Acid–Base Bifunctional Hf Nanohybrids Enable High Selectivity in the Catalytic Conversion of Ethyl Levulinate to γ -Valerolactone

: The catalytic upgrading of bio-based platform molecules is a promising approach for biomass valorization. However, most solid catalysts are not thermally or chemically stable, and are difficult to prepare. In this study, a stable organic phosphonate–hafnium solid catalyst (PPOA–Hf) was synthesized, and acid–base bifunctional sites were found to play a cooperative role in the cascade transfer hydrogenation and cyclization of ethyl levulinate (EL) to γ -valerolactone (GVL). Under relatively mild reaction conditions of 160 ◦ C for 6 h, EL was completely converted to GVL with a good yield of 85%. The apparent activation energy was calculated to be 53 kJ/mol, which was lower than other solid catalysts for the same reaction. In addition, the PPOA-Hf solid catalyst did not significantly decrease its activity after five recycles, and no evident leaching of Hf was observed, indicating its high stability and potential practical application.


Introduction
Nowadays, with the continuous development of human society, the demand for energy and fine chemicals is increasing [1]. However, the use and gradual depletion of fossil resources need people to face and solve a series of problems, such as environmental pollution, greenhouse effects, and the energy crisis [2]. The development of renewable energy is, thus, highly demanded, where biomass sources are the only sustainable organic carbon feedstock, showing great potential for practical applications [3]. Lignocellulose is abundant in nature and was demonstrated as capable of being efficiently converted to a series of highly valuable chemicals and biofuels through chemo-catalytic reactions coupled with well-designed processes [4,5].
As a biomass-derived versatile platform molecule, γ-valerolactone (GVL) can be used as a green solvent for biomass conversion and organic transformations [6]. In addition, it can be employed for producing biofuels and fuel additives (e.g., 2-methyltetrahydrofuran) [7], and as a key intermediate in the synthesis of fine chemicals (e.g., pentenoic acid and α-methylene-γ-valerolactone (MeGVL)), as shown in Scheme 1 [8,9]. Typically, GVL can be prepared from lignocellulose via sequential catalytic pathways involving various reactions such as hydrolysis, isomerization, dehydration, etherification, esterification, hydrogenation, and lactonization [10][11][12][13][14][15][16]. Amongst these conversion processes, cascade hydrogenation and cyclization were deemed in recent years as the key step in catalytically upgrading levulinic acid and its esters to GVL [17,18]. Organic phosphonates as ligands combined with metal ions can react quickly under liquid-phase conditions to afford corresponding inorganic-organic metal phosphonates with enhanced chemical and thermal stability [35][36][37][38][39][40][41]. Through the coordination of metal ions with organic phosphoric acid, additional micro-and mesopores are introduced into the resulting Catalytic transfer hydrogenation (CTH) is widely used in the reduction of carbonyl compounds, where H 2 gas is replaced by other liquid molecules (e.g., formic acid and alcohols) as hydrogen donors [19][20][21]. It is worth noting that there is a certain requirement for the quality of the used reactor and the catalyst stability to tolerate acidic reaction conditions [22,23]. In this regard, alcohols seem to be a better candidate for CTH. A well-known example, Zr-incorporated zeolites with appropriate Lewis acidity, were reported as able to efficiently catalyze the CTH of biomass-derived carboxides, alike to the Meerwein-Ponndorf-Verley (MPV) reduction [24][25][26].
In the past decade, Zr-based catalysts were reported as efficient for the CTH of levulinic acid and its esters to GVL, and their reactivity is highly dependent on the catalyst composition. For instance, ZrO 2 [27,28], Zr(OH) 4 [29], ZrFeO x [30], Al-Zr [31], Zr-B [32], and ZrOCl 2 [33] need relatively harsh conditions (ca. 200 • C or >6 h) to achieve moderate yields of GVL (Table 1). The stability and catalytic performance can be improved via the incorporation of Zr species into solid supports like SBA-15 (Santa Barbara Amorphous-15); however, it generally involves complicated preparation procedures and relatively high production costs due to the use of expensive template agents [34]. Therefore, it is necessary to overcome these shortcomings by improving the stability of solid catalysts with a facile preparation method. Organic phosphonates as ligands combined with metal ions can react quickly under liquid-phase conditions to afford corresponding inorganic-organic metal phosphonates with enhanced chemical and thermal stability [35][36][37][38][39][40][41]. Through the coordination of metal ions with organic phosphoric acid, additional micro-and mesopores are introduced into the resulting catalysts, thus greatly increasing specific surface areas [42,43], and the catalyst functionalities can be simply tuned by changing the organic ligand or preparation method [44]. In the presented study, a novel and stable inorganic-organic metal phosphonate catalyst (PPOA-Hf) was prepared from phenylphosphonic acid (PPOA) and hafnium (Hf, in the same group as Zr on the periodic table) chloride using a simple assembly method. This acid-base bifunctional solid catalyst was able to efficiently promote the conversion of EL into GVL under mild reaction conditions, and systematic studies were thereby conducted.

Catalyst Characterization
Prior to conducting catalytic reactions, HfO 2 and PPOA-Hf-1:1.5 were characterized using Brunauer-Emmett-Teller (BET), scanning transmission electron microscopy (STEM), transmission electron microscopy (TEM), thermogravimetry (TG), X-ray diffraction (XRD), and pyridine-absorbed infrared (PY-IR) spectroscopy. Compared to HfO 2 having a low surface area (23 m 2 /g) with a large average pore diameter (28.9 nm), PPOA-Hf-1:1.5 was examined to be mesoporous (average pore diameter: 3.4 nm) with a surface area of 215 m 2 /g and a pore volume of 0.16 cm 3 /g using N 2 adsorption-desorption isotherms ( Figures 1A and S1). From the PY-IR spectra in Figure 1B, a characteristic peak can be seen at 1450 cm −1 , which is indicative of Lewis acid sites in PPOA-Hf-1:1.5. Moreover, there were small peaks at 1490 cm −1 and 1520 cm −1 , showing the presence of weak Brønsted acid sites in PPOA-Hf-1:1.5. In contrast, HfO 2 lacks Brønsted acid sites. The hydrogen transfer reaction is typically catalyzed by Lewis acid sites, while Brønsted acid sites present in PPOA-Hf-1:1.5 may promote the adsorption of substrates, as well as the lactonization step. TG analysis was conducted to study the thermal stability of PPOA-Hf and HfO 2 ( Figure 1C). It is interesting to note that less than 10% of the catalyst weight was lost until 400 • C, beyond which PPOA-Hf showed better stability than HfO 2 . Increased weight loss was observed upon reaching 550 • C. This result indicates that the PPOA-Hf catalyst is thermally stable, and can be a good candidate for chemical reactions under thermal conditions. XRD analyses show that the commercial catalyst, HfO 2 , has a good crystalline form (JPCDS # 06-0318), while PPOA-Hf does not have a highly crystalline nature ( Figure 1D), with some broad bands belonging to tetragonal (t) and monoclinic (m) phases. Furthermore, the peak at 2θ = 6 • possibly resulted from the interlayer clearance of the phosphate [45]. catalysts, thus greatly increasing specific surface areas [42,43], and the catalyst functionalities can be simply tuned by changing the organic ligand or preparation method [44]. In the presented study, a novel and stable inorganic-organic metal phosphonate catalyst (PPOA-Hf) was prepared from phenylphosphonic acid (PPOA) and hafnium (Hf, in the same group as Zr on the periodic table) chloride using a simple assembly method. This acid-base bifunctional solid catalyst was able to efficiently promote the conversion of EL into GVL under mild reaction conditions, and systematic studies were thereby conducted.

Catalyst Characterization
Prior to conducting catalytic reactions, HfO2 and PPOA-Hf-1:1.5 were characterized using Brunauer-Emmett-Teller (BET), scanning transmission electron microscopy (STEM), transmission electron microscopy (TEM), thermogravimetry (TG), X-ray diffraction (XRD), and pyridine-absorbed infrared (PY-IR) spectroscopy. Compared to HfO2 having a low surface area (23 m 2 /g) with a large average pore diameter (28.9 nm), PPOA-Hf-1:1.5 was examined to be mesoporous (average pore diameter: 3.4 nm) with a surface area of 215 m 2 /g and a pore volume of 0.16 cm 3 /g using N2 adsorption-desorption isotherms ( Figures 1A and S1). From the PY-IR spectra in Figure 1B, a characteristic peak can be seen at 1450 cm −1 , which is indicative of Lewis acid sites in PPOA-Hf-1:1.5. Moreover, there were small peaks at 1490 cm −1 and 1520 cm −1 , showing the presence of weak Brønsted acid sites in PPOA-Hf-1:1.5. In contrast, HfO2 lacks Brønsted acid sites. The hydrogen transfer reaction is typically catalyzed by Lewis acid sites, while Brønsted acid sites present in PPOA-Hf-1:1.5 may promote the adsorption of substrates, as well as the lactonization step. TG analysis was conducted to study the thermal stability of PPOA-Hf and HfO2 ( Figure 1C). It is interesting to note that less than 10% of the catalyst weight was lost until 400 °C, beyond which PPOA-Hf showed better stability than HfO2. Increased weight loss was observed upon reaching 550 °C. This result indicates that the PPOA-Hf catalyst is thermally stable, and can be a good candidate for chemical reactions under thermal conditions. XRD analyses show that the commercial catalyst, HfO2, has a good crystalline form (JPCDS # 06-0318), while PPOA-Hf does not have a highly crystalline nature ( Figure 1D), with some broad bands belonging to tetragonal (t) and monoclinic (m) phases. Furthermore, the peak at 2θ = 6° possibly resulted from the interlayer clearance of the phosphate [45].  TEM images further confirmed that PPOA-Hf-1:1.5 ( Figure 2A) is non-crystalline when compared with HfO 2 ( Figure 2B), and the detected lamellar structure is consistent with the result (2θ = 6 • ) clarified using XRD ( Figure 1A). Gratifyingly, the particle size of PPOA-Hf-1:1.5 seems to be smaller than that of HfO 2 (Figure 2), due to its amorphous structure. Furthermore, STEM elemental mappings indicate the even and well-connected combination of the organic ligand and Hf ( Figure S2). TEM images further confirmed that PPOA-Hf-1:1.5 ( Figure 2A) is non-crystalline when compared with HfO2 ( Figure 2B), and the detected lamellar structure is consistent with the result (2θ = 6°) clarified using XRD ( Figure 1A). Gratifyingly, the particle size of PPOA-Hf-1:1.5 seems to be smaller than that of HfO2 (Figure 2), due to its amorphous structure. Furthermore, STEM elemental mappings indicate the even and well-connected combination of the organic ligand and Hf ( Figure S2). The base and acid properties of the PPOA-Hf-x catalysts in various molar ratios of PPOA/Hf were determined using CO2-temperature programmed desorption (TPD) and NH3-TPD, respectively. As shown in Figure 3, it can be clearly observed that PPOA-Hf is an acid-base bifunctional catalyst, and the contents of the acid and base sites increase with the increase in Hf relative to PPOA. The Lewis acid and base sites were Hf 4+ and O 2− species, respectively, and their contents increased with the augmentation of Hf, due to the appropriate formation of Hf-O-P. Notably, the acid-base site density remained nearly unchanged after recycling five times (Table S1), indicating that the PPOA-Hf catalyst was stable and reusable. The base and acid properties of the PPOA-Hf-x catalysts in various molar ratios of PPOA/Hf were determined using CO 2 -temperature programmed desorption (TPD) and NH 3 -TPD, respectively. As shown in Figure 3, it can be clearly observed that PPOA-Hf is an acid-base bifunctional catalyst, and the contents of the acid and base sites increase with the increase in Hf relative to PPOA. The Lewis acid and base sites were Hf 4+ and O 2− species, respectively, and their contents increased with the augmentation of Hf, due to the appropriate formation of Hf-O-P. Notably, the acid-base site density remained nearly unchanged after recycling five times (Table S1), indicating that the PPOA-Hf catalyst was stable and reusable.  The strengths of the acid and base sites were investigated using X-ray photoelectron spectroscopy (XPS) analysis, and the results are provided in Figures 4 and S3, and Table S2. Typically, low and high binding energy of O 1s and Hf 4f are indicative of the high strength of both base and acid sites [46]. The binding energy intensity of Hf 4f (Lewis acid) in PPOA-Hf shows the positive charge on the Hf atoms, which resulted in a stronger Lewis acidity with a higher Hf ratio [47]. Furthermore, the binding energy of the O element was also studied, where the lower binding energy of O 1s was correlated with a higher negative charge on the O atom, which resulted in stronger Lewis basicity of O [48]. It is not difficult to see that the strength of acidic and basic sites in the PPOA-Hf-x catalysts is negatively correlated with the increase in PPOA/Hf ratio ( Figure 4). In this respect, both the content and strength of acid-base sites in PPOA-Hf-x can be controlled by adjusting the molar ratio of PPOA/Hf. To clearly elucidate the functional structure of PPOA-Hf-x, Fourier-transform infrared (FT-IR) spectroscopy was conducted, and the spectra are shown in Figure 5. In area A, the peak of Hf-O (500-800 cm −1 ) is clearly visible in the spark line of HfO2. On the other hand, the peaks at 600 cm −1 (corresponding to an aromatic ring) and 700 cm −1 (out-of-plane bending vibration of a C-H bond) decreased sharply with an increase in Hf content, implying the tight combination of hafnium and the organic ligand. Interestingly, with the combination of PPOA and Hf, the positions of the O-H (2400-3200 cm −1 ) bond and the Ph-H (1900-2300 cm −1 ) bond shifted to 3200-3700 cm −1 and 3000-3100 cm −1 , respectively. In addition, the characteristic peaks of the P-O (1000 cm −1 ), C-P (1150-1200 cm −1 ), and C=C (1400-1700 cm −1 ) bonds were all present, indicating the strong connection between the The strengths of the acid and base sites were investigated using X-ray photoelectron spectroscopy (XPS) analysis, and the results are provided in Figures 4 and S3, and Table S2. Typically, low and high binding energy of O 1s and Hf 4f are indicative of the high strength of both base and acid sites [46]. The binding energy intensity of Hf 4f (Lewis acid) in PPOA-Hf shows the positive charge on the Hf atoms, which resulted in a stronger Lewis acidity with a higher Hf ratio [47]. Furthermore, the binding energy of the O element was also studied, where the lower binding energy of O 1s was correlated with a higher negative charge on the O atom, which resulted in stronger Lewis basicity of O [48]. It is not difficult to see that the strength of acidic and basic sites in the PPOA-Hf-x catalysts is negatively correlated with the increase in PPOA/Hf ratio ( Figure 4). In this respect, both the content and strength of acid-base sites in PPOA-Hf-x can be controlled by adjusting the molar ratio of PPOA/Hf.  The strengths of the acid and base sites were investigated using X-ray photoelectron spectroscopy (XPS) analysis, and the results are provided in Figures 4 and S3, and Table S2. Typically, low and high binding energy of O 1s and Hf 4f are indicative of the high strength of both base and acid sites [46]. The binding energy intensity of Hf 4f (Lewis acid) in PPOA-Hf shows the positive charge on the Hf atoms, which resulted in a stronger Lewis acidity with a higher Hf ratio [47]. Furthermore, the binding energy of the O element was also studied, where the lower binding energy of O 1s was correlated with a higher negative charge on the O atom, which resulted in stronger Lewis basicity of O [48]. It is not difficult to see that the strength of acidic and basic sites in the PPOA-Hf-x catalysts is negatively correlated with the increase in PPOA/Hf ratio ( Figure 4). In this respect, both the content and strength of acid-base sites in PPOA-Hf-x can be controlled by adjusting the molar ratio of PPOA/Hf. To clearly elucidate the functional structure of PPOA-Hf-x, Fourier-transform infrared (FT-IR) spectroscopy was conducted, and the spectra are shown in Figure 5. In area A, the peak of Hf-O (500-800 cm −1 ) is clearly visible in the spark line of HfO2. On the other hand, the peaks at 600 cm −1 (corresponding to an aromatic ring) and 700 cm −1 (out-of-plane bending vibration of a C-H bond) decreased sharply with an increase in Hf content, implying the tight combination of hafnium and the organic ligand. Interestingly, with the combination of PPOA and Hf, the positions of the O-H (2400-3200 cm −1 ) bond and the Ph-H (1900-2300 cm −1 ) bond shifted to 3200-3700 cm −1 and 3000-3100 cm −1 , respectively. In addition, the characteristic peaks of the P-O (1000 cm −1 ), C-P (1150-1200 cm −1 ), and C=C (1400-1700 cm −1 ) bonds were all present, indicating the strong connection between the To clearly elucidate the functional structure of PPOA-Hf-x, Fourier-transform infrared (FT-IR) spectroscopy was conducted, and the spectra are shown in Figure 5. In area A, the peak of Hf-O (500-800 cm −1 ) is clearly visible in the spark line of HfO 2 . On the other hand, the peaks at 600 cm −1 (corresponding to an aromatic ring) and 700 cm −1 (out-of-plane bending vibration of a C-H bond) decreased sharply with an increase in Hf content, implying the tight combination of hafnium and the organic ligand. Interestingly, with the combination of PPOA and Hf, the positions of the O-H (2400-3200 cm −1 ) bond and the Ph-H (1900-2300 cm −1 ) bond shifted to 3200-3700 cm −1 and 3000-3100 cm −1 , respectively. In addition, the characteristic peaks of the P-O (1000 cm −1 ), C-P (1150-1200 cm −1 ), and C=C (1400-1700 cm −1 ) bonds were all present, indicating the strong connection between the organic ligand and Hf, and the possible origin of acid and base sites (e.g., Brønsted acid sites: −OH; Lewis acid-base sites: -Hf-O-P-).

Catalytic Performance of PPOA-Hf-x
The catalytic activity of PPOA-Hf-x with various PPOA/Hf molar ratios in the CTH reaction of EL to GVL was investigated at first, and the results are shown in Figure 6. It is obvious that as the ratio of PPOA/Hf changed from 2:1 to 1:1.5, the conversion rate of EL and the yield of GVL increased from 72% and 55% to 100% and 85%, respectively. This tendency is approximately consistent with the content and strength of the acid-base sites (Figures 3 and 4B). However, a further increase in the PPOA/Hf ratio to 1:2 did not improve the yield of GVL, showing that the acidity and basicity of PPOA-Hf-1:1.5 is appropriate for GVL synthesis from EL. Therefore, PPOA-Hf-1:1.5 was considered as the optimal catalyst for subsequent studies.

Catalytic Performance of PPOA-Hf-x
The catalytic activity of PPOA-Hf-x with various PPOA/Hf molar ratios in the CTH reaction of EL to GVL was investigated at first, and the results are shown in Figure 6. It is obvious that as the ratio of PPOA/Hf changed from 2:1 to 1:1.5, the conversion rate of EL and the yield of GVL increased from 72% and 55% to 100% and 85%, respectively. This tendency is approximately consistent with the content and strength of the acid-base sites (Figures 3 and 4B). However, a further increase in the PPOA/Hf ratio to 1:2 did not improve the yield of GVL, showing that the acidity and basicity of PPOA-Hf-1:1.5 is appropriate for GVL synthesis from EL. Therefore, PPOA-Hf-1:1.5 was considered as the optimal catalyst for subsequent studies.

Catalytic Performance of PPOA-Hf-x
The catalytic activity of PPOA-Hf-x with various PPOA/Hf molar ratios in the CTH reaction of EL to GVL was investigated at first, and the results are shown in Figure 6. It is obvious that as the ratio of PPOA/Hf changed from 2:1 to 1:1.5, the conversion rate of EL and the yield of GVL increased from 72% and 55% to 100% and 85%, respectively. This tendency is approximately consistent with the content and strength of the acid-base sites (Figures 3 and 4B). However, a further increase in the PPOA/Hf ratio to 1:2 did not improve the yield of GVL, showing that the acidity and basicity of PPOA-Hf-1:1.5 is appropriate for GVL synthesis from EL. Therefore, PPOA-Hf-1:1.5 was considered as the optimal catalyst for subsequent studies.   In the study of the mechanism, the acid-base sites in PPOA-Hf-1:1.5 played a cooperative role in the reaction of EL to GVL (Scheme 2). Firstly, 2-propanol was activated via combination with the Lewis acid sites (Hf 4+ ) and Lewis base sites (O 2− ) of PPOA-Hf. Concurrently, the carbonyl group in EL was activated via the Lewis acid sites (Hf 4+ ). As a result, a hydrogen transfer reaction was carried out successfully with PPOA-Hf-1:1.5. Subsequently, lactonization occurred via a five-membered ring, which was facilitated by the Brønsted acid. Notably, more than 90% carbon balance was detected for the conversion of EL to GVL. In the study of the mechanism, the acid-base sites in PPOA-Hf-1:1.5 played a cooperative role in the reaction of EL to GVL (Scheme 2). Firstly, 2-propanol was activated via combination with the Lewis acid sites (Hf 4+ ) and Lewis base sites (O 2− ) of PPOA-Hf. Concurrently, the carbonyl group in EL was activated via the Lewis acid sites (Hf 4+ ). As a result, a hydrogen transfer reaction was carried out successfully with PPOA-Hf-1:1.5. Subsequently, lactonization occurred via a five-membered ring, which was facilitated by the Brønsted acid. Notably, more than 90% carbon balance was detected for the conversion of EL to GVL.

Effect of Reaction Time and Temperature
Reaction temperature and time are important parameters for reactivity control in chemical reactions. The effect of reaction temperature (120-180 °C) on the conversion of EL to GVL catalyzed by PPOA-Hf-1:1.5 over 6 h was studied, and the results are shown in Figure 7. Relatively high yield of GVL (ca. 85%) was obtained in 6 h at 160 °C, and in 4 h at 180 °C. Isopropyl levulinate (IPL) was detected as the dominant byproduct, which reduced the selectivity of GVL. From an economic point of view, the optimal reaction conditions should be 160 °C and 6 h.

Effect of Reaction Time and Temperature
Reaction temperature and time are important parameters for reactivity control in chemical reactions. The effect of reaction temperature (120-180 • C) on the conversion of EL to GVL catalyzed by PPOA-Hf-1:1.5 over 6 h was studied, and the results are shown in Figure 7. Relatively high yield of GVL (ca. 85%) was obtained in 6 h at 160 • C, and in 4 h at 180 • C. Isopropyl levulinate (IPL) was detected as the dominant byproduct, which reduced the selectivity of GVL. From an economic point of view, the optimal reaction conditions should be 160 • C and 6 h. In the study of the mechanism, the acid-base sites in PPOA-Hf-1:1.5 played a cooperative role in the reaction of EL to GVL (Scheme 2). Firstly, 2-propanol was activated via combination with the Lewis acid sites (Hf 4+ ) and Lewis base sites (O 2− ) of PPOA-Hf. Concurrently, the carbonyl group in EL was activated via the Lewis acid sites (Hf 4+ ). As a result, a hydrogen transfer reaction was carried out successfully with PPOA-Hf-1:1.5. Subsequently, lactonization occurred via a five-membered ring, which was facilitated by the Brønsted acid. Notably, more than 90% carbon balance was detected for the conversion of EL to GVL.

Effect of Reaction Time and Temperature
Reaction temperature and time are important parameters for reactivity control in chemical reactions. The effect of reaction temperature (120-180 °C) on the conversion of EL to GVL catalyzed by PPOA-Hf-1:1.5 over 6 h was studied, and the results are shown in Figure 7. Relatively high yield of GVL (ca. 85%) was obtained in 6 h at 160 °C, and in 4 h at 180 °C. Isopropyl levulinate (IPL) was detected as the dominant byproduct, which reduced the selectivity of GVL. From an economic point of view, the optimal reaction conditions should be 160 °C and 6 h.  The kinetics of the EL-to-GVL conversion were studied under the assumption of a pseudo first-order reaction, as illustrated in previous reports [49]. In this study, four reaction temperatures of 120 • C (393 K), 140 • C (413 K), 160 • C (433 K), and 180 • C (453 K) were selected. Well-fitted linear curves were obtained by plotting −ln(1−X) (X = EL conversion) with time for various reaction temperatures, as shown in Figure 8A. The apparent activation energy (E a ) was calculated to be 53 kJ/mol according to the Arrhenius equation, after the obtained reaction rate constant (lnk) was plotted with temperature (1/T; Figure 8B). This value is much lower than other previously reported catalytic systems, such as Ti-Beta (69 kJ/mol) [49], Shvo-Ru (69 kJ/mol) [50], and Ru tris(m-sulfonatophenyl)phosphine (61 kJ/mol) [51], indicating that PPOA-Hf-1:1.5 is a more effective and promising solid catalyst for the catalytic conversion of EL to GVL. The kinetics of the EL-to-GVL conversion were studied under the assumption of a pseudo first-order reaction, as illustrated in previous reports [49]. In this study, four reaction temperatures of 120 °C (393 K), 140 °C (413 K), 160 °C (433 K), and 180 °C (453 K) were selected. Well-fitted linear curves were obtained by plotting −ln(1−X) (X = EL conversion) with time for various reaction temperatures, as shown in Figure 8A. The apparent activation energy (Ea) was calculated to be 53 kJ/mol according to the Arrhenius equation, after the obtained reaction rate constant (lnk) was plotted with temperature (1/T; Figure 8B). This value is much lower than other previously reported catalytic systems, such as Ti-Beta (69 kJ/mol) [49], Shvo-Ru (69 kJ/mol) [50], and Ru tris(m-sulfonatophenyl)phosphine (61 kJ/mol) [51], indicating that PPOA-Hf-1:1.5 is a more effective and promising solid catalyst for the catalytic conversion of EL to GVL.

Effect of Catalyst Dosage and Reactivity Comparison with Various Catalysts
In this section, the influence of catalyst dosage was examined (Figure 9). The absence of catalyst led to almost no GVL formed, indicating that the reaction required the participation of the catalyst. When the catalyst dosage increased, the yield of GVL rose accordingly. At a catalyst dosage of 72 mg, both the GVL yield and EL conversion reached a maximum. There was no further increase in GVL yield when more than 72 mg PPOA-Hf-1:1.5 was used, indicating that 72 mg (mass ratio 2:1) is the best catalyst dosage.
For comparison, several oxides and the precursor, PPOA, were used for the catalytic conversion of EL to GVL (Table 2). Weak acids or base oxides, such as SiO2, TiO2, and MgO, had nearly no catalytic activity for the reaction. In contrast, amphoteric oxides, including HfO2, Al2O3, and ZrO2, produced GVL in low yields of 6%, 1%, and 2%, respectively. PPOA, due to its high acidity, could catalyze the conversion of EL into IPL (13% yield). Notably, when a strong base (CaO) was used, a 17% yield of GVL and a 43% yield of IPL were obtained. Considering the above results, it can be deduced that base sites are helpful for GVL synthesis, while potentially resulting in the formation of IPL. On the other hand, strong acids in the absence of Lewis acid species are unable to catalyze the production of GVL, while potentially promoting the cyclization or lactonization steps. Due to the appropriate acid-base site content and strength, PPOA-Hf-1:1.5 can efficiently catalyze the synthesis of GVL (85% yield) from EL, with a yield much higher than other tested catalysts. Moreover, hafnium has stronger metal properties than zirconium. Accordingly, there is a weaker Lewis acid in the Zr-based organic phosphonic acid ligand catalyst (PPOA-Zr-1:1.5), which, when produced using the same method as PPOA-Hf-1:1.5, resulted in PPOA-Zr-1:1.5 showing a relatively poor catalytic performance (Table 2, entry 10).

Effect of Catalyst Dosage and Reactivity Comparison with Various Catalysts
In this section, the influence of catalyst dosage was examined (Figure 9). The absence of catalyst led to almost no GVL formed, indicating that the reaction required the participation of the catalyst. When the catalyst dosage increased, the yield of GVL rose accordingly. At a catalyst dosage of 72 mg, both the GVL yield and EL conversion reached a maximum. There was no further increase in GVL yield when more than 72 mg PPOA-Hf-1:1.5 was used, indicating that 72 mg (mass ratio 2:1) is the best catalyst dosage.

Catalyst Leaching Experiments and Recycling Study
Based on the results of the TG analysis, the catalyst has good thermal stability. To examine the chemical stability of the solid catalyst (PPOA-Hf-1:1.5), a hot filtration experiment was carried out. During the catalytic conversion of EL to GVL, PPOA-Hf-1:1.5 was filtered out after 3 h as soon as the reaction system cooled to ca. 80 °C. Then, the GVL yield was measured per hour for the next three hours. No significant increase in GVL yield was observed (Figure 10), and ICP analysis shows that almost no Hf and P were leached (<0.01 ppm). This result demonstrates that PPOA-Hf-1:1.5 is a heterogeneous catalyst, and is chemically stable in the reaction system. Furthermore, the reusability of the solid catalyst was investigated (Figure 11), and the PPOA-Hf catalyst could be reused five consecutive times without a significant reduction in GVL yield and EL conversion. The IR spectra in Figure 7 show that the reused catalyst kept an intact structure after being recycled five times. In addition, the acid and base activity sites were retained in the reused catalyst, as illustrated by the NH3-TPD and CO2-TPD (Figure 4). These results prove the good reusability of the solid catalyst, PPOA-Hf.

Catalyst Leaching Experiments and Recycling Study
Based on the results of the TG analysis, the catalyst has good thermal stability. To examine the chemical stability of the solid catalyst (PPOA-Hf-1:1.5), a hot filtration experiment was carried out. During the catalytic conversion of EL to GVL, PPOA-Hf-1:1.5 was filtered out after 3 h as soon as the reaction system cooled to ca. 80 • C. Then, the GVL yield was measured per hour for the next three hours. No significant increase in GVL yield was observed (Figure 10), and ICP analysis shows that almost no Hf and P were leached (<0.01 ppm). This result demonstrates that PPOA-Hf-1:1.5 is a heterogeneous catalyst, and is chemically stable in the reaction system. Furthermore, the reusability of the solid catalyst was investigated (Figure 11), and the PPOA-Hf catalyst could be reused five consecutive times without a significant reduction in GVL yield and EL conversion. The IR spectra in Figure 7 show that the reused catalyst kept an intact structure after being recycled five times. In addition, the acid and base activity sites were retained in the reused catalyst, as illustrated by the NH 3 -TPD and CO 2 -TPD ( Figure 4). These results prove the good reusability of the solid catalyst, PPOA-Hf.

Catalyst Preparation
Hafnium phenylphosphonates (PPOA-Hf-x; x denotes the used molar ratio of PPOA to Hf) were prepared from PPOA and HfCl4 with corresponding PPOA/Hf ratios. In a typical procedure

Catalyst Preparation
Hafnium phenylphosphonates (PPOA-Hf-x; x denotes the used molar ratio of PPOA to Hf) were prepared from PPOA and HfCl4 with corresponding PPOA/Hf ratios. In a typical procedure

Catalyst Preparation
Hafnium phenylphosphonates (PPOA-Hf-x; x denotes the used molar ratio of PPOA to Hf) were prepared from PPOA and HfCl 4 with corresponding PPOA/Hf ratios. In a typical procedure for the synthesis of PPOA-Hf-1:1.5, 20 mmol PPOA (0.3162 g) was initially dissolved into 60 mL of N,N-dimethylformamide (DMF) in a Teflon-lined tube, followed by a dropwise addition of 30 mmol HfCl 4 (0.9609 g) under vigorous stirring conditions. After stirring for 20 min, the hydrothermal reactor was sealed and placed into an oven heated to 120 • C, for 24 h. Upon completion, the solid precipitates were separated from the liquid mixture via filtration, then successively washed with DMF (100 mL), ethanol (100 mL), and methanol (100 mL) 2-3 times, and finally, dried at 45 • C overnight to give the catalyst, PPOA-Hf-1:1.5.

Catalyst Characterization Techniques
Brunauer-Emmett-Teller (BET) surface areas of the porous materials were determined from nitrogen physisorption measurements at liquid-nitrogen temperature on a Micromeritics ASAP 2460 instrument (Micromeritics, Norcross, GA, USA). Fourier-transform infrared (FT-IR) spectra were measured by a Thermo Fisher Nicolet iS50 spectrometer (Thermo Fisher Scientific, Waltham, MA, USA) with a wavenumber range of 400-4000 cm −1 . The Lewis and Brønsted acid sites of PPOA-Hf were determined via a vacuum adsorption surface reaction infrared in situ characterization analysis system (Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China) with a Thermo Fisher Nicolet iS50 AEM with a wavenumber range of 1400-1600 cm −1 . Contents of Hf and P species in the reaction system were determined using an inductively coupled plasma-optical emission spectrometer (ICP-OES) on a PerkinElmer Optima 5300 DV (LabX, Midland, Canada). Scanning transmission electron microscopy (STEM) and transmission electron microscopy (TEM) tests were measured using a JEOL 2100 TEM/STEM (JEOL, Akishima, Japan). Particle size distribution was calculated via the Nano Measurer 1.2, Visual Basic 6.0 software. Thermogravimetry (TG) analysis was carried out using a NETZSCH STA 449 F3 Jupiter thermal gravimetric analyzer (NETZSCH, Selb, German). The acidity and basicity of the catalysts were measured by NH 3 -temperature programmed desorption (TPD) and CO 2 -TPD using a Micromeritics AutoChem 2920 chemisorption analyzer (Micromeritics, Norcross, GA, USA). The pyridine adsorption process was carried out at room temperature, followed by heating to 100 • C, and kept for 5 min. Then, the spectrum was obtained after cooling down to room temperature. X-ray photoelectron spectroscopy (XPS) measurements were recorded using a Physical Electronics Quantum 2000 Scanning ESCA Microprobe (Physical Electronics Inc., Chanhassen, MN, USA) equipped with a monochromatic Al Kα anode. The X-ray diffraction (XRD) (Rigaku, Akishima, Japan) data of the powder samples were obtained using a Rigaku International D/max-TTR III X-ray powder diffractometer with Cu Kα radiation, and 2θ scanned from 5 • to 80 • .

Catalytic Activity Measurements
The reactions for the conversion of EL to GVL were all carried out in a 10-mL Teflon-lined autoclave heated by an oil bath. In a general procedure, 1 mmol EL (144 mg), 72 mg of catalyst, and 5 mL of 2-propanol were added into the Teflon-lined reactor. The sealed reaction kettle was then put into the oil bath at a prefixed temperature, and the reaction time was accordingly recorded. After the reaction, the solid catalyst was removed by centrifugation, and the liquid mixture was passed through a filter membrane (0.22 µm) prior to GC and GC-MS analysis.

Product Analysis
Liquid products were identified using an Agilent 6890N GC-MS (Agilent, Santa Clara, CA, USA) with a 5973MS mass spectrometer. For the quantitative analysis of EL and GVL, an Agilent GC7890B equipped with a HP-5 19091J-413 column (30 m × 0.32 mm × 0.25 mm) and a flame ionization detector (FID) was used. an internal standard method was adopted for the quantitative calculation based on standard curves (R 2 > 0.99) of EL and GVL, and naphthalene was used as the internal standard. Substrate conversion (X, %) and product yield (Y, %) were calculated using the following equations: X (%) = [1 − (mole of substrate after reaction)/(mole of initial substrate)] × 100%; (1) Y (%) = (mole of obtained product)/(mole of initial substrate) × 100%.

Catalyst Recycling
After each cycle of reactions, the catalyst was separated by centrifugation from the reaction mixture, successively washed with 10 mL of DMF, ethanol, and methanol, and then dried at 45 • C for 12 h. The resulting solid catalyst was directly used for the next run.

Conclusions
In summary, a stable Hf-containing acid-base bifunctional solid catalyst was prepared, and was determined to be highly efficient for the catalytic conversion of EL to GVL. A high GVL yield of 85% was obtained at 160 • C after 6 h, which was superior to the other tested catalysts. Acid and base sites were found to play a synergistic role in the hydrogenation step, while Brønsted acid species improved the adsorption of the substrate and the lactonization step, thus efficiently promoting the cascade reaction. In addition, the solid catalyst, PPOA-Hf-1.5, had good reusability, with five cycles of use without obvious activity decline.

Conflicts of Interest:
There are no conflicts to declare.