Various Natural and Anthropogenic Factors Responsible for Water Quality Degradation: A Review

Recognition of sustainability issues around water resource consumption is gaining traction under global warming and land utilization complexities. These concerns increase the challenge of gaining an appropriate comprehension of the anthropogenic activities and natural processes, as well as how they influence the quality of surface water and groundwater systems. The characteristics of water resources cause difficulties in the comprehensive assessment regarding the source types, pathways, and pollutants behaviors. As the behavior and prediction of widely known contaminants in the water resources remain challenging, some new issues have developed regarding heavy metal pollutants. The main aim of this review is to focus on certain essential pollutants’ discharge from anthropogenic activities categorized based on land-use sectors such as industrial applications (solid/liquid wastes, chemical compounds, mining activities, spills, and leaks), urban development (municipal wastes, land use practices, and others), and agricultural practices (pesticides and fertilizers). Further, important pollutants released from natural processes classified based on climate change, natural disasters, geological factors, soil/matrix, and hyporheic exchange in the aquatic environment, are also discussed. Moreover, this study addresses the major inorganic substances (nitrogen, fluoride, and heavy metals concentrations). This study also emphasizes the necessity of transdisciplinary research and cross-border communication to achieve sustainable water quality using sound science, adaptable legislation, and management systems.


Introduction
Water resources are essential for life as we know it, in cultivated farmland, sustainability, human consumption, economic development, and environmental systems [1]. Globally, over five billion inhabitants are dependent on groundwater and surface water systems since people use these resources in numerous ways such as potable water, housing, crop production, and manufacturing applications [2,3]. The degradation of water resources is a much-studied phenomenon and can be caused by natural processes (climate change, water-rock interactions, and geological factors) and human activity (agriculture practices and urban waste), as well as the presence of considerable chemical compounds since the industrial revolution [4]. Despite this, the management of surface water and groundwater as resources remains complicated in many circumstances and relevant information remains unknown [5]. Apart from anthropogenic activities, natural heterogeneities of rock/soil interact with water, influencing natural water cycles and affecting water quality across all domains [6]. Such modifications can have severe repercussions for the functioning of human health and the living organism [7]. In addition, the physicochemical and biological Surface water contaminations (specifically in rivers and streams) are mainly due to urbanization, agriculture, and manufacturing discharge [8]. In addition, environmental physical factors can also cause contamination, whereas the temperature of an aquatic environment can fluctuate with heated water discharged from power plants [9]. Moreo- Surface water contaminations (specifically in rivers and streams) are mainly due to urbanization, agriculture, and manufacturing discharge [8]. In addition, environmental physical factors can also cause contamination, whereas the temperature of an aquatic environment can fluctuate with heated water discharged from power plants [9]. Moreover, hydro-heated water or water containing certain contaminants may not become an issue at any time of the year if it is immediately diluted by combining with surface water [10]. Further, pollutants released by agriculture activities include metals, pesticides, pathogens, nutrients, and salts that influence surface water [11,12]. Moreover, untreated and partially treated sewage, construction waste, and solid/liquid waste factors contain hazardous substances emitted into the river water by urban activities [13].
Some inorganic substances, such as zinc, iron, copper, nickel, etc., are necessary for the development of animals and plants, but these substances are harmful for animals or plants when the concentrations go above the acceptable limitations [14]. In addition, certain heavy metals such as lead, mercury, cadmium, and arsenic are no longer essential for the growth of plants and animals [15]. These toxic metals are mainly attributed to wastewater effluent in surface water due to conventional wastewater treatment, municipal waste based on activated sludge activities, and household waste [16]. Such pollutants are found widely at low concentrations from nanograms/liter (ng/L) to micrograms/litre (µg/L) [17]. Consequently, these toxic pollutants are released into river water either directly or indirectly, mainly by industrial waste, municipal and urban factors, as well as contaminated surface water discharge into the groundwater aquifer system by infiltration through soils and land-use practices [18].
Groundwater aquifer vulnerability and its pollution risk in the anthropogenic environment increases from the complicated interactions of the natural mechanisms of the hydrological system with the physical changes to the land surface, discharge waste from human factors, and water resource exploitation [19]. Further, physical landscape alterations cause an increase in the vulnerability of groundwater systems through topography changes, artificial water bodies, construction, river channeling, surface sealing, and changes in surface ruggedness [20]. In addition to the change in land use and land cover, the widespread utilization of synthetic and natural chemical compounds (pesticides and fertilizers) is also part of anthropogenic activity [21]. Utilization of these compounds generates agricultural productivity and can be beneficial for animal and human health, sufficient energy, functional infrastructure, and production of materials [22,23]. Nevertheless, numerous compounds used extensively today have been revealed to be persistent, mobile and soluble in aquifer systems, which is harmful to human health and environment systems [24]. Several other substances are still unknown threats, and thus far, the risk that chronic product exposure to a combination of substances has been difficult to quantify in many environmental areas.
When groundwater is polluted with toxic chemical compounds through human activities it can become unsuitable for several years [25]. The residence time of chemical pollutants can be retained in the groundwater system for weeks to months, years, and decades [26]. It depends upon the properties of the physicochemical compounds and environmental scenarios, and further lack of water supplies does not remove the effects of the groundwater pollution. Previous studies have identified the flow of groundwater through the hydrological cycle of pollutants from waste sewage or spill areas to surrounding rivers, channels, and lakes [2,27]. In the scientific community, problems in the context of groundwater pollution are widely known. Regulatory bodies have determined the high level of numerous toxic compounds in potable water systems at many places of the world. For instance, nitrate and fertilizer compounds have been recorded at high concentrations in groundwater systems [28]. Therefore, the contamination resulting directly from agriculture and industrial activities is a persistent and growing problem. According to recent estimates, 80% of the world's population in 25 countries suffer the horrible death of infectious diseases caused by groundwater contamination [29]. The current expansion of human practices is often contrasted directly with what is required to safeguard groundwater supplies for future consumption [30,31].
This review discusses several major contaminants of water resources degraded by natural and human factors, as well as several critical inorganic pollutant classifications released from anthropogenic activities. Furthermore, this study highlights several case studies in the literature investigating historical and emerging issues in polluted water resources and the diversity of issues in various areas of the globe. The impacts of these activities are described to emphasize the multiple issues arising if anthropogenic regulations are present on top of natural controls [32]. Scientific and government regulations have highlighted the critical need for better comprehension of pollutant processes in water resources and the environment [33]. The complicated interactions between types, sources, and transport pathways of water resource pollutants in various settings have been addressed in this study. Consequently, sustainable water quality should be secured rapidly, and transdisciplinary and transboundary activity is required, especially as humans go towards 2025 [23,34].
The main aim of this study was to discuss the water quality degradation due to natural and anthropogenic factors, as well as the contaminants' sources, types, and pathways. Therefore, there were three objectives: (1) to discuss anthropogenic factors such as industry (solid/liquid wastes, chemical compounds, mining activities, spills, and leaks), urban development (municipal wastes, land use practices and others), and agricultural practices (pesticides and fertilizers), (2) to address natural sources such as climate change, natural disasters, geological factors, soil/matrix, and hyporheic exchange in the aquatic environment, and(3) to focus on major pollutants based on their relevance such as inorganic substances (nitrogen, fluoride, and heavy metals concentrations). An overview of this review is shown as a flow chart in Figure 2.
Water 2021, 13, x FOR PEER REVIEW 4 of 36 studies in the literature investigating historical and emerging issues in polluted water resources and the diversity of issues in various areas of the globe. The impacts of these activities are described to emphasize the multiple issues arising if anthropogenic regulations are present on top of natural controls [32]. Scientific and government regulations have highlighted the critical need for better comprehension of pollutant processes in water resources and the environment [33]. The complicated interactions between types, sources, and transport pathways of water resource pollutants in various settings have been addressed in this study. Consequently, sustainable water quality should be secured rapidly, and transdisciplinary and transboundary activity is required, especially as humans go towards 2025 [23,34].
The main aim of this study was to discuss the water quality degradation due to natural and anthropogenic factors, as well as the contaminants' sources, types, and pathways. Therefore, there were three objectives: (1) to discuss anthropogenic factors such as industry (solid/liquid wastes, chemical compounds, mining activities, spills, and leaks), urban development (municipal wastes, land use practices and others), and agricultural practices (pesticides and fertilizers), (2) to address natural sources such as climate change, natural disasters, geological factors, soil/matrix, and hyporheic exchange in the aquatic environment, and(3) to focus on major pollutants based on their relevance such as inorganic substances (nitrogen, fluoride, and heavy metals concentrations). An overview of this review is shown as a flow chart in Figure 2.

Classification of Water Pollution
Water pollution indicates the addition of compounds, elements, chemical substances, organisms, and/or pathogens into the surface water or groundwater that change the physical, chemical, and biological composition of water resources through natural and anthropogenic activities, as shown in (Figure 1). Water pollution authorities and researchers have always attempted to classify types of pollution. Sources of pollution have

Classification of Water Pollution
Water pollution indicates the addition of compounds, elements, chemical substances, organisms, and/or pathogens into the surface water or groundwater that change the physical, chemical, and biological composition of water resources through natural and anthropogenic activities, as shown in (Figure 1). Water pollution authorities and researchers have always attempted to classify types of pollution. Sources of pollution have been divided into five major categories since the 1970s: residential, municipal, agricultural, industrial, and natural [35]. Several sources of classification for the origin of water pollution have been identified, which have also been prepared for sub-classification. For example, municipal waste is a major water pollution source category and its sub-categories such as solid waste and liquid waste can be described. Moreover, the character of the chemicals in the waste can be sub-categorized into organic waste as well as inorganic solid waste. Since the 1980s, the classification system of the Office of Technology Assessment (OTA) in the United States has been modified and expanded into six categories [36,37]. The addition of naturally occurring sources seems to have been an especially important change which is described as below: Sources discharging substances because of other planned activities II. Sources providing conduit or inducing discharge by altered flow patterns III. Naturally occurring sources; where the discharge is created and/or exacerbated by human activity IV. Sources designed to retain substances during transport or transmission; discharge by accident or negligence V.
Sources designed to store, treat, and/or dispose of substances; discharge through the unplanned release VI. Sources designed to discharge substances Finally, two major types of water pollution have been defined by the United States Environmental Protection Agency (EPA), these are point-source and non-point-source pollution [38]. According to the EPA, point-source pollution is any pollutant released from a single point entering the environment from easily identified and confined areas such as smokestacks, drainage tubes, industrial waste, municipal wastewater treatment plants, factories, and power plants. Non-point-source pollution does not come from a specific source and is a combination of pollutants that are released from a large area. It means that pollution does not come from a specific source, it comes all at once from a large distance and several locations, however, it is harder to find and more difficult to address (e.g., thunderstorm, runoff, oils, grease, animal wastes, pesticides, and fertilizer). According to the EPA (1996), six categories have been classified based on point and non-point sources such as industry and mining, forestry and agriculture, waste mismanagement, miscellaneous, urbanization, and natural sources. Moreover, the identification of contamination sources based on origin will be adhered to in this study. Generally acceptable utilization, simplicity of physical identification, and flexibility are the main reasons for its selection. In this study, the sources of contamination have been classified into two categories based on natural and anthropogenic activities, which describe their origins, pathways, and locations such as land surface and underground formations, as shown in Table 1. Due to high gas solubility, high water viscosity, and wind dynamics, evapotranspiration (heat exchange, soil-humidity radiation), and dilution of water by heavy rainfall and acid precipitation flows into surface water directly or indirectly and affects the groundwater quality.
Natural disasters Droughts, floods, and landslides Increased drought periods and higher temperatures rates are projected to affect the distribution of rainfall that produces flooding, as well as landslides which are high quantities of earth, rock, or mudthat flow quickly down mountainsides and have an enormous effect on the water resources. Mineral dissolution and radioactive decay Mineral dissolution is a slow process that takes several days, years, or decades, depending on the mineral solubility. Radiation material is due to emissions in the atmosphere of toxic ionizing radiation (beta-alpha particles, gamma rays, or neurons) and the radioactive decay of minerals that affects the water resources.
Soil-matrix Grain size and pore spaces Soil type or matrix (sand, clay, and silt) can control pollution with variable recharge or discharge rates; redox reactions are usually retarded in inorganic sediments or soils, whereas organic compounds or microorganisms bacteria tend to accelerate the rate of reactions in soil-matrix strata.

Hyporheic exchange
Solutes exchange, pathogen exchange, and SW and GW interaction Further, the availability of dissolved substances, solutes, organic-rich matter, and oxygen are highly reactive in the hyporheic exchange zone, and with the addition of microorganisms (viruses, bacteria, and protozoa) can lead to the death of animals under aerobic and anaerobic conditions, through both slow and quick flow routes in the groundwater. Further, the physical, chemical, and biological properties of water can change due to these elements mixing, and the intrusion of seawater makes the coastal groundwater system vulnerable to salinization.

Anthropogenic processes
Industrial waste Solid/liquid waste and chemical compounds Landfills (including tailings facilities) are the most frequent places of disposal of solid waste globally and landfill leachate from waste disposal, as well as the presence of organic liquid compounds in industries (proteins, lipids, and carbohydrates) and dissolved inorganic contaminants is a source of water resources pollutants. Further, chemical materials in the industrialization sectors are utilized both outdoors (susceptible to photolysis destruction which is accompanied by soil biodegradation) and indoors (distinct routes of degradation which move through a wastewater plant).

Accidental spills and leaks
Spills and leaks in manufacturing products such as tanks and pipelines can also impact water resources, including manufacturing of environment products and chemical waste (benzene, methylbenzene, toluene, xylene) which get into surface water and contaminate groundwater

Mining processes
Mining practices have effects on the groundwater and surface water by excavating solid waste due to sinkholes, erosion, coal exploration, and chemicals released from mining processes and heavy utilisation of water in mineral processing. The groundwater pumped out of the mine disperse on the Earth's surface or drain into streamswhere it penetrates the subsurface water, releasing dissolved, disintegrated, oxidized, and leached minerals, causing groundwater pollution.

Agriculture Pesticides
Pest chemicals (herbicides, insecticides, rodenticides, and fungicides) can runoff from the surface and enter groundwater systems for a considerable time with their degradation products.

Fertilizers
When the nutrient concentration (nitrates and phosphates) supassesthe plant absorption capability, it can lead to surface runoff and percolate into the groundwater.

Urban activities
Municipal waste Solid garbage (wood, plastics, metals, food waste, papers, inert materials, etc.) is dumped and transported to the waste processing plant until it reaches rivers and pollutes the groundwater. Further, liquid wastewater can penetrate groundwater by way of sewage sanitary leaks connected to a storage tank or faulty structure, disturbing the water quality.

Cemeteries
Water pollution from cemeteries was a historical issue, as 0.4-0.6 litres of leachate with a density of 1.23 g·cm −3 per 1 kg body weight are released during the decomposition process of the human body and can pollute aquifers.

Transportation
Transportation produces air pollution and can directly contribute to water pollution, thus storm events; precipitation extracts air pollution from the land surface, absorbs road deposits, and flows into water bodies.

Livestock productions
Livestock and poultry farms create animal waste which may be transferred to surrounding lakes, streams, and groundwater across the agricultural land surface, as well as animal manure, which can be used on farms to fertilize plants and add/recover nutrients to the soil.

Land use practices
The impact of land use activities on the water system from infrastructure, which includes construction, pipelines, and highways roads.

Effect of Natural Factors to Water Quality
Natural processes influence the surface water and groundwater quality by various sources such as climate changes, natural disasters, geological factors, soil-matrix, and hyporheic exchange, as shown in Figure 3. The natural factors described below are considered the most widespread in terms of water quality degradation through various processes as discussed in Table 2.

Climate Change
Climate change not only influences ecological, hydrological, and biological systems; it also affects life and economy [39]. The primary and foremost occurrence and vulnerability of surface water and groundwater are natural regional climate oscillations and weather changes [40]. However, this also includes past weather patterns in the context of fossil groundwater. Consequently, precipitation, humidity, and evapotranspiration are the most significant climatic factors. Another characteristic of climatic factors is a seasonal variation in temperature [41]. It affects processing and affects coagulation and winter's softer reactions. Due to the increased solubility of gases and high viscosity of water, low temperatures cause issues with the air binding of filters, cause pressure drops by the filter beds to raise the expulsion gas and disrupt the movement [42]. The sudden river water dilution through heavy precipitation can severely affect water quality, and high rainfall can directly or indirectly charge surface water. Further, high humidity and precipitation are a primary charge for most aquifers, either through direct infiltration or indirect runoff regimes. Moreover, evapotranspiration includes other climate factors (heat exchange, radiation, and wind dynamics) that influence the quality and quantity of water resources [43]. Rainfall is irregular and evapotranspiration is typically high, leading to a reduction of recharge and a concentrated impact of solutes within the groundwater system, especially in semi-arid and arid regions [44].

Natural Disasters
The large number of wastes caused by natural disasters such as volcanic activities, earthquakes, hurricanes, tornados, flooding, and tsunami contributes considerably to the water pollution issue [45]. More than 5000 disasters concerning water-related injuries were recorded from 2001 to 2018 worldwide, representing 73.9% of natural disasters. About 1.7 trillion USD (US dollars) in economic damages and a total of 300,000 deaths and personal injuries were caused by water-related disasters through floods, storms, landslides, and droughts throughout the world [46]. Particularly in recent years, floods and droughts, which accounted for over 60% of water-related natural disasters, have had significant economic repercussions [47]. Due to around 2100 floods and 430 droughts worldwide, an estimated 365 billion USD was lost throughout the 20th century. In the 21st century, water-related catastrophes and their effect have been significantly greater. Approximately 600 billion USD has been lost globally between 2001 and 2018 because of over 2900 floods or 290 drought disasters [46]. The health of 2.8 billion humans was also affected by these catastrophes. For example, during 2001-2018, about 300,000 humans suffered severe losses from floods. Flooding and other disasters can destroy wells of drinking water and cause well pollution by human sewage, pollution of animals, human waste, chemicals, livestock waste, and other impurities [48]. Further, natural hazards contribute to huge quantities of pollutants in surface water and groundwater resources. A multitude of pollutants can disturb the water resources after devastation, including lead, total dissolved solids, chlorine, nitrates, fecal coliform, and total coliform [49].

Geological Factors
Geological factors (soil types, topography slope, plant roots, dissolution of water with minerals/soils, and radioactive decay of elements) are essential for water resource quality [50]. The regional and local geological formations, as well as tectonic deformation, indicate natural dynamics of groundwater recharge, subsurface flow, and the physical characteristics of the aquifer [51]. Soil types can fluctuate considerably between landscape forms, according to the geological formations and processes beneath the surface area, as well as recharge rates exchange. A further factor affecting how much water is transferred between the surface and groundwater resources through land cover comprises flora (both dying and living) and surface water bodies [52]. Flat terrains have lower surface runoff to accommodate higher infiltration rates, while steep slopes have tended to raise surface runoff and reduce the residence time of groundwater [51]. Further, plant root or vegetation systems can produce preferential flow routes in the unsaturation zone, whereas heavy floral cover can lead to decreased surface runoff and high rates of evapotranspiration [53]. Water is a solvent and is capable of dissolving and interacting with organic and inorganic components of soils, minerals (anions or cations), and various types of bedrock [54]. Mineral dissolution is a slow process that takes days, years, or decades and depends on the mineral solubility, and affects many of the qualitative characteristics of aquifers, for example, hardness and pH [55].
Radioactive contamination arises if radioactive materials are already present or deposited in the environment. Radioactive decay can be detrimental to ground quality. The damage caused by radiation materials is due to emissions in the atmosphere of toxic ionizing radiation (radioactive decay), such as beta or alpha particles, gamma rays, or neurons [56]. As radiation characterizes the substances, since the particles in the radioactive materials are very unstable, they can seriously harm, change, and even kill plants, animals, and humans [57,58]. In drinking water, there are two sources of nuclear pollution. The first is natural radionuclide found in soil and rock through which the water passes. Some areas are vulnerable to phosphate-rich soils and rock pollution [59]. The second radioactive source comes from human-made sources. Further, artificial radionuclides are developed due to human activities such as nuclear reactors, nuclear testing, and the development and use of radioactive sources [60]. Drinking water radionuclide consists of three radioactive radium series, plutonium, thorium, and actinium, that comprise the natural elements radium and plutonium, and the radioactive gas radon [61]. These contaminants can cause various kinds of biological damage. Radium in the bones becomes concentrated and can cause cancers, and uranium can also cause bone cancer and have toxic effects on the kidneys [62].

Soil or Sediment Matrix
All parental geological materials combined with the weathering impact of climate indicate the soil/sediment matrix characteristics which define the grain size, pore spaces, and the existence of unconfined/confining beds [63]. These physical properties of the soil/sediments matrix evaluate the pathways of water and affect the storage of groundwater aquifers, particularly the transport, magnitude, and rate of recharge [51]. Further, these factors show the mean residence time along with aquifer depth. Sediments and soil matrixes regularly interact with solutes through physical, chemical, and biological processes such as ion exchange, sorption, solute, degradation (biotic and abiotic), and rainfall [64]. In addition, redox reactions are usually retarded in inorganic sediments or soils, whereas organic compounds or microorganisms/bacteria tend to accelerate the rate of reactions in these strata [65]. To a large extent, they govern the persistence of pollution in organic matter in these strata. Oxygen deficiencies tend to occur in typically deep groundwater, while oxygen-rich groundwater often tends to be in fissured aquifers or shallow groundwater [66]. Therefore, these reactions will impact ion exchange and reduction processes whether the groundwater is shallow or deep. These variables influence how specific solutes or contaminants moving through the pores or space in the sediment matrix are degraded [40].

Hyporheic Exchange
The exchange of surface water and groundwater through streambed sediments between near-channel and in-channel water, as well as the mechanism of solute mixing between the exchange area surrounding alluvial rivers, are known as a hyporheic exchange [67][68][69][70]. Further, the availability of dissolved and suspended materials, organic-rich matter, and oxygen are highly reactive in the hyporheic exchange area [71,72]. Due to these interactions, physical, chemical, and biological processes take place. Moreover, infiltration occurs in space, either along preferential routes or across the whole wetted region, in a relatively homogenous formation [73]. Further, flow and recharge occur primarily within systems of fractures, cracks, and other isolated openings for karstic, confined, and fractured hard-rock aquifers, which permit quick and slow recharging [74]. Specific flow routes are only active during or after precipitation events or snowmelt in these environments.
One of the most complex and widely dispersed environmental issue is brackish water or seawater intrusion which pose a danger to the groundwater quality and sustainability in coastal aquifers [75]. The intrusion of seawater and up coning makes the coastal groundwater system vulnerable to salinization. The groundwater and seawater interactions can be classified into two distinct water flows: seawater flows into an aquifer (seawater intrusion) and groundwater flows into the sea or ocean water (submarine groundwater discharge) [76]. The seawater infiltration into groundwater can affect the aquifer quality and availability, and it will cause stress to the coastal aquifer. Thus, the intrusion of salty water is the transfer of saline water into freshwater aquifer systems.

Effects of Anthropogenic Factors to Water Quality
Anthropogenic pollutants are substances caused by human actions, mostly resulting from land-use practices. Surface water differs from groundwater because it may contain many hazardous chemicals from human practices; as a result, it is highly contaminated [2]. Anthropogenic changes have a substantial influence both in terms of modifying the magnitude of existing conditions and adding new variables on each part of the water cycle (leakages, irrigation, extraction, or wastewater) [2,31,77]. Further, the consideration of local social factors in relation to current and historical land-use practices, such as waste treatment processes and infrastructure, should not be excluded to take account of the natural setting. However, several anthropogenic activities (agricultural, industrial and urban) contaminating the surface water and groundwater systems, as well as pollutants moved various pathways has been shown in Figure 4. region, in a relatively homogenous formation [73]. Further, flow and recharge occur primarily within systems of fractures, cracks, and other isolated openings for karstic, confined, and fractured hard-rock aquifers, which permit quick and slow recharging [74]. Specific flow routes are only active during or after precipitation events or snowmelt in these environments. One of the most complex and widely dispersed environmental issue is brackish water or seawater intrusion which pose a danger to the groundwater quality and sustainability in coastal aquifers [75]. The intrusion of seawater and up coning makes the coastal groundwater system vulnerable to salinization. The groundwater and seawater interactions can be classified into two distinct water flows: seawater flows into an aquifer (seawater intrusion) and groundwater flows into the sea or ocean water (submarine groundwater discharge) [76]. The seawater infiltration into groundwater can affect the aquifer quality and availability, and it will cause stress to the coastal aquifer. Thus, the intrusion of salty water is the transfer of saline water into freshwater aquifer systems.

Effects of Anthropogenic Factors to Water Quality
Anthropogenic pollutants are substances caused by human actions, mostly resulting from land-use practices. Surface water differs from groundwater because it may contain many hazardous chemicals from human practices; as a result, it is highly contaminated [2]. Anthropogenic changes have a substantial influence both in terms of modifying the magnitude of existing conditions and adding new variables on each part of the water cycle (leakages, irrigation, extraction, or wastewater) [2,31,77]. Further, the consideration of local social factors in relation to current and historical land-use practices, such as waste treatment processes and infrastructure, should not be excluded to take account of the natural setting. However, several anthropogenic activities (agricultural, industrial and urban) contaminating the surface water and groundwater systems, as well as pollutants moved various pathways has been shown in Figure 4.

Industrial Applications
Water pollution is caused by industrial waste mainly released from mills, factories, and mining sectors. These sectors pose a potential hazard of polluting water resources. Those sources are placed on the Earth's surface while the industrial waste material drains into the surface water that percolates directly or indirectly into the groundwater. In recent years, various attempts have been made both in developed and developing countries to recognize these sources of water pollution. Monitoring and clean-up activities have been implemented. Despite these challenges, there is still a great deal of work required to define and store these sources and evaluate the effects of the steps taken. It is estimated that 3% of the land surface is occupied by industrial and urban uses, including mineral extraction exploration areas [78]. These two responsible factors of pollutants are the most-often addressed in water resources literature, considering the tremendous amount of liquid and solid waste discharged.
Collectively manufacturing industries contribute more waste than urban and agricultural operations, especially mining activities that produce a larger amount of waste around the world [31]. In recent decades, exponential industrial development within energy production, raw substances, and engineering applications has resulted from the discharge into the environment of an ever-expanding and diversified variety of waste products that have left their mark on water resources quality [2]. Globally, over 80% of wastewater has been reported to be discharged into the environment without treatment [79]. There are several possible primary sources of water contamination due to industrial activities including solid or liquid waste, mining practices, spills, and leaks.

Solid and Liquid Waste
Industrial waste is waste released through the manufacturing process that involves any useless products produced throughout industrial operations such as factories and mills [31]. Manufacturing industries develop liquid, solid, and gaseous wastes that can have adverse environmental and human impacts; acid rain is an instance of sulfur dioxides and nitrogen oxides emissions from chimneys and exhaust pipes [79,80]. Industrial waste can pollute the air, soil, or nearby water sources and eventually end up in the seas and rivers.
The presence, coverage, type, and maintenance of infrastructure, such as landfills, may have been the most critical deciding variables for the quality of water resources and the threat of solid waste pollution from solid waste materials [81]. Landfills (including tailings facilities) are the most frequent method of disposal of solid waste globally and remain typically the cheapest disposal option, especially for huge amounts of manufacturing solid waste [82]. Despite landfill leachate from waste disposal being a recognized source of groundwater pollutants, solid landfill lining is not enforced everywhere. Moreover, landfills with inadequate or non-existent lining dating from the industrial revolution are also widespread. At present, regions without access to efficient preservation or disposal systems can depend on their solid residues in shallow subsurface disposal. Further, solid waste comprises a variety of applications, such as plastic, cardboard, paper, scrap metal, packaging materials, wood, automobile parts, food waste, and all other solid garbage that cannot fulfil its intended use any longer [83].
Industrial liquid waste is considered wastewater. Such contamination is caused by the presence in industrial fluids of organic compounds (proteins, lipids, and carbohydrates) and dissolved inorganic contaminants [84]. Most manufacturing industries require massive quantities of water which can enter the interface along with dangerous chemicals. The specific infrastructure for liquid waste includes drainage systems, drains, septic reservoirs, and sewer networks [85]. The recommended solution is centralized wastewater collecting systems, associated with a properly operating treatment facility using modern treatment technology and frequent maintenance, as effluent is often better tracked for environmental protection. Comprehensive gasoline storage and pipeline networks utilized in the industrial sector are another class of infrastructure. These components are potential causes of nonaqueous liquid pollution by leakage or accidental spills [31,86].
There is a possible serious threat to the quality of groundwater from petrol stations and in numerous networks with above and subsurface routes and pipelines containing petroleum substances [87]. Accidental spills and leaks in manufacturing product tanks and pipelines can also impact the water resources. Accidents are related to the manufacturing environment products, chemicals, or hazardous waste (benzene, toluene, xylene, etc.) and their entry into freshwater [88].
A particular problem in the manufacturing process is the use of injection and disposal wells, which harm water resources. At disposal wells, industrial effluents and water for cooling and processing reach the groundwater system through the bottom of the well or through well-screens [89]. These wells, particularly industrial waste, are a source of chemicals and microorganisms that can directly contaminate aquifers. Injection wells are commonly associated with hazardous waste disposal in deep-seated rock formations that are supposed to have no interaction with freshwater resources [90]. Waste that can be deposited through injection wells include brines, radioactive products, hydrocarbons chlorinated, and liquors for bearing steel.
Improper well field design is another problem in the groundwater system; it can change the local groundwater flow as well as chemical and biological conditions. Thus, the direction of groundwater flow may be reversed or changed, and the hydrological chemistry of underground aquifer and the redox potential can also be changed [51,91]. For instance, improper screening and sitting of the well can change redox values in groundwater rich in iron and bacteria and contribute to iron, manganese, and slime precipitation into the groundwater and in well-screening and pumping [92]. Another example is improperly screened wells sitting in aquifer systems in which pesticides, fertilizers, liquid, and solid waste are present due to human-induced pollutants [93]. Moreover, the movement of pollutant infiltration by semi-confining formations may decrease groundwater quality in deeper water aquifers and enter well screens [94]. Thus, improper screening and sifting of wells will worsen the impact of human-induced and natural contaminants and can be referred to as a secondary pollution mechanism.
The use of chemical materials in pest control or the improvement of substance characteristics are common in industrial activities [95]. Pest control materials are typically known as biocides in these settings. Chemical materials in the industrialization and urbanization sectors are utilized both outdoors and indoors, but are used almost exclusively outdoors as compared to agricultural products [31]. Furthermore, outdoor materials can continue to run in sewer networks which leads to penetration into the groundwater environment, either as a point or line source [96].

Mining Processes
Environmental effects of mining can occur at point, large, regional, and global scales through indirect and direct mining practices. Its effects can be found due to sinkholes, erosion, biodiversity loss, exploration of radioactive substances, salt, coal, phosphate, or the chemicals emitted from mining processes [97]. Consequently, mining practices affect groundwater and surface water systems through the excavation of solid waste, heavy use of water in processing ore, seepage from tailings, waste rock impoundments, and water pollution from discharged mine effluent [98]. In addition, mining and ore processing activities mostly extract groundwater either in open-pit mines, whereas groundwater infiltrates frequently or in subsurface dewatering operations.
Observation wells or abandoned production and boreholes exploration by drilling may serve as vertical conduits for the movement of toxic pollutants [99]. Acid mine-water runoff is another cause of contamination that leads to groundwater pollution by mining waste, for example, tailings facilities [100]. This issue is most often related to coal mining. Crushed waste rock and liquid are composed of dumping tailings facilities which typically hold large amounts of by-products of host-rocks like pyrite [31]. The oxidized substance is diluted with water, and the water from the mine becomes acidic. The mine-water drainage has no usual compound but usually has relatively high sulphate, iron, and other metal concentrations; low pH; and high acidity. Water used to reduce mine dust, equipment cooling, washing, and processing, etc. can accumulate harmful compounds.
Nevertheless, previous findings demonstrate that the absorption of heavy metals from mine leachate, based on pH, soil types and leachate quantities, can be extremely effective in shallow and deep aquifers [101]. The fact that the subsurface geology has not contained calcite or carbonate or cessation of lime addition to tailings facilities decreases the ability of groundwater to tamp down the leachate from the mine. Only a minor reduction in pH has resulted in higher concentrations of soluble elements. While the leachate and groundwater pH fall to below 5, significantly higher levels of aluminums and copper can be observed in groundwater that severely affects the quality of the surface water and groundwater and its associated ecosystems [101].

Agriculture Practices
Agriculture is one of the most common activities of human beings that can affect both surface water and groundwater. The activities of this category include fish farming, crop cultivation, livestock, pesticides and fertilizers, cattle, and poultry farming. These activities take place on the Earth's surface; therefore, soil, vegetation, rainfall, surface, and irrigation water penetration can lead to pollutants entering the groundwater. Forestry can also have adverse impacts on water resources. Stockpiles of a wide range of irrigation materials and crop residues may also become possible point sources of underground water pollution. No systematic research on the contaminating impacts of crop residues has yet been performed.

Pesticides
Pesticides are chemicals that are used to remove undesirable organisms in community gardens, agricultural areas, and other public areas [102]. The word "pesticide" encompasses all chemicals used in killing or controlling pests. In the early 1960s, people became aware of pesticides as environmental hazards. Chemical controls have become a core of the development of farmland and are also common in rapid urbanization and industrialization. Massive surveillance estimates from 1989 reveal that pesticide usage continued to rise, with up to 3 million tonnes being consumed in 2007 [31]. In the last two decades, especially within Europe and North America, the use of pesticides has increased significantly, and global pesticide use is noticeable [103]. Pesticides remain a chronic concern for worldwide groundwater supplies notwithstanding restrictions.
In addition to plant protection against insects, pesticides include herbicides, nematicides (nematodes), insecticides (insects), rodenticides (vertebrate poisons), and fungicides (fungi). They are also crucial in food growth and protect or increase crop yields, and enable a plant to be cultivated on the same land numerous times per year [104]. The differences in pesticide degradation and sorption rates (that are the two most essential mechanisms for the control of persistence of pesticides) and their characterization of sediment and groundwater media complicate the movements of pesticide products in the subsurface. Porous groundwater aquifers generally improve the filtration of pesticides from underground, but karstic ones are more susceptible due to quick flow and low sediment reactivity to long-term pesticides contamination problems. Thus, pesticides can easily be moved over a broad geographical region to pollute surface water and groundwater [105]. Numerous pesticides are soluble in water, and are applied with water and consumed by the target. The more soluble a pesticide is the higher chance of leaching, whereas residual herbicides usually are less soluble to help bind the soil [106]. A further aspect that influences pesticide water contamination is precipitation, with high precipitation rates increasing the hazard of pesticides polluting the water. The slow movement of groundwater means it can take decades to get polluted water out of the affected wells.
Pesticides that have been used historically and that are now prohibited are nevertheless detected as enduring substances in groundwater. The reason for this is not always clear. There are currently limited operating ways or techniques for tracing the damage to the environment or for making relevant forecasts of its sustainability within water resources.
Conventional methods to identify the origins and routes of pesticide pollutants in water bodies include time series for concentration, isotopes investigation for specific compounds, and compound ratios for parent-to-metabolite.

Fertilizers
Improperly controlled fertilizer components may transfer through field runoff or leach into water bodies [107]. The two major fertilizer compounds that are most concerning for contamination of water resources are nitrogen (N) and phosphorus (P). Improper or excessive utilization of fertilizer can contribute to water body nitrate contamination. Nitrogen fertilizer is biologically converted to nitrate, which is highly soluble in water, either organic or inorganic [108]. Additionally, soluble nitrate is extraordinarily mobile and can be extracted from soil with percolating water, rendering it inaccessible for crop uptake and accumulation. When pollution enters drinking water sources, fertilizer nitrates can cause serious health hazards, particularly for young livestock and babies [109].
The use of nitrates can affect methemoglobinemia (blue baby syndrome) in children, by decreasing the blood's oxygen-carrying capacity. Phosphorus is another significant component of fertilizer [110]. Phosphorus can be moved easily with the soil in some circumstances. Moreover, 60 to 90% of phosphorus typically travels with the soil. Phosphorus is globally the primary cause of water quality impairments in lakes. Proper storage, handling, and usage on farms or acreages of fertilizer are crucial if water supplies are protected from chemical pollution. This is partly because fertilizer rubbings in surface water can lead to surplus algae growth and can kill fish-secure permanent storage and combining fertilizers from spills, leakage, or storm-water penetration is needed to solve this problem.
Previous studies indicated that many silage-making cases lead to the creation of polluted liquids with excessive BOD requirements and the release of phenols and sulfates [111]. The most common chemical pollutant in groundwater aquifers globally is agricultural nitrate. Agriculture is the biggest cause of pollution in streams and rivers, the second main wetland, and the third most important lake source in the United States of America [112]. Agriculture is also accountable for the huge amount of surface water pollution and groundwater pollution through nitrogen in China [78]. The intensive use of chemicals such as pesticides and chemical fertilizers has accomplished the global growth of agricultural productivity. Excess nitrogen and phosphates can leak into groundwater or be transferred into waterways by surface runoff. Phosphate is not as soluble as nitrate, and is absorbed into soil and then transferred through soil erosion to the water resource.

Urbanization
Urbanization is an all-embracing form of land-use and land cover change that is rapidly increasing globally [113]. It includes the conversion into croplands, wetlands, forests, pastures, grasslands, and other land cover forms to commercial, industrial uses, residential, and transportation practices, thus growing the areas of impervious surfaces [2]. Therefore, impervious surfaces are measurable factors that closely correlate with rises in polluted runoff sources that decrease water resource quality [114]. Construction work often includes river embankments, sluice, irrigation and drainage works, galleries for penetration, water wells, dams, and reservoirs. In this section, major pollutants released from urban activities have been discussed such as municipal practices, land development, forestation, and deforestation.

Municipal Wastes
Municipal (household or domestic) wastes are derived from many sources of various human activity and socio-economic areas worldwide, which may be liquid or solid and are challenging to use as raw materials [83]. Consequently, these wastewaters come from our everyday lives and include preparing food, washing, bathing, and toileting [115]. Moreover, grey water and black water are released from domestic dwellings with access to piped water, as well as business premises and establishments in residential areas such as schools and health centers.
The term sewage is used to describe all these forms of liquid waste in combination and with surface run-off. Commercial wastewaters that comprise companies, shops, stores, open markets, restaurants, and cafés are similar mainly to that of households [116]. Liquid waste such as urine, human excrement, and washing water, are released into shafts to avoid them becoming hazardous on the land's surface and, if the liquid is high, in the water table and polluted water systems near the site [46]. Particularly in densely populated urban areas, septic tanks can pollute local groundwater supplies.
Furthermore, solid waste materials are incredibly heterogeneous with variable physical properties depending on their source such as wood, plastics, metals, food waste, papers, inert materials, paint containers, yard waste, demolishing materials, construction, and textiles [2]. However, most of these sources are no longer rising in size and number of recycling purposes.
Water pollution from cemeteries has been a historical issue from several decades. Around 0.4-0.6 L of leachate with a density of 1.23 g·cm −3 per 1 kg body weight are released during the decomposition process of the human body. Leachate includes 10% organic compound, 30% salts in nitrogen ions, phosphorus, Cl, Na, and various metal compounds (Cr, Cd, Pb, Fe, Mn, Ni), and 30% water [117]. The liquid has high conductivity, pH, and BOD value distinguished by its distinctive fishy odor. Pollutants originate in the body and may include chemical compounds used in chemotherapy and embalming procedures (arsenic, formaldehyde, and methanol), make-up (cosmetics, dye, and chemical compounds), and several other compounds [31]. Moreover, these leachates include microorganisms that can contaminate the groundwater.
The average daily traffic is higher in urban areas than in rural areas, and as a result, water pollution is substantially higher in urban areas. According to the EPA [38], transport directly affects water quality in four ways: a.
The construction and maintenance of roads, including impervious surfaces, can adversely influence water quality because of higher rushes, lower groundwater recharge rates, and increased erosion. b.
Pollutants, including oil, vehicle exhaust, dirt, and de-icing chemicals, are deposited into roadways and streams' dehydration. c.
Oil spills, especially on the marine side, affect the water quality of inland waterways and coastal regions. d.
Leaking subsurface storage tanks release petroleum into groundwater.

Livestock Productions
Most countries have many livestock and poultry farms: the United States has an estimated 1.2 million livestock and poultry farms. In addition, this number covers all activities which increase the production of beef or dairy cattle, hogs, and swine, including both confinement and non-containment (grassing and range-fed) [118]. Furthermore, animal manure can be used on farms to fertilize plants and add/recover nutrients to the soil. Nevertheless, animal production changes, particularly the growing trend towards animal farming in major feedlots, have produced more severe issues in animal waste use and disposal. According to the assimilative land production capacity on farms, the quantity of manure nutrients has increased, especially in China, India, Australia, the USA, and South Africa, since animal farming has become denser and more spatially concentrated. Animal waste may be transferred to surrounding lakes, streams, and groundwater across the agricultural land surface. Therefore, leakage to surface water, groundwater, soil, and air of waste from animal feedlots seems to have an extensive range of environmental and human health impacts. Animal waste also contains salts and trace elements, and antibiotics, pesticides, and hormones to a limited extent. Additionally, nutrients (especially phosphorus and nitrogen), pathogens, solids, organic matter, and odor/volatile compounds are the primary pollutants concerning animal waste [119].

Land Use Practices
Urban areas have been estimated to cover 3% of the world's usable land since 2010. For instance, urban areas include diversified aspects of land use, large population, development of transportation systems, heavy resource usage, and heavy waste disposal, and cities can cause an even greater or equivalent risk of groundwater contamination compared to surrounding farmland regions [2]. Thus, intensity and density of their events are similar, but not higher from industries and agriculture, in relation to their spatial extent. Further, land cover modifications are typically the first step in the evolution of a region. It covers alteration of vegetation, the permeability or porosity of soil, topography, and surface water properties that all influence recharging and groundwater movements [31]. There are some examples of these impacts such as changing present topography, contributing to exotic types of vegetation (usually for cultivation), wetland drainage, soil tillage, diluting, and clearing any vegetation cover [120]. Moreover, the alteration of soil and vegetation is the driving factor underlying variation in evapotranspiration rates. The water requirements of the dominant species and alterations in the absorption or reflection of solar radiation can increase or decrease recharge. Topographic modifications are caused by various land management processes [2].
Another impact of land use activities in water systems is infrastructure, which includes construction, pipelines, highways, and roads [121]. In contrast to land-based alterations, the conceptual framework of an anthropogenic water balance must be contribute to manmade source and sink components emerging from an infrastructure. Significantly transformed landscapes produced with such elements potentially transform the water balance, affecting solute mass flows and quality [12,114]. In addition to liquid chemicals, manure spread is regularly practiced in farming and works as a means of transporting a number of chemicals into the environment.
The most regular leads of anthropogenic surroundings are concrete or compacted surfaces, comprising roadways, construction sites, and park sites. Such surfaces generate elevations in storm and snowfall run-offs, and significant decreases in diffuse inflow and evapotranspiration, typical in urban and industrial areas [31]. At the same time, urban waste treatment and wastewater are an ongoing problem if we assume that more than half the global inhabitants live in urban areas. This percentage is estimated to rise to about 70% in 2050, according to the UN World Urbanization Prospects 2018 [122]. This provides an acute risk to urban residents that are adjacent to badly managed waste and that pose an increased risk to urban water sources.

Major Pollutants of Water Resources
An important problem for environmental researchers and decision-makers remains the improvement of understanding the extent and behavior of polluting chemicals on the surface and subsurface as well as the combined impact of a combination of substances [38,123,124]. Some countries have been performed and created a standard with limitations based on information on current regulations for water resource concentration, especially drinking water [125][126][127]. These are critical factors that must be recognized, regardless of the complexity of solvent movement, reaction, and surface activity, whether compound control, mitigation, or water system rehabilitation is to effectively protect or enhance water quality. In this section, the characteristics of several prominent inorganic water pollutants are discussed (nitrate, fluoride, and heavy metal concentration).

Inorganic Substances
Non-carbon-based materials are referred to as inorganic pollutants. The most significant inorganic substances are naturally found in the environment system, such as nitrogen, fluoride, and heavy metals [14]. Furthermore, arsenic, fluoride, and iron pollutants are geogenic, while nitrates and some other heavy metals are mainly caused by anthropogenic behavior such as weak wastewater systems, poor agricultural practices, and industrial discharges [128]. In groundwater, in many regions of the world, including India, high levels of metals (mainly heavy metals) and other toxicants, such as fluoride and nitrate, have been found beyond the threshold limit, rendering them unfit for drinking. The most studied heavy metals produced by different wastewater factories are arsenic, copper, chromium, mercury, nickel, and zinc [129]. The impact of inorganic contaminants and their organic forms on flora and fauna of the Earth's environment is devastating (atmosphere, lithosphere, and hydrosphere), as they cause many health-related issues (abnormal growth, high risk of breast cancer, diabetes, obesity, etc.).
This results in oxygen depletion as the phase of decomposition occurs. These components overgrow and use a lot of oxygen during their development. The dissolved oxygen may be used more than can be filled during the decomposition process, contributing to the shortage of oxygen and having severe implications for the biota stream [130]. Failure to provide oxygen may destroy aquatic species. When marine species die, the components break down and cause more oxygen depletion. A type of organic pollution can occur when aquatic environments accumulate inorganic contaminants such as nitrogen and phosphates [2]. In this section, inorganic contaminants such as nitrogen and fluoride are discussed, as well as in Table 4.

Nitrogen
Nitrogen is an inorganic compound which becomes harmful to human health and the environment in concentrations. Nitrate is the world's largest mobile form of nitrogen [131]. Nitrogen persistence in the subsurface is largely driven by the denitrification and nitrification of biological reactions in response function of redox environmental factors [132]. Ammonia or nitrites oxidize easily into the highly mobile nitrate in the presence of oxygen. Without oxygen, the conditions for denitrification are reduced, and nitrate converts into nitrogen gas. Nitrate remains chemically unreactive in such oxidizing conditions because of negative charging and hence it is not absorbed in the case of material such as clay in shallow groundwater zones [133].
A majority of individual actions can lead to high nitrogen levels in water resources, such as crop fertilizers and wastewater generation [134]. As a result, there has been a long history of recorded nitrate pollution in water systems, mainly through agricultural production usage; hence agriculture is considered the primary nitrate source in the environment [135] (Figure 5). Underground nitrogen pollution in several areas is a crucially relevant issue. The estimated losses from the soil-plant system through diffuse leaching are 50-70% of all the nitrogen applied for crop production [136]. Whereas the distribution of fertilizers in several nations has been moderated, the worldwide fertilizer manufacturing rate continuously grows, consuming 113 million tonnes in 2014 [103]. In addition, regulations have significantly reduced the application of agricultural nitrogen throughout many regions (especially Switzerland and the European Union) [103]. Further, the expansion of urban nitrogen pollution in agriculture is less worldwide, although urban sources are substantially larger in overall diversity. In urban areas, wastewater, atmospheric deposition, stormwater, construction places, water supply, solid waste, urban parks, and gardens are nitrogen sources [137] (Figure 5). turing rate continuously grows, consuming 113 million tonnes in 2014 [103]. In addition, regulations have significantly reduced the application of agricultural nitrogen throughout many regions (especially Switzerland and the European Union) [103]. Further, the expansion of urban nitrogen pollution in agriculture is less worldwide, although urban sources are substantially larger in overall diversity. In urban areas, wastewater, atmospheric deposition, stormwater, construction places, water supply, solid waste, urban parks, and gardens are nitrogen sources [137] (Figure 5). Several sources and types of nitrogen discharged into the metropolitan region will influence the microbial communities involved in nitrogen transformation activities [138]. Wastewater nitrogen most typically appears in its ammonia type, although in the oxic conditions of certain reservoirs it can be easily changed into nitrates. Further, nitrates from wastewater are particularly common in municipalities that overlook shallow groundwater and that lack appropriate underground sewage infrastructure, but where municipal wastewater is allowed to penetrate in a somewhat diffused way [135].
Nitrate ( 15 N) and water ( 2 H, 3 H, and 18 O) isotopic tracers were applied in a study on High Plains aquifers in several parts of the United States to estimate nitrates deposited in the subsurface and their transit duration [31]. Unsaturated areas of the were compared with some of those connected with irrigated farmland areas, and chemical substances were used. McMahon et al. [139] showed how natural salt mobilization resulted in Several sources and types of nitrogen discharged into the metropolitan region will influence the microbial communities involved in nitrogen transformation activities [138]. Wastewater nitrogen most typically appears in its ammonia type, although in the oxic conditions of certain reservoirs it can be easily changed into nitrates. Further, nitrates from wastewater are particularly common in municipalities that overlook shallow groundwater and that lack appropriate underground sewage infrastructure, but where municipal wastewater is allowed to penetrate in a somewhat diffused way [135].
Nitrate ( 15 N) and water ( 2 H, 3 H, and 18 O) isotopic tracers were applied in a study on High Plains aquifers in several parts of the United States to estimate nitrates deposited in the subsurface and their transit duration [31]. Unsaturated areas of the were compared with some of those connected with irrigated farmland areas, and chemical substances were used. McMahon et al. [139] showed how natural salt mobilization resulted in broader nitrate concentration under thick unsaturated areas below irrigated places due to evaporative concentration and irrigation return flow. This deposit approximated 60% of the nitrate detected below irrigated croplands in the groundwater basins. Although it was estimated that advective transit periods in the unsaturated zones were between 50 and 375 years (longer than any of the agricultural locations), agrochemicals have been identified in the ground water at 66% of irrigated crop sites. According to McMahon et al. [139], movement takes place across numerous flow pathways from slow routes (connected with small or no-flow finely grained sediments) to rapid routes (linked with focused recharge areas, including depressions, rivers, or playas). Therefore, the authors suggested that although the input was entirely stopped, the number of pollutants coming from irrigated locations reaching towards the shallow groundwater could increase since the mass of historically stored substances continues to move down slowly through the thick unsaturated zone under irrigated conditions. This pollutant storage in sediments is one reason for high nitrate, which has continuously increased in several groundwater systems as recorded over time.

Fluoride
Fluoride is another inorganic compound. Excess concentrations of fluoride in water resources is dangerous to human health and the environment [140]. Fluoride affects the water body through various sources, such as natural remedies, industrial, and agricultural practices. The parent rock itself is the primary natural source of fluoride in the soil. Weathering, mineral disintegration, and volcanic eruptions are natural phenomena that increase fluoride content in groundwater [141]. Fluorite, the only primary fluorine mineral in nature, is typically found in granite rocks as an accessory. The presence of small fluoride concentrations in groundwater causes malnutrition, particularly for children in remote and semi-urban regions [142].
As fluoride does not change the smell, color, and taste of drinking water, it typically cannot be identified unless analyzed. The precipitation that falls directly or indirectly into the surface system enriched with CO 2 throughout its downward movement in the soil, air, and biochemical interactions of the microorganisms and organic material increases the fluoride concentration in the subsurface [140]. Further, additional soil ions (a combination of NaHCO 3 , NaCl, and Na 2 SO 4 ) are also leached out. Additionally, the soil may have different amounts of fluoride-bearing compounds when phosphate fertilizers are applied. A simultaneous ion exchange reaction takes place in the soil clay material complex with exchangeable cations. Fluoride is likely to result in soil and fertilizer-borne fluoridated water for food and beverage processing in agricultural production (for example, tea, wheat, spinach, carrot, and cabbage) [143]. Nõmmik [144] discovered that fluoride in the soil moisture is water-soluble an comprises approximately 5-10% of the total fluoride in the soil. The pathways of inorganic fluorides in groundwater depend mainly on chemical composition, deposition rate, soil chemistry, and climate condition [140]. Extensive irrigation fertilizer application leads to the occurrence of fluoride in groundwater. In the groundwater from agricultural land and soils, higher fluoride concentration has been seen mainly by alkalinization.
Some anthropogenic activities such as coal combustion, improper disposal of waste generated from various industrial processes, including nickel, steel, copper, aluminum smelting, hydrofluoric acid, enamel, glass, brickworks, textile dyeing, plastics and glass factories, and industries that consume high sulfur non-coking coal-like thermal power contribute to the fluoride contamination in groundwater [145]. Large quantities are produced from high-tech companies producing semiconductors and integrated circuits of industrial fluoride effluents [140,146,147]. In addition, fluoride formation is affected by various other water characteristics, including pH, total solids, alkalinity and hardness, apart from the geographical and hydrological peculiarity of a specific place [148].

Sources of Heavy Metals
Heavy metals are found on the Earth's surface by natural and anthropogenic activities [149]. Heavy metals are naturally released from volcanic eruptions, metal corrosion, soil erosion, atmospheric sources, and weathering of rocks or minerals. Heavy metals are discharged primarily from industries, domestic wastes, mining, smelting or treating of ores, landfills, and livestock, and secondarily from pesticides and fertilizers. Heavy metals are a broad concept in the metals/metalloids group, and they have a more dominant atomic density of more than 4000 kg/m 3 [14]. Even with low metal ions' concentration in water supplies, nearly every heavy metal is harmful to human beings [150]. The quantity and quality of water resources are affected by the high concentration of heavy metals as well as availability for human consumption.
High quantities of these toxic substances are dangerous to humanity and may interact with several aspects of the earth because of their harmful effects and portability. In addition, these toxic metals are non-biodegradable and challenging to clean. Heavy metal contaminations in water resources and the environment must be monitored, recognized, and regulated. Toxic elements are released mainly from the exploitation of treated wastewater, industrial wastewater, sewage sludge, fertilizers, mining operation, and soil minerals; thus, the discharge of this waste into water becomes polluted [14]. Moreover, heavy metal concentrations are absorbed into the water bodies by various industries' effluents (tanneries, electrical products, electroplating, dyes, and others) and cause significant environmental problems even at low concentrations of metal ions. These substances are directly or indirectly discharged into the surface water, which increases the concentration of the ions and percolates in the groundwater, as well as polluting both [3].

Heavy Metals Risk in the Environment
The environment is affected by humans, animals, plants, and other living organisms. The discharge of heavy metals can cause different physical, chemical and biological mechanisms into water sources [151]. The two groups can be isolated, including the effects of heavy metal pollutants on the environment and the impact of the environment on toxic metals [14,152]. The first categorization relies on natural circumstances, whereas the population's density, diversity, community structure, and species composition might be changed. The degree and nature of modification are primarily dependent on the toxic element concentration in water and dregs. The second category emphasizes how it leads to a speciation and harmfulness adjustment of heavy metal concentration in terms of conditions in the water consumption. These circumstances include the contrast between artificial and geochemical substances, as well as the type and nature of untreated wastewater, suspended particles, and chelating agent quantities [153]. In suspended solids, colloidal particulate matter, and naturally/synthetic compounds, the aquatic environment is described in longitudinal variations and vertical variations in the living form concentrations densities, blending level, and redox condition [154].
These factors depend heavily on the metals' destiny in characteristic waters. For instance, the reduction in metallic shape and variations in methylation has an environmental influence on heavy metals. Similarly, a decrease of metals' development to the base of typical water resources comes from associative sedimentation and suspended particles [155]. Organic ligands are complex elements that decrease the process of sorption and increase the residence time in the water. Metal speciation is mainly determined by nature, and variations in speciation are responses to amendments. Heavy metal impacts are profound in aquatic plants. Although the typical responses, for example, decreased population density and diversity, occur primarily in highly defaced places, there are many more contradictory regions in either intolerantly or softly polluted locations [156]. In common environmental factors such as light and temperature, the population response to harmful toxic substances is likewise entirely affected by the natural varieties.
Biological observation initiatives are responsible for significant distinctive difficulties in the view of community criteria [157]. This implies that the assessment and control of these hazardous heavy metal releases should not be exclusively based on measurements of diversity and density. Heavy metal exposures can also cause physical alteration in the aquatic systems in which they are received. The variations in water pH, organic compound concentration, and water particle size are included here [14]. Plants in aquatic environments respond to these difficulties with a decrease in diversity, density, and species composition. Consequently, this concern can be experienced in depicting the influence from the physical effects of heavy metal contamination, which are indirectly carried out.

Heavy Metals Risk on the Plant
The plants are sessile forms of life that should be changed to adapt their existence and reproduction to varied compositions of the soils. Soils are often stored at high concentrations based on the plant species and the soil characteristics with an inadequate amount of essential and unessential components. Many elements are widely used to regulate their basic mortality mechanisms and the plants use general elimination routes to manage these metals. The impacts of toxic metals are exacerbated by competition because the large concentrations of one metal can unbalance other metals' removal or movement, producing the behavior of toxicity.
Plants typically produce soil minerals as inorganic ions. The enlarged root and ionic components are able to be absorbed even at low levels to make the use of minerals even more effective. Mineral components can be categorized into two classes: non-essential nutrients and essential nutrients (micro and macronutrients). The main constituents of a plant structure and its metabolisms are the necessary micronutrients (iron, copper, sodium, copper, nickel, zinc, and manganese,) and the macronutrients (nitrogen, calcium, sulfur and other ions). However, several heavy metals such as copper, nickel, iron, and nickel, are essential growth requirements for plants, but are harmful if their concentrations go beyond the limits acceptable for plants and creatures [158]. Further, for animals and plants to grow, other toxic substances such as arsenic, lead, mercury, and cadmium are not essential [159]. Even at low concentrations, various metals such as arsenic, chromium, mercury, and cadmium are hazardous for plant growth [160]. The growth in the focus on heavy metal toxicity means that the negative consequences in these initially exposed (metal take-up cells) cells are likely to be seen.
Toxic elements interact with enzyme activities and ion homeostasis, which are evident in physiological practices consisting of single organs (such as the addition of the roots) through the use of more broad practices such as photosynthesis, crucial digestion, germination, multiplication, and plant water balance [157]. In fact, the undiscovered adverse effects of the hazardous toxic metals include low biomass generation, incorporate chlorosis, shriveling, senescence, hindered development, leaf rolling and putrefaction, limited seed quantity, and long-term demise. The large dispersion of heavy metals in the environment, and the (acute and chronic) consequences of heavy metal contamination in the agricultural soil on the growth of the plant, are serious environmental issues [161]. High amounts of copper intake in plants cause reactive oxygen species to develop and oxidative stress to be produced. Because of the phytotoxicity of both copper and zinc, plant growth and its metabolic activities, as well as oxidative risk have been seen in many species. In many plant species, increased levels of lead in the soil cause instigate irregular morphology. Elevated nickel concentrations in plant tissues lead to dispersion of cell membrane capacities and demonstrate a disability in the nutrient balance.
Exposure to plants by chromium in large amounts affects the photosynthesis process in terms of photophosphorylation and electron transport, enzyme activity, and carbon dioxide fixation [162]. Symptoms of arsenic phytotoxicity include shrinking and leaf putrefaction which can be tracked by root stain and the impediment of the growth of the shoot. Research has shown that arsenic behavior is observable in flagging routes, especially those related to membrane damage, reactive oxygen species generation, and electrolyte spillage. Due to large exposures to mercury, physiological problems and visual damage were found in the plants.

Heavy Metals Risk on the People Health
Heavy metals concentrations in soil are often higher than acceptable standard values, which can lead to serious health problems. Some essential metals are crucial for maintenance of skeletal structures such as the colloidal system, acid-base equilibrium regulation, structural proteins, key enzymes, and hormones [151]. For instance, iron is essential for hemoglobin and zinc for many enzymes. Further, non-essential metals do not have a major role in the human body but may affect the human nervous system. Heavy metal toxicity may damage cell components, cellular organelles, mental and central nerve activities, cell membrane, nuclei, and blood compositions; and destroy lungs and kidneys. Extended exposure periods of toxic metals can lead to multiple sclerosis, Alzheimer's disease, muscle degeneration, and various types of cancer. Moreover, metal ions interact with nuclear proteins and DNA, resulting in damage to DNA and thus causing cell cycle modulation, carcinogenesis, or apoptosis. A pathway illustrating the impacts of heavy metal contamination is shown in Figure 6. essential for hemoglobin and zinc for many enzymes. Further, non-essential metals do not have a major role in the human body but may affect the human nervous system. Heavy metal toxicity may damage cell components, cellular organelles, mental and central nerve activities, cell membrane, nuclei, and blood compositions; and destroy lungs and kidneys. Extended exposure periods of toxic metals can lead to multiple sclerosis, Alzheimer's disease, muscle degeneration, and various types of cancer. Moreover, metal ions interact with nuclear proteins and DNA, resulting in damage to DNA and thus causing cell cycle modulation, carcinogenesis, or apoptosis. A pathway illustrating the impacts of heavy metal contamination is shown in Figure 6.
Toxicity of heavy metals in humans has largely been reported via three remarkable pathways: dermal exposure, oral intake, and inhalation. The main path of human heavy metals exposure in inhabitants is dependent on heavy metal characteristics. Because heavy metals are water-soluble in nature, oral intake is the most effective pathway for copper to enter the people body. Mercury can bioaccumulate in living organism species, which is a key route for mercury intake in marine living organisms. Figure 6. This is showing the source pathways and human exposure of heavy metals [14]. Figure 6. This is showing the source pathways and human exposure of heavy metals [14].
Toxicity of heavy metals in humans has largely been reported via three remarkable pathways: dermal exposure, oral intake, and inhalation. The main path of human heavy metals exposure in inhabitants is dependent on heavy metal characteristics. Because heavy metals are water-soluble in nature, oral intake is the most effective pathway for copper to enter the people body. Mercury can bioaccumulate in living organism species, which is a key route for mercury intake in marine living organisms.
Exposure to heavy metals via the skin is only concerning for certain. A number of metals can enter the internal human system in combination with other substances. Heavy metals have become common sensitizers in human contacts, particularly nickel, which has a growing rate of hypersensitivity in children, especially in industrialized nations or developed countries [163,164]. Some heavy metals are well known environmental pollutants found in water bodies throughout the world in high concentrations, including iron, copper, nickel, cadmium, zinc, aluminum, chromium, arsenic, cobalt, manganese, mercury, and lead, as shown in Table 3.

Discussion and Future Directions
A complete understanding and assessment of the environmental behavior and types of pollutants that cause significant damage are required to address the management of water bodies and their quality issues [213]. A crucial component of this assessment is the demand for enhanced awareness of the sources and nature of chemical contaminants in and around effective water systems, which contribute to providing humans with drinking water and residence to aquatic organisms [214]. Water sources are often polluted or contaminated by a specific availability of natural factors and anthropogenic activities. Natural factors influence water quality through geological processes, natural disasters, climate change, and hyporheic exchange. These factors can pollute surface water and groundwater gradually and rapidly. Such factors also take place over several years to thousands of years to contribute to the pollution in water resources. Further, changes in seasonal rainfall, variations in rainfall rates, increasing temperature, and the direct effects of increased atmospheric carbon dioxide are the main repercussions of climate change [116]. Surface water and groundwater interact at the hyporheic zone and their solutes mix, as well as during hyporheic exchange near channels, which mixes with shallow aquifers rapidly at shallow depth.
Human (anthropogenic) activities have increased because of demographic changes, consumer behavior, rapid industrialization, and urbanization, as well as the fast-growing population [3]. Decision-makers in developing countries are confronted with major new issues regarding solid/liquid waste management. Over the last several years, many communities have increased their efforts to develop long-term sustainable solutions to the solid/liquid waste management challenge [215]. Liquid waste factors have been increased such as industrial waste (chemical compounds and wastewater) and municipal waste (sanitary sewers). Integrated solid waste has increased such as in the maintenance of sanitary landfills, construction, manufacturing applications, and municipal waste effluents [83]. Wastewater and other toxic compounds (heavy metals) from urban practices and industries have been discharged into surface water, which then infiltrates into groundwater through soil/rock formations. Therefore, many reasons are still unidentified, although there is very little knowledge regarding contaminant types and pathways, particularly in developed countries. Many other types of urban and industrial compounds with pollution risks have not been extensively discussed in this study. Although there are still limited publications on this topic regarding human activities, the risk is becoming more widely recognized in the hydrological and environmental sciences.
The use of fertilizers and pesticides in agriculture, industrial applications, and some urban practices increases the toxicity in water resources [216]. These changes in soil mineralization, agriculture, leaching, recharging, and groundwater pathways are controlled at the receptor by a number of competing consequences. Specific processes have been widely investigated, but the overall influence remains challenging to estimate. In agriculture practices, substances such as nitrate and fluoride are simultaneously released into the water bodies by numerous causes which are mostly unknown [131,140,143]. There is a lack of proper knowledge about contaminant hydro-geochemistry, especially in areas with high levels of both. Future studies should aim to understand the potential relationships of co-occurring pollutants and other characteristics with co-contaminants. The degree to which their co-occurrence has an impact on the local environment, geological processes, geochemistry, and hydrological processes of the water sources is still unknown [214]. It is necessary to determine how these anions work in the vicinity of others, and the antagonistic/synergistic relationship that may change under different circumstances. In addition, it creates a much wider path that allows for additional investigation into the nature and behavior of co-occurrence.
Due to significant advancements in technology, there have been significant advances over the past several decades towards enhancing water resources characterization. Numerical modelling of transportation and flow of water, isotope monitoring, water quality method, and improved analytical strength for synthetic substances have been used to understand the issues of water resources [31]. For example, geophysical surveying has been used to investigate groundwater pollution at the local scale, and remote sensing techniques developed at local to regional scale for surface and groundwater systems. Nevertheless, these methods persist with significant uncertainties. The extensive assessment of connections of surface water and groundwater systems in response to changes in land use and the consequent risk of contamination remains a challenge because of heterogeneity in the spatial and temporal scale of the activities [139]. At present, there is no single criterion for any water resources that can characterize water quality. Uncertainty is also the consequence of insufficient assessment of how anthropogenic practices may affect water resources, extending with additional activities. For instance, in temperature changes or illness outbreaks, groundwater vulnerability and susceptibility to medication is little-known. The problem of antibiotic resistance and the proliferation of substances in the water body should concern us, with an increasing number of publications finding pharmaceuticals in water systems [97]. Additional research on the determinants of these compounds in their quantities and cocktails in the aqueous environment is required.
Future research is needed to better understand the impact of products utilized in new technologies. As a result, there is a worldwide necessity for a comprehensive preventive warning system that can predict problems associated with inorganic substances (nitrogen, fluoride, and heavy metals) [216,217]. It is vital to remove harmful heavy from water resources or wastewater since they are significant health hazards to people and other living things. In order to reduce pollution in nature, treatment techniques are necessary in order to eliminate dangerous metal ions from multiple water systems. Heavy metals monitoring technologies, such as wireless technology, treatment methods, automated detectors, and new tracers, have all contributed to the enormous increase in data accessibility, implying that elevated, increased data collection and data management should develop the capacity to track and share knowledge in environmental science and related fields [217]. The relationship between water resources and their dependent industries and urban practices, as well as water governance, should be recognized and expressed, both in legislation and in practice, in order to address these and other shortcomings [2]. It is crucial to highlight that some countries are decreasing their tracking expenditures. Monitoring pollutants in the affected system will become critical in a world where water use is expected to rise, water scarcity to increase, and dependency on water reuse to become common practice [213]. In the context of resource restrictions, it is essential to the research community to properly emphasize the importance of monitoring networks and the maintenance and improvement of long-term data sets, while recognizing the need for installation and maintenance of monitoring equipment [217]. Adaptive management techniques and transdisciplinary studies give a mechanism to tackle sustainable natural resource management under uncertain conditions, as situations change faster than researchers or legislators can anticipate.

Conclusions
This study focused on some of the major serious water resources pollution issues resulting from both natural and anthropogenic activities. Anthropogenic activities such as industrial applications and agricultural practices as well as toxic contaminants, have been addressed in this study. Geological processes, natural disasters, climate change, and surface water and groundwater interactions are the main natural causes of contamination. There are case studies available that cover various issues such as surface water and groundwater quality and contaminating sources. However, there are few case studies that examine specific topics such as water resources pollution types, sources, and pathways. The multitude of cases demonstrates the wide range of subjective challenges to water systems as a result of long-term supplies for human utilization and environmental protection. Challenges include food production, urban development, increased drug production and usage, and inadequate sewage facilities, as well as declining scientific evidence on water quality. In such cases, a lack of importance placed on water resources as renewable hampers the complicated problem of maintaining water quality. Transdisciplinary study and practice can serve to gain better knowledge to understand the pollution processes, types, pathways, and their consequences on water resources. This makes for a lot of possibilities for interdisciplinary research areas (environmental sciences and related fields) and transboundary communication.