Chiral Photoresponsive Liquid Crystalline Materials Derived from Cyanoazobenzene Central Core: E ﬀ ect of UV Light Illumination on Mesomorphic Behavior

: One of the most frequently utilized liquid crystalline (LC) materials is a rod-like (calamitic) compound 4-cyano-4 (cid:48) -pentylbiphenyl (5-CB). The main objective of this work is to enhance its functionality by introducing a photoresponsive diazenyl spacer in the aromatic core and replace the non-chiral pentyl chain with various chiral alkyl carboxylate units. The mesomorphic properties of the prepared materials have been studied using polarizing optical microscopy and di ﬀ erential scanning calorimetry. It has been found that materials with an extended aromatic system possess the liquid crystalline behavior. The studied LC materials have shown mesophases at lower temperatures than previously reported analogous substances. Furthermore, one of them exhibits a chiral orthogonal frustrated twist grain boundary smectic phase, which has not been previously observed for this structural type of materials. We also investigated photoresponse of the mesophases under illumination with UV-light (365 nm) using a polarizing optical microscope. A non-conventional photoresponse of the prepared materials in a crystalline phase is presented and discussed. and


Introduction
Due to their extraordinary ability to form various self-organized supramolecular structures between solid and liquid states (mesophases) [1], thermotropic liquid crystals (LCs) are widely used as smart organic materials. Since in a mesophase, the LCs combine the fluidity of liquids and ordering of crystals, their structure, and the optical properties, can be easily tuned by an applied electric field or by a temperature change. Tunability of mesophases using light requires the introduction of a photoresponsive moiety into the structure of LC molecules. Illumination with light then induces changes in geometry of LC molecules, which leads to the isothermic changes in the structure of formed mesophases, eventually to supercooling of a phase transition [2]. During last decade, the photoresponsive materials have received considerable attention due to their possible application in data storage systems [3], tunable photonic devices [4,5], artificial muscles [6,7], and other smart applications [8][9][10].
General structure of calamitic LC molecules can be described as a combination of relatively rigid parts, typically aromatic cores with/without linking groups, with flexible parts, usually represented by terminal alkyl chains [11]. The introduction of a chiral center in the flexible alkyl chain gives rise to chiral

Design and Synthesis of the Materials
The design of the target chiral photoresponsive materials Ia-c and IIa-b was inspired by the basic structure of 5-CB, which was modified in two different ways. Firstly, the biphenyl core was extended using the photoresponsive diazenyl N = N linker (Figure 2, green). Secondly, a non-chiral elongating alkyl chain (C5H11 in 5-CB) was replaced by a chiral unit R (Figure 2, blue), which was attached to the central core through an ester linking unit (Figure 2, red). In order to investigate structureproperty relationships, various chiral units were connected to the central core. Materials Ia,b contained lactic or 4-methylhexanoic acid-based chiral units. For the material Ic, the chiral part was extended by an aromatic core, in order to investigate the effect of moving the chiral unit close to the center of the molecule. Materials II then contained the rigid core elongated with 4-hydroxybenzoic acid. Therefore, the system of connected aromatic rings was extended from two (for materials Ia,b) to three (for materials Ic and IIa,b). A compound IIc has not been synthesized due to expected high transition temperatures imposed by four aromatic rings in such a structure. Designed materials were synthesized in high yields by connection of the known building blocks: phenol 1 [41] with acids 2a-c [13,42,43] or acids 3a,b [44][45][46] using DIC-mediated acylation reaction (A) or by acylation using corresponding acid chloride in the presence of DMAP (B) (Figure 2). The method B was used for direct acylation of the central core 1 with (S)-2-octyloxypropanoic acid chloride because of potential racemization of the chiral acid in the DIC-mediated esterification reaction [46][47][48].
The structure of final products was confirmed by IR spectroscopy, NMR spectroscopy, and mass spectrometry. IR spectra were recorded using Thermo Scientific™ Nicolet™ iS™10 FT-IR Spectrometer (Thermo Fischer Scientific, Waltham, MA, USA) on KBr discs. 1 H and 13 C NMR spectra were acquired on Agilent 400-MR DDR2 spectrometer (Agilent Technologies, Santa Clara, CA, USA), chemical shifts (δ) are given in ppm, and spin-spin coupling constants (J) in Hz. Deuterated chloroform (CDCl 3 ) was used as a solvent. The residual non-deuterated solvent peak was used as an internal standard for 1 H and 13 C NMR spectra. Multiplicity of recorded peaks is described using following abbreviations: d-doublet, t-triplet, q-quartet, m-multiplet. The exact mass of the target compounds was obtained with high-resolution mass spectrometer LTQ Orbitrap Velos (Thermo Fischer Scientific, Waltham, MA, USA).
Two methods of acylation A, B were used to prepare target molecules. Method A was used for the synthesis of all target materials (except for the compound Ib) and, therefore, it is described as a general method.
General method A. The solution of an alcohol 1 (1.1 mmol) in DCM (25 mL) was added dropwise to a solution of a corresponding acid (1.0 mmol) with N,N-diisopropylcarbodiimide (DIC) (1.1 mmol) and a catalytic amount of N,N-dimethylaminopyridine (DMAP) (1.0 mmol) in DCM (50 mL) in the inert atmosphere of argon. The reaction mixture was stirred for 2 h and then the reaction was quenched with water. Layers were separated and the aqueous layer was extracted with toluene (2 × 20 mL). The combined organic solution was washed with brine (10 mL) and dried with anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure and the crude orange product was purified by column chromatography (eluent: chloroform) and crystallization from ethanol (3 times).
Crystals 2020, 10, x FOR PEER REVIEW 5 of 17 known procedures and their analytical data corresponded to that described in the literature. Dry dichloromethane (DCM) was taken from a solvent purification system PureSolv MD7 (Amesbury, MA, USA). Kieselgel 60-100 μm (Merck, Darmstadt, Germany) silica was used for column chromatography.
The structure of final products was confirmed by IR spectroscopy, NMR spectroscopy, and mass spectrometry. IR spectra were recorded using Thermo Scientific™ Nicolet™ iS™10 FT-IR Spectrometer (Thermo Fischer Scientific, Waltham, MA, USA) on KBr discs. 1 H and 13 C NMR spectra were acquired on Agilent 400-MR DDR2 spectrometer (Agilent Technologies, Santa Clara, CA, USA), chemical shifts (δ) are given in ppm, and spin-spin coupling constants (J) in Hz. Deuterated chloroform (CDCl3) was used as a solvent. The residual non-deuterated solvent peak was used as an internal standard for 1 H and 13 C NMR spectra. Multiplicity of recorded peaks is described using following abbreviations: d-doublet, t-triplet, q-quartet, m-multiplet. The exact mass of the target compounds was obtained with high-resolution mass spectrometer LTQ Orbitrap Velos (Thermo Fischer Scientific, Waltham, MA, USA).
Two methods of acylation A, B were used to prepare target molecules. Method A was used for the synthesis of all target materials (except for the compound Ib) and, therefore, it is described as a general method.
General method A. The solution of an alcohol 1 (1.1 mmol) in DCM (25 ml) was added dropwise to a solution of a corresponding acid (1.0 mmol) with N,N-diisopropylcarbodiimide (DIC) (1.1 mmol) and a catalytic amount of N,N-dimethylaminopyridine (DMAP) (1.0 mmol) in DCM (50 ml) in the inert atmosphere of argon. The reaction mixture was stirred for 2 h and then the reaction was quenched with water. Layers were separated and the aqueous layer was extracted with toluene (2 × 20 ml). The combined organic solution was washed with brine (10 ml) and dried with anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure and the crude orange product was purified by column chromatography (eluent: chloroform) and crystallization from ethanol (3 times).

(S)-4-[(4-Cyanophenyl)diazenyl]phenyl 4-methylhexanoate (Ia)
The material Ia was prepared according to the method A in 74% (118 mg) yield as orange crystals, m.p. 92-93 C. Method B. A mixture of an acid (1.2 mmol) with a catalytic amount of DMF (0.05 ml) in oxalyl chloride (10 ml) was stirred at room temperature for 2 h. The excess of oxalyl chloride was distilled from the mixture. The residue was dissolved in hexane (10 ml) and treated with active charcoal at reflux. After the mixture was filtered while hot, hexane was evaporated and the crude acid chloride was mixed with a solution of DMAP (1.1 mmol) and the phenol 1 (1 mmol) in DCM (5 ml). The mixture was stirred in an argon atmosphere at room temperature for 8 h and then decomposed with 17% aq. hydrochloric acid. Layers were separated and the aqueous layer was extracted with toluene (2 × 20 ml). The combined organic solution was washed with brine (10 ml) and dried with anhydrous magnesium sulfate. The solvent was removed, and the crude orange product was purified by column chromatography (eluent: chloroform) and multiple crystallizations from ethanol.
Method B. A mixture of an acid (1.2 mmol) with a catalytic amount of DMF (0.05 mL) in oxalyl chloride (10 mL) was stirred at room temperature for 2 h. The excess of oxalyl chloride was distilled from the mixture. The residue was dissolved in hexane (10 mL) and treated with active charcoal at reflux. After the mixture was filtered while hot, hexane was evaporated and the crude acid chloride was mixed with a solution of DMAP (1.1 mmol) and the phenol 1 (1 mmol) in DCM (5 mL). The mixture was stirred in an argon atmosphere at room temperature for 8 h and then decomposed with 17% aq. hydrochloric acid. Layers were separated and the aqueous layer was extracted with toluene (2 × 20 mL). The combined organic solution was washed with brine (10 mL) and dried with anhydrous magnesium sulfate. The solvent was removed, and the crude orange product was purified by column chromatography (eluent: chloroform) and multiple crystallizations from ethanol.

(R)-4-[(4-Cyanophenyl)diazenyl]phenyl-2-[4-(octyloxy)phenoxy]propanoate (Ic)
The material Ic was prepared according to the method A in 84% (268 mg) yield as orange crystals, m.p. 87-88 • C. Method B. A mixture of an acid (1.2 mmol) with a catalytic amount of DMF (0.05 ml) in oxalyl chloride (10 ml) was stirred at room temperature for 2 h. The excess of oxalyl chloride was distilled from the mixture. The residue was dissolved in hexane (10 ml) and treated with active charcoal at reflux. After the mixture was filtered while hot, hexane was evaporated and the crude acid chloride was mixed with a solution of DMAP (1.1 mmol) and the phenol 1 (1 mmol) in DCM (5 ml). The mixture was stirred in an argon atmosphere at room temperature for 8 h and then decomposed with 17% aq. hydrochloric acid. Layers were separated and the aqueous layer was extracted with toluene (2 × 20 ml). The combined organic solution was washed with brine (10 ml) and dried with anhydrous magnesium sulfate. The solvent was removed, and the crude orange product was purified by column chromatography (eluent: chloroform) and multiple crystallizations from ethanol.

Experimental on Mesomorphic Behavior and Photoresponse of the Target Materials
Sequence of phases and phase transition temperatures of the IIa,b materials were determined by observations of characteristic textures and their changes in polarizing optical microscope (POM) NIKON Elipse E600Pol (Nikon, Tokyo, Japan) and checked by Differential Scanning Calorimetry (DSC) Perkin-Elmer 8000 (Perkin-Elmer, Waltham, MA, USA) on cooling and heating runs at a rate of 5 K min -1 . The DSC samples of 3-8 mg were placed in a nitrogen atmosphere and hermetically sealed in aluminum pans. Temperature and enthalpy change values were calibrated on the extrapolated onset temperatures and the enthalpy changes of the melting points of water, indium, and zinc. The study of characteristic textures by observation in POM have been carried out using home-made glass cells with indium-tin oxide (ITO) transparent electrodes (5 x 5 mm 2 ) and polyimide layers unidirectionally rubbed, which ensured planar-aligned (quasi-bookshelf) geometry. The sample thickness was defined by Mylar sheets as 5 μm. The temperature of the samples was precisely controlled by using Linkam LTS E350 (Linkam, Tadworth, UK) heating/cooling stage with a TMS 93 temperature controller (Linkam, Tadworth, UK); it assures the temperature stability of 0.1 K.
The photoresponse of the materials IIa,b in each mesophase was studied using POM on ITOcells (5 thick, planar alignment) filled with the studied materials at temperature several degrees above the clearing point. The designed LC materials were cooled down to a desired temperature and illuminated with UV-light (wavelength 365 nm, intensity 11.3 mWcm −2 ) using a LED diode source (Height-Led, Shenzhen, China). After reaching the photostationary state, the sample was left to relax.

Experimental on Mesomorphic Behavior and Photoresponse of the Target Materials
Sequence of phases and phase transition temperatures of the IIa,b materials were determined by observations of characteristic textures and their changes in polarizing optical microscope (POM) NIKON Elipse E600Pol (Nikon, Tokyo, Japan) and checked by Differential Scanning Calorimetry (DSC) Perkin-Elmer 8000 (Perkin-Elmer, Waltham, MA, USA) on cooling and heating runs at a rate of 5 K min −1 . The DSC samples of 3-8 mg were placed in a nitrogen atmosphere and hermetically sealed in aluminum pans. Temperature and enthalpy change values were calibrated on the extrapolated onset temperatures and the enthalpy changes of the melting points of water, indium, and zinc. The study of characteristic textures by observation in POM have been carried out using home-made glass cells with indium-tin oxide (ITO) transparent electrodes (5 × 5 mm 2 ) and polyimide layers unidirectionally rubbed, which ensured planar-aligned (quasi-bookshelf) geometry. The sample thickness was defined by Mylar sheets as 5 µm. The temperature of the samples was precisely controlled by using Linkam LTS E350 (Linkam, Tadworth, UK) heating/cooling stage with a TMS 93 temperature controller (Linkam, Tadworth, UK); it assures the temperature stability of 0.1 K. The photoresponse of the materials IIa,b in each mesophase was studied using POM on ITO-cells (5 µm thick, planar alignment) filled with the studied materials at temperature several degrees above the clearing point. The designed LC materials were cooled down to a desired temperature and illuminated with UV-light (wavelength 365 nm, intensity 11.3 mW·cm −2 ) using a LED diode source (Height-Led, Shenzhen, China). After reaching the photostationary state, the sample was left to relax.

Mesomorphic Properties
Mesomorphic properties of the prepared materials were studied using POM and DSC. Results of these measurements are summarized in Table 1. DSC heating/cooling runs are presented in Figure 3. To compare properties of the designed novel materials with those known from the literature (Figure 2), we have summarized their properties in Table 2. In order to provide the full picture for considering the structure-property relationships, and related effects of the diazenyl linking unit and chiral units, the data on chiral cyanobiphenyl-based materials listed as well.  To compare properties of the designed novel materials with those known from the literature (Figure 2), we have summarized their properties in Table 2. In order to provide the full picture for considering the structure-property relationships, and related effects of the diazenyl linking unit and chiral units, the data on chiral cyanobiphenyl-based materials listed as well.  The presented data show that in contrast to known 8-COOCB and its homologues [51], the material Ia is not liquid crystalline. Similarly, the material Ib bearing the chiral lactate group was crystalline only. Moreover, the acylated OCB material, namely H 17 C 8 OPhO-CH(CH 3 )CO-OCB, exhibited a low temperature chiral nematic phase [13], while the material Ic, possessing the same molecular structure, except for the diazenyl unit in the central core, was also crystalline. This indicates that the elongation of the biphenyl core by the introduction of the diazenyl spacer into the molecular structure can potentially suppress the formation of mesophases. The introduction of this linker induces a change in the geometry of the central core. Moreover, there is a difference in the ratio between the size of the central core and the length of the connected flexible chain. Both these aspects may play a role in the resulting loss of the mesomorphic behavior. The extension of the rigid part of the molecule from two to three aromatic cores in materials IIa,b was favorable for the formation of mesophases. The material IIa exhibited a sequence of three mesophases, namely the TGBA*, SmA*, and N*, in a relatively broad temperature range. The material IIb possessing the lactic acid-based chiral center formed two mesophases SmA* and N*. Such behavior is similar to the non-chiral materials n-OC 6 H 4 -CO-OCAB, which exhibited SmA and N phases, eventually with a re-entrant nematic phase ( Table 2). The introduction of the chiral center in the terminal part of the molecule led in case of the material IIb to the reduction of transition temperatures and, consequently, to the narrowing of the interval of mesomorphic behavior in comparison with the non-chiral materials. In case of the material IIa, the clearing temperature remained similar to the non-chiral material, while the crystallization temperature dropped down resulting in a significant broadening of the interval of the mesomorphic behavior. Furthermore, the compound IIb can be directly compared with the material Ic that possesses the chiral unit between aromatic cores, which breaks up the system of three interconnected aromatic units. It is obvious that placing the chiral center close to the terminus of the molecule in IIb (and IIa) is favorable for mesogenicity of the material.
Comparing the properties of IIa,b with the chiral representative of the OCAB family (5*-OC 6 H 4 -CO-OCAB) [40], the materials IIa,b form several mesophases. This can be attributed to the elongation of the terminal alkyl chain, which contributes to the stabilization of lamellar order. Additionally, there could be contribution from the ester linkage unit, which was used to connect the chiral terminal unit. This structural feature most probably contributes the stabilization of the lamellar order and the formation of the frustrated mesophase. To the best of our knowledge, material IIa is the only representative of the OCAB-family, which exhibits the frustrated TGBA* phase before the crystal phase.

Photoresponsiveness of the Materials
Since molecules of the liquid crystalline materials IIa,b comprise the photoswitchable diazenyl group, their geometry can be modulated using UV-light (365 nm). Light induced changes in geometry (switch from Eto Z-isomer, Figure 4) result in changes of the supramolecular arrangement. Commonly, a mesophase is isothermally switched to the isotropic state [2] or to a different mesophase under UV-light irradiation [50,52,53]. Crystalline phase, usually, shows no response to UV-light irradiation, relatively few examples of such behavior found in liquid crystals has recently been reviewed [54]. Thus, in this aspect, materials IIa and IIb showed an unusual response to irradiation.

Photoresponsiveness of the Materials
Since molecules of the liquid crystalline materials IIa,b comprise the photoswitchable diazenyl group, their geometry can be modulated using UV-light (365 nm). Light induced changes in geometry (switch from E-to Z-isomer, Figure 4) result in changes of the supramolecular arrangement. Commonly, a mesophase is isothermally switched to the isotropic state [2] or to a different mesophase under UV-light irradiation [50,52,53]. Crystalline phase, usually, shows no response to UV-light irradiation, relatively few examples of such behavior found in liquid crystals has recently been reviewed [54]. Thus, in this aspect, materials IIa and IIb showed an unusual response to irradiation. The N* phase of IIa showed an ordinary response to irradiation; it was immediately switched to the isotropic phase. The SmA* phase of IIa, however, switched first to a remarkably stable N* phase. Up to 4 min of illumination with UV-light was required to force full conversion of the formed N* phase to the Iso phase ( Figure 5). The isothermal SmA* → N* phase transition was observed during almost whole temperature range of the SmA* phase existence, which is rather remarkable behavior, since UV light-triggered supercooling in phototropic LCs is usually limited to maximum tens of °C [5,55]. Isothermal relaxation of the UV-light induced Iso phase to the SmA* phase also went through the formation of N* phase. The TGBA* phase has shown an identical behavior. The N* phase of IIa showed an ordinary response to irradiation; it was immediately switched to the isotropic phase. The SmA* phase of IIa, however, switched first to a remarkably stable N* phase. Up to 4 min of illumination with UV-light was required to force full conversion of the formed N* phase to the Iso phase ( Figure 5). The isothermal SmA* → N* phase transition was observed during almost whole temperature range of the SmA* phase existence, which is rather remarkable behavior, since UV light-triggered supercooling in phototropic LCs is usually limited to maximum tens of • C [5,55]. Isothermal relaxation of the UV-light induced Iso phase to the SmA* phase also went through the formation of N* phase. The TGBA* phase has shown an identical behavior. During studies of photoresponse, the IIa sample crystallized at 65 °C. Interestingly, UV-light irradiation of this crystalline phase lead to the direct formation of a coexisting mixture of the N* and Iso phases, skipping the SmA* phase ( Figure 6). It should be stressed, that isotropic phase was formed at 65 °C instead of 260 °C. The crystalline phase at 60 °C had firstly the same response to UV-light, but during further irradiation crystals grew up in the formed N* + Iso phases mixture, indicating, that at this temperature the crystallization process is already preferred. Below this temperature Cr phase showed no response to the UV-light. Observed Cr → N*+Iso phase transition clearly proves, that this change was not induced by overheating of the material, as the SmA* phase, which should be formed in between Cr and N* phases, was missing. It could be argued that the assumed isotropic phase was in fact homeotropic SmA* phase. We cannot exclude this possibility, although planar cells were used, and we were not able to identify the SmA* phase on repeating the experiment. During studies of photoresponse, the IIa sample crystallized at 65 • C. Interestingly, UV-light irradiation of this crystalline phase lead to the direct formation of a coexisting mixture of the N* and Iso phases, skipping the SmA* phase ( Figure 6). It should be stressed, that isotropic phase was formed at 65 • C instead of 260 • C. The crystalline phase at 60 • C had firstly the same response to UV-light, but during further irradiation crystals grew up in the formed N* + Iso phases mixture, indicating, that at this temperature the crystallization process is already preferred. Below this temperature Cr phase showed no response to the UV-light. Observed Cr → N* + Iso phase transition clearly proves, that this change was not induced by overheating of the material, as the SmA* phase, which should be formed in between Cr and N* phases, was missing. It could be argued that the assumed isotropic phase was in fact homeotropic SmA* phase. We cannot exclude this possibility, although planar cells were used, and we were not able to identify the SmA* phase on repeating the experiment. Material IIb has also shown an unusual response to UV-light. The N* phase has shown two types of response depending on the temperature of the sample. The common isothermal N* → Iso phase transition induced by illumination with the UV light was observed near the Iso → N* phase transition temperature (around 175 °C). Illumination of the sample at 170 °C induced an N* → N* phase transition. Most probably, the concentration of the UV light induced Z-isomer was not high enough to facilitate the transition to isotropic liquid and only a modification of the ordered fluid due to viscosity difference occurred. To clarify this observation, additional measurements providing information on viscosity (e.g., rheological experiment under irradiation) or even the molecular arrangement are required. Irradiation of the SmA* phase close to the phase transition (at 160 °C , measured by POM) resulted in the formation of two N* phases (Figure 7). At 140 °C -135 °C , no UV light-triggered phase transition was observed, but the size of domains changed reversibly (please see the supplementary video file Mov-SI). Material IIb has also shown an unusual response to UV-light. The N* phase has shown two types of response depending on the temperature of the sample. The common isothermal N* → Iso phase transition induced by illumination with the UV light was observed near the Iso → N* phase transition temperature (around 175 • C). Illumination of the sample at 170 • C induced an N* → N* phase transition. Most probably, the concentration of the UV light induced Z-isomer was not high enough to facilitate the transition to isotropic liquid and only a modification of the ordered fluid due to viscosity difference occurred. To clarify this observation, additional measurements providing information on viscosity (e.g., rheological experiment under irradiation) or even the molecular arrangement are required. Irradiation of the SmA* phase close to the phase transition (at 160 • C, measured by POM) resulted in the formation of two N* phases (Figure 7). At 140-135 • C, no UV light-triggered phase transition was observed, but the size of domains changed reversibly (please see the supplementary video file Mov-SI). Material IIb has also shown an unusual response to UV-light. The N* phase has shown two types of response depending on the temperature of the sample. The common isothermal N* → Iso phase transition induced by illumination with the UV light was observed near the Iso → N* phase transition temperature (around 175 °C). Illumination of the sample at 170 °C induced an N* → N* phase transition. Most probably, the concentration of the UV light induced Z-isomer was not high enough to facilitate the transition to isotropic liquid and only a modification of the ordered fluid due to viscosity difference occurred. To clarify this observation, additional measurements providing information on viscosity (e.g., rheological experiment under irradiation) or even the molecular arrangement are required. Irradiation of the SmA* phase close to the phase transition (at 160 °C , measured by POM) resulted in the formation of two N* phases (Figure 7). At 140 °C -135 °C , no UV light-triggered phase transition was observed, but the size of domains changed reversibly (please see the supplementary video file Mov-SI).

Conclusions
In the current study, we designed two series of novel chiral photosensitive compounds Ia-c and IIa,b. We have found that only materials IIa,b with central core containing three benzene rings and the chiral center located in the terminal part of the molecule possess the liquid crystalline behavior. The materials IIa,b exhibited chiral mesophases in a quite broad temperature range up to high temperatures. Both are polymorphic and exhibit chiral smectic and nematic mesophases at low temperatures. To the best of our knowledge, the material IIa is the first cyanoazobenzene-based material exhibiting the frustrated TGBA* mesophase.
We have also performed the first study of photoresponse of the monomeric chiral CAB-based materials. We have shown that under irradiation, the N* phase of the material IIa is switched to the isotropic liquid. Interestingly, the SmA* and TGBA* phases first switch to a stable N* phase, which on longer irradiation switches to the isotropic phase. Moreover, the crystalline state can be at a certain temperature switched to the coexisting N* and Iso phases. We observed that the N* phase of the material IIb at higher temperatures transforms to isotropic liquid and at lower temperatures to a second N* phase. Similarly, the SmA* phase at higher temperatures transforms into two N* phases, while at lower temperatures modulation of the size of its domains has been observed. The obtained results will contribute to better understanding of the molecular structure-mesomorphic property relationship for the liquid crystalline materials possessing the photosensitive moiety as such materials attract considerable attention of the scientific community due to high application potential of those materials for various photonic devices [5,8,56].