RHO Family GTPases in the Biology of Lymphoma
1
Department of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Torino, Italy
2
Department of Pathology, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA
*
Author to whom correspondence should be addressed.
Cells 2019, 8(7), 646; https://doi.org/10.3390/cells8070646
Received: 2 May 2019
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Revised: 10 June 2019
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Accepted: 20 June 2019
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Published: 26 June 2019
(This article belongs to the Collection Rho GTPases in Health and Disease)
RHO GTPases are a class of small molecules involved in the regulation of several cellular processes that belong to the RAS GTPase superfamily. The RHO family of GTPases includes several members that are further divided into two different groups: typical and atypical. Both typical and atypical RHO GTPases are critical transducers of intracellular signaling and have been linked to human cancer. Significantly, both gain-of-function and loss-of-function mutations have been described in human tumors with contradicting roles depending on the cell context. The RAS family of GTPases that also belong to the RAS GTPase superfamily like the RHO GTPases, includes arguably the most frequently mutated genes in human cancers (K-RAS, N-RAS, and H-RAS) but has been extensively described elsewhere. This review focuses on the role of RHO family GTPases in human lymphoma initiation and progression.
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Keywords:
RHO family GTPases; RHOA; RHOH; VAV; mutations; chromosomal translocations; lymphoma
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MDPI and ACS Style
Voena, C.; Chiarle, R. RHO Family GTPases in the Biology of Lymphoma. Cells 2019, 8, 646. https://doi.org/10.3390/cells8070646
AMA Style
Voena C, Chiarle R. RHO Family GTPases in the Biology of Lymphoma. Cells. 2019; 8(7):646. https://doi.org/10.3390/cells8070646
Chicago/Turabian StyleVoena, Claudia, and Roberto Chiarle. 2019. "RHO Family GTPases in the Biology of Lymphoma" Cells 8, no. 7: 646. https://doi.org/10.3390/cells8070646
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