Dynamics of Cardiovascular Muscle Using a Non-Linear Symmetric Oscillator

: In this paper, a complete non-linear symmetric oscillator model using the Hamiltonian approach has been developed and used to describe the cardiovascular conduction process’s dynamics, as the signal generated from the cardiovascular muscle is non-deterministic and random. Electrocardiogram (ECG) signal is a signiﬁcant factor in the cardiovascular system as most of the medical diagnoses can be well understood by observing the ECG signal’s amplitude. A non-linear cardiovascular muscle model has been proposed in this study, where a modiﬁed vanderPol symmetric oscillator-based equation is used. Gone are the days whena non-linear system had been designed using the describing function technique. It is better to design a non-linear model using the Hamiltonian dynamical equation for its high accuracy and ﬂexibility. Varying a non-linear spring constant using this type of approach is more comfortable than the traditional describing function technique. Not only that but different initial conditions can also be taken for experimental purposes. It never affects the overall modeling. The Hamiltonian approach provides the energy of an asymmetric oscillatory system of that cardiovascular conduction system. A non-linear symmetric oscillator was initially depicted by the non-linear mass-spring (two degrees of freedom) model. The motion of an uncertain non-linear cardiovascular system has been solved considering second-order approximation, which also demonstrates the possibility of introducing spatial dimensions. Finally, the model’s natural frequency expression has also been simulated and is composed of the previously published result.


Introduction
It has long been known that a linear system cannot entirely model the human cardiovascular system's activities as the heart rate is not a linear function or a constant [1,2]. The proper reason for the ECG signal variability is not clearly understood, making it an open research area. Cardiovascular signals contain [3] a considerable number of symmetric oscillatory components, which are unpredictable and not strictly periodic. It is more realistic to model the above system in a non-linear approach. One of the famous methods is the mass-spring-based non-linear modeling approach [4]. Some non-linear model under supply chain framework was studied by Sarkar [5] Tayyab et al. [6].
Days are gone when the Hodgkin-Huxley equation [7] was used to describe the non-linear equations, and the van der Pol approach had been used in the 20th century to design asymmetric relaxation oscillator for the study of conduction methods in the cardiovascular system [8,9]. A non-linear manufacturing model with inflation was solved by Sarkar et al. [10]. In the same direction, some non-linear manufacturing model under the consideration of reliability was developed by Sarkar [11] and Sarkar [12]. Here, the concept related to coupled symmetric oscillator has been introduced to represent the nonlinearity. This type of model played an essential role in the last recent years, along with the mass-spring-type model.
Hamiltonian mechanics is a sophisticated formulation of classical mechanics. This approach is generally used to represent the oscillating system in nature or involving very complex dynamical equations. Hamiltonian dynamics has a significant advantage in that it can represent a system that is coordinate independent. This concept of representation of the complex dynamical equation has been used in this work or the proposed model of cardiovascular conduction process is based on it as the model shows nonlinearity [13,14]. As a result, the non-linear spring constant can easily be changed depending on the environmental situation and simulated according to the design. A non-linear system can easily be represented in the well-known function technique, but the whole design or mathematical model must vary the spring constant. That is why Hamiltonian dynamics comes into the picture. The nonlinearity present in cardiovascular muscle dynamics has been studied in this work in Section 10. In the Hamiltonian approach of nonlinearity, the parameter accountable for nonlinearity has been changed. It is found that the variation of the spring constant does not affect the modeling.
Here, an attempt is taken using a modified van der Pol symmetric oscillator equation to design the above-proposed model. The work's beauty incorporates [15,16] Hamiltonian approach towards the multiple coupled symmetric oscillators. It has also been used to find the amplitude-frequency relation for the two degrees of freedom of the proposed non-linear model [17]. A non-linear system for healthcare was developed by Jemai and Sarkar [18]. In this paper, using the Hamiltonian approach, the non-linear natural frequency has been calculated and simulated to develop the cardiovascular conduction system's dynamics.

Review on Cardiovascular Conduction Process towards the Prosthetic Heart
The study of the cardiovascular conduction process is significant for developing a prosthetic heart as the conduction process is a substantial part of the artificial heart. The development of modeling of cardiovascular conduction process and simulation technique of ECG signal faces numerous problems. This problem analysis improves the development process of a simulative model of ECG signal through research. This research analysis improvises the development process esthetically, depicted in a tabular forma given below in Table 1. Table 1. A short literature review on the cardiovascular conduction process.

An Author with Reference Number Theme Future Scope Limitation
Yamada [19] An implantable motor-driven artificial heart was tested.
The pump-based system tested on some animals may improve system efficiency.
The control analogy of this non-linear system is not illustrated.
Love [20] A mechanical, hydraulic circulation system was tested for developing an artificial heart system. This mechanical circulation system generates an initial idea of the artificial heart.
The system and control dynamics is not mentioned. Kurita [21] The whole operation is described as the development of an artificial heart.
Modification of the pump system provides development towards the artificial heart.
The heart model's pumping operation is proposed, but the other operational parameters are not considered. For example, transportation delay, nonlinearity Konieczny [22] The non-invasive pressure monitoring system in an artificial heart was proposed and analyzed.
The future scope is aimed at the development of non-invasive heart prostheses or assistive devices.
The pressure sensing technique for various conditions was not illustrated.
Baldoni [23] A magnetic heart valve sensing system was proposed for tracking heart valve prosthetic.
The monitoring system will be a step towards the development of the entire prosthetic heart monitoring system The valve activity during monitoring is elaborated in this study, but the controlling analogy is not exact.
Rosli [24] A smart wireless heart monitoring system was developed that uses heartbeat data for alarming.
This system may recognize the specific heart problem and alert the medical person.
The parametric analysis on several critical factors like system stability, sensitivity, and reliability was not pointed out.
Marom [25] Three different Numerical models of artificial heart systems were developed in the aspect of flow control. The various numerical model may develop the artificial model of the human heart.
The proposed design is incapable of generating a transfer function analogy.
Shi [26] The proposed artificial heart model was based on physical and numerical analysis.
The actual artificial heart model may be developed by electrical and mathematical analysis, comparing with a simulative approach.
Analysis of disease-related issues with cardiovascular system is depicted in this article.
Pohlmann [27] Some optimization techniques were realized in the artificial heart for optimal system performance.
The optimization technique drives towards functional improvement in the development of the artificial heart.
Optimization parameters of artificial heart modeling systems have not been considered.

Importance of van der Pol Equation
In practical, almost all the system behaves like a non-linear system. For analyzing a non-linear system, the basic equation is modified using the van der Pol equation. Without this equation, it is challenging to study any basic non-linear symmetric oscillator system. Here, in this study, a non-linear symmetric oscillator-based approach is used to represent a cardiovascular muscle. That is why the van der Pol equation is used here.

Why Hamiltonian Approach
The Hamiltonian operator is nothing but an energy operator that represents the total energy of a system. As energy cannot be created or destroyed, the concept of conservation of energy can be applied for both linear and non-linear systems. In this study, the modeling of the cardiovascular conduction process is shown in a non-linear way. The Hamiltonian approach is used to represent the overall nonlinearity. Hamiltonian dynamics' main advantage is that it is coordinate independent, so the non-linear spring constant can easily be varied and simulated according to one's wishes.

Background and Related Work
In the artificial heart pumping system, a suitable heartbeat has been maintained using medium-speed motor that pumps the blood very efficiently (Frazier, 1994). The process of blood circulation was clearly described, with most transportation delay time with 1 ms. The goal was to accomplish the desired step response that contains less than 4% and 9% steady-state error, overshoot, respectively. The use of a controller has improved the system characteristics. Researchers started working on the Study and Analysis of the Human Cardiovascular system in 1940, while in 2004, VAD had been patented for uninterrupted blood flow (Choi and Min, 2014). From previous research work, it has been observed that the cardiovascular conduction process in the ventricular assist device was incorporated and had also been modified so many times considering the activities of cardiovascular muscle in a linear approach. Sustainable practice in the healthcare system was studied by Jemai et al. In this direction, a non-linear smart system was developed by Dey et al. Implementation of the artificial lower limb under non-linear stability was proposed by Das et al. Herbal medicines have a good impact described by Garai et al. The natural or essential cardiovascular muscle behavior was modeled using some necessary elementary substances like mass and spring, and those were considered a linear element. However, ECG that generates from cardiovascular muscle is indeterministic. A flower pollination algorithm was developed by Sahaet al. [28]. to maintain any machine. So, an ambiguity comes between the theoretical result and experimental result. These elements (mass and spring) do not show linearity when it goes under a real-life experiment or used in some implementation. One of the reasons is transportation delay in any practical system (it is also called nonzero reaction time); nonlinearity comes into the picture. Cardiac muscle also has nonzero reaction time, due to which the overall model becomes non-linear. Here, in our work, a complete non-linear symmetric oscillator model using the Hamiltonian approach has been used to represent the energy of the cardiovascular conduction system's dynamics in a non-linear way.

Contributions and Organization
For describing the non-linear dynamics of the cardiovascular conduction system, modeling is necessary, representing the system's activities. Here, a complete non-linear symmetric oscillator-based model using the Hamiltonian approach has been developed to describe the cardiovascular conduction system dynamics in a non-linear way [29,30]. Reality shows the nonlinearity of spring and damper. The above-discussed transport delay in the cardiovascular conduction system is mainly responsible for making the overall designed model non-linear. As the non-linear system does not obey the additivity and homogeneity property, its overall energy must be represented. The proposed non-linear cardiovascular conduction system's total energy is characterized by Hamiltonian dynamics, as it talks about the system energy. Finally, for the validation of the model, simulation of the non-linear model has been done considering different spring constant values.
Modified van der Pol equation has been used for model formation. How the real work has been organized is given below. Initially, the modified van der Pol equation was used for model formation, where spring is considered a non-linear element in Section 2. Hamiltonian dynamics is described for the linear mass-spring model, which is unable to explain the nonlinearity. So, in Section 3, Hamiltonian dynamics is again applied for the non-linear model. Due to the loading effect, the Hamiltonian approach is also tested for the series connection of two mass-spring models in Section 5. The degree of freedom has also been determined by varying the spring constant, simulation is done for our proposed design, which shows periodicity and proves that the proposed model is correct as the ECG signal is periodic. The phase portrait of the model has also been simulated. It is found from the simulation aspect that state point came closer to the saddle point, which ensures the stability of the proposed design.

General Objective of the Study
In this study, a non-linear symmetric oscillator-based model using the Hamiltonian approach has been developed to explain overall the cardiovascular conduction system dynamics in a non-linear way, which is better than describing the function approach of nonlinearity. In the proposed modeling, the nature of nonlinearity is found among spring and damper. Lag phase or slow time introduces nonlinearity within the model. However, the proposed design of the entire cardiovascular conduction process has been formulated using the Hamiltonian approach, and after simulation, it was found that the design gives stability. Here, a two-dimensional phase portrait of the proposed design considering different initial conditions has been tested. At the same time, the three-dimensional phase portrait for the proposed method has also been depicted. From all the phase portraits, it is observed that the system is stable towards the proposed design. A detailed explanation of the simulation result is given in the Section 8.

Modified Symmetric Oscillator Equation-Based Non-Linear Model of the Proposed Design
The following notation is utilized for the modelling of this study. Table 2 is given below, representing the parameters used in the entire work. The Van der Pol symmetric oscillator is nothing but a primary type of non-linear symmetric oscillator used to represent any non-linear model. Our cardiac muscle (a part of the cardiovascular conduction system) can also be described as a non-linear symmetric oscillator. So, it is represented in terms of a modified van der Pol symmetric oscillatorbased equation. The Hamiltonian approach is used to describe the nonlinearity in words of energy. Here, non-linear symmetric oscillator is used to represent the cardiovascular conduction system [31] toproduce its fundamental behavior. The non-linear dynamical equation of the modified van der Pol symmetric oscillator is given below.
Equation (1) has been modified and given in a general form to maintain the symmetric oscillator's constant amplitude and synchronize the intrinsic frequency.
where m is the distance between nodes and n is an integer always taken positively in this model. At x = −m, saddle point or breakaway point occurs. At x = −n·m, the stable node is found for every positive value of n. Here, "n" represents integers.
In the previous work [32], the above equation was only tested for only n = 2. However, the above modification has drastically changed the properties and the stability of the whole system after considering the value of n greater than 2. With the repetitive experiments, it is seen that the system gives optimum stability at n = 4. The simulation result has also been observed that the simulated distance between saddle point nodes is fixed. A new parameter (γ) has been introduced in this model to varying the distance [33]. The mathematical equations are needed to introduce (γ) are given below. .
Considering the above modification . y i can be written in terms of f(x i , y i ), where f(x i , y i ) is given as follows.
The other difficulty with the previous model is that the fixation of amplitude means amplitude could not be controlled. In our proposed design, by varying the parameter σ, the system amplitude has also been maintained. It is seen from the simulation result that simulation curves come and move closer to the saddle point, which is the most essential desired result towards the non-linear model of the cardiovascular system. All simulation results are given later in the Section 8.

Hamiltonian Approach for Linear System
The general formula to find the degree of freedom of any system is given by (3N-M) [34,35] where M is number of constrains and N is denoted by the number of free particles. For example, on the sphere, the degree of freedom is (3 × 1 − 1) = 2, whereas, for a simple pendulum, the degree of freedom is (3 × 1 − 2) = 1 as the number of constrains is 2(angel of deflection and sufficient length). Similarly, our proposed non-linear symmetric oscillatory model towards the cardiovascular system's conduction is also having more than two degrees of freedom, which possess some advantages as the number of independent Symmetry 2021, 13, 151 7 of 18 coordinates is less. A PID controller with two degrees of freedom would have related to the proposed design in the future. It would have been able to reject the disturbances quickly. Newtonian mechanics (1670) reformulated progressively in the 1800 centuries made solutions to a far greater number of problems. It was first constructed in 1780 by scientist Lagrange and then again reformulated by William. R. Hamilton in 1830. The Lagrangian mechanics is based on the difference of kinetic energy and potential energy usually written in terms of position and velocity. Still, the Hamiltonian mechanics [36,37] is generally written in the momentum and position form. In some previous research work, the cardiovascular system model was represented by a frictionless mass-spring mechanical system where the model was considered a linear system. Figure 1 illustrates the system, as mentioned earlier, is given below. Newtonian mechanics (1670) reformulated progressively in the 1800 centuries made solutions to a far greater number of problems. It was first constructed in 1780 by scientist Lagrange and then again reformulated by William. R. Hamilton in 1830. The Lagrangian mechanics is based on the difference of kinetic energy and potential energy usually written in terms of position and velocity. Still, the Hamiltonian mechanics [36,37] is generally written in the momentum and position form. In some previous research work, the cardiovascular system model was represented by a frictionless mass-spring mechanical system where the model was considered a linear system. Figure 1 illustrates the system, as mentioned earlier, is given below. To find the Lagrangian and Hamiltonian expression for the above model, in which "F(t)" denotes the applied force on the mass, "x" represents displacement, and "m" expresses the model's mass k means spring constant. KE is given by m x . That represents the energy due to the motion of the system while the PE = − (−kx)dx ∝ = k x . So, the Lagrangian L can be calculated [21] as Considering Px = m x , Equation (7) can be written as Hence, the generalized momentum In terms of Hamiltonian where P is generalized momentum and q is generalized velocity. Finally, the expression of H becomes H= So Hamiltonian H represents the total energy, and the equation of motions is framed below. To find the Lagrangian and Hamiltonian expression for the above model, in which "F(t)" denotes the applied force on the mass, "x" represents displacement, and "m" expresses the model's mass k means spring constant. KE is given by 1 2 m . x 2 . That represents the energy due to the motion of the system while the PE = − x ∝ (−kx)dx = 1 2 k x 2 . So, the Lagrangian L can be calculated [21] as Considering Px = m .
x, Equation (7) can be written as Hence, the generalized momentum In terms of Hamiltonian where P j is generalized momentum and . q j is generalized velocity. Finally, the expression of H becomes Symmetry 2021, 13, 151 8 of 18 So Hamiltonian H represents the total energy, and the equation of motions is framed below. .
Multiplying Equation (15) by m and then comparing with Equation (16), it can be written as Again, it is known to us that . P x = −K. x, thus, rearranging this equation, .. ..
where ω = k m The natural frequency. The period of oscillation is also given by

Hamiltonian Approach for Non-Linear System
For explaining the essential dynamic characteristics of a vibrating system quickly, one degree of freedom can generally be modeled. However, when two cells of the cardiovascular wall [38,39] are connected in series, it should be represented as a non-linear system having two degrees of freedom. In this section, the symmetric oscillator has thoroughly been analyzed using the Hamiltonian approach is given below. m j δ ij ..
where δ ij is called Kronecker delta. By the Hamiltonian approach, the system Hamiltonian H can be written as where T = 2π ω . It denotes the time of the non-linear modeled symmetric oscillator. So, the potential energy is given by m j x i 2 and PE = F(x 1 , x 2 , . . . . . . , x n ).
As the Hamiltonian approach is suitable for the conservative systems, the total energy remains the same during the movement of an uncertain non-linear [40] model related to the human cardiovascular system. Taking integration of Equation (24), a new functionĤ(v) has been defined describing the energy of the system considering multiple inputs and given below.
For simplicity, a sinusoidal form-based displacement is taken to describe the dynamics approximately.
x j (t) = B n cos ωt, where B n is the generalized varying amplitude, where n varies from 1 to N and ω denotes the angular frequency for the oscillation [41]. Putting the value of (28) into (27)

Modeling of the Proposed Design
In this section, the series connection of two mass-spring models [42,43] is taken together, and the Hamiltonian approach analyzes the nonlinearity. Series connection of two cardiovascular muscle cells is represented as cardiac fiber, or a muscle is a chain connection of cardiac cells. Modeling one cell can be described in a linear approach, but two cells' loading effect series connection cannot be represented by a linear model [44]. That is why the Hamiltonian method is introduced. The following Figure 2 describes the non-linear proposed model to explain the human cardiovascular system's conduction process. where B is the generalized varying amplitude, where n varies from 1 to N and ω denotes the angular frequency for the oscillation [41]. Putting the value of (28) into (27)

Modeling of the Proposed Design
In this section, the series connection of two mass-spring models [42,43] is taken together, and the Hamiltonian approach analyzes the nonlinearity. Series connection of two cardiovascular muscle cells is represented as cardiac fiber, or a muscle is a chain connection of cardiac cells. Modeling one cell can be described in a linear approach, but two cells' loading effect series connection cannot be represented by a linear model [44]. That is why the Hamiltonian method is introduced. The following Figure 2 describes the non-linear proposed model to explain the human cardiovascular system's conduction process. Here, k1 and k2 represents the linear coefficient of spring, whereas k and k represents the non-linear coefficient of spring. d1 and d2 represent the displacement of mass M. Applying Hamiltonian H to the system H can be written as Considering the first-order approximate solution in the sinusoidal form, d1 = B cos ω t and d2 = (B −B)cos ωt and then putting the value d1(t) and d2(t) in Equation (30), H can be written as given below.
Taking the first derivative of the above equation and making equals zero for getting the frequency of oscillation.
The frequency amplitude relation has been established and given below.
The above equation can be rearranged as follows: Here, k 1 and k 2 represents the linear coefficient of spring, whereas k 1 N and k 2 N represents the non-linear coefficient of spring. d1 and d2 represent the displacement of mass M. Applying Hamiltonian H to the systemĤ can be written aŝ Considering the first-order approximate solution in the sinusoidal form, d 1 = B 1 cos ωt and d 2 = (B 1 − B) cos ωt and then putting the value d 1 (t) and d2(t) in Equation (30),Ĥ can be written as given below.
Taking the first derivative of the above equation and making equals zero for getting the frequency of oscillation.
The frequency amplitude relation has been established and given below.
The above equation can be rearranged as follows: Combining Equations (32) and (33) Special cases: For more accurate results, d1(t) and d2(t) have been formulated for simulation in sinusoidal form and are shown below: As cardiovascular muscle does not consist of one or two cells, preferably Z number of cells connected in series should be used to design cardiovascular muscle dynamics [45,46]. When only one cell is considered, it has been observed that the degree of freedom (DOF) is 1(3 × 1 − 2 = 1), whereas it will be two if two cells are connected in series as several constraints are four (3 × 2 − 4 = 2). The degree of freedom can be determined in three cells using the same formula, three (3 × 3 − 6 = 3). It means if the Z number of cells are connected in series, the degree of freedom will be Z. So, Equation (30) will be working correctly without any difficulties with a variable Z.

Generation of Action Potential and Coupling of Nodes
When the cell membrane crosses a specific threshold value or threshold potential, an action potential is generated [47,48] across the cell wall. Current is flowing due to this action potential [49] in or out of the cell. Spontaneous depolarization is one of the essential properties of the cardiac conduction system. The action potential is automatically generated in this system without external input. The degree of an action potential depends on how fast the depolarization occurs. However, in our proposed design considering unidirectional coupling, the term for the mass-spring non-linear model is (k1d1-k2d2) used for action potentials. The difference in coefficient tells us the asymmetry in the collar. Initially, to observe the interaction between two nodes, k1 and k2 have been considered equal to one. Finally, by varying the value of k1 and k2, different coupling simulation result has been observed and given in the next section.

Muscle Dynamics Traditional Describing Function Method to Determine Nonlinearity
The describing function technique can describe the non-linear behavior of any nonlinear system in control system engineering [49,50]. This method has also been used. This method is nothing but a frequency domain analysis related to the system. This technique is also called the "describing function analysis technique," whose mathematical representation can be given as V(V, ω) = Y 1 X ∠Φ. Now this, "Φ" denotes overall phase shift. Figure 3 represents the simple block of the above analysis technique. It has already been explained that response (i/p vs. o/p) of cardiovascular muscle shows a finite dead zone followed by constant in Figure 4. Let incoming signal is given by x(t) = Xsinωt, and due to this, input-output is given by Now the value of B has to be calculated and given as follows. It has already been explained that response (i/p vs. o/p) of cardiovascular muscle shows a finite dead zone followed by constant in Figure 4. It has already been explained that response (i/p vs. o/p) of cardiovascular muscle shows a finite dead zone followed by constant in Figure 4. Let incoming signal is given by x(t) = Xsinωt, and due to this, input-output is given by Now the value of B has to be calculated and given as follows. Let incoming signal is given by x(t) = Xsinωt, and due to this, input-output is given by Now the value of B 1 has to be calculated and given as follows.
As input is x(t) = X.sinωt, and at ωt = θ1, amplitude is M 2 .M = 2Xsin θ1. So, sin θ1 = M 2X . Similarly, at ωt = θ2, the amplitude is s. So V = Xsin θ2. So, sin θ2 = V X . Putting these values Hence, the mathematical representation of describing function for the proposed model is given by Equation (48) represents the proposed model equation considering all kinds of nonlinearity.

Simulation Result
The proposed non-linear Hamiltonian approached model has been simulated keeping mass and amplitude fix along with linear spring constant and varying the value of non-linear spring constant values and the periodic functions x1(t) and x2(t) are plotted concerning time. Here, mass M = 1 and k1 = 5 and k2 = 3 and B = 10 are kept constant. Figure 5 represents the simulation with k 1 N = 1 and k 2 N = 5 where Figure 6 represents the simulation with k 1 N = 3 and k 2 N =7.
Symmetry 2021, 13, x FOR PEER REVIEW 13 Figure 5. Plot of x1(t) and x2(t) when k = 1, k = 5.    Table 3 represents the parameters taken for simulation, and the corresponding values for every parameter have also been included in it. Table 3. value of the parameters taken for simulation.

Parameter
Values Here, in the simulation, three different lines are used. Those are solid, dot, and dashed. The solid line represents the numerical values, whereas the other lines represent the first order and second-order Hamiltonian, respectively. It has been observed that the first-order and second-order Hamiltonian overlaps with numerical solutions. At time0.05 µs, the numerical solution is 3.7, whereas at the same time, the simulated value of firstorder and second-order Hamiltonian modeling-based simulated results are 3.69 and 3.73, respectively, which are very close to accurate or mathematical work.
Similarly, at the time0.15 µs, the numerical solution is −7, whereas at the same moment, the simulated value of first-order and second-order modeling based simulated results are −6.68 and −7.01, respectively. The previous section has already discussed that by varying the parameter, the system amplitude, means the amplitude of the modified symmetric oscillator equation-based non-linear model, can be controlled. By running the sim-  Table 3 represents the parameters taken for simulation, and the corresponding values for every parameter have also been included in it. Here, in the simulation, three different lines are used. Those are solid, dot, and dashed. The solid line represents the numerical values, whereas the other lines represent the first order and second-order Hamiltonian, respectively. It has been observed that the first-order and second-order Hamiltonian overlaps with numerical solutions. At time 0.05 µs, the numerical solution is 3.7, whereas at the same time, the simulated value of first-order and second-order Hamiltonian modeling-based simulated results are 3.69 and 3.73, respectively, which are very close to accurate or mathematical work.
Similarly, at the time 0.15 µs, the numerical solution is −7, whereas at the same moment, the simulated value of first-order and second-order modeling based simulated results are −6.68 and −7.01, respectively. The previous section has already discussed that by varying the parameter, the system amplitude, means the amplitude of the modified symmetric oscillator equation-based non-linear model, can be controlled. By running the simulation, the results are shown below. Figure 7a represents a two-dimensional (2D) phase portrait of the proposed design considering all different initial conditions, whereas Figure 7b shows a 3D phase portrait for the proposed method. From the 2D phase portrait, it is evident that whatever may be the initial condition; ultimately, all state points are converging towards the equilibrium points. Hence the non-linear proposed design is stable. From the 3D phase, portrait stability can also be explained in a more prominent way than a 2D portrait. In Figure 7b, it has been observed that the initial condition may start from three independent different coordinates-based points. Still, all topics are converging towards the center of the figure, which assures stability.
From the above phase portrait, it is found that every point in the phase portrait is bounded for time, which means that the system is always converging to its equilibrium states considering any initial conditions. Hence the system is stable considering all types of nonlinearities. It is observed from the above phase portrait that, at time 25 µs, the phase's value is positive, but after 1 µs again, the step is positive, which means that the degree may vary for time. Still, ultimately, it does not go into the negative region. Symmetry2020, 12, x; doi: FOR PEER REVIEW www.mdpi.com/journal/symmetry dent that whatever may be the initial condition; ultimately, all state points are converging towards the equilibrium points. Hence the non-linear proposed design is stable. From the 3D phase, portrait stability can also be explained in a more prominent way than a 2D portrait. In Figure 7b, it has been observed that the initial condition may start from three independent different coordinates-based points. Still, all topics are converging towards the center of the figure, which assures stability. From the above phase portrait, it is found that every point in the phase portrait is bounded for time, which means that the system is always converging to its equilibrium states considering any initial conditions. Hence the system is stable considering all types of nonlinearities. It is observed from the above phase portrait that, at time 25 µs, the phase's value is positive, but after 1 µs again, the step is positive, which means that the degree may vary for time. Still, ultimately, it does not go into the negative region.
In the above figure, the x-axis represents states while the y-axis represents the responses. Initially, we considered the value of σ equal to unity, which is one of the van der Pol equation's essential parameters. Here, the variation has also been considered and simulated. It is found that the interpretation does not affect our system stability. Instead, Figure 8 shows that the equilibrium state point or only state points came closer to the saddle point, ensuring the design reliability. The polar plot of cardiovascular muscle is depicted in Figure 9 that will be essential to find stability in the traditional describing function method.  In the above figure, the x-axis represents states while the y-axis represents the responses. Initially, we considered the value of σ equal to unity, which is one of the van der Pol equation's essential parameters. Here, the variation has also been considered and simulated. It is found that the interpretation does not affect our system stability. Instead, Figure 8 shows that the equilibrium state point or only state points came closer to the saddle point, ensuring the design reliability. The polar plot of cardiovascular muscle is depicted in Figure 9 that will be essential to find stability in the traditional describing function method. From the above phase portrait, it is found that every point in the phase portrait is bounded for time, which means that the system is always converging to its equilibrium states considering any initial conditions. Hence the system is stable considering all types of nonlinearities. It is observed from the above phase portrait that, at time 25 µs, the phase's value is positive, but after 1 µs again, the step is positive, which means that the degree may vary for time. Still, ultimately, it does not go into the negative region.
In the above figure, the x-axis represents states while the y-axis represents the responses. Initially, we considered the value of σ equal to unity, which is one of the van der Pol equation's essential parameters. Here, the variation has also been considered and simulated. It is found that the interpretation does not affect our system stability. Instead, Figure 8 shows that the equilibrium state point or only state points came closer to the saddle point, ensuring the design reliability. The polar plot of cardiovascular muscle is depicted in Figure 9 that will be essential to find stability in the traditional describing function method.  Equation (48), representing the cardiovascular muscle model's nonlinearity, has been simulated along with a polar story shown below in Figure 10. Here, the describing function has been plotted from Equation (48) in blue color. Equation (48), representing the cardiovascular muscle model's nonlinearity, has been simulated along with a polar story shown below in Figure 10. Here, the describing function has been plotted from Equation (48) in blue color. Equation (48), representing the cardiovascular muscle model's nonlinearity, has been simulated along with a polar story shown below in Figure 10. Here, the describing function has been plotted from Equation (48) in blue color. In the above diagram, the polar plot of the ordinary cardiovascular muscle system and its describing function characteristics has been depicted at a time. It is observed from the simulation result that an expected limit cycle is found along the path "V" for our proposed design. Moving points E and F represents the intersection points of the polar plot and describing functions. A completely converging limit cycle has been observed within this limit. If the points E and F move away from the polar plot, the system would be unstable. Thus, the design can work for real-life situations for a particular bounded region.

Comparative Study of Our Proposed Design with Traditional Describing Function and Future Scope
In the conventional describing function technique, a non-linear system can easily be analyzed. The nonlinearity present in cardiovascular muscle dynamics has been studied in this work in Section 10. However, the parameter responsible for nonlinearity could not be varied. In the Hamiltonian approach of nonlinearity, the parameter accountable for nonlinearity has been changed. It is observed that the variation of the spring constant does not affect our modeling. As both approaches are based on energy, the result in terms of stability remains the same. Interpretation of the non-linear parameter and strength using the Hamiltonian process is the main advantage of our proposed design over the tradi- In the above diagram, the polar plot of the ordinary cardiovascular muscle system and its describing function characteristics has been depicted at a time. It is observed from the simulation result that an expected limit cycle is found along the path "V" for our proposed design. Moving points E and F represents the intersection points of the polar plot and describing functions. A completely converging limit cycle has been observed within this limit. If the points E and F move away from the polar plot, the system would be unstable. Thus, the design can work for real-life situations for a particular bounded region.

Comparative Study of Our Proposed Design with Traditional Describing Function and Future Scope
In the conventional describing function technique, a non-linear system can easily be analyzed. The nonlinearity present in cardiovascular muscle dynamics has been studied in this work in Section 10. However, the parameter responsible for nonlinearity could not be varied. In the Hamiltonian approach of nonlinearity, the parameter accountable for nonlinearity has been changed. It is observed that the variation of the spring constant does not affect our modeling. As both approaches are based on energy, the result in terms of stability remains the same. Interpretation of the non-linear parameter and strength using the Hamiltonian process is the main advantage of our proposed design over the traditional describing function method. A comparative study-based approach for human cardiovascular disease detection can be modeled in the future, considering our proposed plan as nonlinearity change parameters from person to person. Different values of the non-linear parameter can be found in various diseases, which will help future research work.

Conclusions
The human cardiovascular system's conduction process has been discussed in this work with the aid of a modified symmetric oscillator equation and an extended Hamiltonian approach for solving the motion of a non-linear system with two degrees of freedom (two degrees of freedom). The second-order approximation is observed from the simulation that the second-order Hamiltonian is overlapped with the numerical result. In our proposed model, a modified van der Pol symmetric oscillator equation has also been used to implement the series connection of two same type conduction cells of the cardiovascular system, which helps describe the complete process of conduction. The modeling can be done using only the describing function, but if the spring constant has to be varied, then the overall model equation has to be modified, which is a tedious job. Analysis of two identical cells using the Hamiltonian dynamical approach is better than describing the function approach. Using the Hamiltonian mechanics, the spring constant can easily be varied. The symmetric oscillator's natural frequency has been evaluated for the above-designed model compared with the previous simulated result, which shows that saddle point or breakaway point came closer with state points. This work's main advantage or beauty allows us to anticipate the human cardiovascular conduction process's properties obtained from different patients. We observed the non-linear parameter variation, which cannot be obtained from the describing function method.