Palladium Nanoparticles Supported on Triphenylphosphine-Functionalized Porous Polymer as an Active and Recyclable Catalyst for the Carbonylation of Chloroacetates

: Dialkyl malonates are important organic intermediates that are widely used as building blocks in organic synthesis. Herein, palladium nanoparticles supported on a triphenylphosphine-functionalized porous polymer were successfully developed as an efﬁcient and recyclable catalyst for the synthesis of dialkyl malonates via the catalytic carbonylation of chloroacetates. The inﬂuence of reaction parameters such as solvent, base, and promoter on activity was carefully investigated. With a 1 mol% of palladium usage, excellent yields of dialkyl malonates were obtained. Importantly, the catalyst can be easily separated and reused at least four times, without a signiﬁcant loss in reactivity. Furthermore, the developed catalyst was also highly active for the alkoxycarbonylation of α -chloro ketones.


Introduction
Carbonylative transformation of organic halides using palladium catalysts represents a versatile method for the synthesis of carboxylic acid and its derivatives [1][2][3][4]. Carbon monoxide, an inexpensive and readily available C 1 building block, is widely used as a carbonyl source for the palladium-catalyzed carbonylation of aryl halides [5][6][7][8][9][10][11][12]. However, except as a cheap carbonyl source, CO could also act as a strong π-acidic ligand for the palladium metal, thus resulting in a decrease of electron density for the palladium center and making the oxidative addition of aryl halide difficult [13,14]. As such, the carbonylation reaction of organic halides is usually more difficult than corresponding non-carbonylative reactions, especially for those reactions where the oxidative addition of the carbon-halide bond is the rate-determining step. Meanwhile, under a CO atmosphere, the palladium atom is easily aggregated, forming the catalytically inactive species [15,16]. To increase the catalytic activity and stability of palladium catalysts in carbonylation reactions, electron-rich ligands are usually needed [17,18].
Homogeneous palladium complexes usually show high catalytic activity and selectivity [1][2][3][4][19][20][21][22]; however, they still suffer from some drawbacks, such as problems of catalyst separation and reuse [23]. Heterogeneous switching of a homogeneous palladium complex by immobilizing the complex or nanoparticle onto the solid support has been expected to address these problems [14][15][16][17][18][19][20][21][22][23][24][25], where traditional polymers and silicas are the most widely used support materials [26]. However, 2 of 12 these traditional supports "anchored" palladium catalysts often suffer from poor stability and inhomogeneously distributed active sites [27]. Moreover, under a CO atmosphere, palladium supported on these traditional supports is easily aggregated, forming catalytically inactive species during the reactions and thus lowering their stability and catalytic activities [16]. Therefore, developing a heterogeneous catalytic system, which has high catalytic activity and an excellent stability, is worthy of further study.
Porous organic polymers (POPs), which feature a high surface area, excellent stabilities, a designable chemical structure, and a flexible synthetic strategy, have attracted tremendous interest recently because of their potential applications in catalysis, adsorption, separation, gas storage, and other fields [28,29]. In recent years, a series of POPs containing a PPh 3 ligand and its derivatives, have been successfully prepared and applied as catalysis supports for immobilizing transition metals [30][31][32][33][34]. Due to the strong interaction between transition metals and phosphine ligands, these catalysts usually exhibit high catalytic activities, long-term reusability, and excellent leaching resistant ability [30][31][32][33][34][35][36][37]. Some of them have even outperformed the activities of their homogeneous analogues [30,[35][36][37]. Although the applications of phosphine functionalized POPs in non-carbonylative cross-coupling reactions of organic halides have been widely investigated in recent years [30,34,36,37], studies of their catalytic applications in the carbonylation of organic halides are relatively unexplored [38].
Dialkyl malonates are important organic intermediates that are widely used as building blocks for the synthesis of vitamins, pharmaceuticals, agrochemicals, and so on [39]. To continue our ongoing efforts for exploring efficient catalysts for the synthesis of dialkyl malonate [40], herein, we reported palladium nanoparticles supported on a triphenylphosphine-functionalized porous polymer (PdNPs@POP-Ph 3 P) as an active and recyclable catalyst for the carbonylation of chloroacetates.

Characterization of the Catalyst
Nitrogen adsorption-desorption analysis of POP-PPh 3 showed that the prepared POP-PPh 3 has a 1146 m 2 ·g −1 BET surface area with a high pore volume (Table 1, entry 1). After immobilization of the palladium metal, the obtained PdNPs@POP-Ph 3 P still preserved a high BET surface area of 987 m 2 ·g −1 and a high pore volume of 1.92 cm 3 /g. The sorption isotherms of the samples ( Figure 1) exhibited combined type I and type IV sorption behaviour. The steep increase at a low relative pressure (P/P 0 < 0.01) indicates the filling of micropores, the hysteresis loop at the relative pressure of 0.7-1.0 implies the presence of mesopores, and the sharp rise at the relative pressure of 0.8-1.0 indicates the presence of macropores. Correspondingly, the pore size distribution curve (inset) of PdNPs@POP-Ph 3 P also indicates its hierarchical pore structure. Table 1. Textural properties of the prepared samples.

Entry
Catalysts SBET (m 2 ·g −1 ) Pore Volume (cm 3 /g) 1 Average Pore Radius (nm) 2 The morphology of POP-Ph3P and PdNPs@POP-Ph3P was further characterized by SEM and TEM. The SEM images in Figure 2a,b suggested that POP-Ph3P and PdNPs@POP-Ph3P were comprised of loosely packed and irregular-shape nanoparticles. A representative TEM image ( Figure  2c) of POP-Ph3P further confirmed the presence of mesopores in the polymer. The TEM image ( Figure  2d) of PdNPs@POP-Ph3P showed the formation of well-dispersed Pd nanoparticles with a relatively narrow size distribution. As depicted in Figure 3, the average diameter of Pd clusters was about 2.9 nm.  The morphology of POP-Ph 3 P and PdNPs@POP-Ph 3 P was further characterized by SEM and TEM. The SEM images in Figure 2a,b suggested that POP-Ph 3 P and PdNPs@POP-Ph 3 P were comprised of loosely packed and irregular-shape nanoparticles. A representative TEM image (Figure 2c) of POP-Ph 3 P further confirmed the presence of mesopores in the polymer. The TEM image (Figure 2d) of PdNPs@POP-Ph 3 P showed the formation of well-dispersed Pd nanoparticles with a relatively narrow size distribution. As depicted in Figure 3, the average diameter of Pd clusters was about 2.9 nm. The morphology of POP-Ph3P and PdNPs@POP-Ph3P was further characterized by SEM and TEM. The SEM images in Figure 2a,b suggested that POP-Ph3P and PdNPs@POP-Ph3P were comprised of loosely packed and irregular-shape nanoparticles. A representative TEM image ( Figure  2c) of POP-Ph3P further confirmed the presence of mesopores in the polymer. The TEM image ( Figure  2d) of PdNPs@POP-Ph3P showed the formation of well-dispersed Pd nanoparticles with a relatively narrow size distribution. As depicted in Figure 3, the average diameter of Pd clusters was about 2.9 nm. FT-IR spectra of 3V-PPh3 and POP-Ph3P are shown in Figure 4. The results revealed that the stretching band of C=C (1627 cm −1 ) disappeared after the polymerization reaction. It indicated that the polymerization of vinyl groups had finished. The characteristic P-Ar stretching vibration (1442 cm −1 ) also suggested the successful incorporation of the phosphine ligand in the polymer [41,42]. XPS analysis was used to study the composition of POP-Ph3P and PdNPs@POP-Ph3P. As shown in Figure 5, P and C elements are present in the two samples. Compared with the POP-Ph3P polymer, an additional Pd band was observed in the XPS full spectrum of PdNPs@POP-Ph3P. The XPS spectrum of Pd 3d revealed that Pd was present in a zero state. As shown in Figure 6a, the binding energy of Pd 3d5/2 was about 334.9 eV, which was about 0.5 eV lower than that of free Pd 0 (335.4 eV) [42]. Simultaneously, the P 2p binding energy of PdNPs@POP-Ph3P was about 0.3 eV higher than that (131.7 eV) of POP-Ph3P (Figure 6b). These results indicated that there was a strong coordination effect between P and Pd nanoparticles [30,36,37]. FT-IR spectra of 3V-PPh 3 and POP-Ph 3 P are shown in Figure 4. The results revealed that the stretching band of C=C (1627 cm −1 ) disappeared after the polymerization reaction. It indicated that the polymerization of vinyl groups had finished. The characteristic P-Ar stretching vibration (1442 cm −1 ) also suggested the successful incorporation of the phosphine ligand in the polymer [41,42]. FT-IR spectra of 3V-PPh3 and POP-Ph3P are shown in Figure 4. The results revealed that the stretching band of C=C (1627 cm −1 ) disappeared after the polymerization reaction. It indicated that the polymerization of vinyl groups had finished. The characteristic P-Ar stretching vibration (1442 cm −1 ) also suggested the successful incorporation of the phosphine ligand in the polymer [41,42]. XPS analysis was used to study the composition of POP-Ph3P and PdNPs@POP-Ph3P. As shown in Figure 5, P and C elements are present in the two samples. Compared with the POP-Ph3P polymer, an additional Pd band was observed in the XPS full spectrum of PdNPs@POP-Ph3P. The XPS spectrum of Pd 3d revealed that Pd was present in a zero state. As shown in Figure 6a, the binding energy of Pd 3d5/2 was about 334.9 eV, which was about 0.5 eV lower than that of free Pd 0 (335.4 eV) [42]. Simultaneously, the P 2p binding energy of PdNPs@POP-Ph3P was about 0.3 eV higher than that (131.7 eV) of POP-Ph3P (Figure 6b). These results indicated that there was a strong coordination effect between P and Pd nanoparticles [30,36,37]. XPS analysis was used to study the composition of POP-Ph 3 P and PdNPs@POP-Ph 3 P. As shown in Figure 5, P and C elements are present in the two samples. Compared with the POP-Ph 3 P polymer, an additional Pd band was observed in the XPS full spectrum of PdNPs@POP-Ph 3 P. The XPS spectrum of Pd 3d revealed that Pd was present in a zero state. As shown in Figure 6a, the binding energy of Pd 3d 5/2 was about 334.9 eV, which was about 0.5 eV lower than that of free Pd 0 (335.4 eV) [42]. Simultaneously, the P 2p binding energy of PdNPs@POP-Ph 3 P was about 0.3 eV higher than that (131.7 eV) of POP-Ph 3 P (Figure 6b). These results indicated that there was a strong coordination effect between P and Pd nanoparticles [30,36,37].

Alkoxycarbonylation Reactions
With the catalyst in hand, we started our investigation with the carbonylation of ethyl chloroacetate (ECA) as a model reaction. Previous results [39,40] showed that the solvent and base have great impacts on the activity and selectivity of this carbonylation reaction. Hence, the effect of solvent and base was first investigated. As shown in Table 2, the reaction was carried out with various solvents (entries 1-9), such as ethanol, anisole, 1,4-dioxane, toluene, and 1,2-diethoxyethane (1,2-DEE). Among them, 1,2-DEE afforded the highest selectivity of diethyl malonate (97.0%), with a high conversion (83.9%) of ethyl chloroacetate (entry 6). Notably, ethanol and THF gave the higher conversions; however, the inferior selectivity of diethyl malonate (DEM) was observed (entries 1 and 9). With 1,2-DEE as the solvent, several bases were screened (entries 10-13). For base screening, Na2HPO4 displayed the best performance (entry 6). For comparison, the commercial Pd/C was also tested under identical reaction conditions. However, Pd/C only provided a 21.3% conversion of ethyl chloroacetate.

Alkoxycarbonylation Reactions
With the catalyst in hand, we started our investigation with the carbonylation of ethyl chloroacetate (ECA) as a model reaction. Previous results [39,40] showed that the solvent and base have great impacts on the activity and selectivity of this carbonylation reaction. Hence, the effect of solvent and base was first investigated. As shown in Table 2, the reaction was carried out with various solvents (entries 1-9), such as ethanol, anisole, 1,4-dioxane, toluene, and 1,2-diethoxyethane (1,2-DEE). Among them, 1,2-DEE afforded the highest selectivity of diethyl malonate (97.0%), with a high conversion (83.9%) of ethyl chloroacetate (entry 6). Notably, ethanol and THF gave the higher conversions; however, the inferior selectivity of diethyl malonate (DEM) was observed (entries 1 and 9). With 1,2-DEE as the solvent, several bases were screened (entries 10-13). For base screening, Na2HPO4 displayed the best performance (entry 6). For comparison, the commercial Pd/C was also tested under identical reaction conditions. However, Pd/C only provided a 21.3% conversion of ethyl chloroacetate.

Alkoxycarbonylation Reactions
With the catalyst in hand, we started our investigation with the carbonylation of ethyl chloroacetate (ECA) as a model reaction. Previous results [39,40] showed that the solvent and base have great impacts on the activity and selectivity of this carbonylation reaction. Hence, the effect of solvent and base was first investigated. As shown in Table 2, the reaction was carried out with various solvents (entries 1-9), such as ethanol, anisole, 1,4-dioxane, toluene, and 1,2-diethoxyethane (1,2-DEE). Among them, 1,2-DEE afforded the highest selectivity of diethyl malonate (97.0%), with a high conversion (83.9%) of ethyl chloroacetate (entry 6). Notably, ethanol and THF gave the higher conversions; however, the inferior selectivity of diethyl malonate (DEM) was observed (entries 1 and 9). With 1,2-DEE as the solvent, several bases were screened (entries 10-13). For base screening, Na 2 HPO 4 displayed the best performance (entry 6). For comparison, the commercial Pd/C was also tested under identical reaction conditions. However, Pd/C only provided a 21.3% conversion of ethyl chloroacetate.
Previous research [39,40] suggested that the iodide promoter could extensively enhance the catalytic activity of this reaction. Therefore, the effect of a promoter was investigated (Table 3). Without any promoter, a 16.5% yield of diethyl malonate was gained (entry 1). Replacing Bu 4 NI with an equal amount of Bu 4 NBr or Bu 4 NCl, a low or non-promotion effect was observed (entries 3 and 4). Notably, with the replacement of Bu 4 NI with Et 4 NI and Me 4 NI, much higher conversions were achieved (entries 5 and 6). In contrast to this, the inorganic KI and NaI afforded relatively low yields, probably due to the low solubility of the reaction solvent (entries 7 and 8). With an optimal promotion in hand, the influence of the amount of Me 4 NI was further studied (entries 9-11). The results showed that a 93.8% conversion of ethyl chloroacetate could be obtained when the molar ratio of Me 4 NI was increased to 15% (entry 10). However, the presence of excess Me 4 NI afforded a little lower yield of diethyl malonate (entry 11). When the reaction time was further prolonged to 9 h, a high yield (94.9%) of diethyl malonate was obtained (entry 12), which was a little bit higher than that of a previously reported homogeneous and colloid catalyst [39,40]. Under the optimal conditions, we tried to lower the CO pressure, while a slight decrease in yield was observed (entry 13).

Alkoxycarbonylation Reactions
With the catalyst in hand, we started our investigation with the carbonylation of ethyl chloroacetate (ECA) as a model reaction. Previous results [39,40] showed that the solvent and base have great impacts on the activity and selectivity of this carbonylation reaction. Hence, the effect of solvent and base was first investigated. As shown in Table 2, the reaction was carried out with various solvents (entries 1-9), such as ethanol, anisole, 1,4-dioxane, toluene, and 1,2-diethoxyethane (1,2-DEE). Among them, 1,2-DEE afforded the highest selectivity of diethyl malonate (97.0%), with a high conversion (83.9%) of ethyl chloroacetate (entry 6). Notably, ethanol and THF gave the higher conversions; however, the inferior selectivity of diethyl malonate (DEM) was observed (entries 1 and 9). With 1,2-DEE as the solvent, several bases were screened (entries 10-13). For base screening, Na2HPO4 displayed the best performance (entry 6). For comparison, the commercial Pd/C was also tested under identical reaction conditions. However, Pd/C only provided a 21.3% conversion of ethyl chloroacetate.    Previous research [39,40] suggested that the iodide promoter could extensively enhance the catalytic activity of this reaction. Therefore, the effect of a promoter was investigated (Table 3). Without any promoter, a 16.5% yield of diethyl malonate was gained (entry 1). Replacing Bu4NI with an equal amount of Bu4NBr or Bu4NCl, a low or non-promotion effect was observed (entries 3 and 4). Notably, with the replacement of Bu4NI with Et4NI and Me4NI, much higher conversions were achieved (entries 5 and 6). In contrast to this, the inorganic KI and NaI afforded relatively low yields, probably due to the low solubility of the reaction solvent (entries 7 and 8). With an optimal promotion in hand, the influence of the amount of Me4NI was further studied (entries 9-11). The results showed that a 93.8% conversion of ethyl chloroacetate could be obtained when the molar ratio of Me4NI was increased to 15% (entry 10). However, the presence of excess Me4NI afforded a little lower yield of diethyl malonate (entry 11). When the reaction time was further prolonged to 9 h, a high yield (94.9%) of diethyl malonate was obtained (entry 12), which was a little bit higher than that of a previously reported homogeneous and colloid catalyst [39,40]. Under the optimal conditions, we tried to lower the CO pressure, while a slight decrease in yield was observed (entry 13). In addition to catalytic activity, the recovery and reusability of the catalyst are also crucial in the evaluation of the economic feasibility of a catalytic process. The reusability and stability of PdNPs@POP-Ph 3 P were evaluated under the optimal conditions. After each run, the catalyst was recovered by centrifugation and washed with 1,2-DEE. The obtained liquid was quantitatively analysed using GC. As shown in Figure 7, the catalyst could be effectively reused at least four times, with only slight loss in its activity. Moreover, ICP analysis suggested that the palladium loading of the recycled PdNPs@POP-Ph 3 P after being reused four times was 1.61 wt%, indicating that 95% of palladium on PdNPs@POP-Ph 3 P was preserved during the recycling. 1 Reaction condition: PdNPs@POP-Ph3P (125 mg, 0.02 mmol Pd), promoter, Na2HPO4 (4 mmol), ethyl chloroacetate (2 mmol), EtOH (4 mmol), 1,2-DEE (3 mL), CO (2 MPa), 80 °C, 8 h, stirring speed (800 rpm). 2 Mole ratio (promoter/ethyl chloroacetate). In addition to catalytic activity, the recovery and reusability of the catalyst are also crucial in the evaluation of the economic feasibility of a catalytic process. The reusability and stability of PdNPs@POP-Ph3P were evaluated under the optimal conditions. After each run, the catalyst was recovered by centrifugation and washed with 1,2-DEE. The obtained liquid was quantitatively analysed using GC. As shown in Figure 7, the catalyst could be effectively reused at least four times, with only slight loss in its activity. Moreover, ICP analysis suggested that the palladium loading of the recycled PdNPs@POP-Ph3P after being reused four times was 1.61 wt%, indicating that 95% of palladium on PdNPs@POP-Ph3P was preserved during the recycling. Then, we turned our focus to the general applicability of this catalytic system ( Table 4). The carbonylation of methyl chloroacetate with methanol could proceed smoothly under the optimized conditions, and an excellent yield (95.8%) of dimethyl malonate was achieved (entry 1). Interestingly, some mixed-alkyl malonates were also prepared in excellent yields under the reaction conditions (entries 2-4), although a competing transesterification reaction with the chloroacetate substrate or with the malonate product was possible. Alkoxycarbonylation of α-chloro ketones represents a valuable alternative for the synthesis of the useful β-keto esters [43]. Considering the similar structure of α-chloro ketones and chloroacetates, the alkoxycarbonylation of α-chloro ketones was also tested under the optimal catalytic system. To our delight, both α-chloroacetone and α-chlorobenzophenone reacted readily, affording corresponding β-keto esters in high yields within 4 h (entries 5-8). Then, we turned our focus to the general applicability of this catalytic system ( Table 4). The carbonylation of methyl chloroacetate with methanol could proceed smoothly under the optimized conditions, and an excellent yield (95.8%) of dimethyl malonate was achieved (entry 1). Interestingly, some mixed-alkyl malonates were also prepared in excellent yields under the reaction conditions (entries 2-4), although a competing transesterification reaction with the chloroacetate substrate or with the malonate product was possible. Alkoxycarbonylation of α-chloro ketones represents a valuable alternative for the synthesis of the useful β-keto esters [43]. Considering the similar structure of α-chloro ketones and chloroacetates, the alkoxycarbonylation of α-chloro ketones was also tested under the optimal catalytic system. To our delight, both α-chloroacetone and α-chlorobenzophenone reacted readily, affording corresponding β-keto esters in high yields within 4 h (entries 5-8).

Preparation of the Porous Polymer (POP-Ph3P)
POP-Ph3P was obtained according to the synthetic procedures reported by the literature [31], with slight modifications. The polymerization reaction was carried out in a stainless-steel autoclave (Teflon-lined). Generally, tris(4-vinylphenyl)phosphane (3V-PPh3, 2.0 g) and AIBN (50 mg) were dissolved in THF (20 mL) in a 100 mL Teflon lining. After replacing air in the Teflon lining with Ar

Preparation of the Porous Polymer (POP-Ph3P)
POP-Ph3P was obtained according to the synthetic procedures reported by the literature [31], with slight modifications. The polymerization reaction was carried out in a stainless-steel autoclave (Teflon-lined). Generally, tris(4-vinylphenyl)phosphane (3V-PPh3, 2.0 g) and AIBN (50 mg) were dissolved in THF (20 mL) in a 100 mL Teflon lining. After replacing air in the Teflon lining with Ar i-PrOH 12

Preparation of the Porous Polymer (POP-Ph3P)
POP-Ph3P was obtained according to the synthetic procedures reported by the literature [31], with slight modifications. The polymerization reaction was carried out in a stainless-steel autoclave (Teflon-lined). Generally, tris(4-vinylphenyl)phosphane (3V-PPh3, 2.0 g) and AIBN (50 mg) were dissolved in THF (20 mL) in a 100 mL Teflon lining. After replacing air in the Teflon lining with Ar

Preparation of the Porous Polymer (POP-Ph3P)
POP-Ph3P was obtained according to the synthetic procedures reported by the literature [31], with slight modifications. The polymerization reaction was carried out in a stainless-steel autoclave (Teflon-lined). Generally, tris(4-vinylphenyl)phosphane (3V-PPh3, 2.0 g) and AIBN (50 mg) were dissolved in THF (20 mL) in a 100 mL Teflon lining. After replacing air in the Teflon lining with Ar

Preparation of the Porous Polymer (POP-Ph3P)
POP-Ph3P was obtained according to the synthetic procedures reported by the literature [31], with slight modifications. The polymerization reaction was carried out in a stainless-steel autoclave (Teflon-lined). Generally, tris(4-vinylphenyl)phosphane (3V-PPh3, 2.0 g) and AIBN (50 mg) were dissolved in THF (20 mL) in a 100 mL Teflon lining. After replacing air in the Teflon lining with Ar

Preparation of the Porous Polymer (POP-Ph3P)
POP-Ph3P was obtained according to the synthetic procedures reported by the literature [31], with slight modifications. The polymerization reaction was carried out in a stainless-steel autoclave (Teflon-lined). Generally, tris(4-vinylphenyl)phosphane (3V-PPh3, 2.0 g) and AIBN (50 mg) were dissolved in THF (20 mL) in a 100 mL Teflon lining. After replacing air in the Teflon lining with Ar

Preparation of the Porous Polymer (POP-Ph3P)
POP-Ph3P was obtained according to the synthetic procedures reported by the literature [31], with slight modifications. The polymerization reaction was carried out in a stainless-steel autoclave (Teflon-lined). Generally, tris(4-vinylphenyl)phosphane (3V-PPh3, 2.0 g) and AIBN (50 mg) were dissolved in THF (20 mL) in a 100 mL Teflon lining. After replacing air in the Teflon lining with Ar

Preparation of the Porous Polymer (POP-Ph3P)
POP-Ph3P was obtained according to the synthetic procedures reported by the literature [31], with slight modifications. The polymerization reaction was carried out in a stainless-steel autoclave (Teflon-lined). Generally, tris(4-vinylphenyl)phosphane (3V-PPh3, 2.0 g) and AIBN (50 mg) were dissolved in THF (20 mL) in a 100 mL Teflon lining. After replacing air in the Teflon lining with Ar i-PrOH 2

Preparation of the Porous Polymer (POP-Ph3P)
POP-Ph3P was obtained according to the synthetic procedures reported by the literature [31], with slight modifications. The polymerization reaction was carried out in a stainless-steel autoclave (Teflon-lined). Generally, tris(4-vinylphenyl)phosphane (3V-PPh3, 2.0 g) and AIBN (50 mg) were dissolved in THF (20 mL) in a 100 mL Teflon lining. After replacing air in the Teflon lining with Ar

Preparation of the Porous Polymer (POP-Ph3P)
POP-Ph3P was obtained according to the synthetic procedures reported by the literature [31], with slight modifications. The polymerization reaction was carried out in a stainless-steel autoclave (Teflon-lined). Generally, tris(4-vinylphenyl)phosphane (3V-PPh3, 2.0 g) and AIBN (50 mg) were dissolved in THF (20 mL) in a 100 mL Teflon lining. After replacing air in the Teflon lining with Ar

Preparation of the Porous Polymer (POP-Ph3P)
POP-Ph3P was obtained according to the synthetic procedures reported by the literature [31], with slight modifications. The polymerization reaction was carried out in a stainless-steel autoclave (Teflon-lined). Generally, tris(4-vinylphenyl)phosphane (3V-PPh3, 2.0 g) and AIBN (50 mg) were dissolved in THF (20 mL) in a 100 mL Teflon lining. After replacing air in the Teflon lining with Ar

Preparation of the Porous Polymer (POP-Ph 3 P)
POP-Ph 3 P was obtained according to the synthetic procedures reported by the literature [31], with slight modifications. The polymerization reaction was carried out in a stainless-steel autoclave (Teflon-lined). Generally, tris(4-vinylphenyl)phosphane (3V-PPh 3 , 2.0 g) and AIBN (50 mg) were dissolved in THF (20 mL) in a 100 mL Teflon lining. After replacing air in the Teflon lining with Ar for 5 min (1 L/min), the Teflon lining was transferred into an autoclave, and heated in an oven at 100 • C for 24 h. After the polymerization reaction, the obtained white solid monolith was washed with ethanol five times, and then dried under vacuum (60 • C).

Preparation of Catalysts
In a typical synthesis, POP-Ph 3 P (1.0 g) was added to 30 mL methanol containing 43 mg of palladium acetate (99%). After stirring at room temperature for 12 h, 10 mL of methanol solution containing 290 mg of NaBH 4 was added into the above solution. The resulting mixture was vigorously stirred for 6 h. PdNPs@POP-Ph 3 P was obtained after filtration and washed with methanol. ICP analysis suggested that the prepared PdNPs@POP-Ph 3 P has a 1.70 wt% palladium loading.

Alkoxycarbonylation of Chloroacetates and Chloracetone
In a 50 mL Teflon-lined stainless-steel autoclave, PdNPs@POP-Ph 3 P (0.02 mmol Pd), Bu 4 NI (0.3 mmol), Na 2 HPO 4 (4 mmol), 1,2-DEE (3 mL), organic chloride (2 mmol), and alcohol (4.0 mmol) were added into the reactor. After purging four times with CO, the autoclave was pressurized with CO to 2.0 MPa. Then, the reaction was reacted at 80 • C for a definite time. After that, the autoclave was cooled to room temperature and carefully depressurized. The catalyst was separated by centrifugation at 8000 rpm for 10 min and washed with 1,2-DEE. The liquid mixture was collected and analyzed qualitatively by GC and GC-MS as reported in the literature [39,40]. All the prepared esters are known products, which we have reported previously [40].

Characterization
Nitrogen physisorption measurements were carried out at 77 K on a Micrometrics ASAP 2020 system (Norcross, USA), and the samples were treated under vacuum at 90 • C for 10 h before the measurements. The surface area and pore size distribution were calculated by the Brunauer-Emmett-Teller (BET) and nonlocal density functional theory (NLDFT) methods, respectively. Fourier transform infrared (FTIR) spectra were recorded on a Bruker Equinox 55 FTIR spectrophotometer (Karlsruhe, Germany). The morphology of the sample was observed with a TESCAN MIRA3 field emission scanning electron microscope (FE-SEM, Brno, Czech) and a FEI Tecnai G2 F30 transmission electron microscope (TEM, Hillsboro, USA). X-ray photoelectron spectroscopy (XPS) experiments were carried out over a VG multilab 2000 spectrometer (Massachusetts, USA) fitted with a Mg-Al Ka X-ray source. The amount of palladium loading and leaching was determined by inductively coupled plasma atomic emission spectroscopy (ICP, PerkinElmer Optima 8000, Massachusetts, USA). Gas chromatography (GC) was performed on a Scientific™ TRACE™ 1310 (Massachusetts, USA) equipped with a TRACE TR-WAX capillary column (Massachusetts, USA) and an FID.

Conclusions
In conclusion, we have developed an active and recyclable catalyst for the synthesis of malonates via the carbonylation of chloroacetates. Under the optimal condition, the solid catalyst displayed high catalytic activity, affording corresponding dialkyl malonates and mixed-alkyl malonates in high yields. Importantly, the catalyst was quite robust, and could be reused four times with only an appreciable leaching of palladium species. Furthermore, the developed catalyst also showed high catalytic activities for the alkoxycarbonylation of α-chloro ketones. Thus, this protocol not only provides an active heterogeneous catalyst for the alkoxycarbonylation of chloroacetates and α-chloro ketones, but also provides some clues to develop efficient heterogeneous catalysts for other carbonylation reactions.