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Open AccessArticle

One-Seventh of Patients with COVID-19 Had Olfactory and Gustatory Abnormalities as Their Initial Symptoms: A Systematic Review and Meta-Analysis

1
Department of Pediatrics, MacKay Children’s Hospital and MacKay Memorial Hospital, Taipei 10449, Taiwan
2
Department of Medicine, MacKay Medical College, New Taipei City 25160, Taiwan
3
Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu 30071, Taiwan
4
Department of Biological Science and Technology, National Chiao-Tung University, Hsinchu city 30010, Taiwan
5
Department of Pediatric Infectious Disease, National Taiwan University Hospital Hsinchu Branch, Hsinchu city 30059, Taiwan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Life 2020, 10(9), 158; https://doi.org/10.3390/life10090158
Received: 1 August 2020 / Revised: 16 August 2020 / Accepted: 20 August 2020 / Published: 22 August 2020
(This article belongs to the Special Issue The New Challenges in Infectious Diseases)
Coronavirus disease 2019 (COVID-19) patients exhibited protean clinical manifestations. Olfactory and gustatory abnormalities (anosmia and ageusia) were observed in COVID-19 patients, but the reported prevalence varied. In this systematic review, the prevalence of olfactory and gustatory abnormalities (OGA) was evaluated in laboratory-confirmed COVID-19 patients. On 8 May 2020, 14,506 articles were screened, while 12 of them were enrolled. A total of 1739 COVID-19 patients were analyzed, with a wide range of prevalence observed (5.6–94%). The pooled prevalence was 48.5% with high heterogeneity (I2, 98.8%; p < 0.0001). In total, 15.5% had OGA as their first symptom (I2, 22.6%; p = 0.27) among the patients analyzed. Contradictory to COVID-19 negative controls, patients with COVID-19 had a higher risk of OGA (odds ratio, 5.3; I2, 66.5%; p = 0.03). In conclusion, approximately half of COVID-19 patients had OGA, and one-seventh of them had OGA as their initial symptoms. OGA were cardinal symptoms of COVID-19, which may serve as clues for early diagnosis. Diagnostic testing for SARS-CoV-2 was suggested in patients with OGA during the COVID-19 pandemic to ensure timely diagnosis and appropriate quarantine. View Full-Text
Keywords: COVID-19; novel coronavirus; SARS-CoV-2; anosmia; ageusia COVID-19; novel coronavirus; SARS-CoV-2; anosmia; ageusia
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MDPI and ACS Style

Chi, H.; Chiu, N.-C.; Peng, C.-C.; Lin, C.-H.; Tai, Y.-L.; Lee, M.-D.; Cheng, Y.-J.; Tan, B.F.; Lin, C.-Y. One-Seventh of Patients with COVID-19 Had Olfactory and Gustatory Abnormalities as Their Initial Symptoms: A Systematic Review and Meta-Analysis. Life 2020, 10, 158. https://doi.org/10.3390/life10090158

AMA Style

Chi H, Chiu N-C, Peng C-C, Lin C-H, Tai Y-L, Lee M-D, Cheng Y-J, Tan BF, Lin C-Y. One-Seventh of Patients with COVID-19 Had Olfactory and Gustatory Abnormalities as Their Initial Symptoms: A Systematic Review and Meta-Analysis. Life. 2020; 10(9):158. https://doi.org/10.3390/life10090158

Chicago/Turabian Style

Chi, Hsin; Chiu, Nan-Chang; Peng, Chun-Chih; Lin, Chao-Hsu; Tai, Yu-Lin; Lee, Ming-Dar; Cheng, Yu-Jyun; Tan, Boon F.; Lin, Chien-Yu. 2020. "One-Seventh of Patients with COVID-19 Had Olfactory and Gustatory Abnormalities as Their Initial Symptoms: A Systematic Review and Meta-Analysis" Life 10, no. 9: 158. https://doi.org/10.3390/life10090158

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