Flash flood early warning coupled with hydrological simulation and the rising rate of the flood stage in a mountainous small watershed in Sichuan province, China

: Flash ﬂoods in mountainous areas have become more severe and frequent as a result of climate change and are a threat to public safety and social development. This study explores the application of distributed hydrological models in ﬂash ﬂoods risk management in a small watershed in Sichuan Province, China, and aims to increase early warning lead time in mountainous areas. The Hydrologic Engineering Center’s Hydrologic Modeling System (HEC-HMS) model was used to simulate the ﬂash ﬂood process and analyze the variation in ﬂood hydrographs. First, the HEC-HMS model was established based on geospatial data and the river network shape, and eight heavy rainfall events from 2010 to 2015 were used for model calibration and validation, showing that the HEC-HMS model was e ﬀ ective for the simulation of mountain ﬂoods in the study area. Second, with the assumption that rainfall and ﬂood events have the same frequency, the ﬂood hydrographs with di ﬀ erent frequencies (p = 1%, 2%, 5%, and 10%) were calculated by the HEC-HMS model. The rising limbs of the ﬂood hydrographs were signiﬁcantly di ﬀ erent and can be divided into three parts (0–5 h, 6–10 h, and 11–15 h). The rising rate of the ﬂood stage for each part of the ﬂood hydrograph increases in multiples. According to the analysis of the ﬂood hydrographs, two critical early warning indicators with an invention patent were determined in the study: the ﬂood stage for immediate evacuation and the rising rate. The application of the indicators in the study shows that it is feasible to advance the time of issuing an early warning signal, and it is expected that the indicators can o ﬀ er a reference for ﬂash ﬂood early warning in the study area and other small watersheds in mountainous areas.


Introduction
With the increasing frequency of extreme weather conditions, flash floods have become one of the most severe natural hazards worldwide [1,2]. Globally, flooding causes over one-third of the total damage and two-thirds of the impact to people affected by natural disasters, with Asia and Africa accounting for 35% and 29% of worldwide losses, respectively [3]. In China, flash floods have caused al., Patent application No. 2019101605606, Patent application publication No. 98 CN109961613A, http://epub.sipo.gov.cn/fullTran.action) of a flash flood early warning system, the rising rate of flood stage was proposed as an early warning index before the stage station at the gauging section reaches the threshold for flash flooding. By taking the variation in the flood stage into account, we aim to advance the issued time of the flash flood early warning signal and increase the lead time for evacuating people in danger in mountainous areas to reduce the losses caused by flash floods.

Study Area
The Baisha River watershed, located in the mountainous area of Sichuan Province, China, was the study area and is shown in Figure 1. The length of the main river stem is approximately 49 km, and the drainage area is 354 km 2 . Because of the complex topographical conditions, the relative height difference is large in the Baisha River watershed, and the meteorological conditions vary significantly in space. The annual average precipitation is approximately 1700 mm, ranging between recorded values of 1400 mm and 2000 mm. The rainfall is unevenly distributed during the year, and more than 60% of the annual precipitation is concentrated in the main flood season from July to September. The river ways in the Baisha River watershed are narrow and deep, with lots of weeds and gravel in the riverbed. Therefore, the Baisha River watershed is prone to flooding in the main flood season, and the runoff formed under the conditions of heavy rainfall, high soil moisture content, and steep channel slope are the characteristics that lead to high peak flood and large flood volume. gov.cn/fullTran.action) of a flash flood early warning system, the rising rate of flood stage was proposed as an early warning index before the stage station at the gauging section reaches the threshold for flash flooding. By taking the variation in the flood stage into account, we aim to advance the issued time of the flash flood early warning signal and increase the lead time for evacuating people in danger in mountainous areas to reduce the losses caused by flash floods.

Study Area
The Baisha River watershed, located in the mountainous area of Sichuan Province, China, was the study area and is shown in Figure 1. The length of the main river stem is approximately 49 km, and the drainage area is 354 km 2 . Because of the complex topographical conditions, the relative height difference is large in the Baisha River watershed, and the meteorological conditions vary significantly in space. The annual average precipitation is approximately 1700 mm, ranging between recorded values of 1400 mm and 2000 mm. The rainfall is unevenly distributed during the year, and more than 60% of the annual precipitation is concentrated in the main flood season from July to September. The river ways in the Baisha River watershed are narrow and deep, with lots of weeds and gravel in the riverbed. Therefore, the Baisha River watershed is prone to flooding in the main flood season, and the runoff formed under the conditions of heavy rainfall, high soil moisture content, and steep channel slope are the characteristics that lead to high peak flood and large flood volume.

Data Collection
The geospatial data, including digital elevation model (DEM) data with a resolution of 30 m, a land use map, and a soil map, are derived from the Chinese Resource and Environment Data Cloud Platform (http://www.resdc.cn/). A land use map was categorized into five types: agricultural land (0.99%), forest (92.29%), water (1.60%), residential area (0.99%), and bare land (4.12%), as shown in Figure 2a. The soil physical property data (e.g., sand, silt, and clay %) were interpreted from the

Data Collection
The geospatial data, including digital elevation model (DEM) data with a resolution of 30 m, a land use map, and a soil map, are derived from the Chinese Resource and Environment Data Cloud Platform (http://www.resdc.cn/). A land use map was categorized into five types: agricultural land (0.99%), forest (92.29%), water (1.60%), residential area (0.99%), and bare land (4.12%), as shown in Figure 2a. The soil physical property data (e.g., sand, silt, and clay %) were interpreted from the 1:1,000,000 scale Chinese national soil map, as shown in Figure 2b-d. Hourly precipitation data in the heavy rainfall events during 2010-2015 were collected from three rainfall stations in the Baisha River watershed (see Figure 1), and the discharge time series were collected from discharge stations at the exit of the watershed for calibration and validation. Moreover, through field investigation, a water stage of 756 m at the discharge station was regarded as the critical stage threshold to evacuate people in danger, otherwise it would cause flood damage. In order to determine the early warning index for flash floods (i.e., the rising rate of the flood stage), four 24 h designed rainfall events with different frequencies (1%, 2%, 5%, 10%), which were designed by the rainstorm handbook of Sichuan Province [25], were run in the HEC-HMS model to study the variation in the stage during the flood process.
Water 2020, 12, x FOR PEER REVIEW 4 of 17 1:1,000,000 scale Chinese national soil map, as shown in Figure 2b-d. Hourly precipitation data in the heavy rainfall events during 2010-2015 were collected from three rainfall stations in the Baisha River watershed (see Figure 1), and the discharge time series were collected from discharge stations at the exit of the watershed for calibration and validation. Moreover, through field investigation, a water stage of 756 m at the discharge station was regarded as the critical stage threshold to evacuate people in danger, otherwise it would cause flood damage. In order to determine the early warning index for flash floods (i.e., the rising rate of the flood stage), four 24 h designed rainfall events with different frequencies (1%, 2%, 5%, 10%), which were designed by the rainstorm handbook of Sichuan Province [25], were run in the HEC-HMS model to study the variation in the stage during the flood process.

Soil Conservation Service (SCS) Curve Number Method
The method used in the study to calculate total infiltration and runoff generation was the Soil Conservation Service (SCS) curve number (CN) method [26], which uses the following formulas: where Pe is the accumulated precipitation excess at time t, P is the accumulated rainfall depth at time t, a I is the initial abstraction, and S is the potential maximum retention.
The parameter CN in the method, which is determined by the hydrologic conditions, land use, soil type, and antecedent moisture [27], can be estimated by the National Engineering Handbook [28].

SCS Unit Hydrograph Method
The SCS unit hydrograph method derived from many small agricultural watersheds has good performance for simulating surface runoff [29]. For the ungauged watershed, the lag time of the SCS unit hydrograph is related to the concentration time as follows: where tlag is the lag time parameter and tc is the concentration time.

Soil Conservation Service (SCS) Curve Number Method
The method used in the study to calculate total infiltration and runoff generation was the Soil Conservation Service (SCS) curve number (CN) method [26], which uses the following formulas: where P e is the accumulated precipitation excess at time t, P is the accumulated rainfall depth at time t, I a is the initial abstraction, and S is the potential maximum retention. The parameter CN in the method, which is determined by the hydrologic conditions, land use, soil type, and antecedent moisture [27], can be estimated by the National Engineering Handbook [28].

SCS Unit Hydrograph Method
The SCS unit hydrograph method derived from many small agricultural watersheds has good performance for simulating surface runoff [29]. For the ungauged watershed, the lag time of the SCS unit hydrograph is related to the concentration time as follows: where t lag is the lag time parameter and t c is the concentration time.

Muskingum-Cunge Method
The Muskingum-Cunge method was used to simulate river routing because the assumptions of this method correspond well to natural channels. The parameters X and K are calculated with the following formulas [30,31]: where ∆x is the length of the reach, c is the flood velocity, Q is the flood flow, B is the top width of the flood area, and S 0 is the slope of the riverbed. By using eight pairs of x, y (distance, elevation) values, the 8-point cross-section configuration in the Muskingum-Cunge method was used to describe the cross section of the routing reach. These values are defined specifically, as shown in Figure 3. The Muskingum-Cunge method was used to simulate river routing because the assumptions of this method correspond well to natural channels. The parameters X and K are calculated with the following formulas [30,31]: where x Δ is the length of the reach, c is the flood velocity, Q is the flood flow, B is the top width of the flood area, and S0 is the slope of the riverbed.
By using eight pairs of x, y (distance, elevation) values, the 8-point cross-section configuration in the Muskingum-Cunge method was used to describe the cross section of the routing reach. These values are defined specifically, as shown in Figure 3.  The detailed parameters descriptions of the three-step process introduced in the HEC-HMS model are listed in Table 1.

The Inverse Distance Weighting (IDW) Method
The inverse distance weighting (IDW) method [32][33][34]] was adopted to calculate the weights of three rain gauges in each sub-watershed in the study area. The general formulas are The detailed parameters descriptions of the three-step process introduced in the HEC-HMS model are listed in Table 1.

The Inverse Distance Weighting (IDW) Method
The inverse distance weighting (IDW) method [32][33][34] was adopted to calculate the weights of three rain gauges in each sub-watershed in the study area. The general formulas are where d g is the distance between the prediction point s and the rain gauge g, G is the number of rain gauges, w g is the corresponding weight of each gauge, Pg is the value measured at gauge g, andp s is the predicted value at s.

The Evaluation Criteria of Model Performance
Three criteria were selected to evaluate the simulation performance of the HEC-HMS model, i.e., the relative error of peak flow, the time difference in peak flow occurrence, and the Nash-Sutcliffe (NS) efficiency. The relative error of peak flow and the time difference in peak flow occurrence are widely adopted as the evaluation criteria of flood simulation [5,18,21]. The NS efficiency is one of the most commonly used indicators to reflect the overall fit of hydrographs [35,36]. The detailed formulas are given in Table 2. Table 2. The evaluation criteria of model performance. NS: Nash-Sutcliffe.

The Evaluation Criteria Formulas Descriptions
The relative error of peak flow

Model Setup
The Baisha River watershed was divided into 15 sub-watersheds based on DEM data and river network shape by using the HEC-GeoHMS extension tool in ArcGIS ( Figure 4). Detailed characteristics for each sub-watershed and channel are shown in Table 3, and the land use of each sub-watershed are listed in Table 4.   The spatially varied rainfall of each sub-watershed was calculated by the inverse distance method based on the hourly rainfall data of the three meteorological stations. The three meteorological stations are located inside the Baisha River watershed, as shown in Figure 1. The areal weights of the three rain-gauges for each sub-watershed are listed in Table 4. The spatially varied rainfall of each sub-watershed was calculated by the inverse distance method based on the hourly rainfall data of the three meteorological stations. The three meteorological stations are located inside the Baisha River watershed, as shown in Figure 1. The areal weights of the three rain-gauges for each sub-watershed are listed in Table 4.

Model Calibration and Validation
Five independent heavy rainfall events that occurred during 2010-2012 were selected to calibrate the parameters of the HEC-HMS model. Three typical floods that occurred during 2013-2015 were then selected to validate the simulation results, as shown in Table 5. The calibrated parameters of each sub-watershed and channel are shown in Table 6. Three typically observed and simulated flood processes used during the calibration and validation processes are shown in Figure 5. The NS efficiency values were between 0.692 and 0.951 with an average value of 0.858, the peak flow relative error was less than 10% and the time difference in the peak flow occurrence was less than 2 h. As shown in Figure 5, the simulated flood process is basically consistent with the observed flood process. The above simulation results of the eight heavy rainfall events show that the HEC-HMS model is effective for simulating the flood process of the Baisha River watershed.

Design Rainfall with Different Frequencies
The Pearson type III distribution, which is widely used in China, was selected for frequency analysis of the annual maximum 24 h rainfall [22,37,38], and the values of the statistical parameters under different frequencies (p = 1%, 2%, 5%, and 10%) were provided by the Hydrology Handbook  The NS efficiency values were between 0.692 and 0.951 with an average value of 0.858, the peak flow relative error was less than 10% and the time difference in the peak flow occurrence was less than 2 h. As shown in Figure 5, the simulated flood process is basically consistent with the observed flood process. The above simulation results of the eight heavy rainfall events show that the HEC-HMS model is effective for simulating the flood process of the Baisha River watershed.

Design Rainfall with Different Frequencies
The Pearson type III distribution, which is widely used in China, was selected for frequency analysis of the annual maximum 24 h rainfall [22,37,38], and the values of the statistical parameters under different frequencies (p = 1%, 2%, 5%, and 10%) were provided by the Hydrology Handbook of Sichuan Province, as shown in Table 7. The distribution of the designed rainfall in time is suggested by the Hydrology Handbook of Sichuan Province, as shown in Table 8. The hyetograph of the designed rainfall for different frequencies in 24 h is shown in Figure 6.    As shown in Figure 6, heavy rainfall mainly occurs between 11 and 14 h and reaches the highest rainstorm warning signal issued by the China Meteorological Administration; that is, rainfall exceeds 100 mm within 3 h. The maximum precipitation intensity for different frequencies of the designed rainfall occurs at 13 h: 58.77 mm/h (P = 10%), 66.40 mm/h (P = 5%), 75.89 mm/h (P = 2%), and 82.77 mm/h (P = 1%).

Simulation Results of Flood Hydrographs
According to the distributions of the four designed 24 h rainfall events, the flood hydrographs with different frequencies were calculated by the HEC-HMS model. Three computation time steps (10 min, 30 min, and 1 h) were used for the simulation to analyze the variation in the flood hydrographs more accurately, and the results are shown in Figure 7.
The results are shown with a similar shape in terms of discharge and stage for different time steps; the 10 min time step produces 10.20% and 21.40% higher discharge with different frequencies of rainfall than those of the 30 min time step and 1 h time step results, respectively.

Simulation Results of Flood Hydrographs
According to the distributions of the four designed 24 h rainfall events, the flood hydrographs with different frequencies were calculated by the HEC-HMS model. Three computation time steps (10 min, 30 min, and 1 h) were used for the simulation to analyze the variation in the flood hydrographs more accurately, and the results are shown in Figure 7.  As the computation time step was reduced, the flood hydrographs became more reasonable, which was conducive to analyzing the variation in the flood stage during the rising flood period. With the hourly data of the designed rainfall events interpolated to shorter computation time steps, the flood hydrographs exhibited a more sensitive response to rainfall, where the flood peak flow was larger, and the flood stage was higher. At 0-5 h, rainfall is lost by infiltration and vegetation interception, and almost no surface runoff occurs. With the soil gradually saturated, surface runoff begins to occur, and the stage rises slowly in 6-10 h. Due to heavy rainfall, the stage rises rapidly within 11-15 h until the peak of the flood hydrographs is reached. In the recession limb of the flood hydrographs, the stage gradually drops below the disaster stage (the critical stage threshold 756 m) after 15 h. The peak of the flood stages with different frequencies, which are shown in Figure 8, exceeds the disaster stage in the Baisha River watershed, and it is necessary to issue early warning signals in time to evacuate people in danger. within 11-15 h until the peak of the flood hydrographs is reached. In the recession limb of the flood hydrographs, the stage gradually drops below the disaster stage (the critical stage threshold 756 m) after 15 h. The peak of the flood stages with different frequencies, which are shown in Figure 8, exceeds the disaster stage in the Baisha River watershed, and it is necessary to issue early warning signals in time to evacuate people in danger.

Discussion
Based on four flood hydrographs with different frequencies, the rising rate of the flood stage was calculated, and the results under three computation time steps are shown in Figure 8.
The variation in the rising rate of the flood stage is more significant as the calculation time step is reduced from 1 h to 10 min. At 0-5 h, due to the relatively large rainfall at the time of 1 h (see Figure  6) and the low initial stage, there is a significant increase in the flood stage at time 1 h, and then the rising rate of the flood stage is almost 0. The rising rate of the flood stage fluctuates (with a rate of 0-1 m/h) together with rainfall during the period of 6-10 h, resulting in the flood stage continuing and rising slowly. During the heavy rainfall period in 11-15 h, the rising rate of the flood stage increases rapidly, exceeding 1 m/h. After 15 h, the flood stage begins to fall as the rising rate of the flood stage is less than 0. The average rising rates in the rising limb of the flood hydrographs increased in multiples from 0-5 h, 6-10 h, and 11-15 h, as shown in Figure 8d. The significant difference in the

Discussion
Based on four flood hydrographs with different frequencies, the rising rate of the flood stage was calculated, and the results under three computation time steps are shown in Figure 8.
The variation in the rising rate of the flood stage is more significant as the calculation time step is reduced from 1 h to 10 min. At 0-5 h, due to the relatively large rainfall at the time of 1 h (see Figure 6) and the low initial stage, there is a significant increase in the flood stage at time 1 h, and then the rising rate of the flood stage is almost 0. The rising rate of the flood stage fluctuates (with a rate of 0-1 m/h) together with rainfall during the period of 6-10 h, resulting in the flood stage continuing and rising slowly. During the heavy rainfall period in 11-15 h, the rising rate of the flood stage increases rapidly, exceeding 1 m/h. After 15 h, the flood stage begins to fall as the rising rate of the flood stage is less than 0. The average rising rates in the rising limb of the flood hydrographs increased in multiples from 0-5 h, 6-10 h, and 11-15 h, as shown in Figure 8d. The significant difference in the rising rate of the flood stage during the flood process can be used to identify flood early warning indicators and allow time to evacuate people in dangerous areas.
The three critical times for flood early warning used in the study are marked in Figure 9. The analysis of the flood stage was made with our patented flash flood warning (Xiekang Wang et al., Patent application No. 2019101605606, Patent application publication No. 98 CN109961613A, http://epub.sipo.gov.cn/fullTran.action). During time 0-T1, the flood stage is at a slow rising rate (less than 0.5 m/h), and the flood stage does not reach the disaster stage. The flood stage is in the risk identification period of the flood early warning system, and people in the dangerous area should be ready for evacuation. At the time of T3, the stage reaches the disaster stage. However, that is not an ideal time to issue the flood warning signal, since it is already too late to evacuate the people to safe locations under actual conditions, so the loss caused by floods is difficult to avoid. In order to increase the lead time to mitigate flood loss, T2 was determined as the time to issue an evacuation warning based on the rising rate of the flood stage. During the rapid rise of the rising limb in the flood hydrographs, the flood stage after two hours (determined by the characteristics of the flood and the distribution of the population in the Baisha river watershed) is calculated based on the rising rate at a certain point in time within T1-T3. If the flood stage after two hours based on the rising rate exceeds the disaster stage, it is time for immediate evacuation, marked as T2 in Figure 10. The three critical times in the four flood hydrographs with different frequencies were calculated, and the results are shown in Table 9.
than 0.5 m/h), and the flood stage does not reach the disaster stage. The flood stage is in the risk identification period of the flood early warning system, and people in the dangerous area should be ready for evacuation. At the time of T3, the stage reaches the disaster stage. However, that is not an ideal time to issue the flood warning signal, since it is already too late to evacuate the people to safe locations under actual conditions, so the loss caused by floods is difficult to avoid. In order to increase the lead time to mitigate flood loss, T2 was determined as the time to issue an evacuation warning based on the rising rate of the flood stage. During the rapid rise of the rising limb in the flood hydrographs, the flood stage after two hours (determined by the characteristics of the flood and the distribution of the population in the Baisha river watershed) is calculated based on the rising rate at a certain point in time within T1-T3. If the flood stage after two hours based on the rising rate exceeds the disaster stage, it is time for immediate evacuation, marked as T2 in Figure 10. The three critical times in the four flood hydrographs with different frequencies were calculated, and the results are shown in Table 9.   ready for evacuation. At the time of T3, the stage reaches the disaster stage. However, that is not an ideal time to issue the flood warning signal, since it is already too late to evacuate the people to safe locations under actual conditions, so the loss caused by floods is difficult to avoid. In order to increase the lead time to mitigate flood loss, T2 was determined as the time to issue an evacuation warning based on the rising rate of the flood stage. During the rapid rise of the rising limb in the flood hydrographs, the flood stage after two hours (determined by the characteristics of the flood and the distribution of the population in the Baisha river watershed) is calculated based on the rising rate at a certain point in time within T1-T3. If the flood stage after two hours based on the rising rate exceeds the disaster stage, it is time for immediate evacuation, marked as T2 in Figure 10. The three critical times in the four flood hydrographs with different frequencies were calculated, and the results are shown in Table 9.    Table 9 shows that the time to immediate evacuation T2 and the time to the disaster stage T3 lag as the frequency of the design rainfall event declines. Under three computation time steps, the flood stage for immediate evacuation, which is the corresponding stage at time T2, varies from 753.83 to 755.39 m for different designed rainfall events. The stage of preparation for evacuation that corresponds to the flood stage at T1 ranges from 752.43 to 753.64 m for different designed rainfall events. Most of the rising rates of the flood stage at the time for immediate evacuation T2 exceed 1 m/h. If the warning information is not released in time, the flood stage reaches the disaster stage in a short time. The advanced time for issuing the early warning signal is the difference between T2 and T3, which is generally greater than 1 h. The average early warning indicators under the three computation time steps was calculated to determine the early warning indicators in the Baisha River watershed, as shown in Figure 10. The flood stage for immediate evacuation is between 754.04 and 754.68 m with an average value of 754.29 m. For conservative considerations, 754.04 m is the critical early warning index in the flood stage for evacuating people to safe locations. Another critical early warning indicator is the rising rate of the flood stage at the time for immediate evacuation T2, which varies from 1.05 to 1.41 m/h, and the average value is 1.23 m/h. When the stage is at 754.04 m and the rising rate exceeds 1.05 m/h, flood damage is very likely to occur in the Baisha River watershed within two hours. According to the critical early warning index in the flood stage and the rising rate, the time of issuing the early warning signal is between 0.72 and 1.40 h for designed rainfall events with different frequencies. The flood stage and the rising rate of the flood stage, as early warning indicators, can effectively increase the lead time for evacuation compared to the flood stage alone.

Conclusions
In this study, flood hydrographs under designed rainfall events with different frequencies for the study area were obtained using the HEC-HMS model. Based on the variation in the rising rate of the flood stage in the rising limb of the flood hydrographs, the early warning indicators for the advanced time to issue warning signals were established. The conclusions of this study are as follows: (1) By using the HEC-GeoHMS extension tool in ArcGIS, the characteristic information (e.g., land use, soil type, and slope) was extracted to determine the parameters for the HEC-HMS model.
The results of the model calibration and validation demonstrated that the HEC-HMS model was effective for the simulation of mountain floods in the study area. The application of the HEC-HMS model to flash flood early warning should be encouraged in other watersheds in China, especially in small watersheds that lack sufficient hydrological data. (2) According to the analysis of flood hydrographs with different frequencies, the rising rates of the flood stage in the rising limb of the flood hydrographs are substantially different, and can be divided into three parts (0-5 h, 6-10 h, 11-15 h). The rising rate of flood stage increases in multiples in the three parts of the flood hydrographs. In addition, the variation in the flood stage has a more sensitive response to rainfall when the computation time step decreases. (3) The two critical early warning indicators, which are the flood stage for immediate evacuation (754.04 m) and the rising rate (1.05 m/h), were determined based on the variation in the flood stage. Therefore, flash flood early warning in mountainous areas is no longer limited to the signal index (e.g., rainfall, flow or flood stage), and the advanced time determined by the rising rate before it reaches the warning flood stage can be applied in emergency management.
Due to the scarcity and incompleteness of hydrologic data in mountainous watersheds, it is difficult to analyze the impact of rainfall uncertainty on critical early warning indicators. Future research in this watershed should be supplemented with relevant data from field measurements, and more influencing factors (e.g., rainfall spatiotemporal resolution, rainfall intensity, and different rainfall patterns) should be taken into account to determine more accurate critical thresholds for flood early warning.
Author Contributions: This research was carried out in collaboration among all authors. H.T. performed the model calculations, analyzed the results and original draft writing; W.Z. and H.P. collected and processed the data, supervised the study and contributed to the paper writing; X.W. provided the general idea of this research, supervised the study and contributed to the paper writing; Q.K. and X.C. provided many language improvements on the manuscript. All authors have read and agreed to the published version of the manuscript.