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Diagnostics, Volume 15, Issue 21

November-1 2025 - 156 articles

Cover Story: In prenatal diagnostics, timing is everything—but technique may matter even more. Drawing on a 15-year, single-operator prospective cohort of 5500 first-trimester procedures, we directly compared transcervical, transabdominal and transvaginal chorionic villus sampling (CVS). Transabdominal CVS achieved the best safety–diagnostic balance, with the lowest fetal loss (0.18%) and highest diagnostic yield. Doppler studies revealed no lasting vascular disruption, while long-term neurodevelopmental follow-up was reassuring. In fetuses with anomalies, targeted microarray revealed clinically significant copy number variations (CNVs) in one out of five cases. Consequently, this study reaffirms transabdominal CVS as the frontline standard in early fetal diagnostics. View this paper
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Articles (156)

  • Article
  • Open Access
748 Views
11 Pages

Diagnostic Assessment of Maxillary Sinus Membrane Thickening Associated with Dental Implant Perforation Using Cone-Beam Computed Tomography: A Retrospective Cross-Sectional Pilot Study

  • Narjesse Kemcha,
  • María Andrés-Veiga,
  • Dolores Hurtado-Celotti,
  • Cristina Meniz-García,
  • Tomás Beca-Campoy and
  • Natalia Martínez-Rodríguez

6 November 2025

Background/Objectives: Perforation of the maxillary sinus floor by dental implants is a complication that can occur during treatment in posterior sectors; however, its clinical and radiological consequences remain controversial. Therefore, this study...

  • Article
  • Open Access
748 Views
16 Pages

6 November 2025

Background: Artificial intelligence (AI) has shown significant promise in augmenting diagnostic capabilities across medical specialties. Recent advancements in generative AI allow for synthesis and interpretation of complex clinical data including im...

  • Article
  • Open Access
400 Views
13 Pages

Neutrophil-to-Lymphocyte Ratio as Potential Marker of Outcome After Standard EVAR

  • Adriana Toncelli,
  • Federico Filippi,
  • Francesco Andreoli,
  • Giulia Colonna,
  • Claudia Panzano,
  • Roberto Silingardi,
  • Claudio Desantis,
  • Massimo Ruggiero,
  • Maurizio Taurino and
  • Pasqualino Sirignano

6 November 2025

Introduction: The neutrophil–lymphocyte ratio (NLR) has proven to be an inexpensive and easily available inflammatory marker for cardiovascular disease. The aim of the present study is to evaluate a possible association between preoperative NLR...

  • Review
  • Open Access
702 Views
27 Pages

5 November 2025

Pediatricians play a crucial role in the early diagnosis and management of inherited metabolic diseases (IMDs). The diagnosis of IMD is based on the principle of selective screening, often requiring highly specialized testing, including biochemical a...

  • Article
  • Open Access
477 Views
16 Pages

Global Myocardial Wall Thickness in Transfusion-Dependent Thalassemia: A Cross-Sectional MRI Analysis

  • Antonella Meloni,
  • Laura Pistoia,
  • Giuseppe Peritore,
  • Michela Zerbini,
  • Stefania Renne,
  • Priscilla Fina,
  • Antonino Vallone,
  • Filomena Longo,
  • Anna Spasiano and
  • Zelia Borsellino
  • + 6 authors

5 November 2025

Background: This retrospective cross-sectional study evaluated the association of the global wall thickness index (GTI), derived from cardiovascular magnetic resonance (CMR), with demographic, clinical, and imaging findings, as well as heart failure...

  • Review
  • Open Access
705 Views
22 Pages

5 November 2025

Background/Objectives: Breast cancer is the most prevalent neoplasm in women. Improved screening and systemic therapies have allowed more patients to choose breast-conserving surgery over mastectomy. However, preserving glandular tissue while achievi...

  • Article
  • Open Access
427 Views
14 Pages

5 November 2025

Background: While gravity-assisted ankle stress AP (GAASA) images have proven effective in evaluating deep deltoid ligament injuries, their efficacy in assessing syndesmosis injuries remains unclear. We aimed to investigate the diagnostic performance...

  • Article
  • Open Access
392 Views
11 Pages

Cranial Morphological Patterns Based on Cranial Index and Petrous Ridge–Midline Angle in Koreans: Implications for Clinical and Forensic Applications

  • Digud Kim,
  • Jeonghyun Park,
  • Jaeho Cho,
  • Yu-Jin Choi,
  • Hyung-Wook Kwon,
  • Yunil Choe,
  • Sookyoung Lee and
  • Kwang-Rak Park

5 November 2025

Background: The human skull has a very complex and diverse structure, and morphological characteristics vary by population. The purpose of this study is to comprehensively analyze the cranial morphology using postmortem computed tomography (PMCT), an...

  • Article
  • Open Access
397 Views
11 Pages

Prevalence of the Sphenoidal Emissary Foramen in a Chilean Osteological Sample: Anatomical and Surgical Implications

  • Juan José Valenzuela Fuenzalida,
  • Catalina Alcaíno Adasme,
  • Trinidad Soublette Tocornal,
  • Felipe Alvial-Ahumada,
  • Macarena Perez Gutierrez,
  • Alejandro Bruna-Mejias,
  • Mathias Orellana-Donoso,
  • Pablo Nova-Baeza,
  • Alejandra Suazo-Santibañez and
  • Hector Gutierrez-Espinoza
  • + 5 authors

5 November 2025

Background: The sphenoidal emissary foramen (SEF) is an inconstant foramen of the sphenoid bone that facilitates venous communication between the pterygoid venous plexus and the cavernous sinus. Understanding its prevalence and laterality is crucial...

  • Article
  • Open Access
466 Views
18 Pages

Machine Learning Models for Point-of-Care Diagnostics of Acute Kidney Injury

  • Chun-You Chen,
  • Te-I Chang,
  • Cheng-Hsien Chen,
  • Shih-Chang Hsu,
  • Yen-Ling Chu,
  • Nai-Jen Huang,
  • Yuh-Mou Sue,
  • Tso-Hsiao Chen,
  • Feng-Yen Lin and
  • Chun-Ming Shih
  • + 3 authors

5 November 2025

Background/Objectives: Computerized diagnostic algorithms could achieve early detection of acute kidney injury (AKI) only with available baseline serum creatinine (SCr). To tackle this weakness, we tried to construct a machine learning model for AKI...

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Diagnostics - ISSN 2075-4418