Recent Advances in the Catalytic Synthesis of Imidazolidin-2-ones and Benzimidazolidin-2-ones

: 2-Imidazolidinone and its analogues are omnipresent structural motifs of pharmaceuticals, natural products, chiral auxiliaries, and intermediates in organic syntheses. Over the years, continuous efforts have been addressed to the development of sustainable and more efﬁcient protocols for the synthesis of these heterocycles. This review gives a summary of the catalytic strategies to access imidazolidin-2-ones and benzimidazolidin-2-ones that have appeared in the literature from 2010 to 2018. Particularly important contributions beyond the timespan will be mentioned. The review is organized in four main chapters that identify the most common approaches to imidazolidin-2-one derivatives: (1) the direct incorporation of the carbonyl group into 1,2-diamines, (2) the diamination of oleﬁns, (3) the intramolecular hydroamination of linear urea derivatives and (4) aziridine ring expansion. Methods not included in this classiﬁcation will be addressed in the miscellaneous section. A(CO)B represents a generic agent that is able to transfer the carbonyl group. In some cases, the process is carried out in the presence of a suitable catalyst. the synthesis of imidazolidin-2-one derivatives [153].


Introduction
Imidazolidin-2-ones and their analogues are widely found in pharmaceuticals, natural alkaloids, and other biologically active compounds ( Figure 1) [1][2][3][4]. Substituted imidazolidin-2-ones are also important synthetic intermediates that can be transformed into a broad variety of complex structures [5][6][7][8][9][10], and represent a useful class of chiral auxiliaries for asymmetric transformations [11][12][13]. Over the past decades, various synthetic routes to access five-membered cyclic ureas have been explored, and substantial advances have been accomplished in the aim of producing more sustainable and environmental-friendly protocols for the preparation of this essential class of molecules. The most common synthetic approach to imidazolidin-2-ones and benzimidazolidin-2-ones is based on the direct incorporation of a carbonyl group into a vicinal diamine (Section 2). A wide variety of carbonylating agents have been explored, and in this context, the catalytic incorporation of carbon monoxide or carbon dioxide can be considered a more sustainable and atom economical alternative compared to the use of toxic carbonylating agents such as phosgene. The transition metal-catalyzed diamination of olefins, thanks to the valuable contributions of Lloyd-Jones, Muñiz and Shi, has been well explored, and is actually an extremely useful tool for the synthesis of richly decorated 2-imidazolidinones in an enantioselective fashion as well (Section 3). Both metals and bases have been exploited to promote the intramolecular hydroamination of urea-tethered alkenes and alkynes (Section 4). exploited to promote the intramolecular hydroamination of urea-tethered alkenes and alkynes (Section 4). Finally, aziridines may be versatile substrates to obtain five-membered cyclic ureas through the reaction with isocyanates (Section 5). Palladium or nickel-based catalysts can be employed for this purpose. Methods not included in this classification will be also treated in the miscellaneous section (Section 6). Therefore, progress in the synthesis of 2-(benz)imidazolidinone core is updated in this paper, which references the literature from 2010 to 2018. However, particularly important contributions beyond the timespan will be also considered. The preparation of hydantoins [14] and 2-imidazolones [15] will not be treated in view of very recent reviews on these topics. For the convenience of the reader, essential breaking and forming bonds are highlighted in blue and red, respectively.

Synthesis of 2-(benz)imidazolidinones by Direct Incorporation of the Carbonyl Group into 1,2-Diamines
The direct incorporation of the carbonyl group into 1,2-diamines is an excellent approach for synthesizing imidazolidin-2-one and benzimidazolidin-2-one derivatives (Scheme 1). Over the years, several different species that are able to "transfer" the carbonyl group (carbonylating agents) have been employed for this purpose, in some cases under the action of a suitable catalytic system. Finally, aziridines may be versatile substrates to obtain five-membered cyclic ureas through the reaction with isocyanates (Section 5). Palladium or nickel-based catalysts can be employed for this purpose. Methods not included in this classification will be also treated in the miscellaneous section (Section 6). Therefore, progress in the synthesis of 2-(benz)imidazolidinone core is updated in this paper, which references the literature from 2010 to 2018. However, particularly important contributions beyond the timespan will be also considered. The preparation of hydantoins [14] and 2-imidazolones [15] will not be treated in view of very recent reviews on these topics. For the convenience of the reader, essential breaking and forming bonds are highlighted in blue and red, respectively.

Synthesis of 2-(benz)imidazolidinones by Direct Incorporation of the Carbonyl Group into 1,2-Diamines
The direct incorporation of the carbonyl group into 1,2-diamines is an excellent approach for synthesizing imidazolidin-2-one and benzimidazolidin-2-one derivatives (Scheme 1). Over the years, several different species that are able to "transfer" the carbonyl group (carbonylating agents) have been employed for this purpose, in some cases under the action of a suitable catalytic system.
The simplest C-1 units (carbon monoxide and carbon dioxide) are undoubtedly the most attractive carbonylation source for the synthesis of (benz)imidazolidinones from 1,2-diamines both from the point of view of atom economy and availability. Accordingly, many efforts have been made in order to activate them in this process by means of an appropriate catalytic system.
The use of CO formally requires the elimination of molecular hydrogen, so the carbonylation of 1,2-diamines with carbon monoxide is usually carried out under oxidative conditions [i.e., in the presence of an external oxidant [OX] that is reduced to [OXH2] under the reaction conditions (Scheme 8)].
The catalytic system consisting of PdI2 in conjunction with KI, which was developed by our research group [65,66] and successfully employed for the oxidative carbonylation of a plethora of acetylenic substrates [67][68][69][70][71][72][73][74][75][76][77], also proved to be efficient for realizing the oxidative carbonylation of aromatic diamines to cyclic ureas, as exemplified in Scheme 9 [78]. In this reaction, the external oxidant is simply molecular oxygen, with the formation of only water as the co-product ([OX] = (1/2)O2, [OXH2] = H2O). The carbonylation process starts with nitrogen palladation (from the reaction between an amino group of the substrate and PdI2), followed by carbon monoxide insertion to give a carbamoylpalladium iodide intermediate (Scheme 10; anionic iodide ligands are omitted for clarity). Then intramolecular nucleophilic displacement by the second amino group [possibly through the formation of an isocyanate as an intermediate from β-H elimination from the HN(CO)PdI moiety] takes place to give the cyclic urea and palladium(0) [78]. The latter is then re-oxidized to catalytically active PdI2 according to the mechanism we demonstrated several years ago [66], involving the oxidative addition of I2 to Pd(0); I2 is obtained in situ by oxidation of two equivalents of HI (also ensuing from the carbonylation process) with O2 (Scheme 10). Scheme 9. Synthesis of benzimidazolidin-2-one by PdI2/KI-catalyzed oxidative carbonylation of 1,2benzenediamine [78]. The catalytic system consisting of PdI 2 in conjunction with KI, which was developed by our research group [65,66] and successfully employed for the oxidative carbonylation of a plethora of acetylenic substrates [67][68][69][70][71][72][73][74][75][76][77], also proved to be efficient for realizing the oxidative carbonylation of aromatic diamines to cyclic ureas, as exemplified in Scheme 9 [78]. In this reaction, the external oxidant is simply molecular oxygen, with the formation of only water as the co-product ([OX] = (1/2)O 2 , [OXH 2 ] = H 2 O). The carbonylation process starts with nitrogen palladation (from the reaction between an amino group of the substrate and PdI 2 ), followed by carbon monoxide insertion to give a carbamoylpalladium iodide intermediate (Scheme 10; anionic iodide ligands are omitted for clarity). Then intramolecular nucleophilic displacement by the second amino group [possibly through the formation of an isocyanate as an intermediate from β-H elimination from the HN(CO)PdI moiety] takes place to give the cyclic urea and palladium(0) [78]. The latter is then re-oxidized to catalytically active PdI 2 according to the mechanism we demonstrated several years ago [66], involving the oxidative addition of I 2 to Pd(0); I 2 is obtained in situ by oxidation of two equivalents of HI (also ensuing from the carbonylation process) with O 2 (Scheme 10). The simplest C-1 units (carbon monoxide and carbon dioxide) are undoubtedly the most attractive carbonylation source for the synthesis of (benz)imidazolidinones from 1,2-diamines both from the point of view of atom economy and availability. Accordingly, many efforts have been made in order to activate them in this process by means of an appropriate catalytic system.
The use of CO formally requires the elimination of molecular hydrogen, so the carbonylation of 1,2-diamines with carbon monoxide is usually carried out under oxidative conditions [i.e., in the presence of an external oxidant [OX] that is reduced to [OXH2] under the reaction conditions (Scheme 8)].
The catalytic system consisting of PdI2 in conjunction with KI, which was developed by our research group [65,66] and successfully employed for the oxidative carbonylation of a plethora of acetylenic substrates [67][68][69][70][71][72][73][74][75][76][77], also proved to be efficient for realizing the oxidative carbonylation of aromatic diamines to cyclic ureas, as exemplified in Scheme 9 [78]. In this reaction, the external oxidant is simply molecular oxygen, with the formation of only water as the co-product ([OX] = (1/2)O2, [OXH2] = H2O). The carbonylation process starts with nitrogen palladation (from the reaction between an amino group of the substrate and PdI2), followed by carbon monoxide insertion to give a carbamoylpalladium iodide intermediate (Scheme 10; anionic iodide ligands are omitted for clarity). Then intramolecular nucleophilic displacement by the second amino group [possibly through the formation of an isocyanate as an intermediate from β-H elimination from the HN(CO)PdI moiety] takes place to give the cyclic urea and palladium(0) [78]. The latter is then re-oxidized to catalytically active PdI2 according to the mechanism we demonstrated several years ago [66], involving the oxidative addition of I2 to Pd(0); I2 is obtained in situ by oxidation of two equivalents of HI (also ensuing from the carbonylation process) with O2 (Scheme 10). Scheme 9. Synthesis of benzimidazolidin-2-one by PdI2/KI-catalyzed oxidative carbonylation of 1,2benzenediamine [78].
More recently, the oxidative carbonylation of benzene-1,2-diamine to benzimidazolidin-2-one was accomplished in a biphasic water-toluene medium using Pd(OAc)2 as palladium(II) source in the presence of BipyDS (disodium 2,2′-bipyridine-4,4′-disulfonate) as the water-soluble ligand [79]. The possibility of incorporating the 11 C radioisotope into a benzimidazolidin-2-one moiety using 11 CO, although in modest yield, has also been demonstrated [80]. The carbonylation of benzene-1,2diamines in the absence of an external oxidant has been reported using Pd(OAc)2 as the catalyst in the presence of PPh3 and Et3N; in this case, the formation of molecular hydrogen accounted for the stoichiometry of the process (Scheme 11) [81]. Scheme 11. Carbonylation of 1,2-benzenediamines to benzimidazoimidazol-2-ones in the absence of an external oxidant. The formation of molecular hydrogen accounts for the stoichiometry of the process [81].
Aliphatic 1,2-diamines have also been converted into the corresponding imidazolidin-2-ones under oxidative carbonylation conditions. Thus, N,N′-dialkylethylenediamines successfully reacted with a CO/O2 mixture (2:1; 1 atm) in the presence of a catalytic amount of selenium (5 mol%) at room temperature for 30 minutes. (Scheme 12) [82]. However, it is worth noting that these conditions fall within the flammability range for a CO/O2 mixture [83]. Mechanistically, the process is believed to occur through the formation of a selenolate intermediate, which then undergoes CO insertion to give a selenocarbamate species. The latter eventually converts into the final product by intramolecular nucleophilic displacement, with the simultaneous elimination of hydrogen diselenide, which is oxidized back to elemental selenium by the action of oxygen (Scheme 12) [82]. More recently, the palladium-catalyzed oxidative carbonylation of simple ethylenediamine to imidazolidin-2-one (72% yield) (carried out in water at 100 °C with 1 mol% of palladium catalyst, under 40 atm of a CO/O2 mixture [83]) was reported [84]. Scheme 10. Mechanism of the PdI 2 /KI-catalyzed oxidative carbonylation of 1,2-benzenediamine leading to benzimidazolidin-2-one [78].
More recently, the oxidative carbonylation of benzene-1,2-diamine to benzimidazolidin-2-one was accomplished in a biphasic water-toluene medium using Pd(OAc) 2 as palladium(II) source in the presence of BipyDS (disodium 2,2 -bipyridine-4,4 -disulfonate) as the water-soluble ligand [79]. The possibility of incorporating the 11 C radioisotope into a benzimidazolidin-2-one moiety using 11 CO, although in modest yield, has also been demonstrated [80]. The carbonylation of benzene-1,2-diamines in the absence of an external oxidant has been reported using Pd(OAc) 2 as the catalyst in the presence of PPh 3 and Et 3 N; in this case, the formation of molecular hydrogen accounted for the stoichiometry of the process (Scheme 11) [81]. More recently, the oxidative carbonylation of benzene-1,2-diamine to benzimidazolidin-2-one was accomplished in a biphasic water-toluene medium using Pd(OAc)2 as palladium(II) source in the presence of BipyDS (disodium 2,2′-bipyridine-4,4′-disulfonate) as the water-soluble ligand [79]. The possibility of incorporating the 11 C radioisotope into a benzimidazolidin-2-one moiety using 11 CO, although in modest yield, has also been demonstrated [80]. The carbonylation of benzene-1,2diamines in the absence of an external oxidant has been reported using Pd(OAc)2 as the catalyst in the presence of PPh3 and Et3N; in this case, the formation of molecular hydrogen accounted for the stoichiometry of the process (Scheme 11) [81]. Scheme 11. Carbonylation of 1,2-benzenediamines to benzimidazoimidazol-2-ones in the absence of an external oxidant. The formation of molecular hydrogen accounts for the stoichiometry of the process [81].
Aliphatic 1,2-diamines have also been converted into the corresponding imidazolidin-2-ones under oxidative carbonylation conditions. Thus, N,N′-dialkylethylenediamines successfully reacted with a CO/O2 mixture (2:1; 1 atm) in the presence of a catalytic amount of selenium (5 mol%) at room temperature for 30 minutes. (Scheme 12) [82]. However, it is worth noting that these conditions fall within the flammability range for a CO/O2 mixture [83]. Mechanistically, the process is believed to occur through the formation of a selenolate intermediate, which then undergoes CO insertion to give a selenocarbamate species. The latter eventually converts into the final product by intramolecular nucleophilic displacement, with the simultaneous elimination of hydrogen diselenide, which is oxidized back to elemental selenium by the action of oxygen (Scheme 12) [82]. More recently, the palladium-catalyzed oxidative carbonylation of simple ethylenediamine to imidazolidin-2-one (72% yield) (carried out in water at 100 °C with 1 mol% of palladium catalyst, under 40 atm of a CO/O2 mixture [83]) was reported [84]. Scheme 11. Carbonylation of 1,2-benzenediamines to benzimidazoimidazol-2-ones in the absence of an external oxidant. The formation of molecular hydrogen accounts for the stoichiometry of the process [81]. Aliphatic 1,2-diamines have also been converted into the corresponding imidazolidin-2-ones under oxidative carbonylation conditions. Thus, N,N -dialkylethylenediamines successfully reacted with a CO/O 2 mixture (2:1; 1 atm) in the presence of a catalytic amount of selenium (5 mol%) at room temperature for 30 minutes. (Scheme 12) [82]. However, it is worth noting that these conditions fall within the flammability range for a CO/O 2 mixture [84]. Mechanistically, the process is believed to occur through the formation of a selenolate intermediate, which then undergoes CO insertion to give a selenocarbamate species. The latter eventually converts into the final product by intramolecular nucleophilic displacement, with the simultaneous elimination of hydrogen diselenide, which is oxidized back to elemental selenium by the action of oxygen (Scheme 12) [82]. More recently, the palladium-catalyzed oxidative carbonylation of simple ethylenediamine to imidazolidin-2-one (72% yield) (carried out in water at 100 • C with 1 mol% of palladium catalyst, under 40 atm of a CO/O 2 mixture [84]) was reported [85].  [82]. Note that the 2:1 CO/O2 mixture that was employed falls within the flammability limit [83].
The direct incorporation of the carbonyl group using CO2 as the carbonylation agent is another very attractive approach to (benz)imidazolidin-2-ones. In this case, no external oxidant is needed, and water is produced as a co-product (Scheme 13). Owing to the relative inertness of CO2, the process is usually carried out in the presence of a suitable catalyst. Moreover, in several cases, the use of a dehydrating agent is needed, because the water produced in the course of the process may negatively affect the product yield. However, the possibility of avoiding catalysts as well as organic solvents and other additives or promoters has also been demonstrated with simple aliphatic 1,2diamines, even though under rather harsh conditions (180 °C under 100 atm of CO2 for 24 h) [85].
The direct incorporation of the carbonyl group using CO 2 as the carbonylation agent is another very attractive approach to (benz)imidazolidin-2-ones. In this case, no external oxidant is needed, and water is produced as a co-product (Scheme 13). Owing to the relative inertness of CO 2 , the process is usually carried out in the presence of a suitable catalyst. Moreover, in several cases, the use of a dehydrating agent is needed, because the water produced in the course of the process may negatively affect the product yield. However, the possibility of avoiding catalysts as well as organic solvents and other additives or promoters has also been demonstrated with simple aliphatic 1,2-diamines, even though under rather harsh conditions (180 • C under 100 atm of CO 2 for 24 h) [86].  [82]. Note that the 2:1 CO/O2 mixture that was employed falls within the flammability limit [83].
The direct incorporation of the carbonyl group using CO2 as the carbonylation agent is another very attractive approach to (benz)imidazolidin-2-ones. In this case, no external oxidant is needed, and water is produced as a co-product (Scheme 13). Owing to the relative inertness of CO2, the process is usually carried out in the presence of a suitable catalyst. Moreover, in several cases, the use of a dehydrating agent is needed, because the water produced in the course of the process may negatively affect the product yield. However, the possibility of avoiding catalysts as well as organic solvents and other additives or promoters has also been demonstrated with simple aliphatic 1,2diamines, even though under rather harsh conditions (180 °C under 100 atm of CO2 for 24 h) [85].
Ceria-based materials are also useful heterogeneous catalysts for the conversion of aliphatic 1,2diamines into imidazolidin-2-ones with CO2. In particular, nanoparticulate CeO2 (obtained by templating with alginate biopolymer) proved to be active for the conversion of ethylenediamine, N-(2-aminoethyl)ethane-1,2-diamine, N,N′-dimethylethane-1,2-diamine, and N- [2-(methylamino)ethyl]acetamide into the corresponding cyclic ureas, even though in low to modest yields (9-37%) [89]. On the other hand, pure ceria turned out to be a useful recyclable heterogeneous catalyst for the carbonylation with CO2 of a variety of aliphatic 1,2-diamines, in isopropanol as the solvent at 160 °C and under a relatively low CO2 pressure (five atm) (Scheme 16) [90]. The proposed reaction mechanism for this latter process involves the formation of a carbamate species on ceria, followed by decarboxylation and the intramolecular nucleophilic attack of the amino group to the carbamate moiety (Scheme 16) [90].

Scheme 14.
Synthesis of imidazolidin-2-ones by carbonylation of 1,2-diamines with carbon dioxide carried out in the presence of tetramethylphenylguanidine (PhTMG) as the basic promoter and diphenylphosphoryl azide (DPPA) as the dehydrative activator [87]. Ceria-based materials are also useful heterogeneous catalysts for the conversion of aliphatic 1,2diamines into imidazolidin-2-ones with CO2. In particular, nanoparticulate CeO2 (obtained by templating with alginate biopolymer) proved to be active for the conversion of ethylenediamine, N-(2-aminoethyl)ethane-1,2-diamine, N,N′-dimethylethane-1,2-diamine, and N- [2-(methylamino)ethyl]acetamide into the corresponding cyclic ureas, even though in low to modest yields (9-37%) [89]. On the other hand, pure ceria turned out to be a useful recyclable heterogeneous catalyst for the carbonylation with CO2 of a variety of aliphatic 1,2-diamines, in isopropanol as the solvent at 160 °C and under a relatively low CO2 pressure (five atm) (Scheme 16) [90]. The proposed reaction mechanism for this latter process involves the formation of a carbamate species on ceria, followed by decarboxylation and the intramolecular nucleophilic attack of the amino group to the carbamate moiety (Scheme 16) [90]. Ceria-based materials are also useful heterogeneous catalysts for the conversion of aliphatic 1,2-diamines into imidazolidin-2-ones with CO 2 . In particular, nanoparticulate CeO 2 (obtained by templating with alginate biopolymer) proved to be active for the conversion of ethylenediamine, N-(2-aminoethyl)ethane-1,2-diamine, N,N -dimethylethane-1,2-diamine, and N-[2-(methylamino)ethyl]acetamide into the corresponding cyclic ureas, even though in low to modest yields (9-37%) [90]. On the other hand, pure ceria turned out to be a useful recyclable heterogeneous catalyst for the carbonylation with CO 2 of a variety of aliphatic 1,2-diamines, in isopropanol as the solvent at 160 • C and under a relatively low CO 2 pressure (five atm) (Scheme 16) [91]. The proposed reaction mechanism for this latter process involves the formation of a carbamate species on ceria, followed by decarboxylation and the intramolecular nucleophilic attack of the amino group to the carbamate moiety (Scheme 16) [91]. Ceria-based materials are also useful heterogeneous catalysts for the conversion of aliphatic 1,2diamines into imidazolidin-2-ones with CO2. In particular, nanoparticulate CeO2 (obtained by templating with alginate biopolymer) proved to be active for the conversion of ethylenediamine, N-(2-aminoethyl)ethane-1,2-diamine, N,N′-dimethylethane-1,2-diamine, and N- [2-(methylamino)ethyl]acetamide into the corresponding cyclic ureas, even though in low to modest yields (9-37%) [89]. On the other hand, pure ceria turned out to be a useful recyclable heterogeneous catalyst for the carbonylation with CO2 of a variety of aliphatic 1,2-diamines, in isopropanol as the solvent at 160 °C and under a relatively low CO2 pressure (five atm) (Scheme 16) [90]. The proposed reaction mechanism for this latter process involves the formation of a carbamate species on ceria, followed by decarboxylation and the intramolecular nucleophilic attack of the amino group to the carbamate moiety (Scheme 16) [90]. Scheme 16. Synthesis of imidazolidin-2-ones by the CeO2-catalyzed carbonylation of aliphatic 1,2diamines with CO2 [90].
In general, the reaction of 1,2-benzenediamines with CO2 to give benzimidazolidin-2-ones is more challenging, owing to the lower nucleophilicity of the aromatic amino groups. However, to date, different methods are known to carry out this process. Recently, N,N′-bis(trimethylsilyl)benzene-1,2diamine was converted into benzimidazolidin-2-one in 73% yield by reaction with CO2 (3 atm) at 110 °C for 12 h in the presence of pyridine and In[N(SiMe3)2]Cl2·(THF)x as catalyst (2 mol%) (Scheme 17) [91]. The process occurs through the formation of an indium amino complex, which reacts with CO2 to give a silyl carbamate. The latter then undergoes intramolecular nucleophilic attack by the second amino moiety to give the cyclic urea with elimination of (Me3Si)2O (Scheme 17) [91].

17.
Indium-catalyzed formation of benzimidazolidin-2-one from N,N′bis(trimethylsilyl)benzene-1,2-diamine and CO2 [91].  [92]. The bifunctional role of the catalyst was to activate both CO2 (cation) and the diamine (anion), as shown in Scheme 18. The reaction did not work with N,N′-disubstituted o-phenylenediamines, which suggested the involvement of an isocyanate as intermediate, from which the final product is obtained by intramolecular nucleophilic addition (Scheme 18) [92].

17.
Indium-catalyzed formation of benzimidazolidin-2-one from N,N -bis(trimethylsilyl)benzene-1,2-diamine and CO 2 [92].  [93]. The proposed mechanism involves the formation of a carbamate species from the reaction between carbon dioxide and the anion of the ionic liquid, which is stabilized by the hydrogen bond interaction with the diamine. This is followed by the nucleophilic attack by the amino group, dehydration to give an isocyanate intermediate, and intramolecular nucleophilic attack by the second amino group to afford the cyclic urea (Scheme 19) [93].
Tungstate catalysts have also been successfully used for the synthesis of benzimidazolidin-2ones from 1,2-benzenediamines (bearing primary amino groups) and low-pressure CO2. Reactions were carried out in NMP (NMP = N-methylpyrrolidin-2-one) at [94]. The proposed mechanism involves the formation of a carbamate species from the reaction between carbon dioxide and the anion of the ionic liquid, which is stabilized by the hydrogen bond interaction with the diamine. This is followed by the nucleophilic attack by the amino group, dehydration to give an isocyanate intermediate, and intramolecular nucleophilic attack by the second amino group to afford the cyclic urea (Scheme 19) [94].  [93]. The proposed mechanism involves the formation of a carbamate species from the reaction between carbon dioxide and the anion of the ionic liquid, which is stabilized by the hydrogen bond interaction with the diamine. This is followed by the nucleophilic attack by the amino group, dehydration to give an isocyanate intermediate, and intramolecular nucleophilic attack by the second amino group to afford the cyclic urea (Scheme 19) [93].
Tungstate catalysts have also been successfully used for the synthesis of benzimidazolidin-2ones from 1,2-benzenediamines (bearing primary amino groups) and low-pressure CO2. Reactions were carried out in NMP (NMP = N-methylpyrrolidin-2-one) at

Synthesis of 2-Imidazolidinones by Catalytic Diamination of Unsaturated C-C Bonds
The metal-catalyzed diamination of unsaturated C-C bonds is an elegant strategy to access imidazolidin-2-ones. In this context, various intramolecular and intermolecular diamination protocols have been developed using ureas or diaziridinones as the nitrogen source. Several enantioselective transformations have been successfully accomplished as well [96][97][98][99].
In general, the challenge in the development of catalytic diamination protocols is presumably due to the capability of diamines to coordinate almost every transition metal, which generates stable organometallic species that are not compatible with a catalytic process.

Synthesis of 2-Imidazolidinones by Catalytic Diamination of Unsaturated C-C Bonds
The metal-catalyzed diamination of unsaturated C-C bonds is an elegant strategy to access imidazolidin-2-ones. In this context, various intramolecular and intermolecular diamination protocols have been developed using ureas or diaziridinones as the nitrogen source. Several enantioselective transformations have been successfully accomplished as well [97][98][99][100].
In general, the challenge in the development of catalytic diamination protocols is presumably due to the capability of diamines to coordinate almost every transition metal, which generates stable organometallic species that are not compatible with a catalytic process.

Synthesis of 2-Imidazolidinones by Catalytic Diamination of Unsaturated C-C Bonds
The metal-catalyzed diamination of unsaturated C-C bonds is an elegant strategy to access imidazolidin-2-ones. In this context, various intramolecular and intermolecular diamination protocols have been developed using ureas or diaziridinones as the nitrogen source. Several enantioselective transformations have been successfully accomplished as well [96][97][98][99].
In general, the challenge in the development of catalytic diamination protocols is presumably due to the capability of diamines to coordinate almost every transition metal, which generates stable organometallic species that are not compatible with a catalytic process.
Excellent results were obtained only with the hypervalent iodine reagent PhI(OAc) 2 . A control experiment, with a stoichiometric amount of palladium without the use of the oxidant, did not give any trace of the expected product, suggesting the intermediacy of Pd(II) and Pd(IV) species. Under mild reaction conditions, privileged structures were conveniently synthesized with predictable stereochemistry, as revealed by deuterium labeling experiments. Later, detailed mechanistic studies led the authors to propose the formation of a Pd(IV) intermediate (Scheme 21) [102].
The use of the more environmentally benign copper(II) bromide as oxidant and the extension to internal alkenes, including acrylates, were further investigated by the same research group [103,104].
In the same years, Muñiz et al. demonstrated that nickel catalysts are highly active in this transformation as well, providing an attractive alternative in terms of catalyst cost and reaction scope [105]. Furthermore, the same author broadened the catalyst scope for the diamination of alkenes by introducing a homogeneous gold(I) catalyst [106].
In 2012, Muñiz et al. reported an impressive metal-free intramolecular diamination of alkenes based on the use of potassium bromide as the catalyst and sodium chlorite as terminal oxidant (Scheme 22) [107,108]. This halide catalysis features general applicability, readily available reagents and catalysts, and can be successfully scaled up. Excellent results were obtained only with the hypervalent iodine reagent PhI(OAc)2. A control experiment, with a stoichiometric amount of palladium without the use of the oxidant, did not give any trace of the expected product, suggesting the intermediacy of Pd(II) and Pd(IV) species. Under mild reaction conditions, privileged structures were conveniently synthesized with predictable stereochemistry, as revealed by deuterium labeling experiments. Later, detailed mechanistic studies led the authors to propose the formation of a Pd(IV) intermediate (Scheme 21) [101].
The use of the more environmentally benign copper(II) bromide as oxidant and the extension to internal alkenes, including acrylates, were further investigated by the same research group [102,103].
In the same years, Muñiz et al. demonstrated that nickel catalysts are highly active in this transformation as well, providing an attractive alternative in terms of catalyst cost and reaction scope [104]. Furthermore, the same author broadened the catalyst scope for the diamination of alkenes by introducing a homogeneous gold(I) catalyst [105].
In 2012, Muñiz et al. reported an impressive metal-free intramolecular diamination of alkenes based on the use of potassium bromide as the catalyst and sodium chlorite as terminal oxidant (Scheme 22) [106,107]. This halide catalysis features general applicability, readily available reagents and catalysts, and can be successfully scaled up.
A rare example of Cu(II)-catalyzed asymmetric intramolecular cyclization of N-alkenyl ureas to access chiral imidazolidinones in moderate to good yields with high to excellent enantioselectivity was recently reported by Fu et al. (Scheme 23) [108]. The bidentate oxazoline ligand L1 was found to be the ligand of choice in order to achieve high enantioselectivities. The basic medium was also essential to impart chirality to the final product.
A rare example of Cu(II)-catalyzed asymmetric intramolecular cyclization of N-alkenyl ureas to access chiral imidazolidinones in moderate to good yields with high to excellent enantioselectivity was recently reported by Fu et al. (Scheme 23) [109]. The bidentate oxazoline ligand L1 was found to be the ligand of choice in order to achieve high enantioselectivities. The basic medium was also essential to impart chirality to the final product. Excellent results were obtained only with the hypervalent iodine reagent PhI(OAc)2. A control experiment, with a stoichiometric amount of palladium without the use of the oxidant, did not give any trace of the expected product, suggesting the intermediacy of Pd(II) and Pd(IV) species. Under mild reaction conditions, privileged structures were conveniently synthesized with predictable stereochemistry, as revealed by deuterium labeling experiments. Later, detailed mechanistic studies led the authors to propose the formation of a Pd(IV) intermediate (Scheme 21) [101].
The use of the more environmentally benign copper(II) bromide as oxidant and the extension to internal alkenes, including acrylates, were further investigated by the same research group [102,103].
In the same years, Muñiz et al. demonstrated that nickel catalysts are highly active in this transformation as well, providing an attractive alternative in terms of catalyst cost and reaction scope [104]. Furthermore, the same author broadened the catalyst scope for the diamination of alkenes by introducing a homogeneous gold(I) catalyst [105].
In 2012, Muñiz et al. reported an impressive metal-free intramolecular diamination of alkenes based on the use of potassium bromide as the catalyst and sodium chlorite as terminal oxidant (Scheme 22) [106,107]. This halide catalysis features general applicability, readily available reagents and catalysts, and can be successfully scaled up.
A rare example of Cu(II)-catalyzed asymmetric intramolecular cyclization of N-alkenyl ureas to access chiral imidazolidinones in moderate to good yields with high to excellent enantioselectivity was recently reported by Fu et al. (Scheme 23) [108]. The bidentate oxazoline ligand L1 was found to be the ligand of choice in order to achieve high enantioselectivities. The basic medium was also essential to impart chirality to the final product.

Metal-Catalyzed Intramolecular Diamination of Allenes with Ureas
Allene-tethered ureas were successfully converted to bicyclic imidazolidin-2-ones in high yield and diastereomeric purity by means of a catalytic 1:1 mixture of Au(I)-N-heterocyclic carbene complex and AgPF 6 under mild reaction conditions (Scheme 24) [110]. This redox-neutral and atom-economic approach does not need stoichiometric oxidant and would provide an alternative to alkene diamination for the synthesis of five-membered ureas.

Metal-Catalyzed Intramolecular Diamination of Alkynes with Ureas
A rare example of intramolecular 1,2-diamination of alkynes for the synthesis of indoleimidazolidinone fused derivatives, has been recently reported by Reddy et al. [6]. Control experiments revealed that urea derivatives, which were likely generated in situ from aminophenyl propargyl alcohols and isocyanates, undergo a Ag(I)-catalyzed sequential vicinal diamination featuring a double cyclization process followed by 1,3-allylic amino dehydroxylation step (Scheme 25).

Metal-Catalyzed Intermolecular Diamination of Dienes with Ureas
The Pd(II)-catalyzed intermolecular diamination of conjugated dienes with dialkyl ureas was firstly reported by Lloyd-Jones and Booker-Milburn in 2005 [110]. This non-asymmetric transformation was carried out without additional ligands, and led to vinyl imidazolidinones in good to excellent yields. Very recently, a highly efficient synthesis of chiral imidazolidin-2-ones through the Pd(II)catalyzed diamination of 1,3-dienes with 1,3-dialkylureas has been reported by Gong and Au(I)-catalyzed intramolecular dihydroamination of allenes to bicyclic imidazolidin-2-ones [110].
This redox-neutral and atom-economic approach does not need stoichiometric oxidant and would provide an alternative to alkene diamination for the synthesis of five-membered ureas.

Metal-Catalyzed Intramolecular Diamination of Alkynes with Ureas
A rare example of intramolecular 1,2-diamination of alkynes for the synthesis of indole-imidazolidinone fused derivatives, has been recently reported by Reddy et al. [6]. Control experiments revealed that urea derivatives, which were likely generated in situ from aminophenyl propargyl alcohols and isocyanates, undergo a Ag(I)-catalyzed sequential vicinal diamination featuring a double cyclization process followed by 1,3-allylic amino dehydroxylation step (Scheme 25). This redox-neutral and atom-economic approach does not need stoichiometric oxidant and would provide an alternative to alkene diamination for the synthesis of five-membered ureas.

Metal-Catalyzed Intramolecular Diamination of Alkynes with Ureas
A rare example of intramolecular 1,2-diamination of alkynes for the synthesis of indoleimidazolidinone fused derivatives, has been recently reported by Reddy et al. [6]. Control experiments revealed that urea derivatives, which were likely generated in situ from aminophenyl propargyl alcohols and isocyanates, undergo a Ag(I)-catalyzed sequential vicinal diamination featuring a double cyclization process followed by 1,3-allylic amino dehydroxylation step (Scheme 25).

Metal-Catalyzed Intermolecular Diamination of Dienes with Ureas
The Pd(II)-catalyzed intermolecular diamination of conjugated dienes with dialkyl ureas was firstly reported by Lloyd-Jones and Booker-Milburn in 2005 [110]. This non-asymmetric transformation was carried out without additional ligands, and led to vinyl imidazolidinones in good to excellent yields. Very recently, a highly efficient synthesis of chiral imidazolidin-2-ones through the Pd(II)catalyzed diamination of 1,3-dienes with 1,3-dialkylureas has been reported by Gong and Han (Scheme 26) [111].

Metal-Catalyzed Intermolecular Diamination of Dienes with Ureas
The Pd(II)-catalyzed intermolecular diamination of conjugated dienes with dialkyl ureas was firstly reported by Lloyd-Jones and Booker-Milburn in 2005 [111]. This non-asymmetric transformation was carried out without additional ligands, and led to vinyl imidazolidinones in good to excellent yields. Very recently, a highly efficient synthesis of chiral imidazolidin-2-ones through the Pd(II)catalyzed diamination of 1,3-dienes with 1,3-dialkylureas has been reported by Gong and Han (Scheme 26) [112].  [111].
High yields and excellent enantioselectivities were achieved under mild reaction conditions by means of a chiral pyridine-oxazoline ligand. The choice of the oxidant was also crucial, since 2,5dimethoxybenzoquinone (2,5-DMBQ) gave the best reaction performance, compared to BQ, chloranil, and oxygen. Molecular sieves were found to improve both the yield and enantioselectivity values. Notably, as for the non-asymmetric transformation [110], this enantioselective diamination reaction involves exclusively the terminal C=C double bond of 1,3-dienes, and for this, it is highly complementary to the asymmetric Shi's protocol [112], which mainly occurs at the internal double bond (Scheme 29).

Metal-Catalyzed Intermolecular Diamination of Alkenes with Diaziridinones
Shi et al. discovered that Pd(0) and Cu(I) were highly effective catalysts for the stereoselective diamination of olefins, dienes, and trienes with di-tert-butyldiaziridinone as a nitrogen source [96]. This strategy relies on the N-N bond activation by means of metal species in their low oxidation state, as depicted in Scheme 27. A metal can oxidatively add to the N-N bond of dialkyldiaziridinone, providing a four-membered metallacycle I. This intermediate could react with an alkene through migratory insertion and subsequent reductive elimination, leading to the diamination product (imidazolidinone derivative) and the active catalytic species.
High yields and excellent enantioselectivities were achieved under mild reaction conditions by means of a chiral pyridine-oxazoline ligand. The choice of the oxidant was also crucial, since 2,5-dimethoxybenzoquinone (2,5-DMBQ) gave the best reaction performance, compared to BQ, chloranil, and oxygen. Molecular sieves were found to improve both the yield and enantioselectivity values. Notably, as for the non-asymmetric transformation [111], this enantioselective diamination reaction involves exclusively the terminal C=C double bond of 1,3-dienes, and for this, it is highly complementary to the asymmetric Shi's protocol [113], which mainly occurs at the internal double bond (Scheme 29).

Metal-Catalyzed Intermolecular Diamination of Alkenes with Diaziridinones
Shi et al. discovered that Pd(0) and Cu(I) were highly effective catalysts for the stereoselective diamination of olefins, dienes, and trienes with di-tert-butyldiaziridinone as a nitrogen source [97]. This strategy relies on the N-N bond activation by means of metal species in their low oxidation state, as depicted in Scheme 27. A metal can oxidatively add to the N-N bond of dialkyldiaziridinone, providing a four-membered metallacycle I. This intermediate could react with an alkene through migratory insertion and subsequent reductive elimination, leading to the diamination product (imidazolidinone derivative) and the active catalytic species.  [111].
High yields and excellent enantioselectivities were achieved under mild reaction conditions by means of a chiral pyridine-oxazoline ligand. The choice of the oxidant was also crucial, since 2,5dimethoxybenzoquinone (2,5-DMBQ) gave the best reaction performance, compared to BQ, chloranil, and oxygen. Molecular sieves were found to improve both the yield and enantioselectivity values. Notably, as for the non-asymmetric transformation [110], this enantioselective diamination reaction involves exclusively the terminal C=C double bond of 1,3-dienes, and for this, it is highly complementary to the asymmetric Shi's protocol [112], which mainly occurs at the internal double bond (Scheme 29).

Metal-Catalyzed Intermolecular Diamination of Alkenes with Diaziridinones
Shi et al. discovered that Pd(0) and Cu(I) were highly effective catalysts for the stereoselective diamination of olefins, dienes, and trienes with di-tert-butyldiaziridinone as a nitrogen source [96]. This strategy relies on the N-N bond activation by means of metal species in their low oxidation state, as depicted in Scheme 27. A metal can oxidatively add to the N-N bond of dialkyldiaziridinone, providing a four-membered metallacycle I. This intermediate could react with an alkene through migratory insertion and subsequent reductive elimination, leading to the diamination product (imidazolidinone derivative) and the active catalytic species.
In a first report, Shi demonstrated that conjugated dienes can be regioselectively and stereoselectively diaminated under palladium catalysis using di-tert-butylaziridinone as a nitrogen source (Scheme 28) [114]. Notably, diamination occurred exclusively at the internal double bond. When trienes were employed, only the middle double bond was involved. In a first report, Shi demonstrated that conjugated dienes can be regioselectively and stereoselectively diaminated under palladium catalysis using di-tert-butylaziridinone as a nitrogen source (Scheme 28) [113]. Notably, diamination occurred exclusively at the internal double bond. When trienes were employed, only the middle double bond was involved. Scheme 28. Pd(0)-catalyzed intermolecular diamination of dienes to imidazolidin-2-ones [113].
An asymmetric version of this diamination process was subsequently disclosed. (E)-1,3-Hexadiene and di-tert-butyldiaziridinone were used as model substrates, while Pd2(dba)3 and several chiral ligands were examined (Scheme 29) [112]. The choice of the ligand was critical in order to achieve high conversion and enantioselectivity. A BINOL-based chiral phosphorus amidite ligand (L4), containing a sterically bulky tetramethylpiperidine, was found to give the best reaction outcome. With the optimal reaction conditions, a variety of conjugated dienes were regioselectively diaminated at the internal double bond in good yields and high enantioselectivities (up to 95% ee).
An asymmetric version of this diamination process was subsequently disclosed. (E)-1,3-Hexadiene and di-tert-butyldiaziridinone were used as model substrates, while Pd 2 (dba) 3 and several chiral ligands were examined (Scheme 29) [113]. The choice of the ligand was critical in order to achieve high conversion and enantioselectivity. A BINOL-based chiral phosphorus amidite ligand (L4), containing a sterically bulky tetramethylpiperidine, was found to give the best reaction outcome. With the optimal reaction conditions, a variety of conjugated dienes were regioselectively diaminated at the internal double bond in good yields and high enantioselectivities (up to 95% ee). In a first report, Shi demonstrated that conjugated dienes can be regioselectively and stereoselectively diaminated under palladium catalysis using di-tert-butylaziridinone as a nitrogen source (Scheme 28) [113]. Notably, diamination occurred exclusively at the internal double bond. When trienes were employed, only the middle double bond was involved. Scheme 28. Pd(0)-catalyzed intermolecular diamination of dienes to imidazolidin-2-ones [113].
An asymmetric version of this diamination process was subsequently disclosed. (E)-1,3-Hexadiene and di-tert-butyldiaziridinone were used as model substrates, while Pd2(dba)3 and several chiral ligands were examined (Scheme 29) [112]. The choice of the ligand was critical in order to achieve high conversion and enantioselectivity. A BINOL-based chiral phosphorus amidite ligand (L4), containing a sterically bulky tetramethylpiperidine, was found to give the best reaction outcome. With the optimal reaction conditions, a variety of conjugated dienes were regioselectively diaminated at the internal double bond in good yields and high enantioselectivities (up to 95% ee).
Interestingly, under solvent-free conditions, the diamination occurred at allylic and homoallylic carbons rather than at the double bond when terminal olefins were treated with Pd(PPh 3 ) 4 and di-tert-butyldiaziridinone (Scheme 30) [118]. In a first report, Shi demonstrated that conjugated dienes can be regioselectively and stereoselectively diaminated under palladium catalysis using di-tert-butylaziridinone as a nitrogen source (Scheme 28) [113]. Notably, diamination occurred exclusively at the internal double bond. When trienes were employed, only the middle double bond was involved. Scheme 28. Pd(0)-catalyzed intermolecular diamination of dienes to imidazolidin-2-ones [113].
An asymmetric version of this diamination process was subsequently disclosed. (E)-1,3-Hexadiene and di-tert-butyldiaziridinone were used as model substrates, while Pd2(dba)3 and several chiral ligands were examined (Scheme 29) [112]. The choice of the ligand was critical in order to achieve high conversion and enantioselectivity. A BINOL-based chiral phosphorus amidite ligand (L4), containing a sterically bulky tetramethylpiperidine, was found to give the best reaction outcome. With the optimal reaction conditions, a variety of conjugated dienes were regioselectively diaminated at the internal double bond in good yields and high enantioselectivities (up to 95% ee).
In this case, the process likely proceeds through the in situ formation of a diene intermediate by palladium catalysis. Remarkably, substrates bearing two terminal double bonds underwent bisdiamination successfully.
A catalytic asymmetric process was also achieved in the presence of Pd 2 (dba) 3 and a chiral BINOL-derived phosphorus amidite ligand (L5) (Scheme 31) [119]. A broad range of chiral imidazolidinones were obtained from terminal alkenes and di-tert-butyldiaziridinone with good yields and high enantioselectivities. In this case, the process likely proceeds through the in situ formation of a diene intermediate by palladium catalysis. Remarkably, substrates bearing two terminal double bonds underwent bisdiamination successfully.
More recently, spirocyclic indolines containing imidazolidinone scaffold were synthesized in good yields through a novel sequential allylic and aromatic C−H amination process starting from α-methylstyrenes, di-tert-butyldiaziridinone and Pd(PPh 3 ) 4 , as the catalyst (Scheme 32). [121] Remarkably, four C−N bonds and one spiro quaternary carbon were generated in a single operation. In this case, the process likely proceeds through the in situ formation of a diene intermediate by palladium catalysis. Remarkably, substrates bearing two terminal double bonds underwent bisdiamination successfully.
Unlike the Pd(0)-catalyzed process (Scheme 28), the Cu(I)-catalyzed diamination occurred mostly at the terminal double bond of dienes with generally high regioselectivities. The diamination reaction likely proceeds via a radical mechanism, which is mechanistically distinct from the Pd(0)-
A variety of conjugated dienes and a triene can be effectively diaminated in good yields with CuCl−P(OPh) 3 and di-tert-butyldiaziridinone under mild reaction conditions (Scheme 33) [122]. In this case, the process likely proceeds through the in situ formation of a diene intermediate by palladium catalysis. Remarkably, substrates bearing two terminal double bonds underwent bisdiamination successfully.
Unlike the Pd(0)-catalyzed process (Scheme 28), the Cu(I)-catalyzed diamination occurred mostly at the terminal double bond of dienes with generally high regioselectivities. The diamination reaction likely proceeds via a radical mechanism, which is mechanistically distinct from the Pd(0)-
Unlike the Pd(0)-catalyzed process (Scheme 28), the Cu(I)-catalyzed diamination occurred mostly at the terminal double bond of dienes with generally high regioselectivities. The diamination reaction likely proceeds via a radical mechanism, which is mechanistically distinct from the Pd(0)-catalyzed process. Trienes were conveniently converted to corresponding diene-tethered imidazolidinones as well. Later, the Cu(I)-catalyzed asymmetric diamination has been found to be feasible [123].
As reported by Shi in 2010, the regioselectivity for the Cu(I)-catalyzed diamination of dienes with di-tert-butyldiaziridinone can be controlled by a careful manipulation of the reaction conditions (Scheme 34) [124]. In this work, various conjugated dienes can be efficiently diaminated at the internal double bond with CuBr, giving the corresponding imidazolidinones in high yields and regioselectivities. catalyzed process. Trienes were conveniently converted to corresponding diene-tethered imidazolidinones as well. Later, the Cu(I)-catalyzed asymmetric diamination has been found to be feasible [122]. As reported by Shi in 2010, the regioselectivity for the Cu(I)-catalyzed diamination of dienes with di-tert-butyldiaziridinone can be controlled by a careful manipulation of the reaction conditions (Scheme 34) [123]. In this work, various conjugated dienes can be efficiently diaminated at the internal double bond with CuBr, giving the corresponding imidazolidinones in high yields and regioselectivities.
Two distinct mechanistic pathways, involving Cu(II) and Cu(III) species, were proposed for this remarkable reactivity [124].
Terminal olefins can be also efficiently diaminated with di-tert-butyldiaziridinone to imidazolidinones in the presence of CuCl−PPh3 [125]. As shown in Scheme 35, a variety of 1,1disubstituted terminal olefins were readily diaminated, affording the corresponding 4,4disubstituted imidazolidin-2-ones in good yields.

Synthesis of 2-Imidazolidinone Derivatives by Catalytic Hydroamination of Unsaturated Ureas
The N-hydroamination reaction represents a robust methodology for the construction of C-N bonds [126][127][128]. This approach consists in the nucleophilic addition of a nitrogen on a C-C unsaturated bond, and it involves the cleavage of an N-H bond with the formation of C-N and C-H bonds. From the thermodynamic point of view, this reaction is slightly exothermic; on the other hand, the kinetic is unfavorable due to the presence of the nucleophile electron density and the π-electrons of the C-C unsaturated bond [129,130]. Hence, a great amount of energy has to be provided to the system in order to overcome the high activation barrier. To solve this issue, both a strong acid [131,132] or a base [133][134][135] can be employed. The first one protonates the double or triple bond, generating a carbocation that is more prone to undergo a nucleophilic attack, while a strong base is required to deprotonate the nitrogen and create a stronger nucleophile. Metal catalysts [136][137][138][139][140][141] can coordinate the unsaturated bond, subtracting electronic density or replacing the hydrogen in the N-H bond. Indeed the nature of the nucleophile greatly affects the required reaction conditions. Amides and related compounds, such as ureas, carbamates, and amidines possess less nucleophilic nitrogen due to the presence of diverse resonance structures. When these compounds are engaged in an Nhydroamination reaction, harsher reaction conditions are expected.
Two distinct mechanistic pathways, involving Cu(II) and Cu(III) species, were proposed for this remarkable reactivity [125].
Terminal olefins can be also efficiently diaminated with di-tert-butyldiaziridinone to imidazolidinones in the presence of CuCl−PPh 3 [126]. As shown in Scheme 35, a variety of 1,1-disubstituted terminal olefins were readily diaminated, affording the corresponding 4,4-disubstituted imidazolidin-2-ones in good yields. catalyzed process. Trienes were conveniently converted to corresponding diene-tethered imidazolidinones as well. Later, the Cu(I)-catalyzed asymmetric diamination has been found to be feasible [122]. As reported by Shi in 2010, the regioselectivity for the Cu(I)-catalyzed diamination of dienes with di-tert-butyldiaziridinone can be controlled by a careful manipulation of the reaction conditions (Scheme 34) [123]. In this work, various conjugated dienes can be efficiently diaminated at the internal double bond with CuBr, giving the corresponding imidazolidinones in high yields and regioselectivities.
Two distinct mechanistic pathways, involving Cu(II) and Cu(III) species, were proposed for this remarkable reactivity [124].
Terminal olefins can be also efficiently diaminated with di-tert-butyldiaziridinone to imidazolidinones in the presence of CuCl−PPh3 [125]. As shown in Scheme 35, a variety of 1,1disubstituted terminal olefins were readily diaminated, affording the corresponding 4,4disubstituted imidazolidin-2-ones in good yields.

Synthesis of 2-Imidazolidinone Derivatives by Catalytic Hydroamination of Unsaturated Ureas
The N-hydroamination reaction represents a robust methodology for the construction of C-N bonds [126][127][128]. This approach consists in the nucleophilic addition of a nitrogen on a C-C unsaturated bond, and it involves the cleavage of an N-H bond with the formation of C-N and C-H bonds. From the thermodynamic point of view, this reaction is slightly exothermic; on the other hand, the kinetic is unfavorable due to the presence of the nucleophile electron density and the π-electrons of the C-C unsaturated bond [129,130]. Hence, a great amount of energy has to be provided to the system in order to overcome the high activation barrier. To solve this issue, both a strong acid [131,132] or a base [133][134][135] can be employed. The first one protonates the double or triple bond, generating a carbocation that is more prone to undergo a nucleophilic attack, while a strong base is required to deprotonate the nitrogen and create a stronger nucleophile. Metal catalysts [136][137][138][139][140][141] can coordinate the unsaturated bond, subtracting electronic density or replacing the hydrogen in the N-H bond. Indeed the nature of the nucleophile greatly affects the required reaction conditions. Amides and related compounds, such as ureas, carbamates, and amidines possess less nucleophilic nitrogen due to the presence of diverse resonance structures. When these compounds are engaged in an Nhydroamination reaction, harsher reaction conditions are expected.

Synthesis of 2-Imidazolidinone Derivatives by Catalytic Hydroamination of Unsaturated Ureas
The N-hydroamination reaction represents a robust methodology for the construction of C-N bonds [127][128][129]. This approach consists in the nucleophilic addition of a nitrogen on a C-C unsaturated bond, and it involves the cleavage of an N-H bond with the formation of C-N and C-H bonds. From the thermodynamic point of view, this reaction is slightly exothermic; on the other hand, the kinetic is unfavorable due to the presence of the nucleophile electron density and the π-electrons of the C-C unsaturated bond [130,131]. Hence, a great amount of energy has to be provided to the system in order to overcome the high activation barrier. To solve this issue, both a strong acid [132,133] or a base [134][135][136] can be employed. The first one protonates the double or triple bond, generating a carbocation that is more prone to undergo a nucleophilic attack, while a strong base is required to deprotonate the nitrogen and create a stronger nucleophile. Metal catalysts [137][138][139][140][141][142] can coordinate the unsaturated bond, subtracting electronic density or replacing the hydrogen in the N-H bond. Indeed the nature of the nucleophile greatly affects the required reaction conditions. Amides and related compounds, such as ureas, carbamates, and amidines possess less nucleophilic nitrogen due to the presence of diverse resonance structures. When these compounds are engaged in an N-hydroamination reaction, harsher reaction conditions are expected.

Intramolecular N-hydroamination of Propargylic Ureas
Propargylic ureas, under appropriate reaction conditions, can result in different cyclization pathways. In order to allow the construction of five-member cyclic ureas via 5-exo-dig cyclization and thus promote the formation of imidazolidin-2-ones, a tailored catalytic methodology is crucial [143]. Based on his previous observations [144], Van der Eycken et al. reported two different metal catalyzed complementary protocols [145] for the cyclization of in situ generated propargylic ureas (Scheme 36). A cationic gold (I) catalysis based on AuPPh 3 Cl/AgOTf system promotes the O-cyclization, while AgOTf-catalyzed reactions allow the formation of imidazolidin-2-ones through an N-cyclization. The authors proposed an explanation for the observed chemoselectivity based on the Pearson's concept HSAB (hard and soft acids and bases). The mechanism involves the coordination of silver to the triple bond. This type of coordination facilitates the hydroamination step through a trans-amidometallation that results in the formation of a five-member ring bearing an exocyclic double bond. Finally, a proton demetallation leads to the formation of the desired product with a retention of configuration (Z-alkene). Propargylic ureas, under appropriate reaction conditions, can result in different cyclization pathways. In order to allow the construction of five-member cyclic ureas via 5-exo-dig cyclization and thus promote the formation of imidazolidin-2-ones, a tailored catalytic methodology is crucial [142]. Based on his previous observations [143], Van der Eycken et al. reported two different metal catalyzed complementary protocols [144] for the cyclization of in situ generated propargylic ureas (Scheme 36). A cationic gold (I) catalysis based on AuPPh3Cl/AgOTf system promotes the Ocyclization, while AgOTf-catalyzed reactions allow the formation of imidazolidin-2-ones through an N-cyclization. The authors proposed an explanation for the observed chemoselectivity based on the Pearson's concept HSAB (hard and soft acids and bases). The mechanism involves the coordination of silver to the triple bond. This type of coordination facilitates the hydroamination step through a trans-amidometallation that results in the formation of a five-member ring bearing an exocyclic double bond. Finally, a proton demetallation leads to the formation of the desired product with a retention of configuration (Z-alkene). Scheme 36. Ag(I)-catalyzed hydroamination of propargylic ureas formed in situ from propargylic amines and tosyl isocyanate [144].
In 2016 Testero and Krchňák observed a remarkable selectivity using gold catalysis when acyclic propargyl ureas were employed as starting materials [145]. An efficient and selective 5-exo-dig cyclization reaction occurred under solid-phase organic synthesis (Scheme 37). Under mild conditions, propargyl ureas anchored on a solid support were efficiently converted into imidazolidinones. This protocol features the use of AuCl as catalyst (5 mol%) and the mixture DCM/MeCN (5:1) as solvent. Subsequent treatment with TFA (TFA = trifluoroacetic acid) afforded a mixture of imidazolidinones and imidazolones.
Over the years, palladium has captured chemists' attention also for hydroamination reactions. Bäckvall et al. proposed a palladium-catalyzed strategy for the N-cyclization of propargylic carbam(othio)ates or propargylic (thio)ureas for the construction of five-member heterocycles [146]. Propargylic carbamates underwent an efficient hydroamination process using Pd(OAc)2 and n-Bu4NOAc in DCE as the solvent. Similar conditions were successfully employed for the selective 5- In 2016 Testero and Krchňák observed a remarkable selectivity using gold catalysis when acyclic propargyl ureas were employed as starting materials [146]. An efficient and selective 5-exo-dig cyclization reaction occurred under solid-phase organic synthesis (Scheme 37). Under mild conditions, propargyl ureas anchored on a solid support were efficiently converted into imidazolidinones. This protocol features the use of AuCl as catalyst (5 mol%) and the mixture DCM/MeCN (5:1) as solvent. Subsequent treatment with TFA (TFA = trifluoroacetic acid) afforded a mixture of imidazolidinones and imidazolones. Propargylic ureas, under appropriate reaction conditions, can result in different cyclization pathways. In order to allow the construction of five-member cyclic ureas via 5-exo-dig cyclization and thus promote the formation of imidazolidin-2-ones, a tailored catalytic methodology is crucial [142]. Based on his previous observations [143], Van der Eycken et al. reported two different metal catalyzed complementary protocols [144] for the cyclization of in situ generated propargylic ureas (Scheme 36). A cationic gold (I) catalysis based on AuPPh3Cl/AgOTf system promotes the Ocyclization, while AgOTf-catalyzed reactions allow the formation of imidazolidin-2-ones through an N-cyclization. The authors proposed an explanation for the observed chemoselectivity based on the Pearson's concept HSAB (hard and soft acids and bases). The mechanism involves the coordination of silver to the triple bond. This type of coordination facilitates the hydroamination step through a trans-amidometallation that results in the formation of a five-member ring bearing an exocyclic double bond. Finally, a proton demetallation leads to the formation of the desired product with a retention of configuration (Z-alkene). Scheme 36. Ag(I)-catalyzed hydroamination of propargylic ureas formed in situ from propargylic amines and tosyl isocyanate [144].
In 2016 Testero and Krchňák observed a remarkable selectivity using gold catalysis when acyclic propargyl ureas were employed as starting materials [145]. An efficient and selective 5-exo-dig cyclization reaction occurred under solid-phase organic synthesis (Scheme 37). Under mild conditions, propargyl ureas anchored on a solid support were efficiently converted into imidazolidinones. This protocol features the use of AuCl as catalyst (5 mol%) and the mixture DCM/MeCN (5:1) as solvent. Subsequent treatment with TFA (TFA = trifluoroacetic acid) afforded a mixture of imidazolidinones and imidazolones.
Over the years, palladium has captured chemists' attention also for hydroamination reactions. Bäckvall et al. proposed a palladium-catalyzed strategy for the N-cyclization of propargylic carbam(othio)ates or propargylic (thio)ureas for the construction of five-member heterocycles [146]. Propargylic carbamates underwent an efficient hydroamination process using Pd(OAc)2 and n-Bu4NOAc in DCE as the solvent. Similar conditions were successfully employed for the selective 5- Over the years, palladium has captured chemists' attention also for hydroamination reactions. Bäckvall et al. proposed a palladium-catalyzed strategy for the N-cyclization of propargylic carbam(othio)ates or propargylic (thio)ureas for the construction of five-member heterocycles [147]. Propargylic carbamates underwent an efficient hydroamination process using Pd(OAc) 2 and n-Bu 4 NOAc in DCE as the solvent. Similar conditions were successfully employed for the selective 5-exo-dig cyclization of propargylic tosylureas (Scheme 38). The mechanism is similar to the previously described one for silver-promoted N-cyclization [145]. exo-dig cyclization of propargylic tosylureas (Scheme 38). The mechanism is similar to the previously described one for silver-promoted N-cyclization [144].
In 2006, Lu et al. reported an innovative approach for the synthesis of polycyclic indoles from propargylic ureas [147]. They initially proposed a mechanism involving a syn amidopalladation of the acetylene moiety as a key step, with the formation of an imidazolidin-2-one ring. In 2010, they published an update with further studies on the mechanism [148]. According to this last report, the first step consists in the hydroamination promoted by K2CO3 at high temperature, followed by a palladium-catalyzed annulation (Scheme 39).
Another example of base-mediated hydroamination for the synthesis of imidazolidin-2-ones was reported by Lubell [149]. The 5-exo-dig cyclization of azapropargyl glicinamides was enabled by 2.5 equivalents of sodium hydride. Also, NaOH can trigger the hydroamination of propargyl(thio)ureas to afford five-member cyclic (thio)ureas [150]. The base was used as the promoter, and it provided yields up to 97% in two hours of reaction time. In 2014, Huguenot exploited the potential of TBAF (TBAF = tetra-n-butylammonium fluoride) as the stoichiometric promoter for the above-mentioned cyclization [151]. An environmentally benign approach was disclosed by Hill in 2014 using non-toxic bis-amide alkaline earth complexes [152]. Diverse propargylamidine derivatives were successfully coupled with a range of isocyanates to afford propargylic ureas that were then cyclized to imidazolidin-2-ones (Scheme 40). The mechanism involves the formation of acyclic ureas; then, the intramolecular hydroamination step leads to the construction of the five-member cyclic urea. A similar approach was reported in 2017, replacing alkaline earth catalysis with zinc [153]. Scheme 38. Pd-catalyzed hydroamination of propargylic tosylureas [147].
In 2006, Lu et al. reported an innovative approach for the synthesis of polycyclic indoles from propargylic ureas [148]. They initially proposed a mechanism involving a syn amidopalladation of the acetylene moiety as a key step, with the formation of an imidazolidin-2-one ring. In 2010, they published an update with further studies on the mechanism [149]. According to this last report, the first step consists in the hydroamination promoted by K 2 CO 3 at high temperature, followed by a palladium-catalyzed annulation (Scheme 39). exo-dig cyclization of propargylic tosylureas (Scheme 38). The mechanism is similar to the previously described one for silver-promoted N-cyclization [144].
In 2006, Lu et al. reported an innovative approach for the synthesis of polycyclic indoles from propargylic ureas [147]. They initially proposed a mechanism involving a syn amidopalladation of the acetylene moiety as a key step, with the formation of an imidazolidin-2-one ring. In 2010, they published an update with further studies on the mechanism [148]. According to this last report, the first step consists in the hydroamination promoted by K2CO3 at high temperature, followed by a palladium-catalyzed annulation (Scheme 39).
Another example of base-mediated hydroamination for the synthesis of imidazolidin-2-ones was reported by Lubell [149]. The 5-exo-dig cyclization of azapropargyl glicinamides was enabled by 2.5 equivalents of sodium hydride. Also, NaOH can trigger the hydroamination of propargyl(thio)ureas to afford five-member cyclic (thio)ureas [150]. The base was used as the promoter, and it provided yields up to 97% in two hours of reaction time. In 2014, Huguenot exploited the potential of TBAF (TBAF = tetra-n-butylammonium fluoride) as the stoichiometric promoter for the above-mentioned cyclization [151]. An environmentally benign approach was disclosed by Hill in 2014 using non-toxic bis-amide alkaline earth complexes [152]. Diverse propargylamidine derivatives were successfully coupled with a range of isocyanates to afford propargylic ureas that were then cyclized to imidazolidin-2-ones (Scheme 40). The mechanism involves the formation of acyclic ureas; then, the intramolecular hydroamination step leads to the construction of the five-member cyclic urea. A similar approach was reported in 2017, replacing alkaline earth catalysis with zinc [153]. Scheme 39. Base-promoted hydroamination followed by Pd-catalyzed heteroannulation to condensed indole-imidazolidin-2-one derivatives [149].
Another example of base-mediated hydroamination for the synthesis of imidazolidin-2-ones was reported by Lubell [150]. The 5-exo-dig cyclization of azapropargyl glicinamides was enabled by 2.5 equivalents of sodium hydride. Also, NaOH can trigger the hydroamination of propargyl(thio)ureas to afford five-member cyclic (thio)ureas [151]. The base was used as the promoter, and it provided yields up to 97% in two hours of reaction time. In 2014, Huguenot exploited the potential of TBAF (TBAF = tetra-n-butylammonium fluoride) as the stoichiometric promoter for the above-mentioned cyclization [152]. An environmentally benign approach was disclosed by Hill in 2014 using non-toxic bis-amide alkaline earth complexes [153]. Diverse propargylamidine derivatives were successfully coupled with a range of isocyanates to afford propargylic ureas that were then cyclized to imidazolidin-2-ones (Scheme 40). The mechanism involves the formation of acyclic ureas; then, the intramolecular hydroamination step leads to the construction of the five-member cyclic urea. A similar approach was reported in 2017, replacing alkaline earth catalysis with zinc [154].

Intramolecular N-hydroamination of Allylic Ureas
The formation of a C-N bond through the hydroamination of a C-C double bond is more challenging than the hydroamination of a triple bond, due to its diminished electron density and thus its lower reactivity. Palladium was found to be a suitable candidate by Wolfe et al., who deeply studied this transformation. In 2006, they published a new synthetic strategy for the synthesis of imidazolidin-2-ones by a palladium-catalyzed carboamination from allylic ureas and aryl bromides [154]. They managed to obtain several products from both terminal and internal double bonds. The latter case led to the formation of the syn isomer in a good diastereomeric excess.
The proposed mechanism (Scheme 41) involves first an oxidative addition of the aryl bromides to Pd(0); then, after deprotonation of the urea moiety by NaOtBu, a Pd-N bond could be formed. The syn insertion of the alkene into the Pd-N bond, followed by reductive elimination, affords the desired imidazolidin-2-one. A few years later, Wolfe et al. further investigated this methodology [155], providing a larger reaction scope and additional mechanistic findings. A catalytic asymmetric access to enantiomerically enriched imidazolidin-2-ones was disclosed by the same research group in 2012 (Scheme 42) [156]. Experimental findings showed that the reductive elimination can be the enantiodetermining step. Indeed, they found a strong correlation between the nucleophilicity of the nitrogen involved in the cyclization and the resulting asymmetric induction. A less nucleophilic nitrogen leads to an increase in the enantiomeric excess and a loss in reactivity, which are both due to the lessfavored final reductive elimination.

Intramolecular N-hydroamination of Allylic Ureas
The formation of a C-N bond through the hydroamination of a C-C double bond is more challenging than the hydroamination of a triple bond, due to its diminished electron density and thus its lower reactivity. Palladium was found to be a suitable candidate by Wolfe et al., who deeply studied this transformation. In 2006, they published a new synthetic strategy for the synthesis of imidazolidin-2-ones by a palladium-catalyzed carboamination from allylic ureas and aryl bromides [155]. They managed to obtain several products from both terminal and internal double bonds. The latter case led to the formation of the syn isomer in a good diastereomeric excess.
The proposed mechanism (Scheme 41) involves first an oxidative addition of the aryl bromides to Pd(0); then, after deprotonation of the urea moiety by NaOtBu, a Pd-N bond could be formed. The syn insertion of the alkene into the Pd-N bond, followed by reductive elimination, affords the desired imidazolidin-2-one. A few years later, Wolfe et al. further investigated this methodology [156], providing a larger reaction scope and additional mechanistic findings. A catalytic asymmetric access to enantiomerically enriched imidazolidin-2-ones was disclosed by the same research group in 2012 (Scheme 42) [157]. Experimental findings showed that the reductive elimination can be the enantio-determining step. Indeed, they found a strong correlation between the nucleophilicity of the nitrogen involved in the cyclization and the resulting asymmetric induction. A less nucleophilic nitrogen leads to an increase in the enantiomeric excess and a loss in reactivity, which are both due to the less-favored final reductive elimination.  [154].
Taking advantage from these pioneering studies, Lin et al. designed and synthesized a new chiral spiro phosphoramidite ligand for the asymmetric synthesis of imidazolidin-2-one derivatives from N-allyl ureas (Scheme 43) [157]. They also noticed a remarkable effect on the asymmetric induction due to the nucleophilicity of the urea nitrogen. Using electron-withdrawing groups, they efficiently obtained high enantiomeric excesses. Scheme 41. Pd-catalyzed syn carboamination of allylureas [155].  [154].
Taking advantage from these pioneering studies, Lin et al. designed and synthesized a new chiral spiro phosphoramidite ligand for the asymmetric synthesis of imidazolidin-2-one derivatives from N-allyl ureas (Scheme 43) [157]. They also noticed a remarkable effect on the asymmetric induction due to the nucleophilicity of the urea nitrogen. Using electron-withdrawing groups, they efficiently obtained high enantiomeric excesses. Scheme 42. Pd-catalyzed asymmetric carboamination of allylureas [157].
Taking advantage from these pioneering studies, Lin et al. designed and synthesized a new chiral spiro phosphoramidite ligand for the asymmetric synthesis of imidazolidin-2-one derivatives from N-allyl ureas (Scheme 43) [158]. They also noticed a remarkable effect on the asymmetric induction due to the nucleophilicity of the urea nitrogen. Using electron-withdrawing groups, they efficiently obtained high enantiomeric excesses.  [158]. The first amination step is responsible for the construction of the imidazolidin-2-one scaffold by trans-aminopalladation of the alkene moiety. The latter amination step involves the formation of a Csp 3 -Nsp 3 bond after reductive elimination from an alkylpalladium complex. The use of the JackiePhos ligand proved to be fundamental for the last step of reductive elimination due to its bulkiness and electron-poor character.

Scheme 44. Diamination of N-allyl ureas [158].
A copper-mediated strategy to synthesize imidazolidin-2-ones through a diamination process of N-allylic ureas was previously reported by Chemler [159,160]. A stoichiometric amount of copper was required in order to minimize by-product formation. The mechanism involves a first step of copper-mediated hydroamination that leads to the formation of an unstable organocopper (II) intermediate. This species undergoes the homolitic cleavage of the C-Cu bond to form a transient radical on a primary carbon that reacts with an external nitrogen nucleophile to afford the desired final product. In 2016, the first copper-catalyzed intramolecular oxidative amination was reported by Xu and Lu [161]. The novel procedure features the use of a cheap source of copper, which is copper(II) 2-ethylhexanoate, and Dess-Martin periodinane (DMP) as the oxidant. Mechanistic insights reveal the formation of an amidyl radical (Scheme 45) that undergoes a 5-exo-trig cyclization to afford an Scheme 43. New chiral ligand for the asymmetric carboamination of allylic ureas [158].
Very recently, Wolfe et al. reported a palladium-catalyzed diamination of alkenes from N-allyl ureas (Scheme 44) [159]. The first amination step is responsible for the construction of the imidazolidin-2-one scaffold by trans-aminopalladation of the alkene moiety. The latter amination step involves the formation of a Csp 3 -Nsp 3 bond after reductive elimination from an alkylpalladium complex. The use of the JackiePhos ligand proved to be fundamental for the last step of reductive elimination due to its bulkiness and electron-poor character.  [158]. The first amination step is responsible for the construction of the imidazolidin-2-one scaffold by trans-aminopalladation of the alkene moiety. The latter amination step involves the formation of a Csp 3 -Nsp 3 bond after reductive elimination from an alkylpalladium complex. The use of the JackiePhos ligand proved to be fundamental for the last step of reductive elimination due to its bulkiness and electron-poor character.

Scheme 44. Diamination of N-allyl ureas [158].
A copper-mediated strategy to synthesize imidazolidin-2-ones through a diamination process of N-allylic ureas was previously reported by Chemler [159,160]. A stoichiometric amount of copper was required in order to minimize by-product formation. The mechanism involves a first step of copper-mediated hydroamination that leads to the formation of an unstable organocopper (II) intermediate. This species undergoes the homolitic cleavage of the C-Cu bond to form a transient radical on a primary carbon that reacts with an external nitrogen nucleophile to afford the desired final product. In 2016, the first copper-catalyzed intramolecular oxidative amination was reported by Xu and Lu [161]. The novel procedure features the use of a cheap source of copper, which is copper(II) 2-ethylhexanoate, and Dess-Martin periodinane (DMP) as the oxidant. Mechanistic insights reveal the formation of an amidyl radical (Scheme 45) that undergoes a 5-exo-trig cyclization to afford an Scheme 44. Diamination of N-allyl ureas [159].
A copper-mediated strategy to synthesize imidazolidin-2-ones through a diamination process of N-allylic ureas was previously reported by Chemler [160,161]. A stoichiometric amount of copper was required in order to minimize by-product formation. The mechanism involves a first step of copper-mediated hydroamination that leads to the formation of an unstable organocopper (II) intermediate. This species undergoes the homolitic cleavage of the C-Cu bond to form a transient radical on a primary carbon that reacts with an external nitrogen nucleophile to afford the desired final product. In 2016, the first copper-catalyzed intramolecular oxidative amination was reported by Xu and Lu [162]. The novel procedure features the use of a cheap source of copper, which is copper(II) 2-ethylhexanoate, and Dess-Martin periodinane (DMP) as the oxidant. Mechanistic insights reveal the formation of an amidyl radical (Scheme 45) that undergoes a 5-exo-trig cyclization to afford an organocuprate species. Finally, β-hydride elimination leads to the formation of the vinyl-substituted imidazolidin-2-one with high trans diastereoselectivity. The effect of gold catalysis in the intramolecular hydroamination of N-allylic ureas to imidazolidin-2-ones has been studied by Widenhoefer et al. [162]. The selected catalytic system involving the use of di-tert-butyl-o-biphenyl phosphine gold(I) chloride and silver hexafluoroantimonate led to the isolation of a wide variety of imidazolidin-2-one derivatives with high diastereoselectivity toward the trans product (Scheme 46). Zhang in 2014 reported a gold(I)-catalyzed 5-exo-trig cyclization of N-allyl-N′-phenylurea followed by a gold (III) C-H functionalization to afford indoline products via formal [3 + 2] annulation [163]. Their optimized reaction conditions include [L7AuNTf2] (L7 = (4-CF3C6H4)3P) as a gold (I) source, selectfluor as an oxidant to afford the active species of gold (III) in THF, and water as additive to enhance the solubility of the oxidant in the reaction media. The reaction mechanism starts with a cationic gold (I) that promotes a 5-exo-trig cyclization to afford the formation of the imidazolidin-2-one scaffold. Then, selectfluor acts as an oxidant to result in a species of gold (III) which, through electrophilic aromatic auration, produces the tricyclic indoline scaffold after reductive elimination (Scheme 47).
The effect of gold catalysis in the intramolecular hydroamination of N-allylic ureas to imidazolidin-2-ones has been studied by Widenhoefer et al. [163]. The selected catalytic system involving the use of di-tert-butyl-o-biphenyl phosphine gold(I) chloride and silver hexafluoroantimonate led to the isolation of a wide variety of imidazolidin-2-one derivatives with high diastereoselectivity toward the trans product (Scheme 46). The effect of gold catalysis in the intramolecular hydroamination of N-allylic ureas to imidazolidin-2-ones has been studied by Widenhoefer et al. [162]. The selected catalytic system involving the use of di-tert-butyl-o-biphenyl phosphine gold(I) chloride and silver hexafluoroantimonate led to the isolation of a wide variety of imidazolidin-2-one derivatives with high diastereoselectivity toward the trans product (Scheme 46). Zhang in 2014 reported a gold(I)-catalyzed 5-exo-trig cyclization of N-allyl-N′-phenylurea followed by a gold (III) C-H functionalization to afford indoline products via formal [3 + 2] annulation [163]. Their optimized reaction conditions include [L7AuNTf2] (L7 = (4-CF3C6H4)3P) as a gold (I) source, selectfluor as an oxidant to afford the active species of gold (III) in THF, and water as additive to enhance the solubility of the oxidant in the reaction media. The reaction mechanism starts with a cationic gold (I) that promotes a 5-exo-trig cyclization to afford the formation of the imidazolidin-2-one scaffold. Then, selectfluor acts as an oxidant to result in a species of gold (III) which, through electrophilic aromatic auration, produces the tricyclic indoline scaffold after reductive elimination (Scheme 47). Zhang in 2014 reported a gold(I)-catalyzed 5-exo-trig cyclization of N-allyl-N -phenylurea followed by a gold (III) C-H functionalization to afford indoline products via formal [3 + 2] annulation [164]. Their optimized reaction conditions include [L7AuNTf 2 ] (L7 = (4-CF 3 C 6 H 4 ) 3 P) as a gold (I) source, selectfluor as an oxidant to afford the active species of gold (III) in THF, and water as additive to enhance the solubility of the oxidant in the reaction media. The reaction mechanism starts with a cationic gold (I) that promotes a 5-exo-trig cyclization to afford the formation of the imidazolidin-2-one scaffold. Then, selectfluor acts as an oxidant to result in a species of gold (III) which, through electrophilic aromatic auration, produces the tricyclic indoline scaffold after reductive elimination (Scheme 47).
Very recently, Prestat and Berhal proposed an iron-catalyzed methodology for the construction of an imidazolidin-2-one scaffold [164]. Their approach consists in the anti aminooxygenation of allylbenzoyloxy ureas using iron acetate and phenanthroline as a catalytic system in acetonitrile at 100 degrees (Scheme 48). Several control experiments were performed in order to define the most plausible reaction mechanism, and they found out that both a fused aziridine and a carbocation could represent potential intermediates.

Catalytic Aziridine Ring Expansion
Aziridines represent a very useful and versatile substrate to obtain imidazolidin-2-ones. Some selected reactions and methodologies are reported in this chapter, with particular regard to innovative and catalytic procedures.
Very recently, Prestat and Berhal proposed an iron-catalyzed methodology for the construction of an imidazolidin-2-one scaffold [165]. Their approach consists in the anti aminooxygenation of allylbenzoyloxy ureas using iron acetate and phenanthroline as a catalytic system in acetonitrile at 100 degrees (Scheme 48). Several control experiments were performed in order to define the most plausible reaction mechanism, and they found out that both a fused aziridine and a carbocation could represent potential intermediates. Scheme 47. Gold(I)-catalyzed 5-exo-trig cyclization followed by a gold III C-H functionalization [163].
Very recently, Prestat and Berhal proposed an iron-catalyzed methodology for the construction of an imidazolidin-2-one scaffold [164]. Their approach consists in the anti aminooxygenation of allylbenzoyloxy ureas using iron acetate and phenanthroline as a catalytic system in acetonitrile at 100 degrees (Scheme 48). Several control experiments were performed in order to define the most plausible reaction mechanism, and they found out that both a fused aziridine and a carbocation could represent potential intermediates.

Catalytic Aziridine Ring Expansion
Aziridines represent a very useful and versatile substrate to obtain imidazolidin-2-ones. Some selected reactions and methodologies are reported in this chapter, with particular regard to innovative and catalytic procedures.

Catalytic Aziridine Ring Expansion
Aziridines represent a very useful and versatile substrate to obtain imidazolidin-2-ones. Some selected reactions and methodologies are reported in this chapter, with particular regard to innovative and catalytic procedures.

Palladium-Catalyzed Aziridine Ring Expansion Reactions
To show significant progresses in this field, it is important to refer first to the reactions performed by Alper et al. Vinyl aziridines have been largely utilized as coupling partners in cycloaddition reactions with isocyanates; the vinyl group on the aziridine enhances the reactivity of the aziridine itself. For example, in Pd-catalyzed coupling reactions, the vinyl group enhances the binding of the aziridine substrate, but also in non-metal mediated reactions, the vinyl group is able to favor the reaction, since it is an activating group. In 2000, Alper et al., who had already published the cycloaddition of aziridines and carbodiimides to form imidazolidinimine [166], reported the catalytic preparation of imidazolidin-2-ones by the ring-opening cyclization reaction of 2-vinylaziridines with isocyanates in the presence of palladium acetate and PPh 3 (Scheme 49) [167]. To show significant progresses in this field, it is important to refer first to the reactions performed by Alper et al. Vinyl aziridines have been largely utilized as coupling partners in cycloaddition reactions with isocyanates; the vinyl group on the aziridine enhances the reactivity of the aziridine itself. For example, in Pd-catalyzed coupling reactions, the vinyl group enhances the binding of the aziridine substrate, but also in non-metal mediated reactions, the vinyl group is able to favor the reaction, since it is an activating group. In 2000, Alper et al., who had already published the cycloaddition of aziridines and carbodiimides to form imidazolidinimine [165], reported the catalytic preparation of imidazolidin-2-ones by the ring-opening cyclization reaction of 2vinylaziridines with isocyanates in the presence of palladium acetate and PPh3 (Scheme 49) [166].
The reaction is carried out under very mild conditions, at room temperature and atmospheric pressure, and gives access to a wide array of imidazolidin-2-one derivatives in good yields (34-97%). The proposed mechanism is reported in Scheme 50. A 16-electron palladium-(0) complex reacts with the substituted alkene, leading to a η 3 intermediate III, thanks to the relatively strong coordinating effect of the nitrogen lone pair of the aziridine cycle. The resulting intermediate III displays a strongly nucleophilic nitrogen, which readily reacts with the electrophilic carbon of the isocyanate (or a different heterocumulene used as the partner reagent), giving rise to intermediate IV in equilibrium with V. Two possible five-membered rings can be generated from complexes IV and V respectively, with the regeneration of the palladium(0) complex. The more thermodynamically stable product is obtained by isomerization because of the equilibrium between the ring closing and opening steps. In the absence of palladium, the reaction did not occur under these conditions. Scheme 49. Pd-catalyzed cyclization of 2-vinylaziridines with isocyanates to imidazolidin-2-ones [167].
The reaction is carried out under very mild conditions, at room temperature and atmospheric pressure, and gives access to a wide array of imidazolidin-2-one derivatives in good yields (34-97%). The proposed mechanism is reported in Scheme 50. A 16-electron palladium-(0) complex reacts with the substituted alkene, leading to a η 3 intermediate III, thanks to the relatively strong coordinating effect of the nitrogen lone pair of the aziridine cycle. The resulting intermediate III displays a strongly nucleophilic nitrogen, which readily reacts with the electrophilic carbon of the isocyanate (or a different heterocumulene used as the partner reagent), giving rise to intermediate IV in equilibrium with V. Two possible five-membered rings can be generated from complexes IV and V respectively, with the regeneration of the palladium(0) complex. The more thermodynamically stable product is obtained by isomerization because of the equilibrium between the ring closing and opening steps. In the absence of palladium, the reaction did not occur under these conditions.  Alper observed that using cis-aziridine resulted in a mixture of products containing an approximately 2:1 ratio of cis and trans stereoisomers. The absence of stereospecificity can be explained by the facile interconversion between intermediates IV and V.
First attempts to control the stereochemistry of this reaction by cooling and using bulkier phosphine ligands, such as DPPB (DPPB = 1,4-bis(diphenylphosphino)butane), lead to isomeric mixtures. In 2003 Trost et al. reported the first asymmetric cycloaddition of isocyanates to vinylaziridines (Scheme 51) [168]. Alper observed that using cis-aziridine resulted in a mixture of products containing an approximately 2:1 ratio of cis and trans stereoisomers. The absence of stereospecificity can be explained by the facile interconversion between intermediates IV and V.
First attempts to control the stereochemistry of this reaction by cooling and using bulkier phosphine ligands, such as DPPB (DPPB = 1,4-bis(diphenylphosphino)butane), lead to isomeric mixtures. In 2003 Trost et al. reported the first asymmetric cycloaddition of isocyanates to vinylaziridines (Scheme 51) [167].
In 2004, Alper et al. reported the same asymmetric cycloaddition using BINAP as the ligand and CeCl3 to promote the reaction (Scheme 52) [168].
The use of CeCl3, acting as Lewis acid, improves the enantioselectivity of the reaction, which is carried out using the readily available BINAP ligand. If an alkynyl aziridine, bearing a 2-aminoalkyl moiety, is caused to react with an isocyanate, two different kinds of biheteroaryl compounds can be obtained by a domino cyclization, as reported by Ohno et al. (Scheme 53) [169]. Scheme 53. Domino cyclization of 2-alkynylaziridines bearing a 2-aminoethyl Group via ring expansion with isocyanate [169].
Accurately tuning the conditions (molar ratios, temperatures, and reaction times) allows selectively obtaining the compound containing two five-membered cycles (3) (rt, equimolar ratio of reagents), or the compound containing a seven-membered cycle (4) (−40 °C, excess of isocyanate), resulting from the addition of a second molecule of isocyanate.
Using a relatively short reaction time (one hour), the main product that was isolated is an iminooxazolidine, which isomerizes to the imidazolidinon-2-one, by the action of a nickel catalyst if the reaction is carried out for longer time. The mechanism reported below (Scheme 55) shows the combined cyclization and isomerization pathways. NiI2 plays a very important role, because iodide Scheme 54. Ni-catalyzed reaction of aziridines with isocyanates [171].
Using a relatively short reaction time (one hour), the main product that was isolated is an iminooxazolidine, which isomerizes to the imidazolidinon-2-one, by the action of a nickel catalyst if the reaction is carried out for longer time. The mechanism reported below (Scheme 55) shows the combined cyclization and isomerization pathways. NiI 2 plays a very important role, because iodide anions act as nucleophiles in the first part to break the aziridine cycle, while in the second part, nickel acts as a Lewis acid to promote the isomerization of iminooxazolidine to imidazolidinon-2-one. anions act as nucleophiles in the first part to break the aziridine cycle, while in the second part, nickel acts as a Lewis acid to promote the isomerization of iminooxazolidine to imidazolidinon-2-one.
In 2008, Louie et al. reported on the ring-expansion reaction of vinylaziridines and isocyanates under thermal conditions, using Ni as the catalyst [171]. If no catalyst is added and thermal conditions (100 °C) are used, no imidazolidinon-2-ones are observed, and compounds such as oxazolidinones or seven-membered heterocycles are found in the final reaction mixtures. When a Ni catalyst is used in combination with NHC ligands, good yields and selectivities can be obtained under relatively mild conditions, and a wide variety of imidazolidinon-2-ones is made accessible (Scheme 56).
In 2008, Louie et al. reported on the ring-expansion reaction of vinylaziridines and isocyanates under thermal conditions, using Ni as the catalyst [172]. If no catalyst is added and thermal conditions (100 • C) are used, no imidazolidinon-2-ones are observed, and compounds such as oxazolidinones or seven-membered heterocycles are found in the final reaction mixtures. When a Ni catalyst is used in combination with NHC ligands, good yields and selectivities can be obtained under relatively mild conditions, and a wide variety of imidazolidinon-2-ones is made accessible (Scheme 56). anions act as nucleophiles in the first part to break the aziridine cycle, while in the second part, nickel acts as a Lewis acid to promote the isomerization of iminooxazolidine to imidazolidinon-2-one.
In 2008, Louie et al. reported on the ring-expansion reaction of vinylaziridines and isocyanates under thermal conditions, using Ni as the catalyst [171]. If no catalyst is added and thermal conditions (100 °C) are used, no imidazolidinon-2-ones are observed, and compounds such as oxazolidinones or seven-membered heterocycles are found in the final reaction mixtures. When a Ni catalyst is used in combination with NHC ligands, good yields and selectivities can be obtained under relatively mild conditions, and a wide variety of imidazolidinon-2-ones is made accessible (Scheme 56).

Other Catalytic Aziridine Ring-Expansion Reactions
In 2005, Nadir et al. reported the ring-opening reactions of N-arylsulfonylaziridines with isocyanates in the presence of iodide anions to give 2-imidazolidinones (Scheme 57) [173].

Other Catalytic Aziridine Ring-Expansion Reactions
In 2005, Nadir et al. reported the ring-opening reactions of N-arylsulfonylaziridines with isocyanates in the presence of iodide anions to give 2-imidazolidinones (Scheme 57) [172].
A wide array of enantiomerically pure imidazolidin-2-one-4-carboxylates can be obtained in a one-step, simple, and highly efficient manner using a Lewis acid-catalyzed ring expansion reaction of the commercially available chiral aziridines with isocyanates. These reactions proceed both regiospecifically and stereospecifically with the retention of the configuration at the C-2 of the chiral aziridines.

Non-Catalytic Aziridine Ring-Expansion Reactions
The ring expansion of aziridines to obtain imidazolidin-2-one derivatives may be also carried out using triphosgene and sodium hydride. This methodology has been recently applied with good results by Lee et al. to obtain precursors of aminoacyl-tRNA synthase inhibitors (Scheme 59) [174].
This methodology based on the reaction of triphosgene and sodium hydride with aziridines has been used by the same authors to prepare more general biologically active compounds. The reagents Scheme 57. Iodide-catalyzed reaction of functionalized aziridines with chiral isocyanates [173].

Other Catalytic Aziridine Ring-Expansion Reactions
In 2005, Nadir et al. reported the ring-opening reactions of N-arylsulfonylaziridines with isocyanates in the presence of iodide anions to give 2-imidazolidinones (Scheme 57) [172].
A wide array of enantiomerically pure imidazolidin-2-one-4-carboxylates can be obtained in a one-step, simple, and highly efficient manner using a Lewis acid-catalyzed ring expansion reaction of the commercially available chiral aziridines with isocyanates. These reactions proceed both regiospecifically and stereospecifically with the retention of the configuration at the C-2 of the chiral aziridines.

Non-Catalytic Aziridine Ring-Expansion Reactions
The ring expansion of aziridines to obtain imidazolidin-2-one derivatives may be also carried out using triphosgene and sodium hydride. This methodology has been recently applied with good results by Lee et al. to obtain precursors of aminoacyl-tRNA synthase inhibitors (Scheme 59) [174].
This methodology based on the reaction of triphosgene and sodium hydride with aziridines has been used by the same authors to prepare more general biologically active compounds. The reagents Scheme 58. Lewis acid-catalyzed reaction of functionalized aziridines and isocyanates [174].
A wide array of enantiomerically pure imidazolidin-2-one-4-carboxylates can be obtained in a one-step, simple, and highly efficient manner using a Lewis acid-catalyzed ring expansion reaction of the commercially available chiral aziridines with isocyanates. These reactions proceed both regiospecifically and stereospecifically with the retention of the configuration at the C-2 of the chiral aziridines.

Non-Catalytic Aziridine Ring-Expansion Reactions
The ring expansion of aziridines to obtain imidazolidin-2-one derivatives may be also carried out using triphosgene and sodium hydride. This methodology has been recently applied with good results by Lee et al. to obtain precursors of aminoacyl-tRNA synthase inhibitors (Scheme 59) [175].

Other Catalytic Aziridine Ring-Expansion Reactions
In 2005, Nadir et al. reported the ring-opening reactions of N-arylsulfonylaziridines with isocyanates in the presence of iodide anions to give 2-imidazolidinones (Scheme 57) [172].
A wide array of enantiomerically pure imidazolidin-2-one-4-carboxylates can be obtained in a one-step, simple, and highly efficient manner using a Lewis acid-catalyzed ring expansion reaction of the commercially available chiral aziridines with isocyanates. These reactions proceed both regiospecifically and stereospecifically with the retention of the configuration at the C-2 of the chiral aziridines.

Non-Catalytic Aziridine Ring-Expansion Reactions
The ring expansion of aziridines to obtain imidazolidin-2-one derivatives may be also carried out using triphosgene and sodium hydride. This methodology has been recently applied with good results by Lee et al. to obtain precursors of aminoacyl-tRNA synthase inhibitors (Scheme 59) [174].
This methodology based on the reaction of triphosgene and sodium hydride with aziridines has been used by the same authors to prepare more general biologically active compounds. The reagents Scheme 59. Synthesis of imidazolidinon-2-ones by triphosgene and sodium hydride [175]. This methodology based on the reaction of triphosgene and sodium hydride with aziridines has been used by the same authors to prepare more general biologically active compounds. The reagents can be obtained by the simple addition of benzyl amines to chiral methyl cis-3-aziridin-2-yl-acrylates and the reaction proceeds with high yields and stereoselectivities (Scheme 60) [176]. can be obtained by the simple addition of benzyl amines to chiral methyl cis-3-aziridin-2-yl-acrylates and the reaction proceeds with high yields and stereoselectivities (Scheme 60) [175].

Miscellaneous
Several other methods that could not be grouped in the previous sections are herein described. One interesting approach for the construction of imidazolidin-2-one scaffold features the involvement of the aza-Michael reaction. Wolfe reported a ruthenium-catalyzed cross-metathesis followed by the aza-Michael reaction of N-allyl ureas and α,β unsaturated compounds [177]. The most efficient catalyst is the Hoveyda-Grubbs II in presence of CuI, and this system gave access to different substituted cyclic ureas with a trans diastereoselectivity (Scheme 62). Scheme 62. Cross-metathesis/aza-Michael strategy to access imidazolidin-2-ones [177]. Scheme 60. Formation of imidazolidinon-2-ones by reaction of azyridine derivatives with triphosgene and NaH [176].

Miscellaneous
Several other methods that could not be grouped in the previous sections are herein described. One interesting approach for the construction of imidazolidin-2-one scaffold features the involvement of the aza-Michael reaction. Wolfe reported a ruthenium-catalyzed cross-metathesis followed by the aza-Michael reaction of N-allyl ureas and α,β unsaturated compounds [177]. The most efficient catalyst is the Hoveyda-Grubbs II in presence of CuI, and this system gave access to different substituted cyclic ureas with a trans diastereoselectivity (Scheme 62). Scheme 62. Cross-metathesis/aza-Michael strategy to access imidazolidin-2-ones [177].

Miscellaneous
Several other methods that could not be grouped in the previous sections are herein described. One interesting approach for the construction of imidazolidin-2-one scaffold features the involvement of the aza-Michael reaction. Wolfe reported a ruthenium-catalyzed cross-metathesis followed by the aza-Michael reaction of N-allyl ureas and α,β unsaturated compounds [178]. The most efficient catalyst is the Hoveyda-Grubbs II in presence of CuI, and this system gave access to different substituted cyclic ureas with a trans diastereoselectivity (Scheme 62). can be obtained by the simple addition of benzyl amines to chiral methyl cis-3-aziridin-2-yl-acrylates and the reaction proceeds with high yields and stereoselectivities (Scheme 60) [175].

Miscellaneous
Several other methods that could not be grouped in the previous sections are herein described. One interesting approach for the construction of imidazolidin-2-one scaffold features the involvement of the aza-Michael reaction. Wolfe reported a ruthenium-catalyzed cross-metathesis followed by the aza-Michael reaction of N-allyl ureas and α,β unsaturated compounds [177]. The most efficient catalyst is the Hoveyda-Grubbs II in presence of CuI, and this system gave access to different substituted cyclic ureas with a trans diastereoselectivity (Scheme 62).
The aza-Michael strategy was also applied in the synthesis of enantioenriched β,γ-diamino acid derived imidazolidin-2-ones by Terada [179]. γ-Amino-α,β-unsaturated esters were caused to react with tosyl isocyanates in a formal [3 + 2] cycloaddition using 10% of DIPEA as the catalyst. The reaction evolves with a perfect anti diastereoselectivity and affords the enantioenriched imidazolidin-2-ones with up to 93% of enantiomeric excess.
A similar approach was applied to the desymmetrization of cyclohexadienones with isocyanates in presence of a catalytic amount of DBU (1,.0)undec-7-ene) [180]. The authors reported the synthesis of a broad range of bicyclic imidazolidin-2-ones with high diastereomeric ratios (Scheme 63). The applicability of this protocol was further displayed with a multi-gram scale reaction. The aza-Michael strategy was also applied in the synthesis of enantioenriched β,γ-diamino acid derived imidazolidin-2-ones by Terada [178]. γ-Amino-α,β-unsaturated esters were caused to react with tosyl isocyanates in a formal [3 + 2] cycloaddition using 10% of DIPEA as the catalyst. The reaction evolves with a perfect anti diastereoselectivity and affords the enantioenriched imidazolidin-2-ones with up to 93% of enantiomeric excess.
A similar approach was applied to the desymmetrization of cyclohexadienones with isocyanates in presence of a catalytic amount of DBU (1,.0)undec-7-ene) [179]. The authors reported the synthesis of a broad range of bicyclic imidazolidin-2-ones with high diastereomeric ratios (Scheme 63). The applicability of this protocol was further displayed with a multi-gram scale reaction.
The same base was also employed as a catalyst in the cyclization of β-amino carbamates to promote the formation of the imidazolidin-2-one scaffold [180].
Nowadays, electrochemistry is considered a fundamental tool in order to pursuit a greener and more sustainable chemistry [181]. In the last few years, the imidazolidin-2-one scaffold has been constructed also, taking advantage from an electrochemical methodology. In 2017, Xu et al. published an electrochemical intramolecular oxidative amination [182]. They formed a nitrogen-centered radical via anodic activation that can react with a double bond, generating a carbon-centered radical. This approach proceeds with the oxidation of the radical-centered carbon with the regeneration of the double bond after proton abstraction (Scheme 64).
The same base was also employed as a catalyst in the cyclization of β-amino carbamates to promote the formation of the imidazolidin-2-one scaffold [181].
Nowadays, electrochemistry is considered a fundamental tool in order to pursuit a greener and more sustainable chemistry [182]. In the last few years, the imidazolidin-2-one scaffold has been constructed also, taking advantage from an electrochemical methodology. In 2017, Xu et al. published an electrochemical intramolecular oxidative amination [183]. They formed a nitrogen-centered radical via anodic activation that can react with a double bond, generating a carbon-centered radical. This approach proceeds with the oxidation of the radical-centered carbon with the regeneration of the double bond after proton abstraction (Scheme 64). The aza-Michael strategy was also applied in the synthesis of enantioenriched β,γ-diamino acid derived imidazolidin-2-ones by Terada [178]. γ-Amino-α,β-unsaturated esters were caused to react with tosyl isocyanates in a formal [3 + 2] cycloaddition using 10% of DIPEA as the catalyst. The reaction evolves with a perfect anti diastereoselectivity and affords the enantioenriched imidazolidin-2-ones with up to 93% of enantiomeric excess.
A similar approach was applied to the desymmetrization of cyclohexadienones with isocyanates in presence of a catalytic amount of DBU (1,.0)undec-7-ene) [179]. The authors reported the synthesis of a broad range of bicyclic imidazolidin-2-ones with high diastereomeric ratios (Scheme 63). The applicability of this protocol was further displayed with a multi-gram scale reaction.
The same base was also employed as a catalyst in the cyclization of β-amino carbamates to promote the formation of the imidazolidin-2-one scaffold [180].
Nowadays, electrochemistry is considered a fundamental tool in order to pursuit a greener and more sustainable chemistry [181]. In the last few years, the imidazolidin-2-one scaffold has been constructed also, taking advantage from an electrochemical methodology. In 2017, Xu et al. published an electrochemical intramolecular oxidative amination [182]. They formed a nitrogen-centered radical via anodic activation that can react with a double bond, generating a carbon-centered radical. This approach proceeds with the oxidation of the radical-centered carbon with the regeneration of the double bond after proton abstraction (Scheme 64).
In 2018, Ahmed proposed a similar methodology involving the electrochemical formation of the nitrogen radical followed by cyclization and then radical recombination using TEMPO (Scheme 65) [184]. In 2018, Ahmed proposed a similar methodology involving the electrochemical formation of the nitrogen radical followed by cyclization and then radical recombination using TEMPO (Scheme 65) [183]. Scheme 65. Electrochemical intramolecular amination of N-allylic ureas [183].
Palladium is known to promote olefin isomerization followed by oxidative olefin amination in order to generate anti-imidazolidin-2-ones. In 2013, White reported this strategy [184] in the presence of palladium acetate, using a Lewis acid as an isomerization promoter and an external oxidant to restore the double-bond functionality (Scheme 66).
Aza-Heck reaction, promoted by a palladium species, was applied to N-allyilic, N′-phenoxy ureas to obtain imidazolidin-2-ones bearing an additional double bond (Scheme 67) [185]. This strategy features the use of a cheap and accessible source of palladium(II) and it gives access to free N-H imidazolidinones with a broad substrate scope and functional group tolerance. Scheme 67. Aza-Heck reaction for the synthesis of free N-H imidazolidinones [185]. Different strategies have been developed for the synthesis of benzimidazolidinones. In 2015, Fu et al. proposed a metal-free oxidative C-H amidation of N,N′-diarylureas (Scheme 68) [186]. PhI(OAc)2 acts as inexpensive oxidant to form an N-I bond, which after heterolysis affords a nitrogen cation that is responsible for an intramolecular electrophilic addition on the aromatic ring. Palladium is known to promote olefin isomerization followed by oxidative olefin amination in order to generate anti-imidazolidin-2-ones. In 2013, White reported this strategy [185] in the presence of palladium acetate, using a Lewis acid as an isomerization promoter and an external oxidant to restore the double-bond functionality (Scheme 66). In 2018, Ahmed proposed a similar methodology involving the electrochemical formation of the nitrogen radical followed by cyclization and then radical recombination using TEMPO (Scheme 65) [183]. Scheme 65. Electrochemical intramolecular amination of N-allylic ureas [183].
Palladium is known to promote olefin isomerization followed by oxidative olefin amination in order to generate anti-imidazolidin-2-ones. In 2013, White reported this strategy [184] in the presence of palladium acetate, using a Lewis acid as an isomerization promoter and an external oxidant to restore the double-bond functionality (Scheme 66).
Aza-Heck reaction, promoted by a palladium species, was applied to N-allyilic, N′-phenoxy ureas to obtain imidazolidin-2-ones bearing an additional double bond (Scheme 67) [185]. This strategy features the use of a cheap and accessible source of palladium(II) and it gives access to free N-H imidazolidinones with a broad substrate scope and functional group tolerance. Scheme 67. Aza-Heck reaction for the synthesis of free N-H imidazolidinones [185]. Different strategies have been developed for the synthesis of benzimidazolidinones. In 2015, Fu et al. proposed a metal-free oxidative C-H amidation of N,N′-diarylureas (Scheme 68) [186]. PhI(OAc)2 acts as inexpensive oxidant to form an N-I bond, which after heterolysis affords a nitrogen cation that is responsible for an intramolecular electrophilic addition on the aromatic ring. Scheme 66. Pd-catalyzed olefin isomerization followed by oxidative amination [185].
Aza-Heck reaction, promoted by a palladium species, was applied to N-allyilic, N -phenoxy ureas to obtain imidazolidin-2-ones bearing an additional double bond (Scheme 67) [186]. This strategy features the use of a cheap and accessible source of palladium(II) and it gives access to free N-H imidazolidinones with a broad substrate scope and functional group tolerance. In 2018, Ahmed proposed a similar methodology involving the electrochemical formation of the nitrogen radical followed by cyclization and then radical recombination using TEMPO (Scheme 65) [183]. Scheme 65. Electrochemical intramolecular amination of N-allylic ureas [183].
Palladium is known to promote olefin isomerization followed by oxidative olefin amination in order to generate anti-imidazolidin-2-ones. In 2013, White reported this strategy [184] in the presence of palladium acetate, using a Lewis acid as an isomerization promoter and an external oxidant to restore the double-bond functionality (Scheme 66).
Aza-Heck reaction, promoted by a palladium species, was applied to N-allyilic, N′-phenoxy ureas to obtain imidazolidin-2-ones bearing an additional double bond (Scheme 67) [185]. This strategy features the use of a cheap and accessible source of palladium(II) and it gives access to free N-H imidazolidinones with a broad substrate scope and functional group tolerance. Scheme 67. Aza-Heck reaction for the synthesis of free N-H imidazolidinones [185]. Different strategies have been developed for the synthesis of benzimidazolidinones. In 2015, Fu et al. proposed a metal-free oxidative C-H amidation of N,N′-diarylureas (Scheme 68) [186]. PhI(OAc)2 acts as inexpensive oxidant to form an N-I bond, which after heterolysis affords a nitrogen cation that is responsible for an intramolecular electrophilic addition on the aromatic ring.  [187]. PhI(OAc) 2 acts as inexpensive oxidant to form an N-I bond, which after heterolysis affords a nitrogen cation that is responsible for an intramolecular electrophilic addition on the aromatic ring.  [186].
Rhodium catalysis was investigated for the synthesis of benzimidazolidinones via a double decarbonylation-cycloaddition strategy [187]. The reported methodology involves a formal [5 − 2 + 2] transformation between isatins and isocyanates as coupling partners (Scheme 69). Intensive mechanistic studies confirmed the double-decarbonylative pathway and led to a proposed fourmember rhodium-containing cycle as intermediate, whose formation was allowed by the presence of 3-methyl-2-pyridinyl, which directs the metal insertion. A wide variety of functional groups was tolerated, affording good to excellent yields of benzimidazolidin-2-ones. Scheme 69. Double decarbonylative cycloaddition between isatins and isocyanates [187].
Rhodium catalysis was investigated for the synthesis of benzimidazolidinones via a double decarbonylation-cycloaddition strategy [188]. The reported methodology involves a formal [5 − 2 + 2] transformation between isatins and isocyanates as coupling partners (Scheme 69). Intensive mechanistic studies confirmed the double-decarbonylative pathway and led to a proposed four-member rhodium-containing cycle as intermediate, whose formation was allowed by the presence of 3-methyl-2-pyridinyl, which directs the metal insertion. A wide variety of functional groups was tolerated, affording good to excellent yields of benzimidazolidin-2-ones.  [186].
Rhodium catalysis was investigated for the synthesis of benzimidazolidinones via a double decarbonylation-cycloaddition strategy [187]. The reported methodology involves a formal [5 − 2 + 2] transformation between isatins and isocyanates as coupling partners (Scheme 69). Intensive mechanistic studies confirmed the double-decarbonylative pathway and led to a proposed fourmember rhodium-containing cycle as intermediate, whose formation was allowed by the presence of 3-methyl-2-pyridinyl, which directs the metal insertion. A wide variety of functional groups was tolerated, affording good to excellent yields of benzimidazolidin-2-ones. Scheme 69. Double decarbonylative cycloaddition between isatins and isocyanates [187].

Conclusions
The omnipresence of imidazolidin-2-one structure in natural products, bioactive molecules, and organic intermediates justifies the continuous interest in developing new and more sustainable protocols for their synthesis. In this review, the most exploited catalytic strategies for the construction of 2-imidazolidinone core have been summarized, and the most important aspects of each protocol have been highlighted. To the best of our knowledge, a comprehensive collection on the existing methods for the synthesis of 2-imidazolidinones and 2-benzimidazolidinones is missing in the literature.
Future developments in the field will probably involve the use of less toxic and easily available reagents or less expensive metal catalysts. The discovery of more efficient organocatalysts for their production is also expected. Variously functionalized 2-imidazolidinones and 2-benzimidazolidinones have been successfully synthesized; however, a higher level of molecular complexity can be obtained in the future, taking advantage of sequential reactions.
Funding: This research received no external funding.

Conflicts of Interest:
The authors declare no conflict of interest.