Quantification of Boron Compound Concentration for BNCT Using Positron Emission Tomography
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals
2.2. [18. F]NaBF4 PET Tracer Production
2.3. Histologic Study and NIS Immunofluorescence Staining
2.4. PET Imaging and Image Processing
2.5. HISPANoS as Epithermal Neutrons Irradiation Facility for BNCT
2.6. Calculation of Boron Concentration
3. Results
3.1. [18F]NaBF4 Radiotracer Production
3.2. IF Staining of NIS in Thyroid Tissue
3.3. [18F]NaBF4 PET Radiotracer Uptake in Thyroid Cells
3.4. Simulation of Epithermal Neutrons Irradiation
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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K1 | k2 | k3 | k4 | Vs | Vt | Kl/k2 | k3/k4 | Flux |
---|---|---|---|---|---|---|---|---|
1.89 | 0.52 | 0.09 | 0.08 | 3.96 | 7.56 | 3.60 | 1.10 | 0.28 |
Normal Thyroid | Tumor Thyroid | |||
---|---|---|---|---|
Concentration | Captured n | Captured n | Dose, Gy | Dose, Gy-e |
1 mM 10B | 257 | 2770 | 0.092 | 0.388 |
2 mM 10B | 513 | 5550 | 0.185 | 0.776 |
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Balcerzyk, M.; De-Miguel, M.; Guerrero, C.; Fernandez, B. Quantification of Boron Compound Concentration for BNCT Using Positron Emission Tomography. Cells 2020, 9, 2084. https://doi.org/10.3390/cells9092084
Balcerzyk M, De-Miguel M, Guerrero C, Fernandez B. Quantification of Boron Compound Concentration for BNCT Using Positron Emission Tomography. Cells. 2020; 9(9):2084. https://doi.org/10.3390/cells9092084
Chicago/Turabian StyleBalcerzyk, Marcin, Manuel De-Miguel, Carlos Guerrero, and Begoña Fernandez. 2020. "Quantification of Boron Compound Concentration for BNCT Using Positron Emission Tomography" Cells 9, no. 9: 2084. https://doi.org/10.3390/cells9092084