Facile Green Preparation of Rhodium Nanoclusters Supported Nano-Scaled Graphene Platelets for Sonogashira Coupling Reaction and Reduction of p-Nitrophenol

: Rhodium nanoclusters were uniformly dispersed on nano-scaled graphene platelets by a simple ‘mix and heat’ method without using any toxic reagents. Distilled water was used to obtain the homogenous dispersion of Rh-nanoclusters on graphene platelets. The morphology of the resultant catalyst (Rh(0)NCs / GNPs) was studied by means of transmission electron microscope (TEM) and atomic force microscope (AFM) analyses. The X-ray photoemission spectroscope (XPS) result conﬁrmed the metallic form of Rh-nanoclusters in Rh(0)NCs / GNPs. The crystalline property and the interaction between Rh-nanoclusters and graphene platelets (GNPs) were studied by means of XRD and Raman analysis. The Rh-loading in Rh(0)NCs / GNPs was conﬁrmed by scanning electron microscope and energy dispersive spectroscope (SEM-EDS) and inductively coupled plasma-mass spectroscope (ICP-MS) analysis. After being optimized, the Rh(0)NCs / GNPs used as catalyst for the reduction of 4-nitrophenol with NaBH 4 and the Sonogashira coupling reaction between iodobenzene with phenylacetylene. To our delight, the Rh(0)NCs / GNPs showed excellent catalytic activity towards the reduction of 4-nitrophenol with an excellent turnover frequency (TOF) value of 112.5 min − 1 . The k app and k’ values were calculated to be 62.07 × 10 − 3 min − 1 (0.002 mg of Rh(0)NCs / GNPs) and 31035 × 10 − 3 mg − 1 min − 1 ,respectively. Alike, under the optimal conditions, the Rh(0)NCs / GNPs gave the desired product, diphenylacetylene, in a good yield of 87% with 91% selectivity. The Rh(0)NCs / GNPs can be reused without signiﬁcant loss in its catalytic activity.


Introduction
Transition metal nanoparticles, such as Ru, Rh, and Pd, are often found to be efficient catalysts for a wide range of organic reactions, including hydrogenation of unsaturated compounds and reductive coupling of aryl halides [1,2]. In particular, Rh-nanoparticles are known for their very high catalytic activity in hydrocarbonylation, hydrogenation, hydroformylation, and reductive coupling reactions [3].

Characterization of Rh(0)NCs/GNPs Catalyst
Toxic reducing or stabilizing agents free simple 'mix and heat' method was adopted for the preparation of Rh(0)NCs/GNPs. Distilled water was used as solvent forachieving uniform mixing of GNPs and Rh(acac) 3 . Finally, the calcination of GNPs/Rh(acac) 3 mixture under inter atmosphere obtained the homogenous dispersion of Rh(0)NCs on nano-scaled graphene platelets. The purpose of this simple preparation is to achieve big size of Rh nanoclusters (between 25-100 nm) on the surface of GNPs. In fact, the high surface energy of small Rh-nanoparticles (0.1-10 nm) would be expected to favor "Rh leaching-catalytic reaction-Rh readsorption" mechanism and dissolution tendency of small Rh-nanoparticles. According to Kanuru et al. [26], the bulky molecules (reactants) can easily accommodate on the big-size Rh-nanoparticles, whereas, in the case of small Rh-nanoparticles, molecular decomposition is possible due to the bond breaking of molecules adsorbed on the surface of Rh-nanoparticles. In addition, they noticed that the catalytic activity of the Rh-catalyst is mainly due to differences in particle size rather than particle morphology. Alike, Yuan et al. [27] found that the small size of Rh-nanoparticles (under~10 nm) is more prone towards self-oxidation, which results in catalytically inactivity or promoting side reactions. We presumed that the present Rh-nanoclusters with an average size of 72 nm supported on GNPs could be highly suitable for the catalytic applications. Figure 1 depicts the TEM images of fresh GNPs and Rh(0)NCs/GNPs catalyst. Figure 1 shows the size distribution of Rh-nanoclusters in Rh(0)NCs/GNPs. It can be seen that the fresh GNPs showed two-dimensional (2D)-sheet like morphology (with thickness of~39 nm) without any impurities. The TEM images of Rh(0)NCs/GNPs confirmed that the Rh-nanoclusters with an average size of~72 nm were strongly attached on the surface of GNPs. The high resolution TEM image of Rh(0)NCs/GNPs (Figure 1e) reveal that the big-size of Rh-nanoclusters are accumulated by very fine Rh-nanoparticles. Figure 1 shows the size distribution of Rh-nanoclusters in Rh(0)NCs/GNPs and the mean size of Rh-nanoclusters is found to be~72 nm and the standard deviation was calculated to be~30 nm. To further one-dimensional (1D) and three-dimensional (3D) AFM profiles of fresh GNPs and Rh(0)NCs/GNPs were also captured ( Figure 2). The AFM profile of fresh GNPs showed smooth and sheet-like surface morphology without the presence of Rh-nanoclusters. However, the 1D and 3D AFM profiles of Rh(0)NCs/GNPs demonstrate rough surface morphology with the uniform decoration of Rh-nanoclusters. The Rh-nanoclusters size of about 75 nm was calculated from the AFM profiles, which agrees well with the TEM results. The mean roughness (Rq) values were obtained for fresh GNPs and Rh(0)NCs/GNPs. The Rq values of 86 and 23 nm were calculated for fresh GNPs and Rh(0)NCs/GNPs, respectively. The significant decrease in the Rq value for Rh(0)NCs/GNPs when compared to fresh GNPs proves the successful decoration of Rh-nanoclusters.  The Rh-content in Rh(0)NCs/GNPs catalyst was determined by means of SEM-EDS analysis. Figure 3 shows the SEM image and EDS spectrum of Rh(0)NCs/GNPs, and the corresponding elemental mapping of C, O, and Rh. It was found that the Rh(0)NCs/GNPs only contains C, O, and Rh elements, indicating that the present Rh(0)NCs/GNPs is highly pure and free from any impurities. The factual content of C, O, and Rh was determined to be 83.78, 12.57, and 3.65 wt%, respectively. Moreover, the elemental mapping of C, O, and Rh demonstrates the homogenous dispersion of Rh-nanoclusters on the surface of GNPs. Atomic force microscope (AFM)one-dimensional (1D) and three-dimensional (3D) profile of (a) graphene platelets (GNPs) and (b,c) Rh(0)NCs/GNPs and (d) the particle size distribution of Rh nanoparticles in Rh(0)NCs/GNPs. The Rh-content in Rh(0)NCs/GNPs catalyst was determined by means of SEM-EDS analysis. Figure 3 shows the SEM image and EDS spectrum of Rh(0)NCs/GNPs, and the corresponding elemental mapping of C, O, and Rh. It was found that the Rh(0)NCs/GNPs only contains C, O, and Rh elements, indicating that the present Rh(0)NCs/GNPs is highly pure and free from any impurities. The factual content of C, O, and Rh was determined to be 83.78, 12.57, and 3.65 wt%, respectively. Moreover, the elemental mapping of C, O, and Rh demonstrates the homogenous dispersion of Rh-nanoclusters on the surface of GNPs. Raman spectra were recorded for fresh GNPs and the Rh(0)NCs/GNPs catalyst. Three characteristic peaks were noticed, D band at ~1350 cm −1 , G band at ~1590 cm −1 and 2D band at ~2730 cm −1 , for both fresh GNPs and Rh(0)NCs/GNPs ( Figure 4). The presence of most intense G band refers to in-plane/out-of-plane vibrational modes of sp 2 hybridized carbon orbitals [28]. The D band at 1350cm −1 (disorder induced) indicates that the defects are present in the GNPs [29].In addition, the 2D band at ~2730 cm −1 is attributed to overtone of D band and D + G band [28]. The 2D peak reflects the stacking structure of graphite along the c-axis. The ID/IG and I2D/IG ratios were calculated for the GNPs and Rh(0)NCs/GNPs catalyst ( Figure 4). The ID/IG ratio of 0.071 ± 0.012 and 0.112 ± 0.012 was calculated for GNPs and Rh(0)NCs/GNPs, respectively. Similarly, the I2D/IG ratio of GNPs and Rh(0)NCs/GNPs was calculated to be 0.426 and 0.461, respectively. The significant increase in the ID/IG and I2D/IG ratios of Rh(0)NCs/GNPs when compared to GNPs shows that the Rh(0)NCs/GNPs has more defects than that of GNPs. The increase in the defect sites is mainly due to the decoration of Rh-nanoclusters on the surface of GNPs [30]. In addition, the mechanical exfoliation of GNPs (during the 'mix and heat' preparation of Rh(0)NCs/GNPs) mightalso be the reason for the relatively high defects present in the Rh(0)NCs/GNPs catalyst. The 2D band intensity of Rh(0)NCs/GNPs) is seen to be high when compared to the GNPs, which also conform the mechanical exfoliation or an increase in the amorphous fraction of GNPs during the preparation process [29]. Raman spectra were recorded for fresh GNPs and the Rh(0)NCs/GNPs catalyst. Three characteristic peaks were noticed, D band at~1350 cm −1 , G band at~1590 cm −1 and 2D band at~2730 cm −1 , for both fresh GNPs and Rh(0)NCs/GNPs ( Figure 4). The presence of most intense G band refers to in-plane/out-of-plane vibrational modes of sp 2 hybridized carbon orbitals [28]. The D band at 1350 cm −1 (disorder induced) indicates that the defects are present in the GNPs [29].In addition, the 2D band at~2730 cm −1 is attributed to overtone of D band and D + G band [28]. The 2D peak reflects the stacking structure of graphite along the c-axis. The I D /I G and I 2D /I G ratios were calculated for the GNPs and Rh(0)NCs/GNPs catalyst ( Figure 4). The I D /I G ratio of 0.071 ± 0.012 and 0.112 ± 0.012 was calculated for GNPs and Rh(0)NCs/GNPs, respectively. Similarly, the I 2D /I G ratio of GNPs and Rh(0)NCs/GNPs was calculated to be 0.426 and 0.461, respectively. The significant increase in the I D /I G and I 2D /I G ratios of Rh(0)NCs/GNPs when compared to GNPs shows that the Rh(0)NCs/GNPs has more defects than that of GNPs. The increase in the defect sites is mainly due to the decoration of Rh-nanoclusters on the surface of GNPs [30]. In addition, the mechanical exfoliation of GNPs (during the 'mix and heat' preparation of Rh(0)NCs/GNPs) mightalso be the reason for the relatively high defects present in the Rh(0)NCs/GNPs catalyst. The 2D band intensity of Rh(0)NCs/GNPs) is seen to be high when compared to the GNPs, which also conform the mechanical exfoliation or an increase in the amorphous fraction of GNPs during the preparation process [29].  XRD analysisinvestigated the crystalline property of GNPs before and after Rh-nanocluster decoration. Figure 5 shows the XRD pattern of GNPs and Rh(0)NCs/GNPs catalyst. It can be seen that the XRD pattern of both GNPs and Rh(0)NCs/GNPs show three dominant peaks at 2θ=26°, 2θ=44°, and 2θ=55° corresponding to (002), (101), and (100) planes of hexagonal graphite structure [31]. However, no new diffraction peaks corresponding to the metallic Rh-nanoclusters were observed for the Rh(0)NCs/GNPs. This is due to the nano-crystalline nature of Rh-nanoclusters and moderately low wt% of Rh in Rh(0)NCs/GNPs (3.65 wt%) [20]. In addition, the fine dispersion of Rh in Rh(0)NCs/GNPs might also be the reason [22]. XRD analysisinvestigated the crystalline property of GNPs before and after Rh-nanocluster decoration. Figure 5 shows the XRD pattern of GNPs and Rh(0)NCs/GNPs catalyst. It can be seen that the XRD pattern of both GNPs and Rh(0)NCs/GNPs show three dominant peaks at 2θ = 26 • , 2θ = 44 • , and 2θ = 55 • corresponding to (002), (101), and (100) planes of hexagonal graphite structure [31]. However, no new diffraction peaks corresponding to the metallic Rh-nanoclusters were observed for the Rh(0)NCs/GNPs. This is due to the nano-crystalline nature of Rh-nanoclusters and moderately low wt% of Rh in Rh(0)NCs/GNPs (3.65 wt%) [20]. In addition, the fine dispersion of Rh in Rh(0)NCs/GNPs might also be the reason [22]. The XPS spectra were recorded for the Rh(0)NCs/GNPs and fresh GNPs ( Figure 6). It can be noticed that two dominant peaks, C 1s peak at 284.5 eV and O 1s peak at 531.5 eV, were noticed for both GNPs and Rh(0)NCs/GNPs. As expected, the XPS spectrum of Rh(0)NCs/GNPs showed a new peak in the Rh 3d region ( Figure 6). The 3d3/2 peak at 313.2 eV and the Rh 3d5/2 peak at 307.5 eV confirmed that the Rh-nanoclusters present in the Rh(0)NCs/GNPs are zerovalent Rh [32]. The content of Rh was determined to be 3.51 wt% (agrees well with the EDS data). In addition to the Rh 3d peaks, the presence of O 1s and C 1s peaks clearly shows that the catalyst has oxygen functional groups. The C 1s and O 1s peaks were deconvoluted to find out the oxygen function groups. The deconvolation of C 1s peak resulted in four peaks at 284.1 (C-C/C=C), 284.4 (C-OH), 284.9 (C-O-C), and 287.6 eV (C=O) (Figure 6b) [33]. Similarly, the deconvolation of O 1s peak confirmed the presence of the oxygen function groups, such as C-OH, C-O-C, and C=O ( Figure 6c) [34]. It is clear that the oxygen function groups were not completely decomposed during the catalyst preparation process, which mightbe due to the low calcination temperature (under inert atmosphere at 150 °C for 2 h). We believe that the presence of oxygen functional groups would improve the dispersion of Rh(0)NCs/GNPs catalyst in the aqueous and organic solvents and are therefore suitable for catalytic applications. The XPS spectra were recorded for the Rh(0)NCs/GNPs and fresh GNPs ( Figure 6). It can be noticed that two dominant peaks, C 1s peak at 284.5 eV and O 1s peak at 531.5 eV, were noticed for both GNPs and Rh(0)NCs/GNPs. As expected, the XPS spectrum of Rh(0)NCs/GNPs showed a new peak in the Rh 3d region ( Figure 6). The 3d 3/2 peak at 313.2 eV and the Rh 3d 5/2 peak at 307.5 eV confirmed that the Rh-nanoclusters present in the Rh(0)NCs/GNPs are zerovalent Rh [32]. The content of Rh was determined to be 3.51 wt% (agrees well with the EDS data). In addition to the Rh 3d peaks, the presence of O 1s and C 1s peaks clearly shows that the catalyst has oxygen functional groups. The C 1s and O 1s peaks were deconvoluted to find out the oxygen function groups. The deconvolation of C 1s peak resulted in four peaks at 284.1 (C-C/C=C), 284.4 (C-OH), 284.9 (C-O-C), and 287.6 eV (C=O) (Figure 6b) [33]. Similarly, the deconvolation of O 1s peak confirmed the presence of the oxygen function groups, such as C-OH, C-O-C, and C=O ( Figure 6c) [34]. It is clear that the oxygen function groups were not completely decomposed during the catalyst preparation process, which mightbe due to the low calcination temperature (under inert atmosphere at 150 • C for 2 h). We believe that the presence of oxygen functional groups would improve the dispersion of Rh(0)NCs/GNPs catalyst in the aqueous and organic solvents and are therefore suitable for catalytic applications. The XPS spectra were recorded for the Rh(0)NCs/GNPs and fresh GNPs ( Figure 6). It can be noticed that two dominant peaks, C 1s peak at 284.5 eV and O 1s peak at 531.5 eV, were noticed for both GNPs and Rh(0)NCs/GNPs. As expected, the XPS spectrum of Rh(0)NCs/GNPs showed a new peak in the Rh 3d region ( Figure 6). The 3d3/2 peak at 313.2 eV and the Rh 3d5/2 peak at 307.5 eV confirmed that the Rh-nanoclusters present in the Rh(0)NCs/GNPs are zerovalent Rh [32]. The content of Rh was determined to be 3.51 wt% (agrees well with the EDS data). In addition to the Rh 3d peaks, the presence of O 1s and C 1s peaks clearly shows that the catalyst has oxygen functional groups. The C 1s and O 1s peaks were deconvoluted to find out the oxygen function groups. The deconvolation of C 1s peak resulted in four peaks at 284.1 (C-C/C=C), 284.4 (C-OH), 284.9 (C-O-C), and 287.6 eV (C=O) (Figure 6b) [33]. Similarly, the deconvolation of O 1s peak confirmed the presence of the oxygen function groups, such as C-OH, C-O-C, and C=O ( Figure 6c) [34]. It is clear that the oxygen function groups were not completely decomposed during the catalyst preparation process, which mightbe due to the low calcination temperature (under inert atmosphere at 150 °C for 2 h). We believe that the presence of oxygen functional groups would improve the dispersion of Rh(0)NCs/GNPs catalyst in the aqueous and organic solvents and are therefore suitable for catalytic applications.

Reduction of 4-Nitrophenol
The catalytic reduction of 4-nitrophenol to 4-aminophenol is one of the significant processes in green chemistry, and the reduction product, 4-aminophenol, is found to be very useful in the preparation of analgesic antipyretic drugs [35,36]. Various mono-and bi-metallic heterogeneous catalysts are reported for the reduction of 4-nitrophenol with NaBH4. In particular, metal nanoparticles supported carbon materials (mainly, graphene materials) are found to be the most efficient catalysts for the reduction reaction due to the high surface area and metal-support interaction [37]. In addition, the graphene oxide supported metal catalysts are stable and highly reusable. For instance, Vilian et al. [38] prepared Pdnanospheres decorated reduced graphene oxide catalyst for the removal of hazardous 4-nitrophenol pollutant from water. Similarly, Liu and co-workers [39] reported Ag nanoparticles/graphene-loading loofah sponge hybrid as a catalyst for the conversion of 4-nitophenol to 4-aminophenol. They found that the catalysts are highly active and reusable. Alike the carbon materials supported catalysts, cellulose nanofibers and mesoporous SBA-15 were also used for the decoration of metal nanoparticles [40,41]. For example, Au, Ag, and Ni nanoparticle immobilized cellulose nanofiber composites were demonstrated to be highly active catalystsinthe reduction of 4-nitrophenol [41]. However, the reusability of the catalysts is highly limited. To our delight, the present Rh(0)NCs/GNPs is found to be highly efficient and reusable. The turnover frequency (TOF) value of Rh(0)NCs/GNPs is calculated to be extremely very high (112.5 min. −1 ). Initially, the reaction condition was optimized. The catalytic reactions were monitored by UV-Visible spectroscopy. Figure 7 shows UV-vis spectra of the reduction of 4-nitrophenol while using different amount of Rh(0)NCs/GNPs (0.001, 0.0015, and 0.002 mg). At first, the UV-vis spectra were recorded for the 4-nitrophenol before and after the addition of NaBH4. The fresh 4-nitrophenol showed band at 317 nm, whereasthe band shifted to 400 nm, after the addition of NaBH4. The band at 400 nm confirms the formation of 4-nitrophenolate ion. It was confirmed that the fresh GNPs is not active in the reduction of 4-nitrophenol with NaBH4. The UV-vis spectra showed that there is no change in the intensity of 4-nitrophenolate ion peak at 400 nm, even after the stirring for 24 h. Moreover, based on the results, 80 μL of 0.01 M 4-nitrophenoland 4 mL of 0.015 M aqueous NaBH4 were found to be the optimal amount forperforming the reduction reaction. Further, the Rh(0)NCs/GNPs was used for the reduction of 4-nitropehnol ( Figure 7). Initially, 1 mg of the catalyst was stirred with a mixture of 80 μL of 0.01 M 4-nitrophenol and 4 mL of 0.015 M aqueous NaBH4. Surprisingly, the 4-nitrophenol immediatelyreduced after the addition of 1 mg of Rh(0)NCs/GNPs, and a new peak corresponding to 4-aminophenol was noticed. Subsequently, the amount of Rh(0)NCs/GNPs was gradually decreased and found that a very low amount of 0.002 mg of catalyst is enough for the complete reduction of 4-nitrophenol to 4-aminophenol. The TOF value of 112.5

Reduction of 4-Nitrophenol
The catalytic reduction of 4-nitrophenol to 4-aminophenol is one of the significant processes in green chemistry, and the reduction product, 4-aminophenol, is found to be very useful in the preparation of analgesic antipyretic drugs [35,36]. Various mono-and bi-metallic heterogeneous catalysts are reported for the reduction of 4-nitrophenol with NaBH 4 . In particular, metal nanoparticles supported carbon materials (mainly, graphene materials) are found to be the most efficient catalysts for the reduction reaction due to the high surface area and metal-support interaction [37]. In addition, the graphene oxide supported metal catalysts are stable and highly reusable. For instance, Vilian et al. [38] prepared Pdnanospheres decorated reduced graphene oxide catalyst for the removal of hazardous 4-nitrophenol pollutant from water. Similarly, Liu and co-workers [39] reported Ag nanoparticles/graphene-loading loofah sponge hybrid as a catalyst for the conversion of 4-nitophenol to 4-aminophenol. They found that the catalysts are highly active and reusable. Alike the carbon materials supported catalysts, cellulose nanofibers and mesoporous SBA-15 were also used for the decoration of metal nanoparticles [40,41]. For example, Au, Ag, and Ni nanoparticle immobilized cellulose nanofiber composites were demonstrated to be highly active catalystsinthe reduction of 4-nitrophenol [41]. However, the reusability of the catalysts is highly limited. To our delight, the present Rh(0)NCs/GNPs is found to be highly efficient and reusable. The turnover frequency (TOF) value of Rh(0)NCs/GNPs is calculated to be extremely very high (112.5 min −1 ). Initially, the reaction condition was optimized. The catalytic reactions were monitored by UV-Visible spectroscopy. Figure 7 shows UV-vis spectra of the reduction of 4-nitrophenol while using different amount of Rh(0)NCs/GNPs (0.001, 0.0015, and 0.002 mg). At first, the UV-vis spectra were recorded for the 4-nitrophenol before and after the addition of NaBH 4 . The fresh 4-nitrophenol showed band at 317 nm, whereasthe band shifted to 400 nm, after the addition of NaBH 4 . The band at 400 nm confirms the formation of 4-nitrophenolate ion. It was confirmed that the fresh GNPs is not active in the reduction of 4-nitrophenol with NaBH 4 . The UV-vis spectra showed that there is no change in the intensity of 4-nitrophenolate ion peak at 400 nm, even after the stirring for 24 h. Moreover, based on the results, 80 µL of 0.01 M 4-nitrophenoland 4 mL of 0.015 M aqueous NaBH 4 were found to be the optimal amount forperforming the reduction reaction. Further, the Rh(0)NCs/GNPs was used for the reduction of 4-nitropehnol (Figure 7). Initially, 1 mg of the catalyst was stirred with a mixture of 80 µL of 0.01 M 4-nitrophenol and 4 mL of 0.015 M aqueous NaBH 4. Surprisingly, the 4-nitrophenol immediatelyreduced after the addition of 1 mg of Rh(0)NCs/GNPs, and a new peak corresponding to 4-aminophenol was noticed. Subsequently, the amount of Rh(0)NCs/GNPs was gradually decreased and found that a very low amount of 0.002 mg of catalyst is enough for the complete reduction of 4-nitrophenol to 4-aminophenol. The TOF value of 112.5 min −1 was calculated for the Rh(0)NCs/GNPscatalyzed reduction of 4-nitrophenol. Three different amounts (0.001, 0.0015, and 0.002 mg) of Rh(0)NCs/GNPs was used to study the catalytic reduction reaction. The 0.002 mg of Rh(0)NCs/GNPsjust required 2 min for the complete reduction of 4-nitrophenol to 4-aminophenol. Alike, 0.0015 mg of catalyst took about 6 min for the 100% reduction 4-nitrophenol. Figure 7 shows that 0.001 mg of catalyst is not enough for the reduction reaction.
min. −1 was calculated for the Rh(0)NCs/GNPscatalyzed reduction of 4-nitrophenol. Three different amounts (0.001, 0.0015, and 0.002 mg) of Rh(0)NCs/GNPs was used to study the catalytic reduction reaction. The 0.002 mg of Rh(0)NCs/GNPsjust required 2 min. for the complete reduction of 4-nitrophenol to 4-aminophenol. Alike, 0.0015 mg of catalyst took about 6 min. for the 100% reduction 4-nitrophenol. Figure 7 shows that 0.001 mg of catalyst is not enough for the reduction reaction.    Figure 7 shows the plots of ln[C t /C 0 ] versusreaction time for the reduction of 4-nitrophenol with NaBH 4 over the different amounts of Rh(0)NCs/GNPs. The linear relationship confirmed that the reduction process follows pseudo-first-order reaction kinetics [39]. The kinetic reaction rate constants (k app ) values were obtained from the slope of ln(C t /C 0 )versustime liner curve. The k app values were calculated to be 14.94 (0.001 mg), 40.05 (0.0015 mg), and 62.07 × 10 −3 min −1 (0.002 mg). The values showed that the reduction process is rapid in the presence of the Rh(0)NCs/GNPs. The k values were also calculated while using the formula: k = k app /m, where m -weight of the metal active site.
Surprisingly, an excellent k value of 14940, 26700, and 31035 × 10 −3 mg −1 min −1 was obtained for the reduction of 4-nitrophenol, with 0.001, 0.0015, and 0.002 mg of Rh(0)NCs/GNPs, respectively. To the best of our knowledge, this is the best k values obtained for the reduction of 4-nitrophenol to date.

Sonogashira Coupling Reaction
Transition metal catalyzed C-C bond forming reactions are significant tools in organic synthesis. Catalytic products that are prepared via Sonogashira coupling reaction between terminal alkynes and aryl halides have significant value in pharmaceuticals and fine chemicals [52]. Todate, several transition metal based heterogeneous catalysts are developed for the Sonogashira coupling reaction [53]. However, most of them are bimetallic catalysts and its preparation method requires toxic reagents. For instance,thePd-Cu bimetallic system was developed for the cross-coupling of terminal acetylenes with sp 2 -carbon halides by Sonogashira [54]. Similarly, monodisperseCuPd alloy nanoparticles supported graphene oxide catalyst was prepared for the Sonogashira coupling reaction [55]. They found that the bimetallic catalyst is very active and selective. Later, affordable mono metallic catalysts based on Pd, Ni, Cu, Fe, and Co were developed for a more sustainable cross-coupling catalysis [56,57]. After being characterized, the Rh(0)NCs/GNPs was used as catalyst for the Sonogashira coupling reaction of iodobenzene with phenylacetylene (Scheme 2). To our delight, the present Rh(0)NCs/GNPs showed good catalytic activity towards the cross-coupling reaction. The reaction condition was optimized. A 20 mg of Rh(0)NCs/GNPs, tetra butyl ammonium acetate (1 mmol) and 10 mL of DMF were found to be optimal parameters forperforming the cross-coupling of iodobenzene with phenylacetylene. The optimal reaction temperature and reaction time were found to be 120 °C and 24 h, respectively. Under the optimal conditions, the Rh(0)NCs/GNPs gave the desired product, diphenylacetylene, in a good yield of 87% with 91% selectivity. Kanuru et al. [26] reported 5 wt% of Rh nanoparticles supported γ-Alumina catalyst (Rh/γ-Al2O3) for the cross-couplingiodobenzene with phenylacetylene. The Rh/γ-Al2O3 catalyst showed just 57% of the targeted product diphenylacetylene. Similarly, the Rh/BaOcatalyst affords 38% of the product. It mightbe due to the good interaction between Rh-nanoparticles and GNPs, high surface area, optimal size of Rh-nanoparticles, and fine dispersion of catalyst. A reusability test

Sonogashira Coupling Reaction
Transition metal catalyzed C-C bond forming reactions are significant tools in organic synthesis. Catalytic products that are prepared via Sonogashira coupling reaction between terminal alkynes and aryl halides have significant value in pharmaceuticals and fine chemicals [52]. Todate, several transition metal based heterogeneous catalysts are developed for the Sonogashira coupling reaction [53]. However, most of them are bimetallic catalysts and its preparation method requires toxic reagents. For instance,thePd-Cu bimetallic system was developed for the cross-coupling of terminal acetylenes with sp 2 -carbon halides by Sonogashira [54]. Similarly, monodisperseCuPd alloy nanoparticles supported graphene oxide catalyst was prepared for the Sonogashira coupling reaction [55]. They found that the bimetallic catalyst is very active and selective. Later, affordable mono metallic catalysts based on Pd, Ni, Cu, Fe, and Co were developed for a more sustainable cross-coupling catalysis [56,57]. After being characterized, the Rh(0)NCs/GNPs was used as catalyst for the Sonogashira coupling reaction of iodobenzene with phenylacetylene (Scheme 2). To our delight, the present Rh(0)NCs/GNPs showed good catalytic activity towards the cross-coupling reaction. The reaction condition was optimized. A 20 mg of Rh(0)NCs/GNPs, tetra butyl ammonium acetate (1 mmol) and 10 mL of DMF were found to be optimal parameters forperforming the cross-coupling of iodobenzene with phenylacetylene. The optimal reaction temperature and reaction time were found to be 120 °C and 24 h, respectively. Under the optimal conditions, the Rh(0)NCs/GNPs gave the desired product, diphenylacetylene, in a good yield of 87% with 91% selectivity. Kanuru et al. [26] reported 5 wt% of Rh nanoparticles supported γ-Alumina catalyst (Rh/γ-Al2O3) for the cross-couplingiodobenzene with phenylacetylene. The Rh/γ-Al2O3 catalyst showed just 57% of the targeted product diphenylacetylene. Similarly, the Rh/BaOcatalyst affords 38% of the product. It mightbe due to the good interaction between Rh-nanoparticles and GNPs, high surface area, optimal size of Rh-nanoparticles, and fine dispersion of catalyst. A reusability test

Sonogashira Coupling Reaction
Transition metal catalyzed C-C bond forming reactions are significant tools in organic synthesis. Catalytic products that are prepared via Sonogashira coupling reaction between terminal alkynes and aryl halides have significant value in pharmaceuticals and fine chemicals [52]. Todate, several transition metal based heterogeneous catalysts are developed for the Sonogashira coupling reaction [53]. However, most of them are bimetallic catalysts and its preparation method requires toxic reagents. For instance, the Pd-Cu bimetallic system was developed for the cross-coupling of terminal acetylenes with sp 2 -carbon halides by Sonogashira [54]. Similarly, monodisperseCuPd alloy nanoparticles supported graphene oxide catalyst was prepared for the Sonogashira coupling reaction [55]. They found that the bimetallic catalyst is very active and selective. Later, affordable mono metallic catalysts based on Pd, Ni, Cu, Fe, and Co were developed for a more sustainable cross-coupling catalysis [56,57]. After being characterized, the Rh(0)NCs/GNPs was used as catalyst for the Sonogashira coupling reaction of iodobenzene with phenylacetylene (Scheme 2). To our delight, the present Rh(0)NCs/GNPs showed good catalytic activity towards the cross-coupling reaction. The reaction condition was optimized. A 20 mg of Rh(0)NCs/GNPs, tetra butyl ammonium acetate (1 mmol) and 10 mL of DMF were found to be optimal parameters forperforming the cross-coupling of iodobenzene with phenylacetylene. The optimal reaction temperature and reaction time were found to be 120 • C and 24 h, respectively. Under the optimal conditions, the Rh(0)NCs/GNPs gave the desired product, diphenylacetylene, in a good yield of 87% with 91% selectivity. Kanuru et al. [26] reported 5 wt% of Rh nanoparticles supported γ-Alumina catalyst (Rh/γ-Al 2 O 3 ) for the cross-couplingiodobenzene with phenylacetylene. The Rh/γ-Al 2 O 3 catalyst showed just 57% of the targeted product diphenylacetylene. Similarly, the Rh/BaOcatalyst affords 38% of the product. It mightbe due to the good interaction between Rh-nanoparticles and GNPs, high surface area, optimal size of Rh-nanoparticles, and fine dispersion of catalyst. A reusability test was also performed for the Rh(0)NCs/GNPs. The catalyst gave good 77% yield even after the fifthcycle. The reaction mixture was centrifuged to remove the catalyst and the mixture was tested by ICP-MS in order to check the leaching of Rh(0) from the Rh(0)NCs/GNPs. It was found that there is no significant leaching of Rh during the reaction (leaching amount of Rh was 1.3 ppm).
was also performed for the Rh(0)NCs/GNPs. The catalyst gave good 77% yield even after the fifthcycle. The reaction mixture was centrifuged to remove the catalyst and the mixture was tested by ICP-MS in order to check the leaching of Rh(0) from the Rh(0)NCs/GNPs. It was found that there is no significant leaching of Rh during the reaction (leaching amount of Rh was 1.3 ppm).  Overall, the present Rh(0)NCs/GNPsfound to be active catalyst for the reduction of 4-nitrophenol and the Sonogashira coupling reaction. In fact, high surface area, good interaction between Rh(0)-nanocluster and GNPs, and the small size of Rh(0)-nanocluster are the main reasons for the good catalytic performance of Rh(0)NCs/GNPs. In addition, the creation of additional defect sites in GNPs by mechanical girding during the catalyst preparation process is also the reason. was also performed for the Rh(0)NCs/GNPs. The catalyst gave good 77% yield even after the fifthcycle. The reaction mixture was centrifuged to remove the catalyst and the mixture was tested by ICP-MS in order to check the leaching of Rh(0) from the Rh(0)NCs/GNPs. It was found that there is no significant leaching of Rh during the reaction (leaching amount of Rh was 1.3 ppm).  Overall, the present Rh(0)NCs/GNPsfound to be active catalyst for the reduction of 4-nitrophenol and the Sonogashira coupling reaction. In fact, high surface area, good interaction between Rh(0)-nanocluster and GNPs, and the small size of Rh(0)-nanocluster are the main reasons for the good catalytic performance of Rh(0)NCs/GNPs. In addition, the creation of additional defect sites in GNPs by mechanical girding during the catalyst preparation process is also the reason. Overall, the present Rh(0)NCs/GNPsfound to be active catalyst for the reduction of 4-nitrophenol and the Sonogashira coupling reaction. In fact, high surface area, good interaction between Rh(0)-nanocluster and GNPs, and the small size of Rh(0)-nanocluster are the main reasons for the good catalytic performance of Rh(0)NCs/GNPs. In addition, the creation of additional defect sites in GNPs by mechanical girding during the catalyst preparation process is also the reason.

Preparation of Rh(0)NCs/GNPs
The preparation method includes no reducing or capping agents to control the morphology of Rh(0)NCs/GNPs. At first, a mixture of 500 mg of GNPs, 100 mg of Rh(acac) 3 , and 25 mL of distilled water was sonicated at 60 • C for 20 min followed by stirring at 100 • C for 3 h. Then the reaction mixture was heated at 110 • C in order to evaporate the water and solid mixture of GNPs/Rh(acac) 3 was obtained. Subsequently, the obtained solid mixture was grinded using mortar and pestle for 15 min to obtain homogenous mixture of GNPs/Rh(acac) 3 . Finally, the resultant homogenous mixture was calcinated under inert atmosphere at 150 • C for 2 h to obtain the Rh(0)NCs/GNPs catalyst.

Procedure for Sonogashira Coupling Reaction
A mixture of iodobenzene (1 mmol, 204 mg), phenylacetylene (1 mmol, 102 mg), base (1 mmol), DMF (10 mL), and Rh(0)NCs/GNPs (5 mg) was stirred under argon atmosphere at 120 • C for 24 h. Carousel reactor station (Radleys, Essex, Saffron Walden CB11 3AZ, United Kingdom) was used to carry out the reaction. After 24 h of stirring, the reaction mixture was centrifuged to remove the catalyst, and GC and NMRwere then used to analyze the mixture. The recovered catalyst was used to test the reusability. GC determined the yield and selectivity of the catalytic products. Diphenylacetylene

Procedure for 4-Nitrophenol Reduction
In a typical procedure, a mixture of aqueous solution of 4-nitrophenol (80 µL, 0.01 M), aqueous solution of NaBH 4 (4 mL, 0.015 M) and Rh(0)NCs/GNPs (0.001 mg, 0.0015, or 0.002 mg) was initially sonicated for 15 s, followed by stirring under open air atmosphere at 27 • C. UV-vis spectroscopy was operated at room temperature to monitor the reaction at regular time intervals. The catalyst was recovered for reusability test after completion of the reaction.

Conclusions
In summary, highly efficient Rh(0)-nanoclusters supported graphenenano-platelets catalyst was prepared by a very simple 'mix and heat' method. The surface morphology, crystalline properties, and chemical state of the resultant Rh(0)NCs/GNPs were investigated by means of various microscopic and spectroscopic techniques. Raman was used to study the interaction between Rh(0)-nanoclusters and GNPs. The factual Rh-loading in Rh(0)NCs/GNPs was confirmed by SEM-EDS and ICP-MS analysis. After being characterized, the Rh(0)NCs/GNPs was used as nanocatalyst for the reduction of 4-nitrophenol and Sonogashira coupling reactions. The Rh(0)NCs/GNPs demonstrated excellent catalytic activity in the reduction of 4-nitrophenol. The k app , k' and TOF values were calculated to be 62.07 × 10 −3 min −1 (0.002 mg of Rh(0)NCs/GNPs), 31035 × 10 −3 mg −1 min −1 and 112.5 min −1 ,respectively. Similarly, under the optimal conditions, the Rh(0)NCs/GNPs gave the desired product, diphenylacetylene, in a good yield of 87% with 91% selectivity. The Rh(0)NCs/GNPs can be reused without significant loss in its catalytic activity. To the best our knowledge, this is the most efficient, stable, and reusable Rh-based graphene catalyst for the reduction of 4-nitrophenol and Sonogashira coupling reaction reported to date.