Correction: Rasheduzzaman, M., et al. Reverse QMRA as a Decision Support Tool: Setting Acceptable Concentration Limits for Pseudomonas aeruginosa and Naegleria fowleri . Water 2019, 11 , 1850

The authors regret to report that the paper “Reverse QMRA as a Decision Support Tool: Setting Acceptable Concentration Limits for Pseudomonas aeruginosa and Naegleria fowleri ” contains some erroneous computations. An S2 confusion between the versus ‘base 10’


1.
Thirteenth sentence (lines 13-15) For N. fowleri, based on the DALY approach, critical concentrations were 0.000030 N. fowleri/L for swimming and 0.00000060 N. fowleri/L for neti pot™ use scenario.

2.
Seventeenth sentence (lines 17-18) For N. fowleri, the 10 −4 annual risk target approach resulted in 0.022 N. fowleri/L and the DALY approach resulted in 0.00000064 N. fowleri/L for the neti pot™ scenario.
In the 'Materials and Methods' Section: 1.

Risk Characterization, Equation (2) descriptions
where, DW is the disability weight, L L is the average duration of the case until death (years) and L D is years lived with infection/illness for non-fatal cases. 2. Table 3 Water  In the 'Results' Section: The details of the goodness of fit (i.e., deviance and combined AIC values) for various dose-response models for N. fowleri are shown in Table 4. 2. Table 4 Third column heading "MLE Estimate" should be changed to "Deviance". 3.
3.2 Risk Characterization, first paragraph (lines 4-6) For P. aeruginosa, the risk of illness per event calculated based on DALY was 2.81 × 10 −9 , which was two orders of magnitude lower than the per event risk of illness based on the annual risk metric (2.74 × 10 −7 ). 5. Table 5  6. 3.2 Risk Characterization, second paragraph (lines 1-5) For N. fowleri, the risk of death for neti pot™ uses per event calculated based on DALYs was 4.77 × 10 −10 , which was five orders of magnitude lower than the per event risk of death calculated based on annual risk metric (1.67 × 10 −5 ). Similarly, for N. fowleri exposure during swimming, DALY and annual risk based per event risks followed the same pattern as neti pot™ exposure, i.e., a five orders of magnitude difference in the risk of death. 7.
3.3 Concentrations, second paragraph (lines 2-4) The highest critical concentration for N. fowleri was obtained for the swimming scenario using the annual risk metric (mean concertation 1.4 N. fowleri/L with a 95% confidence interval of (0.29, 4.0)). 8.

Concentrations, third paragraph (lines 1-3)
Similarly, the concentration for the neti pot™ scenario was found to be 0.021 N. fowleri/L with a 95% confidence interval of (0.010, 0.034) for the annual risk approach. Based on the DALY approach, limits of concentrations were 0.000030 N. fowleri/L for swimming and 0.00000060 N. fowleri/L for neti pot™ use scenario. 9. Considering the hot water scenario, the annual risk approach resulted in 0.022 N. fowleri/L, and the DALY approach resulted in 0.00000064 N. fowleri/L for the neti pot™ scenario (Scenario 5).  Table 6. Concentration of P. aeruginosa and N. fowleri before and after heat inactivation 1 . In the 'Discussion' Section:

Fifth paragraph (lines 3-5)
In general, the tolerable critical concentrations of N. fowleri are much lower compared to those for P. aeruginosa except for the swimming scenario with the annual risk metric which is still more than an order of magnitude below the P. aeruginosa values.

2.
Fifth paragraph (lines 9-14) The tolerable mean critical concentration of N. fowleri for the swimming scenario with the annual risk metric has a mean concentration 1.4 CFU/L, with a range from 0.29 to 4.0 CFU/L. Given that the end response is death with a 100% percent mortality rate, it may be wise to pick a lower range of critical concentration (0.29 CFU/L) for developing standards, and the same can be applied for developing standards for other scenarios related to N. fowleri.