A Minimum Set of Physiological Parameters to Diagnose Obstructive Sleep Apnea Syndrome Using Non-Invasive Portable Monitors. A Systematic Review

Introduction. Despite its high accuracy, polysomnography (PSG) has several drawbacks for diagnosing obstructive sleep apnea (OSA). Consequently, multiple portable monitors (PMs) have been proposed. Objective. This systematic review aims to investigate the current literature to analyze the sets of physiological parameters captured by a PM to select the minimum number of such physiological signals while maintaining accurate results in OSA detection. Methods. Inclusion and exclusion criteria for the selection of publications were established prior to the search. The evaluation of the publications was made based on one central question and several specific questions. Results. The abilities to detect hypopneas, sleep time, or awakenings were some of the features studied to investigate the full functionality of the PMs to select the most relevant set of physiological signals. Based on the physiological parameters collected (one to six), the PMs were classified into sets according to the level of evidence. The advantages and the disadvantages of each possible set of signals were explained by answering the research questions proposed in the methods. Conclusions. The minimum number of physiological signals detected by PMs for the detection of OSA depends mainly on the purpose and context of the sleep study. The set of three physiological signals showed the best results in the detection of OSA.


Introduction
Nowadays, sleep disorders are divided into seven categories according to the prevailing international classification of sleep disorders (ICSD-3): sleep breathing disorders, central hypersomnia, insomnia, isolated symptoms, parasomnias, sleep movement disorders, and circadian rhythm disturbances [1]. Within this classification, obstructive sleep apnea (OSA) is one of the most common sleep disorders [2]. OSA is caused by successive events of partial reduction (hypopnea) or total reduction (apnea) of the upper airways; this fact can lead to several issues such as arousals, hypoxia, and fragmentation of sleep [1][2][3]. Despite being one of the most common sleep disorders, OSA screening techniques are unavailable for many patients. Some studies state that up to 75% of patients remain undiagnosed and untreated [4]. This is due to several facts, but the most relevant is that the gold standard for OSA diagnosis is polysomnography (PSG). PSG is known to be the best performing OSA detection technique in terms of accuracy. However, PSG has several drawbacks that contribute to the delay in the diagnosis of many patients. First, PSG requires the patient to stay overnight in a sleep lab setting, and second, the study must be supervised by a physician using multichannel monitoring. These two requirements imply that PSG is expensive and time-consuming since a trained technician is necessary, along with the availability of a sleep laboratory to proceed with the clinical evaluation of OSA [5][6][7].
Considering the pitfalls derived from PSG, several OSA screening approaches have been proposed as an alternative to PSG, such as questionnaires and home sleep apnea tests (HSAT). Questionnaires such as the Berlin questionnaire, STOP-BANG, or NoSAS have been developed to evaluate and screen patients with OSA [8]. Nonetheless, according to the American Academy of Sleep Medicine (AASM), it is recommended that questionnaires are not applied to detect OSA without the use of technical devices since sleep-apneafocused questionnaires and clinical prediction rules lack sufficient diagnostic accuracy by themselves [9]. Therefore, the principal substitute for PSG seems to be the application of HSAT using a portable monitor (PM).
A large number of PMs to detect apnea have been developed, since the first classification of practice parameters concerning the use of PM devices to detect OSA was carried out by the AASM in 1994. Since this classification was released, the AASM has applied several updates to it; however, as a consequence of the exponential growth of technological advances in the clinical realm over the years, Collop et al. [10] proposed a new classification that covers all the features of PMs that do not fit the categorization elaborated by the AASM. This classification is based on sensors used to measure physiological parameters related to "Sleep", "Cardiovascular", "Oximetry", "Position", "Effort", and "Respiratory" and is known as SCOPER classification.
In this classification, the AASM classified sleep studies into four types based on the number of channels or physiological signals on the PM: type I (standard PSG; attended), type II (minimum of seven channels; unattended), type III (minimum of four channels; unattended), and type IV (one or two channels; unattended) [5,7,11].
A large number of manufacturers have contributed to the development of commercial PMs for the detection of OSA over the years [12]. Currently, there are many different approaches to developing PMs for OSA detection based on both research and commercial projects [3,10,12]. It is clear that to classify a PM for the detection of OSA, it is necessary to consider the physiological signals collected by the medical device. Despite this fact and together with the AASM recommendation for HSAT, which indicates a minimum of three physiological signals (airflow, respiratory effort, and oximetry) in order to achieve adequate OSA detection, there is no consensus among researchers on the minimum set of physiological parameters that a PM for OSA detection should include. Therefore, this article aims to investigate HSATs to evaluate the physiological signals of PMs to find the best minimum combination of biomedical signals that achieve both excellent accuracy in diagnosis and as little intrusiveness as possible for the patient.
For the search for a minimum set of physiological parameters for OSA, a systematic review was performed. Before the review was conducted, both the main and the set of specific questions were formulated. What are the main requirements for the application of an in-home medical device to diagnose sleep apnea? 3.
Is there a set of minimum physiological signals that distinguish between detection of sleep and arousal? 4.
How does it affect the outcome (OSA detection) when PMs do not include oximetry measurement?

5.
What physiological signals are included in those PMs that meet the criteria of positive likelihood ratios (LR+) of ≥5 and sensitivities (Sen) of ≥0.825?
The criteria for the inclusion and exclusion of papers and searches in databases are explained primarily in the Methods section. In the Results section, all publications that meet the criteria are analyzed, focusing on the number of physiological signals used and the precision in the detection of OSA. Finally, the discussion and the conclusion include a general interpretation of the results and the most relevant information extracted from the analysis. It is important to note that, contrary to another systematic review of PMs for OSA detection, the study does not focus on the features of medical devices, but on the physiological parameters collected by them.

Materials and Methods
This review was carried out following the "The PRISMA 2020 statement", an update of the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guideline [13].

Eligibility Criteria
According to [10], a PM for OSA detection should have an LR+ of ≥5 and a sensitivity not less than 0.825 after in-lab PSG-an apnea-hypopnea index (AHI) of ≥5 [14]. However, as shown in several publications, the achievement of LR+ of ≥5 is complicated. As a consequence, the number of publications is reduced to the minimum to perform an analysis. Therefore, for this study, publications were only included, if they met the criteria of having a sensitivity equal to or greater than 0.825 at AHIs of ≥5.
Inclusion criteria are shown as following:

Search Strategy and Information Sources
The searches were performed from April 2021 to June 2021. The PubMed query was as follows: ("home"[TITLE] OR "portable"[TITLE] OR "ambulatory"[TITLE] OR "device"[TITLE]) AND (obstructive sleep apnea OR hypopnea) AND ("detection" OR "diagnosis" OR "monitoring"). For ScienceDirect, the query used was as following: TI-TLE: (home OR portable OR device OR ambulatory) AND ("obstructive sleep apnea" OR hypopnea) AND (detection OR diagnosis OR monitoring). Finally, for the IEEE Xplore Digital Library search, the query used was as following: ("Full Text Only": "obstructive sleep apnea" OR "Full Text Only": hypopnea) AND ("Full Text Only": detection OR "Full Text Only": diagnosis OR "Full Text Only": monitoring) AND ("Document Title": home OR "Document Title": portable OR "Document Title": device OR "Document Title": ambulatory).
Six hundred and sixty-six references (before removing duplications) were collected from the databases (241 from PubMed, 334 from ScienceDirect, and 91 from the IEEE). The records were downloaded in a text format, and after removing duplications, a total of 629 references were qualified for the data evaluation step. One hundred forty-four articles were selected after the evaluation of the publications by reading their titles and abstracts. Eventually, full-text reading took place, ensuring that the inclusion/exclusion criteria for the articles assessed were met. The number of the studies included in the systematic review was 58. Statistical methods were used to analyze 45 publications. The remaining 13 were used to answer the main/specific questions.

Selection Process and Data Extraction
The studies identified after the search explained in the above section were exported to the Mendeley free reference manager tool. Subsequently, duplicates were automatically identified and eliminated. The next step was to select the remaining publications, first by their titles and then by their abstracts. The titles and abstracts of non-duplicated publications were selected, and then all publications that did not relate to the topic were removed.
The final step was the full reading of all the publications. For this purpose, a predefined form was filled with the data from the publication (manually by a researcher). The fields in the form were as following: paper name, year, SCOPER classification, PM sensitivity, PM specificity, LR+, AHI, population, arousal detection, and type of device. Those publications that consisted of reviews of several PMs were classified independently and reserved for answering the specific questions stated in the Introduction section.

Assessment of the Risk of Bias
The PMs were classified according to the physiological parameters used for each independent study. This means that for publications using the same type of device, the variation proposed by Mendonça et al. [3] for the SCOPER classification was performed to avoid bias in the outcome. The primary purpose of this systematic review was to analyze the set physiological signals, not the features of the medical device itself.

Synthesis Methods
Statistical analysis was carried out using a suite of Python packages (Pandas, NumPy, Seaborn, Matplotlib, and SciPy). Statistical data visualizations were presented to aid in understanding the results. Statistics were performed using Sen and specificity (Spe) reported by PMs and their relation to the number of physiological parameters used. As far as possible, statistics were presented to explain the relevant information collected during the systematic review. Figure 1 shows the list of publications that met the inclusion/exclusion criteria and were selected for statistical analysis: the years of publications ranged from 2011 to 2021. The highest number of the selected articles was published in 2018 (20.69% of all publications), and the lowest number of the selected articles was in 2021 (1.72% of all publications). The research materials selected for this systematic review were divided into two main groups. A group was known as "Research and Commercial PMs" (see Figure 2) that included publications related to the use of standalone PMs. The publications of this group were used for statistical analysis. The other group, known as "Other(s)", included publications that contained relevant information to answer the research questions stated in the Introduction and could not be included in the statistical analysis.

Synthesis Results and Questions of Interest
In this section, the central and specific questions stated in the Introduction section are answered and explained in detail. The statistical analysis with the information extracted from the publications in Table 1 indicated that PMs can be implemented to collect up to six physiological parameters. Figure 3a shows that 31.1% of the PMs analyzed collected one signal only. The most relevant physiological parameter of these PMs was the respiratory signal; only three PMs did not collect respiratory signals, but cardiovascular or position signals. Single-channel PMs underperformed at all levels of OSA severity detection by other PMs measuring more than one signal. Only PMs with six or five channels worsened the results (in terms of Sen and Spe) for the detection of the severity of OSA compared to PMs with a single channel. In particular, for AHI of ≥15 and AHI of ≥30. On the other hand, 20% the PMs analyzed measured two physiological signals and obtained good results in detecting different levels of OSA severity. Together with the set of three signals (which represented 17.8% of PMs included in this study), the set of two physiological parameters reported the best results, always being one of the three best results for AHI of ≥5, AHI ≥15, and AHI of ≥30 (see Figure 3b-d). The combination of four physiological signals (13.3% of the PMs included in this study) reported the second-best result for the detection of severe OSA, only worse than the set of three signs. It should be noted that all but one four-channel PM included oximetry. Finally, the sets of five and six psychological signals represented 8.9% of the total each. For both AHI of ≥5 and AHI of ≥15, the PMs that used five signals obtained the secondhighest result in terms of Sen. Taking into account the results of the statistical analysis, the minimum set of signals that a PM should collect to obtain the best result when it comes to detecting OSA is two or three. In general, considering all levels of OSA severity, PMs with three channels showed the best results.
Regarding the group of publications known as "Other(s)", five studies address this question. Hesselbacher et al. [11] state that the PM selection for OSA detection depends on many factors, along with the fact that on PMs with fewer signals, each independent channel becomes more important for the final clinical assessment. Berry et al. [60] conclude that PMs should measure airflow, respiratory effort, and blood oxygenation at a minimum. Dawson et al. [62] note that type III monitors performed better than type IV monitors in predicting AHI scores for OSA severity detection. Mendonça et al. [3] highlight the use of breathing analysis, alone or in combination with other sensors, as the method that yields the best results in detecting OSA. In addition to this, Mendonça indicates that a combination of oximetry and sound analysis can provide the best choice for respiratory analysis with minimal invasion. Jiang et al. [65] evaluated a set of physiological signals measured by PMs against PSG. A combination of four different sets of physiological signals was tested to obtain the AHI. The sets of parameters were as following: the first combination with a single nasal airflow, the second combination with nasal airflow + body activity, the third combination with nasal airflow + SpO2, and finally, the fourth combination with nasal airflow + SpO2 + body activity. Combination number four (S 3 O 1x P 2 E 4 R 3 ) drew the best agreement with PSG and obtained for AHI of ≥5, the highest Sen of 96.5%, and an Spe of 100%.

SRQ-1: Does the Outcome (OSA Detection) Improve if the Number of Psychological Parameters Measured Increases?
As shown in Figure 3, the PMs included in this systematic review that collected more than three physiological signals to detect OSA did not report a significant improvement in their results for any of the AHIs. Only for AHI of ≥5 did the results of those PMs that collected five physiological parameters show better results than those that collected three. For AHI of ≥15 and AHI of ≥30, there was an improvement when looking at Spe for PMs that collected five and six physiological parameters, respectively, but no betterment was shown for Sen. In fact, PMs that measured at least six physiological parameters obtained the poorest results for AHI of ≥15 and AHI of ≥30. However, this may be due to several factors, such as the methodology when working with PMs that include more channels that are more similar to that proposed by the AASM, which can lead to more accurate results. Although it is more feasible than in this systematic review, the number of PMs that collected several physiological parameters equal to or greater than five represented the lowest number of PMs among the entire selection of PMs (17.8% of the total). Therefore, poor results in some PMs can affect Sen or Spe more significantly.

SRQ-2: What Are the Main Requirements for the Application of an In-Home Medical Device to Diagnose Sleep Apnea?
A wide variety of publications in Other(s) highlight the importance of following the clinical guideline created by the AASM with a series of recommendations for the use of PMs for the detection of OSA at home [4,11,60,[63][64][65][66]68]. In general, this guideline comprises three key factors: PM features, patients, and HSAT methodology. Regarding PMs, one of the most important is the minimal set of measured physiological signals (airflow, airflow, respiratory effort, and oxygen saturation). It is strongly recommended that the PM be easy to use. The PM setup is also crucial, as the potential for complications during HSAT increases with the complexity of the device. There should be an HSAT methodology available to assess the quality of the recordings, along with a sleep physician who supervises the sleep study. Lastly, with regard to the patient, there must be no comorbid conditions, since it could reduce the precision of the PM and present a high probability of moderate to severe OSA before the test [11,60,70]. Although such requirements were suggested by the AASM, as shown in this systematic review, most sleep studies on PM development agree on the fact that to devise a PM for OSA detection, there should exist a balance between the patient comfortability, the simplicity of the PM, and the precision of results.

SRQ-3: Is There a Set of Minimum Physiological Signals That Distinguish between the Detection of Sleep and Arousal?
A total of seven publications from the group known as Other(s) address this question. According to Hesselbacher et al. [11], one of the most significant pitfalls with respect to the HSAT is that most PMs do not include electroencephalogram (EEG) or electrooculography (EOG) recordings. These physiological signals are needed to differentiate between the sleep-wake state and arousal. This fact has several implications. In principle, PMs cannot meet the arousal criteria recommended by the AASM to identify hypopnea, due to the impossibility to measure the total sleep time (TST) and the lack of the identification of respiratory events that meet the flow reduction criteria for hypopneas associated with microarousals instead of O 2 desaturation [4,67]. As a consequence, the severity of OSA may be miscalculated as a lower detection of hypopnea due to the lack of EEG and the inclusion of respiratory events in the total recording time (TRT) rather than the TST, leading to a longer study time of sleep [4,11].
Although EEG or EOG is strongly recommended to detect awakenings, several alternatives have been proposed to work as surrogate signals in the detection of the sleep-wake state. Body movement, heart rates, and changes in sympathetic tone are surrogate signals used in the detection of sleep versus wakefulness [11,66]. Peripheral arterial tonometry (PAT) measures the volume of arterial pulse waves at the fingertip, and it can be combined with an accelerometer to determine wake/sleep. In this way, this combination detects an attenuation of the pulse amplitude that, combined with the acceleration of the pulse rate or an increase in wrist activity, indicates arousal or a respiratory event [11]. Other studies, such as Lachapelle et al. [67], state that pulse-oximetry-derived heart rate increases can be easily used as a surrogate marker of arousal in most type III PM. Vat et al. [4] conclude that drops in pulse wave amplitude (PWA) can be considered as a sensitive surrogate marker for EEG awakenings and used by PMs as a secondary criterion in the definition of hypopnea. Berry et al. [60] note that the combination of actigraphy and PAT signal has been used to determine estimates of wakefulness, non-rapid eye movement (NREM) sleep, and REM sleep, because the sympathetic tone characteristics of these sleep stages differ. On the other hand, Bianchi et al. [64] state that actigraphy works as a surrogate for EEG, because it overestimates sleep when movement is the only input due to quiet wake appearing similar to sleep. In [65], an accelerometer was used to calculate sleep time by subtracting the waking time from the time in bed. Light [66] suggests that using a single EEG lead may be possible to provide a helpful way to obtain the actual TST in an ambulatory HSAT.
From our statistical analysis with the publications of the group "Research and Commercial PM", nine publications state that they detect arousals. The physiological parameters incorporated into these PMs ranged from three to six with a distribution of 33.33% for three signals, 33.33% for four signals, 22.22% for six signals, and 11.11% for five signals. The entire set of PMs was commercial devices, and seven of them included oximetry as one of their set of the collected physiological parameters. The two PMs which met the requirements of Sen of ≥0.825 and LR+ of ≥5 at AHI of ≥5 had a categorization of S3C2O1x (Sen = 95.8%, Spe = 100%, and LR+ = inf) [21] and P2R5A1 (Sen = 85%, Spe = 90%, and LR+ = 8.5) [30]. The lowest results were obtained with the PM that collected six physiological signals with a categorization of S 3 C 4 O 1 P 2 E 4 R 2 A 2 (Sen = 88.2%, Spe = 72.7%, and LR+ = 3.23).

SRQ-4: How Does It Affect the Outcome (OSA Detection) When PMs Do Not Include Oximetry Measurements?
The main inconvenience is related to the scoring of hypopnea and the classification of the severity of OSA. Pulse oximetry is required to calculate oxygen saturation levels [62]. Therefore, many research studies do not consider valid PMs that do not include the measurements of saturation signals for more than half the duration of the sleep study [2,3]. However, in this systematic research, both types of PM (concerning oximetry incorporation) were accepted, as PMs, which do not include oximetry, reported good results in Sen and Spe in the past [30,33,44].
Approximately 51% of the PMs from the publications included in Table 1 used oximetry. The rest of the PMs from the publications (49%) did not include oximetry as physiological parameters. Both sets of PMs (based on oximetry inclusion) reported similar results to those reported by Sen and Spe. The Sen and Spe results for these PMs, which included oximetry, were 86.65% and 89.06%, respectively. PMs which did not include oximetry obtained an Sen of 86.40% and an Spe of 82.24%. When looking at the results on the number of physiological parameters and the inclusion of oximetry, the results varied significantly, as shown in Figure 4. Only four studies obtained results above the cut-off points set by Collop et al. [10] regarding the assessment of PMs to detect OSA. The only measure that did not include any of the PMs was effort, as shown in Table 3.

Discussion
The difficulty in diagnosing patients with OSA is a widely known problem. This problem lies mainly in the bottleneck caused by the waiting list of patients with a high probability of having OSA due to the time required to perform PSG. In addition to this, sleep studies are also expensive. As a solution, for some time now, more and more PMs have been developed to facilitate OSA detection.
The use of PMs for the diagnosis of OSA has been extensively studied and validated [5,6,12,14]. Therefore, in this systematic review, this issue has not been addressed. However, this study focuses on searching for the minimum set of parameters that a PM should collect for the accurate detection of OSA.
Although the AASM provides recommendations on PM use, they are not always followed. Based on the results obtained in this systematic review, the main objective when developing new PMs is usually to achieve the maximum patient comfort, together with adequate accuracy as close as possible to that obtained by PSG.
As a general rule, the AASM recommends for HSAT monitoring a minimum of three physiological parameters: airflow, respiratory effort, and SaO2 [9,62,70]. In theory, for monitoring such physiological parameters, the following sensors should be applied: generally, two sensors should be used for airflow measurement, an oronasal thermal sensor for apnea detection, and a pressure sensor for hypopnea detection. Regarding respiratory effort, respiratory inductance plethysmography (RIP) should be used. For SaO2 detection, oximetry is recommended [60,68].
This systematic review showed that not all PMs followed this recommendation. In contrast, the number of channels and the set of physiological signals collected varied widely. The statistical analysis of this study in Section 3.3.1 showed that a set of two or three channels can achieve the best results for OSA detection. Specifically, the set formed by three physiological signals was the one that yielded the best results. In this case, there was a correlation with what was declared by the AASM about the minimum set of physiological signals for accurate OSA detection. However, there was no concordance with the AASM recommendation on the nature of physiological signals that should constitute the set. This fact can be seen in Table 1, where PMs that recorded a set of three signals used different sets of channels from each other, obtaining similar results in OSA detection in terms of Sen and Spe. An example is that only two PMs of three channels coincided in the selection of the same set of physiological signals.
In addition to the aforementioned studies that validate the use of PMs for OSA detection, there are other studies on features that PMs should include, along with the set of signals they should collect. For example, Mendonça et al. [3] conclude that breath analysis, individually or with other combination of sensors, provides the best results in detecting OSA. Collop et al. [10] perform a comprehensive evaluation of the detection of PMs to detect OSA. It also provides a set of criteria for evaluating PMs that yield an accurate detection of OSA. Despite the number of publications, there is still no consensus on the minimum set of physiological signals that should be used to detect OSA using PMs. This systematic review aims to help to achieve this goal. However, this study has the limitation that it cannot provide a final set of physiological signals, as combinations are varied, as shown in the statistical analysis. This issue will be addressed in the future with the search for the best combination of signals for a three-channel PM, together with experimentation under the same study conditions. This is because in this type of research, the conditions of the experiments vary a lot between the studies using different PM configurations.
In general, in this study, a wide variety of PMs measured physiological signals, and the results obtained by these PMs in the detection of OSA have been analyzed. Once the signal measurement has been carried out, the methods used to assess whether the patient has OSA have not been evaluated in this analysis. Therefore, the calculation methods, algorithms, etc. have not been evaluated. It is also an interesting field to study in the future.
Another important aspect addressed in this study is the use of oximetry by PMs and the search for a minimum set of signals to detect arousals. Regarding the use of oximetry, there is a large division, with practically half of the PMs analyzed including oximetry and the rest which did not include it (see Section 3.3.5). There were no significant differences in the results, depending on whether oximetry was included or not. Regarding the minimum set of parameters for the detection of arousals, the sets that obtained the best results had a categorization of S 3 C 2 O 1x (Sen = 95.8%, Spe = 100%, and LR+ = inf) [21] and P 2 R 5 A 1 (Sen = 85%, Spe = 90%, and LR+ = 8.5) [30]. They also met the criteria proposed in [10], which are an Sen of ≥0.825 and an LR+ of ≥5 at AHI of ≥5.
The fact that there is no agreement on the selection of metrics for the presentation of results in the scientific publications selected in this systematic review implies that many metrics obtained by PMs have not been taken into account. Sensitivity and specificity were chosen as study metrics to assess the diagnostic accuracy of PMs, because most publications include them in their analyzes, and Collop et al. [10] stated an Sen of >0.825 is one of the requirements for an adequate PM development. On the one hand, the cut-off points for AHIs (AHI of >5; AHI of >15; AHI of >30) were chosen, because most publications include them. On the other hand, these cut-off points are relevant indicators for distinguishing between mild, moderate, and severe OSA levels.
The SCOPER classification was selected, because it allows the inclusion of many PMs that remain unidentified with the proposal on the use of PMs for OSA detection by the AASM. Specifically, the specification made by Mendonça et al. [3] has been used in this analysis with relevant results. This variant of the SCOPER classification allows PMs to implement microphones for the collection of acoustic signals.
In this systematic review, a distinction was made between the two types of publications. First, those articles contained information on the validity of PMs in the detection of OSA. Second, those publications that included reviews, book chapters, or publications could help answer specific questions, but were not appropriate for inclusion in the statistical analysis, as they did not evaluate a single PM in particular. This was to avoid the removal of relevant information, since the publications contained in Table 2 could provide answers to specific questions.
In general, in response to the central question of this systematic review, it can be stated that the results are not significantly different from the guidelines developed by AASM in the number of physiological signals that are necessary to detect OSA. In contrast, the results of this review showed that there are a large number of signal combinations.

Conclusions
There is a large body of literature on the use of PMs to detect sleep disorders such as OSA. However, there is a less variety in terms of the physiological signals that should be used to develop such PMs. In this article, we carried out a systematic review of publications that include PM to detect OSA. We analyzed the number and characteristics of the physiological parameters used by the PMs mentioned above. Some aspects of arousal detection or alternative oximetry were also studied.
In summary, the answer to the main question of this systematic review after our statistical analysis is in agreement with the AASM recommendations. The set of three physiological signals for OSA detection is the best performing set. The set of the selected physiological parameters is affected by the type of sleep study, and the context in which it is found is greatly affected by the circumstances of the patient when using the device. On the other hand, increasing the number of physiological signals collected by PMs does not improve the overall results in OSA detection. Funding: This work has been partly supported by the German "Bundesministerium für Wirtschaft und Energie"; funding program "Zentrales Innovationsprogramm Mittelstand (ZIM)" project "Sleep Lab at Horne (SLaH)" under contract no. ZF4825301AW9 and ZF4029428AW9. The article processing charge was funded by the Baden-Württemberg Ministry of Science, Research and Culture in the funding programme Open Access Publishing.
Institutional Review Board Statement: Not applicable.

Informed Consent Statement: Not applicable.
Data Availability Statement: The authors will make available the data sets that support the conclusions of this article upon reasonable request.

Conflicts of Interest:
The authors declare no conflict of interest.