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Review

The Role of Cardiolipin in Mitochondrial Function and Neurodegenerative Diseases

by
José M. Fuentes
1,2,3,* and
Patricia Morcillo
4,*
1
Departamento de Bioquímica y Biología Molecular y Genética, Facultad de Enfermería y Terapia Ocupacional, Universidad de Extremadura, 10003 Cáceres, Spain
2
Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Instituto de Salud Carlos III (CIBER-CIBERNED-ISCIII), 28029 Madrid, Spain
3
Instituto Universitario de Investigación Biosanitaria de Extremadura (INUBE), 10003 Cáceres, Spain
4
Departmentof Neurology, Columbia University, New York, NY 10032, USA
*
Authors to whom correspondence should be addressed.
Cells 2024, 13(7), 609; https://doi.org/10.3390/cells13070609
Submission received: 18 February 2024 / Revised: 28 March 2024 / Accepted: 29 March 2024 / Published: 30 March 2024

Abstract

Cardiolipin (CL) is a mitochondria-exclusive phospholipid synthesized in the inner mitochondrial membrane. CL plays a key role in mitochondrial membranes, impacting a plethora of functions this organelle performs. Consequently, it is conceivable that abnormalities in the CL content, composition, and level of oxidation may negatively impact mitochondrial function and dynamics, with important implications in a variety of diseases. This review concentrates on papers published in recent years, combined with basic and underexplored research in CL. We capture new findings on its biological functions in the mitochondria, as well as its association with neurodegenerative diseases such as Alzheimer’s disease or Parkinson’s disease. Lastly, we explore the potential applications of CL as a biomarker and pharmacological target to mitigate mitochondrial dysfunction.
Keywords: cardiolipin; mitochondria; biological functions; neurodegenerative diseases; therapeutic applications cardiolipin; mitochondria; biological functions; neurodegenerative diseases; therapeutic applications
Graphical Abstract

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MDPI and ACS Style

Fuentes, J.M.; Morcillo, P. The Role of Cardiolipin in Mitochondrial Function and Neurodegenerative Diseases. Cells 2024, 13, 609. https://doi.org/10.3390/cells13070609

AMA Style

Fuentes JM, Morcillo P. The Role of Cardiolipin in Mitochondrial Function and Neurodegenerative Diseases. Cells. 2024; 13(7):609. https://doi.org/10.3390/cells13070609

Chicago/Turabian Style

Fuentes, José M., and Patricia Morcillo. 2024. "The Role of Cardiolipin in Mitochondrial Function and Neurodegenerative Diseases" Cells 13, no. 7: 609. https://doi.org/10.3390/cells13070609

APA Style

Fuentes, J. M., & Morcillo, P. (2024). The Role of Cardiolipin in Mitochondrial Function and Neurodegenerative Diseases. Cells, 13(7), 609. https://doi.org/10.3390/cells13070609

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