Water : Friend or Foe in Catalytic Hydrogenation ? A Case Study Using Copper Catalysts

Copper oxide supported on alumina and copper chromite were synthesized, characterized, and subsequently tested for their catalytic activity toward the hydrogenation of octanal. Thereafter, the impact of water addition on the conversion and selectivity of the catalysts were investigated. The fresh catalysts were characterized using X-ray diffraction (XRD), BET surface area and pore volume, SEM, TEM, TGA-DSC, ICP, TPR, and TPD. An initial catalytic testing study was carried out using the catalysts to optimize the temperature and the hydrogen-to-aldehyde ratio—which were found to be 160 ◦C and 2, respectively—to obtain the best conversion and selectivity to octanol prior to water addition. Water impact studies were carried out under the same conditions. The copper chromite catalyst showed no deactivation or change in octanol selectivity when water was added to the feed. The alumina-supported catalyst showed no change in conversion, but the octanol selectivity improved marginally when water was added.


Introduction
Catalytic hydrogenation reactions are often used in the chemical industry to convert productswith little commercial importance, obtained from other processes, to products with an increased demand and need in the chemical industry [1].Such reactions find applications in the preparation of pharmaceuticals and fine chemicals [2].Oxygenated compounds, such as aldehydes, are an example of the starting material utilized in catalytic hydrogenation in the fine chemicals sector to produce alcohols.Typically, Ni systems are utilized for aldehyde hydrogenation, however, they sometimes, due to their high activity, lead to abnormal levels of side products, such as esters, acetals, and other aldol condensation type products.Consequently, Cu has been used in certain instances for the hydrogenation of aldehydes or similar compounds to limit such side reaction products [3,4].
However, due to their lower activity, Cu catalysts need to operate at higher temperatures.In industry this may require higher steam pressures in heat exchangers, which are responsible for heating up the feed to the reactors [5].It is possible for these heat exchangers to develop leaks, resulting in water ingress into the reactor via the feed, thus affecting the activity of the catalyst [6].Sometimes, the effect can be detrimental, depending on how much water has ingressed into the reactor.Another source of water could recycle to the hydrogenation reactor when distillation processes upfield of the reactor experience process upsets, for example, reboiler tube leaks [7].In any case, water is certainly a potential problem in any catalytic process, and its effect warrants some investigation [8][9][10].
In regards to copper catalysts, much of the deactivation studies have been focused on catalysts for CO hydrogenation for methanol synthesis, low-temperature water-gas shift, and selective hydrogenation catalysts, amongst others [11][12][13][14].A fundamental question that arises is whether water can actually be identified as a poison or not.In fact, in some hydrogenation reactions, the addition of water enhances the activity [15].Water as a poison is usually associated with the oxidation of the active metal, acceleration of sintering, and even leaching of the active metals [16].
Typically, copper chromite catalysts have been used for hydrogenation applications, however, Cr has been identified as being environmentally unfriendly [17].Nonetheless, copper chromite catalysts are still being used in various catalytic processes globally [4].Thus, various other relatively safer supports have been studied to replace chromium, e.g., alumina [18].However, in so doing, its impact against poisons will also need consideration when compared to copper chromite.
Hence, for this study, as part of our interest in catalyst deactivation and regeneration in catalytic hydrogenation [19], octanal hydrogenation to octanol was used as a model reaction to investigate the influence of water during the hydrogenation process using copper catalysts supported on Al 2 O 3 and as copper chromite, and to ascertain its effect on the octanal conversion and product selectivity.

Catalyst Characterization
The copper loading for each catalyst is listed in Table 1 and was between 24 and 26 wt.%, reasonably close to the nominal loading of 25%.From the BET surface area measurements listed in Table 1, it can be observed that the surface area of CuO/Al 2 O 3 is significantly higher than that of CuCr 2 O 4 .Both the variance in surface area and in crystallite size is ascribed to the manner in which the materials were synthesized, with CuO supported for the alumina material, compared to the particles of co-precipitated CuCr 2 O 4 .S1a-c, respectively, in the Supplementary Information.Individual peaks corresponding to CuO are observed in Figure S1a, however, peaks corresponding to gamma alumina (γ-Al 2 O 3 ) are not seen in the diffractogram [20].This is most probably due to the overlap of these peaks with those of the CuO, since the JCPDS files for each compound list similar d-spacing values.Upon examining the diffractogram of γ-Al 2 O 3 (Figure S1b), broad low-intensity peaks are seen.The position of these peaks coincides with the high-intensity CuO peaks, thus confirming the overlap of these peaks with those of CuO.Peaks corresponding to CuCr 2 O 4 are observed in Figure S1c,confirming this phase as the dominant phase for this catalyst system [21].CuO could not be detected, however, overlapping of the peaks with those of CuCr 2 O 4 does not preclude its presence.
The TPR profiles for CuO/Al 2 O 3 , CuCr 2 O 4 , and unsupported CuO are presented in Figure 1a-c, respectively.The data obtained from these profiles (temperature at maximum and degree of reducibility) are given in Table 2.The reduction peak seen for CuO/Al 2 O 3 (Figure 1a) at 231 • C and the first shoulder peak for CuCr 2 O 4 (Figure 1b) seen at 240 • C correspond to the reduction of dispersed CuO.The reduction peaks at 298 • C and 308 • C, respectively, correspond to the reduction of bulk CuO that interacts with the support [22][23][24].The CuCr 2 O 4 catalyst shows another reduction peak between 400 and 500 • C, which can be ascribed to the bulk reduction of CuCr 2 O 4 .The TPR profile of unsupported CuO (as shown in Figure 1c) displays a reduction peak at 416 • C that corresponds to the reduction of bulk CuO.The broadness of the peak is an indication of the particle size range and the inherent difficulty associated with the reduction of unsupported CuO.From Table 2, it is observed that both catalysts show very similar values with respect to the degree of reducibility, suggesting that the active site density is very similar for both systems.
size range and the inherent difficulty associated with the reduction of unsupported CuO.From Table 2, it is observed that both catalysts show very similar values with respect to the degree of reducibility, suggesting that the active site density is very similar for both systems.The NH3 TPD results of the catalysts indicating acid strength and acid site concentration are presented in Table 3.The acid strength of the catalysts is described by three regions, namely, weak, medium, and strong acid sites over the temperature ranges 200-310 °C, 310-500 °C, and 500-1000 °C, respectively.The data listed in Table 3 show that the alumina-supported CuO has both weak and strong acid sites, whilst CuCr2O4 shows the presence of weak, medium, and strong acid sites.Although the total acidity is higher for CuCr2O4, it is the acid site density of the different regions that is significant for the reactions occurring during the process.The backscattered SEM images for each of the different catalytic systems are presented in Figure 2.For CuO supported on alumina, the backscattered SEM image shows brighter regions, which correspond to CuO particles, and darker/gray regions corresponding to alumina (Figure 2a).The CuO particles are seen to exist as clusters and appear to be present on the surface of the alumina particles.The SEM image for the copper chromite catalyst does not show any distinct morphology.Owing to the synthesis method to prepare this catalyst, it appears quite chunky and irregular.This corresponds  The NH 3 TPD results of the catalysts indicating acid strength and acid site concentration are presented in Table 3.The acid strength of the catalysts is described by three regions, namely, weak, medium, and strong acid sites over the temperature ranges 200-310 • C, 310-500 • C, and 500-1000 • C, respectively.The data listed in Table 3 show that the alumina-supported CuO has both weak and strong acid sites, whilst CuCr 2 O 4 shows the presence of weak, medium, and strong acid sites.Although the total acidity is higher for CuCr 2 O 4 , it is the acid site density of the different regions that is significant for the reactions occurring during the process.The backscattered SEM images for each of the different catalytic systems are presented in Figure 2.For CuO supported on alumina, the backscattered SEM image shows brighter regions, which correspond to CuO particles, and darker/gray regions corresponding to alumina (Figure 2a).The CuO particles are seen to exist as clusters and appear to be present on the surface of the alumina particles.
The SEM image for the copper chromite catalyst does not show any distinct morphology.Owing to the synthesis method to prepare this catalyst, it appears quite chunky and irregular.This corresponds well to the lower surface area obtained for this system.Due to the similarity in atomic number between Cu and Cr, the backscattered SEM image of the catalyst (Figure 2b) provides no unambiguous information.
well to the lower surface area obtained for this system.Due to the similarity in atomic number between Cu and Cr, the backscattered SEM image of the catalyst (Figure 2b) provides no unambiguous information.The TEM images for the catalysts are given in Figure 3.The CuO particles appear spherical or somewhat lobed shaped for both systems, the difference being the particle sizes.Table 1 gives the average particle size obtained from TEM for each of the catalysts, with the alumina-supported catalyst having the smaller average size.
The chromia catalyst has a larger average particle size owing to the synthesis method, and this is also reflected in the surface area.

Catalytic Testing-Water Impact Studies
Water impact studies were carried out at 160 °C and with a hydrogen-to-aldehyde ratio of 2 (H2:octanal, 2:1).These conditions were established in a previous study as the optimum for octanal conversion and octanol selectivity [25].Once steady-state conversion was reached using the fresh feed, the water-spiked feed was introduced to the system.

Effect of Water on the Hydrogenation of Octanal Using CuO/Al2O3
Figure 4 shows the conversion of octanal and the selectivity to octanol when the reaction was carried out using the fresh feed and the water-spiked feed.Prior to water addition, the conversion of octanal reached steady state after 1 h on stream at a value of 99% and remained steady at this value for 30 h.After this time, the water-spiked feed was introduced into the system and the reaction was allowed to proceed for a further 70 h.During this time, the conversion remained at the high level (99%), indicating that the presence of water in the feed did not have a negative impact on the catalyst.The TEM images for the catalysts are given in Figure 3.The CuO particles appear spherical or somewhat lobed shaped for both systems, the difference being the particle sizes.Table 1 gives the average particle size obtained from TEM for each of the catalysts, with the alumina-supported catalyst having the smaller average size.
The chromia catalyst has a larger average particle size owing to the synthesis method, and this is also reflected in the surface area.
well to the lower surface area obtained for this system.Due to the similarity in atomic number between Cu and Cr, the backscattered SEM image of the catalyst (Figure 2b) provides no unambiguous information.The TEM images for the catalysts are given in Figure 3.The CuO particles appear spherical or somewhat lobed shaped for both systems, the difference being the particle sizes.Table 1 gives the average particle size obtained from TEM for each of the catalysts, with the alumina-supported catalyst having the smaller average size.
The chromia catalyst has a larger average particle size owing to the synthesis method, and this is also reflected in the surface area.

Catalytic Testing-Water Impact Studies
Water impact studies were carried out at 160 °C and with a hydrogen-to-aldehyde ratio of 2 (H2:octanal, 2:1).These conditions were established in a previous study as the optimum for octanal conversion and octanol selectivity [25].Once steady-state conversion was reached using the fresh feed, the water-spiked feed was introduced to the system.

Effect of Water on the Hydrogenation of Octanal Using CuO/Al2O3
Figure 4 shows the conversion of octanal and the selectivity to octanol when the reaction was carried out using the fresh feed and the water-spiked feed.Prior to water addition, the conversion of octanal reached steady state after 1 h on stream at a value of 99% and remained steady at this value for 30 h.After this time, the water-spiked feed was introduced into the system and the reaction was allowed to proceed for a further 70 h.During this time, the conversion remained at the high level (99%), indicating that the presence of water in the feed did not have a negative impact on the catalyst.

Catalytic Testing-Water Impact Studies
Water impact studies were carried out at 160 • C and with a hydrogen-to-aldehyde ratio of 2 (H 2 :octanal, 2:1).These conditions were established in a previous study as the optimum for octanal conversion and octanol selectivity [25].Once steady-state conversion was reached using the fresh feed, the water-spiked feed was introduced to the system.

Effect of Water on the Hydrogenation of Octanal Using CuO/Al 2 O 3
Figure 4 shows the conversion of octanal and the selectivity to octanol when the reaction was carried out using the fresh feed and the water-spiked feed.Prior to water addition, the conversion of octanal reached steady state after 1 h on stream at a value of 99% and remained steady at this value for 30 h.After this time, the water-spiked feed was introduced into the system and the reaction was allowed to proceed for a further 70 h.During this time, the conversion remained at the high level (99%), indicating that the presence of water in the feed did not have a negative impact on the catalyst.The selectivity to octanol reached a value of approximately 97% during the first 30 h of the reaction in the absence of water.However, once the water-spiked feed was introduced, the selectivity increased to approximately 98.5% and remained at this value for the duration of the reaction.The selectivity to octanol reached a value of approximately 97% during the first 30 h of the reaction in the absence of water.However, once the water-spiked feed was introduced, the selectivity increased to approximately 98.5% and remained at this value for the duration of the reaction.With the slight increase in the selectivity to octanol, there was a corresponding decrease in the acid/base catalyzed reaction products, such as C16 diol and C24-acetal [26][27][28].It is clear from the results that the presence of water did not oxidize the available Cu during the reaction, considering that the conversion remained unchanged.Wang et al. reported in their study on the hydrogenation of hexanal and propanal using sulfided Ni-Mo/Al2O3 as catalysts that water proved beneficial in improving the selectivity to the alcohols, however, they noticed a decrease in conversion [26].It is surprising, however, that the selectivity to octanol does not decrease owing to the possibility of forming more Brønsted sites with the addition of water.This is reasoned by water interacting with the Brønsted site via hydrogen bonding.The interaction occurs either via one molecule of water or clusters that may have formed, depending on the proximity of the acid sites and the concentration of water on the surface.Similar behavior has been reported for zeolite materials [29].The result of this behavior caused a slight reduction in the total acidity of the catalyst and thus allowed an increase in the octanol selectivity.A more comprehensive list of other byproducts are shown in the Supplementary Information, Figure S2, for one of the data points.

Effect of Water on the Hydrogenation of Octanal Using CuCr2O4
The conversion of octanal and the selectivity to octanol during the hydrogenation of octanal using the fresh feed and the water-spiked feed are shown in Figure 5.The octanal conversion reached 99% over the CuCr2O4 catalyst and remained steady at this value for 26 h.Upon introduction of the water-spiked feed, the conversion remained at 99%.The selectivity to octanol reached approximately 96.3% during the first 31 h of the reaction when using the fresh feed, and after introducing the waterspiked feed, an insignificant increase in selectivity was observed.With the slight increase in the selectivity to octanol, there was a corresponding decrease in the acid/base catalyzed reaction products, such as C16 diol and C24-acetal [26][27][28].It is clear from the results that the presence of water did not oxidize the available Cu during the reaction, considering that the conversion remained unchanged.Wang et al. reported in their study on the hydrogenation of hexanal and propanal using sulfided Ni-Mo/Al 2 O 3 as catalysts that water proved beneficial in improving the selectivity to the alcohols, however, they noticed a decrease in conversion [26].It is surprising, however, that the selectivity to octanol does not decrease owing to the possibility of forming more Brønsted sites with the addition of water.This is reasoned by water interacting with the Brønsted site via hydrogen bonding.The interaction occurs either via one molecule of water or clusters that may have formed, depending on the proximity of the acid sites and the concentration of water on the surface.Similar behavior has been reported for zeolite materials [29].The result of this behavior caused a slight reduction in the total acidity of the catalyst and thus allowed an increase in the octanol selectivity.A more comprehensive list of other byproducts are shown in the Supplementary Information, Figure S2, for one of the data points.

Effect of Water on the Hydrogenation of Octanal Using CuCr 2 O 4
The conversion of octanal and the selectivity to octanol during the hydrogenation of octanal using the fresh feed and the water-spiked feed are shown in Figure 5.The octanal conversion reached 99% over the CuCr 2 O 4 catalyst and remained steady at this value for 26 h.Upon introduction of the water-spiked feed, the conversion remained at 99%.The selectivity to octanol reached approximately 96.3% during the first 31 h of the reaction when using the fresh feed, and after introducing the water-spiked feed, an insignificant increase in selectivity was observed.The major byproduct formed during the reaction with the fresh feed and the water-spiked feed was the C16 diol.The selectivity to the C16 diol when using the fresh feed was about 2%, which remained unchanged when water was introduced.Similarly, all other byproducts showed only minor changes in selectivity after introducing the water-spiked feed into the system.The full selectivity list of byproducts for an arbitrary data point is shown in the Supplementary Information, Figure S3.
For the alumina catalyst, it was observed that the presence of water in the feed stream improved the selectivity to octanol by suppressing the formation of byproducts.However, a key factor favoring this trend is the presence of surface hydroxyls on the catalyst support.A minor increase in the selectivity to octanol was obtained when using CuCr2O4 as the catalyst, indicating that the effect of water on the hydrogenation of octanal was not as pronounced as when CuO/Al2O3 was used as the catalyst.

Used Catalyst Characterization
The diffractograms for Cu/Al2O3 and CuCr2O4after the reaction with the fresh feed and the waterspiked feed are shown in Figures 6 and 7, respectively.These diffractograms show the presence of characteristic copper (Cu 0 ) peaks (JCPDS 4-0836) and some CuO peaks.In addition, the diffractogram for the CuCr2O4 catalyst (Figure 7) reveals peaks attributed to the phases CuCr2O4, Cr2O3, and Cu2O.The full width at half-maximum (FWHM) and the X-ray diffraction (XRD) crystallite size are listed in Table 4.The FWHM for Cu/Al2O3 used for the reaction with the water-spiked feed was negligibly different to the value obtained for the catalyst used for the reaction with the fresh feed, however, a significant change was observed for the CuCr2O4, with an increase of 0.5° for the FWHM of the catalyst used for the reaction with the water-spiked feed.The major byproduct formed during the reaction with the fresh feed and the water-spiked feed was the C16 diol.The selectivity to the C16 diol when using the fresh feed was about 2%, which remained unchanged when water was introduced.Similarly, all other byproducts showed only minor changes in selectivity after introducing the water-spiked feed into the system.The full selectivity list of byproducts for an arbitrary data point is shown in the Supplementary Information, Figure S3.
For the alumina catalyst, it was observed that the presence of water in the feed stream improved the selectivity to octanol by suppressing the formation of byproducts.However, a key factor favoring this trend is the presence of surface hydroxyls on the catalyst support.A minor increase in the selectivity to octanol was obtained when using CuCr 2 O 4 as the catalyst, indicating that the effect of water on the hydrogenation of octanal was not as pronounced as when CuO/Al 2 O 3 was used as the catalyst.

Used Catalyst Characterization
The diffractograms for Cu/Al 2 O 3 and CuCr 2 O 4 after the reaction with the fresh feed and the water-spiked feed are shown in Figures 6 and 7, respectively.These diffractograms show the presence of characteristic copper (Cu 0 ) peaks (JCPDS 4-0836) and some CuO peaks.In addition, the diffractogram for the CuCr 2 O 4 catalyst (Figure 7) reveals peaks attributed to the phases CuCr 2 O 4 , Cr 2 O 3 , and Cu 2 O.The full width at half-maximum (FWHM) and the X-ray diffraction (XRD) crystallite size are listed in Table 4.The FWHM for Cu/Al 2 O 3 used for the reaction with the water-spiked feed was negligibly different to the value obtained for the catalyst used for the reaction with the fresh feed, however, a significant change was observed for the CuCr 2 O 4 , with an increase of 0.5 • for the FWHM of the catalyst used for the reaction with the water-spiked feed.This indicates that the catalyst suffered a loss of crystallinity during the reaction with the waterspiked feed.The average particle size for both catalysts after the reaction with the water-spiked feed was slightly smaller in comparison to the catalyst used for the reaction with the fresh feed.This smaller particle size translated to a higher BET surface area, shown in Table 4, compared to the catalysts prior to testing.It was noted that the average particle size of the catalyst used with the waterfree feed was slightly larger compared to that of the fresh catalyst, yet the BET surface area was higher.This could be attributed to some sintering of the copper allowing the higher-exposed alumina support and, to some extent, the chromite phase, to cause the increase.This indicates that the catalyst suffered a loss of crystallinity during the reaction with the waterspiked feed.The average particle size for both catalysts after the reaction with the water-spiked feed was slightly smaller in comparison to the catalyst used for the reaction with the fresh feed.This smaller particle size translated to a higher BET surface area, shown in Table 4, compared to the catalysts prior to testing.It was noted that the average particle size of the catalyst used with the waterfree feed was slightly larger compared to that of the fresh catalyst, yet the BET surface area was higher.This could be attributed to some sintering of the copper allowing the higher-exposed alumina support and, to some extent, the chromite phase, to cause the increase.This indicates that the catalyst suffered a loss of crystallinity during the reaction with the water-spiked feed.The average particle size for both catalysts after the reaction with the water-spiked feed was slightly smaller in comparison to the catalyst used for the reaction with the fresh feed.This smaller particle size translated to a higher BET surface area, shown in Table 4, compared to the catalysts prior to testing.It was noted that the average particle size of the catalyst used with the water-free feed was slightly larger compared to that of the fresh catalyst, yet the BET surface area was higher.This could be attributed to some sintering of the copper allowing the higher-exposed alumina support and, to some extent, the chromite phase, to cause the increase.The SEM images for Cu/Al 2 O 3 and CuCr 2 O 4 after the reaction with the fresh feed and the water-spiked feed are shown in Figures 8 and 9, respectively.These images show minor differences in the morphology of the used catalyst between Cu/Al 2 O 3 and CuCr 2 O 4 used for the reaction with the fresh feed and the water-spiked feed.This shows that the catalysts were robust to the water, showing no signs of breakage.The EDS composition scanning map data for Cu/Al 2 O 3 and CuCr 2 O 4 after the reaction with the fresh feed and the water-spiked feed are shown in Figures S4-S7 in the Supplementary Information, respectively.These maps show that the distribution of the Cu-rich particles is relatively similar for the catalysts after exposure to both the feeds.However, a change in the morphology of the Cu/Al 2 O 3 catalyst could possibly have occurred, thus also influencing the selectivity in that way.The SEM images for Cu/Al2O3 and CuCr2O4 after the reaction with the fresh feed and the waterspiked feed are shown in Figures 8 and 9, respectively.These images show minor differences in the morphology of the used catalyst between Cu/Al2O3 and CuCr2O4 used for the reaction with the fresh feed and the water-spiked feed.This shows that the catalysts were robust to the water, showing no signs of breakage.The EDS composition scanning map data for Cu/Al2O3 and CuCr2O4 after the reaction with the fresh feed and the water-spiked feed are shown in Figures S4-S7 in the Supplementary Information, respectively.These maps show that the distribution of the Cu-rich particles is relatively similar for the catalysts after exposure to both the feeds.However, a change in the morphology of the Cu/Al2O3 catalyst could possibly have occurred, thus also influencing the selectivity in that way.The SEM images for Cu/Al2O3 and CuCr2O4 after the reaction with the fresh feed and the waterspiked feed are shown in Figures 8 and 9, respectively.These images show minor differences in the morphology of the used catalyst between Cu/Al2O3 and CuCr2O4 used for the reaction with the fresh feed and the water-spiked feed.This shows that the catalysts were robust to the water, showing no signs of breakage.The EDS composition scanning map data for Cu/Al2O3 and CuCr2O4 after the reaction with the fresh feed and the water-spiked feed are shown in Figures S4-S7 in the Supplementary Information, respectively.These maps show that the distribution of the Cu-rich particles is relatively similar for the catalysts after exposure to both the feeds.However, a change in the morphology of the Cu/Al2O3 catalyst could possibly have occurred, thus also influencing the selectivity in that way.

Materials and Methods
The method of co-precipitation was used to synthesize CuCr 2 O 4 and the wet impregnation method was used to prepare CuO/Al 2 O 3 .The syntheses of the catalysts were carried out using modifications of the method of Gredig et al. [30] and Bando et al. [31].
The CuCr 2 O 4 catalyst was synthesized from metal nitrate solutions with sodium hydroxide (NaOH) at a constant temperature of 298 K and at a pH of approximately 7. The metal nitrate solutions were added dropwise to a round-bottomed flask containing distilled water under vigorous stirring.At the same time, 2 M NaOH was added dropwise to regulate the pH and assist in precipitation.The slurry was aged for half an hour at room temperature and constant pH (7).The resulting precipitate was filtered, washed with distilled water, and dried overnight at 120 • C. The dried catalyst was crushed and thereafter calcined in air for 8 h at 550 • C. For the alumina-supported catalyst, a copper nitrate solution was prepared by dissolving the required amount of copper nitrate in sufficient water to allow dissolution of the metal salt.The solution was then added to the catalyst support under stirring.The slurry obtained was stirred for 24 h.There after, the water was slowly evaporated by gentle heating with vigorous stirring.resulting solid obtained was oven-dried overnight at 120 • C and thereafter calcined in air for 8 h at 600 • C (alumina catalyst).The catalysts were pelletized and sieved to a particle size of 300-600 microns.
X-ray diffraction (XRD) diffractograms were obtained using a Bruker D8 ADVANCE X-ray diffractometer (Bruker, Karlsruhe, Germany) employing Cu K α radiation (λ = 1.5418Å).Prior to the SEM and EDS analyses, the samples were mounted on an aluminium stub using double-sided carbon tape and subsequently gold sputter-coated using a Polaron E5100 coating unit and carbon-coated using a Jeol JEE-4C vacuum evaporator (Joel, Peabody, MA, USA)for the SEM and EDS analyses, respectively.The secondary (normal) and backscattered SEM images were viewed on a Leo 1450 scanning electron microscope (Carl Zeiss AG, Oberkochen, Germany).The EDS composition scanning and certain secondary images were done on a Jeol JSM-6100 scanning microscope (Joel, Peabody, MA, USA) fitted with a Bruker EDX detector.The TEM images were viewed on a Jeol JEM-1010 electron microscope (Joel, Peabody, MA, USA).The elemental composition of the catalysts was determined by ICP-OES on a Perkin Elmer Precisely Optical Emission Spectrometer Optima 5300 DV (PerkinElmer, Shelton, CT, USA).Prior to analysis, the catalyst samples were digested with concentrated nitric acid.The specific surface area and pore volumes of the catalyst were obtained by using the BET nitrogen physisorption analysis using a Micrometrics Gemini instrument (Micrometrics, Atlanta, GA, USA) with nitrogen adsorbate at −196 • C. TPR and TPD were carried out on a Micrometrics Autochem II Chemisorption Analyzer (Micrometrics, Atlanta, GA, USA).Prior to both analyses, the samples were pre-treated with argon flowing at a rate of 30 mL/min, upto 350 • C, at a rate of 20 • C/min.For the H 2 -TPR, the pre-treated sample was then subjected to 5% H 2 in argon flowing at a rate of 30 mL/min, whilst the temperature was linearly increased from 90 • C to 600 • C at a rate of 10 • C/min.The hydrogen consumption was monitored by a thermal conductivity detector.For the NH 3 -TPD, the pre-treated sample was reduced with 5% H 2 in argon and thereafter treated with helium for 1 h to remove excess hydrogen.A 4% NH 3 in helium gas mixture was then passed through the system and allowed to adsorb onto the surface of the catalyst for half an hour.Helium gas was then passed through at a flow rate of 30 mL/min, whilst the temperature was linearly increased from 100 • C to 1000 • C at a rate of 10 • C/min.The amount of ammonia desorbed was monitored using a thermal conductivity detector.
The hydrogenation reaction was carried out using a fixed bed reactor.A stainless-steel (grade 316) tube with an inner diameter of 15 mm and a length of 325 mm was used as the reactor tube.The amount of gas entering the reactor was controlled by means of Brooks's mass flow meters (0-300 mL/min) (Brooks Instruments, Hatfield, PA, USA), which were calibrated before use.The liquid feed was introduced to the reactor by means of a LabAlliance Series II isocratic HPLC pump (ASI, Richmond, CA, USA).Due to the high exotherm associated with the hydrogenation of octanal, a 10 wt.% octanal in octanol (diluent) feed was used as the fresh feed, whilst for the water impact

Figure 4 .
Figure 4. Conversion of octanal and the selectivity to octanol for the hydrogenation of octanal using the fresh feed and the water-spiked feed over CuO/Al2O3.(60 bars, 160 °C, H2:octanal ratio of 2:1).

Figure 4 .
Figure 4. Conversion of octanal and the selectivity to octanol for the hydrogenation of octanal using the fresh feed and the water-spiked feed over CuO/Al 2 O 3 .(60 bars, 160 • C, H 2 :octanal ratio of 2:1).

Figure 6 .
Figure 6.Diffractogram of the used Cu/Al2O3 after the reaction with fresh feed only and water-spiked feed.

Figure 7 .
Figure 7. Diffractogram of the used CuCr2O4after the reaction with fresh feed only and water-spiked feed.

Figure 6 .
Figure 6.Diffractogram of the used Cu/Al 2 O 3 after the reaction with fresh feed only and water-spiked feed.

Figure 6 .
Figure 6.Diffractogram of the used Cu/Al2O3 after the reaction with fresh feed only and water-spiked feed.

Figure 7 .
Figure 7. Diffractogram of the used CuCr2O4after the reaction with fresh feed only and water-spiked feed.

Figure 7 .
Figure 7. Diffractogram of the used CuCr 2 O 4 after the reaction with fresh feed only and water-spiked feed.

Figure 8 .
Figure 8. SEM image of Cu/Al2O3 after (a) the reaction with fresh feed and (b) reaction with the waterspiked feed.

Figure 9 .
Figure 9. SEM image of CuCr2O4 after (a) the reaction with fresh feed and (b) reaction with the waterspiked feed.

Figure 8 .
Figure 8. SEM image of Cu/Al 2 O 3 after (a) the reaction with fresh feed and (b) reaction with the water-spiked feed.

Figure 8 .
Figure 8. SEM image of Cu/Al2O3 after (a) the reaction with fresh feed and (b) reaction with the waterspiked feed.

Figure 9 .
Figure 9. SEM image of CuCr2O4 after (a) the reaction with fresh feed and (b) reaction with the waterspiked feed.

Figure 9 .
Figure 9. SEM image of CuCr 2 O 4 after (a) the reaction with fresh feed and (b) reaction with the water-spiked feed.
a Pore volume of alumina in parenthesis.The diffractograms for CuO/Al 2 O 3 , Al 2 O 3 , and CuCr 2 O 4 are shown in Figure

Table 2 .
List of temperature at maximum (Tm) and degree of reduction of Cu, as determined by H2-TPR.

Table 3 .
The acid strength and acidity of each catalyst.

Table 2 .
List of temperature at maximum (Tm) and degree of reduction of Cu, as determined by H 2 -TPR.

Table 3 .
The acid strength and acidity of each catalyst.

Table 4 .
Full width at half-maximum (FWHM) values and the crystallite size of the highest-intensity Cu peak for each catalyst and BET surface area after the reaction using fresh feed and water-spiked feed.

Table 4 .
Full width at half-maximum (FWHM) values and the crystallite size of the highest-intensity Cu peak for each catalyst and BET surface area after the reaction using fresh feed and water-spiked feed.

Table 4 .
Full width at half-maximum (FWHM) values and the crystallite size of the highest-intensity Cu peak for each catalyst and BET surface area after the reaction using fresh feed and water-spiked feed.