abstract

White matter hyperintensities (WMH) are associated with brain aging and behavioral symptoms as a possible consequence of disrupted white matter pathways. In this study, we investigated, in a cohort of asymptomatic subjects aged 50 to 80, the relationship between WMH, hippocampal atrophy, and subtle, preclinical cognitive and neuropsychiatric phenomenology. Thirty healthy subjects with WMH (WMH+) and thirty individuals without (WMH−) underwent comprehensive neuropsychological and neuropsychiatric evaluations and 3 Tesla Magnetic Resonance Imaging scan. The presence, degree of severity, and distribution of WMH were evaluated with a semi-automated algorithm. Volumetric analysis of hippocampal structure was performed through voxel-based morphometry. A multivariable logistic regression analysis indicated that phenomenology of subclinical apathy and anxiety was associated with the presence of WMH. ROI-based analyses showed a volume reduction in the right hippocampus of WMH+. In healthy individuals, WMH are associated with significant preclinical neuropsychiatric phenomenology, as well as hippocampal atrophy, which are considered as risk factors to develop cognitive impairment and dementia. View Full-Text

Keywords: white matter hyperintensities (WMH); elderly subjects; hippocampus; apathy; anxiety; small vessel disease; magnetic resonance imaging (MRI)

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Spalletta, G.; Iorio, M.; Vecchio, D.; Piras, F.; Ciullo, V.; Banaj, N.; Sensi, S.L.; Gianni, W.; Assogna, F.; Caltagirone, C.; Piras, F. Subclinical Cognitive and Neuropsychiatric Correlates and Hippocampal Volume Features of Brain White Matter Hyperintensity in Healthy People. J. Pers. Med. 2020, 10, 172. https://doi.org/10.3390/jpm10040172

AMA Style

Spalletta G, Iorio M, Vecchio D, Piras F, Ciullo V, Banaj N, Sensi SL, Gianni W, Assogna F, Caltagirone C, Piras F. Subclinical Cognitive and Neuropsychiatric Correlates and Hippocampal Volume Features of Brain White Matter Hyperintensity in Healthy People. Journal of Personalized Medicine. 2020; 10(4):172. https://doi.org/10.3390/jpm10040172

Chicago/Turabian Style

Spalletta, Gianfranco, Mariangela Iorio, Daniela Vecchio, Federica Piras, Valentina Ciullo, Nerisa Banaj, Stefano L. Sensi, Walter Gianni, Francesca Assogna, Carlo Caltagirone, and Fabrizio Piras. 2020. "Subclinical Cognitive and Neuropsychiatric Correlates and Hippocampal Volume Features of Brain White Matter Hyperintensity in Healthy People" Journal of Personalized Medicine 10, no. 4: 172. https://doi.org/10.3390/jpm10040172

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Subclinical Cognitive and Neuropsychiatric Correlates and Hippocampal Volume Features of Brain White Matter Hyperintensity in Healthy People

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