A Reusable Palladium / Cationic 2 , 2 ′-Bipyridyl System-Catalyzed Double Mizoroki-Heck Reaction in Water

Abstract: A reusable PdCl2(NH3)2/cationic 2,2′-bipyridyl system was used to catalyze the double Mizoroki-Heck reaction of aryl iodides with electron-deficient alkenes in water in the absence of inert gas, giving β,β-diarylated carbonyl derivatives in good to excellent yields. The formation of unsymmetrical β,β-diarylated alkenes were also studied by coupling aryl iodides with the corresponding aryl-substituted α,β-unsaturated carbonyl compounds. This water-soluble catalyst can be swiftly separated from the organic layer using simple extraction for the further reuse, and, thus, makes it an operationally-simple and environmentally-benign procedure.

We have recently reported that the PdCl 2 (NH 3 ) 2 /cationic 2,2 -bipyridyl catalytic system can very efficiently catalyze monoarylation of activated olefins using water as a solvent [50].Based on these results, we slightly modified the reaction conditions in order to study the double Mizoroki-Heck reaction using the same catalytic system.This water-soluble catalyst can be swiftly separated from organic products and reactants, by simple extraction, for further reuse runs (Scheme 1).
Catalysts 2017, 7, 177 2 of 11 and tert-butyl acrylate has been performed; no reuse or recycling study has been performed for this water-soluble oxime-derived palladacycle catalyst [48,49].Thus, the development of a recyclable or reusable procedure for the double Mizoroki-Heck reaction, using water as the medium, is highly valuable to approach the goal of practical application.
We have recently reported that the PdCl2(NH3)2/cationic 2,2′-bipyridyl catalytic system can very efficiently catalyze monoarylation of activated olefins using water as a solvent [50].Based on these results, we slightly modified the reaction conditions in order to study the double Mizoroki-Heck reaction using the same catalytic system.This water-soluble catalyst can be swiftly separated from organic products and reactants, by simple extraction, for further reuse runs (Scheme 1).Scheme 1. Reusable Pd(II)/cationic 2,2′-bipyridyl-catalyzed double Mizoroki-Heck reaction in water.

Results and Discussion
As shown in Entry 1 of Table 1, with the treatment of iodobenzene 1a (2.5 mmol) with n-butyl acrylate 2a (1.0 mmol), in the presence of PdCl2(NH3)2/cationic 2,2′-bipyridyl (1 mol %) and Bu3N (2.5 mmol) in H2O (2 mL), at 140 °C for 24 h, the double Mizoroki-Heck product, 3a, was isolated in a 95% yield after extracting the reaction mixture with hexane/EtOAc (1/1, 3 × 3 mL) and purifying using column chromatography.The reuse of the residual aqueous solution provided a 90% yield of 3a when the same reactants and base were recharged, and the process was conducted under identical conditions.Moreover, an 84% yield could still be obtained in the second reuse run (Entry 1).These reuse studies indicated that this catalytic system is stable in an aqueous solution under air, and can be separated from the organic phase using simple extraction.Although the leaching of Pd into the organic layer was not found by ICP-MASS (inductively coupled plasma mass spectrometry) analysis, the gradual loss of catalyst activity due to consecutive extractions, or the formation of a small portion of Pd black in the aqueous phase, which was invisible to the naked eye, cannot be excluded.Under identical conditions, aryl iodides, containing electron-withdrawing groups at the 4-position, such as 1b and 1c, gave slightly lower yields of β,β-diarylated products (Entries 2 and 3).It was previously reported that 4-substituted aryl iodides, with strong electron-withdrawing groups, such as NO2and CF3-, make the second Mizoroki-Heck reaction inert [25,33].As a result, the employment of such functional groups in our catalytic system only delivered mono-arylated products in near quantitative yields.Electron-donating aryl iodides, 1d and 1e, β,β-diarylated to 2a smoothly, which furnish 3d and 3e in excellent yields in the initial runs; over 70% yields can be reached in the second reuse runs (Entries 4 and 5).3-substituted aryl iodides, 1f and 1g, possessed no electronic and steric effects on arylation; therefore, similar results to 1a were observed (Entries 6 and 7).A dramatic decrease in the yield of the double Mizoroki-Heck reaction was found with the use of sterically-congested 1h and 1i, which afforded 3h and 3i in only 60% and 68% yields, respectively, in the initial run.However, the residual aqueous solution was still active; thus, further reuse studies provided the corresponding products in good yields (Entries 8 and 9).
With respect to aryl bromides, we found that only strongly-activated aryl bromides could be utilized for the mono Mizoroki-Heck reaction in the presence of tetrabutylammonium bromide [50].Unfortunately, double Mizoroki-Heck coupling failed when these aryl bromides were used [25,33].Similar results to aryl bromides were observed when aryl triflates were employed as the aryl halide partner in this catalytic system.Scheme 1. Reusable Pd(II)/cationic 2,2 -bipyridyl-catalyzed double Mizoroki-Heck reaction in water.

Results and Discussion
As shown in Entry 1 of Table 1, with the treatment of iodobenzene 1a (2.5 mmol) with n-butyl acrylate 2a (1.0 mmol), in the presence of PdCl 2 (NH 3 ) 2 /cationic 2,2 -bipyridyl (1 mol %) and Bu 3 N (2.5 mmol) in H 2 O (2 mL), at 140 • C for 24 h, the double Mizoroki-Heck product, 3a, was isolated in a 95% yield after extracting the reaction mixture with hexane/EtOAc (1/1, 3 × 3 mL) and purifying using column chromatography.The reuse of the residual aqueous solution provided a 90% yield of 3a when the same reactants and base were recharged, and the process was conducted under identical conditions.Moreover, an 84% yield could still be obtained in the second reuse run (Entry 1).These reuse studies indicated that this catalytic system is stable in an aqueous solution under air, and can be separated from the organic phase using simple extraction.Although the leaching of Pd into the organic layer was not found by ICP-MASS (inductively coupled plasma mass spectrometry) analysis, the gradual loss of catalyst activity due to consecutive extractions, or the formation of a small portion of Pd black in the aqueous phase, which was invisible to the naked eye, cannot be excluded.Under identical conditions, aryl iodides, containing electron-withdrawing groups at the 4-position, such as 1b and 1c, gave slightly lower yields of β,β-diarylated products (Entries 2 and 3).It was previously reported that 4-substituted aryl iodides, with strong electron-withdrawing groups, such as NO 2 -and CF 3 -, make the second Mizoroki-Heck reaction inert [25,33].As a result, the employment of such functional groups in our catalytic system only delivered mono-arylated products in near quantitative yields.Electron-donating aryl iodides, 1d and 1e, β,β-diarylated to 2a smoothly, which furnish 3d and 3e in excellent yields in the initial runs; over 70% yields can be reached in the second reuse runs (Entries 4 and 5).3-substituted aryl iodides, 1f and 1g, possessed no electronic and steric effects on arylation; therefore, similar results to 1a were observed (Entries 6 and 7).A dramatic decrease in the yield of the double Mizoroki-Heck reaction was found with the use of sterically-congested 1h and 1i, which afforded 3h and 3i in only 60% and 68% yields, respectively, in the initial run.However, the residual aqueous solution was still active; thus, further reuse studies provided the corresponding products in good yields (Entries 8 and 9).
With respect to aryl bromides, we found that only strongly-activated aryl bromides could be utilized for the mono Mizoroki-Heck reaction in the presence of tetrabutylammonium bromide [50].Unfortunately, double Mizoroki-Heck coupling failed when these aryl bromides were used [25,33].Similar results to aryl bromides were observed when aryl triflates were employed as the aryl halide partner in this catalytic system.The utility of this reaction protocol for cyclohexyl acrylate, 2b, was then evaluated (Table 2).β,βdiarylation of 1a onto 2b took place to afford excellent yields in the initial and reuse runs (Entry 1).However, 1b and 1c furnished yields of 4b and 4c between 61% and 78% (Entries 2 and 3).As   The utility of this reaction protocol for cyclohexyl acrylate, 2b, was then evaluated (Table 2).β,βdiarylation of 1a onto 2b took place to afford excellent yields in the initial and reuse runs (Entry 1).However, 1b and 1c furnished yields of 4b and 4c between 61% and 78% (Entries 2 and 3).As   The utility of this reaction protocol for cyclohexyl acrylate, 2b, was then evaluated (Table 2).β,βdiarylation of 1a onto 2b took place to afford excellent yields in the initial and reuse runs (Entry 1).However, 1b and 1c furnished yields of 4b and 4c between 61% and 78% (Entries 2 and 3).As   The utility of this reaction protocol for cyclohexyl acrylate, 2b, was then evaluated (Table 2).β,βdiarylation of 1a onto 2b took place to afford excellent yields in the initial and reuse runs (Entry 1).However, 1b and 1c furnished yields of 4b and 4c between 61% and 78% (Entries 2 and 3).As   The utility of this reaction protocol for cyclohexyl acrylate, 2b, was then evaluated (Table 2).β,βdiarylation of 1a onto 2b took place to afford excellent yields in the initial and reuse runs (Entry 1).However, 1b and 1c furnished yields of 4b and 4c between 61% and 78% (Entries 2 and 3).As   The utility of this reaction protocol for cyclohexyl acrylate, 2b, was then evaluated (Table 2).β,βdiarylation of 1a onto 2b took place to afford excellent yields in the initial and reuse runs (Entry 1).However, 1b and 1c furnished yields of 4b and 4c between 61% and 78% (Entries 2 and 3).As   The utility of this reaction protocol for cyclohexyl acrylate, 2b, was then evaluated (Table 2).β,βdiarylation of 1a onto 2b took place to afford excellent yields in the initial and reuse runs (Entry 1).However, 1b and 1c furnished yields of 4b and 4c between 61% and 78% (Entries 2 and 3).As   The utility of this reaction protocol for cyclohexyl acrylate, 2b, was then evaluated (Table 2).β,βdiarylation of 1a onto 2b took place to afford excellent yields in the initial and reuse runs (Entry 1).However, 1b and 1c furnished yields of 4b and 4c between 61% and 78% (Entries 2 and 3).As   The utility of this reaction protocol for cyclohexyl acrylate, 2b, was then evaluated (Table 2).β,βdiarylation of 1a onto 2b took place to afford excellent yields in the initial and reuse runs (Entry 1).However, 1b and 1c furnished yields of 4b and 4c between 61% and 78% (Entries 2 and 3).As   The utility of this reaction protocol for cyclohexyl acrylate, 2b, was then evaluated (Table 2).β,βdiarylation of 1a onto 2b took place to afford excellent yields in the initial and reuse runs (Entry 1).However, 1b and 1c furnished yields of 4b and 4c between 61% and 78% (Entries 2 and 3).As   The utility of this reaction protocol for cyclohexyl acrylate, 2b, was then evaluated (Table 2).β,βdiarylation of 1a onto 2b took place to afford excellent yields in the initial and reuse runs (Entry 1).However, 1b and 1c furnished yields of 4b and 4c between 61% and 78% (Entries 2 and 3).As  The utility of this reaction protocol for cyclohexyl acrylate, 2b, was then evaluated (Table 2).β,βdiarylation of 1a onto 2b took place to afford excellent yields in the initial and reuse runs (Entry 1).However, 1b and 1c furnished yields of 4b and 4c between 61% and 78% (Entries 2 and 3).As   The utility of this reaction protocol for cyclohexyl acrylate, 2b, was then evaluated (Table 2).β,βdiarylation of 1a onto 2b took place to afford excellent yields in the initial and reuse runs (Entry 1).However, 1b and 1c furnished yields of 4b and 4c between 61% and 78% (Entries 2 and 3).As  The utility of this reaction protocol for cyclohexyl acrylate, 2b, was then evaluated (Table 2).β,βdiarylation of 1a onto 2b took place to afford excellent yields in the initial and reuse runs (Entry 1).However, 1b and 1c furnished yields of 4b and 4c between 61% and 78% (Entries 2 and 3).As   The utility of this reaction protocol for cyclohexyl acrylate, 2b, was then evaluated (Table 2).β,βdiarylation of 1a onto 2b took place to afford excellent yields in the initial and reuse runs (Entry 1).However, 1b and 1c furnished yields of 4b and 4c between 61% and 78% (Entries 2 and 3).As  The utility of this reaction protocol for cyclohexyl acrylate, 2b, was then evaluated (Table 2).β,βdiarylation of 1a onto 2b took place to afford excellent yields in the initial and reuse runs (Entry 1).However, 1b and 1c furnished yields of 4b and 4c between 61% and 78% (Entries 2 and 3).As   The utility of this reaction protocol for cyclohexyl acrylate, 2b, was then evaluated (Table 2).β,βdiarylation of 1a onto 2b took place to afford excellent yields in the initial and reuse runs (Entry 1).However, 1b and 1c furnished yields of 4b and 4c between 61% and 78% (Entries 2 and 3).As  The utility of this reaction protocol for cyclohexyl acrylate, 2b, was then evaluated (Table 2).β,βdiarylation of 1a onto 2b took place to afford excellent yields in the initial and reuse runs (Entry 1).However, 1b and 1c furnished yields of 4b and 4c between 61% and 78% (Entries 2 and 3).As The utility of this reaction protocol for cyclohexyl acrylate, 2b, was then evaluated (Table 2).β,β-diarylation of 1a onto 2b took place to afford excellent yields in the initial and reuse runs (Entry 1).However, 1b and 1c furnished yields of 4b and 4c between 61% and 78% (Entries 2 and 3).As expected, 1d-1g reacted very efficiently with 2b to provide high yields in the initial, as well as the reuse, runs (Entries 4-7); 4h was obtained in yields between 34% and 47%, in the initial and reuse runs, when 1h was employed (Entry 8).Unfortunately, a β,β-diarylated product was unable to be obtained when tert-butyl acrylate was employed.In this case, only a quantitative yield of monoarylated product was observed.This result was in contrast with a report from Nájera's group [48,49].They achieved a β,β-diarylated reaction in water with only tert-butyl acrylate for acrylate substrates in order to avoid the hydrolysis of primary and secondary alkyl acrylates; in our system, β,β-diarylation was active for both n-butyl and cyclohexyl acrylates, without any hydrolysis of ester functions, but was inert for tert-butyl acrylate.expected, 1d-1g reacted very efficiently with 2b to provide high yields in the initial, as well as the reuse, runs (Entries 4-7); 4h was obtained in yields between 34% and 47%, in the initial and reuse runs, when 1h was employed (Entry 8).Unfortunately, a β,β-diarylated product was unable to be obtained when tert-butyl acrylate was employed.In this case, only a quantitative yield of monoarylated product was observed.This result was in contrast with a report from Nájera's group [48,49].They achieved a β,β-diarylated reaction in water with only tert-butyl acrylate for acrylate substrates in order to avoid the hydrolysis of primary and secondary alkyl acrylates; in our system, β,β-diarylation was active for both n-butyl and cyclohexyl acrylates, without any hydrolysis of ester functions, but was inert for tert-butyl acrylate.expected, 1d-1g reacted very efficiently with 2b to provide high yields in the initial, as well as the reuse, runs (Entries 4-7); 4h was obtained in yields between 34% and 47%, in the initial and reuse runs, when 1h was employed (Entry 8).Unfortunately, a β,β-diarylated product was unable to be obtained when tert-butyl acrylate was employed.In this case, only a quantitative yield of monoarylated product was observed.This result was in contrast with a report from Nájera's group [48,49].They achieved a β,β-diarylated reaction in water with only tert-butyl acrylate for acrylate substrates in order to avoid the hydrolysis of primary and secondary alkyl acrylates; in our system, β,β-diarylation was active for both n-butyl and cyclohexyl acrylates, without any hydrolysis of ester functions, but was inert for tert-butyl acrylate.expected, 1d-1g reacted very efficiently with 2b to provide high yields in the initial, as well as the reuse, runs (Entries 4-7); 4h was obtained in yields between 34% and 47%, in the initial and reuse runs, when 1h was employed (Entry 8).Unfortunately, a β,β-diarylated product was unable to be obtained when tert-butyl acrylate was employed.In this case, only a quantitative yield of monoarylated product was observed.This result was in contrast with a report from Nájera's group [48,49].They achieved a β,β-diarylated reaction in water with only tert-butyl acrylate for acrylate substrates in order to avoid the hydrolysis of primary and secondary alkyl acrylates; in our system, β,β-diarylation was active for both n-butyl and cyclohexyl acrylates, without any hydrolysis of ester functions, but was inert for tert-butyl acrylate.expected, 1d-1g reacted very efficiently with 2b to provide high yields in the initial, as well as the reuse, runs (Entries 4-7); 4h was obtained in yields between 34% and 47%, in the initial and reuse runs, when 1h was employed (Entry 8).Unfortunately, a β,β-diarylated product was unable to be obtained when tert-butyl acrylate was employed.In this case, only a quantitative yield of monoarylated product was observed.This result was in contrast with a report from Nájera's group [48,49].They achieved a β,β-diarylated reaction in water with only tert-butyl acrylate for acrylate substrates in order to avoid the hydrolysis of primary and secondary alkyl acrylates; in our system, β,β-diarylation was active for both n-butyl and cyclohexyl acrylates, without any hydrolysis of ester functions, but was inert for tert-butyl acrylate.expected, 1d-1g reacted very efficiently with 2b to provide high yields in the initial, as well as the reuse, runs (Entries 4-7); 4h was obtained in yields between 34% and 47%, in the initial and reuse runs, when 1h was employed (Entry 8).Unfortunately, a β,β-diarylated product was unable to be obtained when tert-butyl acrylate was employed.In this case, only a quantitative yield of monoarylated product was observed.This result was in contrast with a report from Nájera's group [48,49].They achieved a β,β-diarylated reaction in water with only tert-butyl acrylate for acrylate substrates in order to avoid the hydrolysis of primary and secondary alkyl acrylates; in our system, β,β-diarylation was active for both n-butyl and cyclohexyl acrylates, without any hydrolysis of ester functions, but was inert for tert-butyl acrylate.expected, 1d-1g reacted very efficiently with 2b to provide high yields in the initial, as well as the reuse, runs (Entries 4-7); 4h was obtained in yields between 34% and 47%, in the initial and reuse runs, when 1h was employed (Entry 8).Unfortunately, a β,β-diarylated product was unable to be obtained when tert-butyl acrylate was employed.In this case, only a quantitative yield of monoarylated product was observed.This result was in contrast with a report from Nájera's group [48,49].They achieved a β,β-diarylated reaction in water with only tert-butyl acrylate for acrylate substrates in order to avoid the hydrolysis of primary and secondary alkyl acrylates; in our system, β,β-diarylation was active for both n-butyl and cyclohexyl acrylates, without any hydrolysis of ester functions, but was inert for tert-butyl acrylate.expected, 1d-1g reacted very efficiently with 2b to provide high yields in the initial, as well as the reuse, runs (Entries 4-7); 4h was obtained in yields between 34% and 47%, in the initial and reuse runs, when 1h was employed (Entry 8).Unfortunately, a β,β-diarylated product was unable to be obtained when tert-butyl acrylate was employed.In this case, only a quantitative yield of monoarylated product was observed.This result was in contrast with a report from Nájera's group [48,49].They achieved a β,β-diarylated reaction in water with only tert-butyl acrylate for acrylate substrates in order to avoid the hydrolysis of primary and secondary alkyl acrylates; in our system, β,β-diarylation was active for both n-butyl and cyclohexyl acrylates, without any hydrolysis of ester functions, but was inert for tert-butyl acrylate.expected, 1d-1g reacted very efficiently with 2b to provide high yields in the initial, as well as the reuse, runs (Entries 4-7); 4h was obtained in yields between 34% and 47%, in the initial and reuse runs, when 1h was employed (Entry 8).Unfortunately, a β,β-diarylated product was unable to be obtained when tert-butyl acrylate was employed.In this case, only a quantitative yield of monoarylated product was observed.This result was in contrast with a report from Nájera's group [48,49].They achieved a β,β-diarylated reaction in water with only tert-butyl acrylate for acrylate substrates in order to avoid the hydrolysis of primary and secondary alkyl acrylates; in our system, β,β-diarylation was active for both n-butyl and cyclohexyl acrylates, without any hydrolysis of ester functions, but was inert for tert-butyl acrylate.expected, 1d-1g reacted very efficiently with 2b to provide high yields in the initial, as well as the reuse, runs (Entries 4-7); 4h was obtained in yields between 34% and 47%, in the initial and reuse runs, when 1h was employed (Entry 8).Unfortunately, a β,β-diarylated product was unable to be obtained when tert-butyl acrylate was employed.In this case, only a quantitative yield of monoarylated product was observed.This result was in contrast with a report from Nájera's group [48,49].They achieved a β,β-diarylated reaction in water with only tert-butyl acrylate for acrylate substrates in order to avoid the hydrolysis of primary and secondary alkyl acrylates; in our system, β,β-diarylation was active for both n-butyl and cyclohexyl acrylates, without any hydrolysis of ester functions, but was inert for tert-butyl acrylate.expected, 1d-1g reacted very efficiently with 2b to provide high yields in the initial, as well as the reuse, runs (Entries 4-7); 4h was obtained in yields between 34% and 47%, in the initial and reuse runs, when 1h was employed (Entry 8).Unfortunately, a β,β-diarylated product was unable to be obtained when tert-butyl acrylate was employed.In this case, only a quantitative yield of monoarylated product was observed.This result was in contrast with a report from Nájera's group [48,49].They achieved a β,β-diarylated reaction in water with only tert-butyl acrylate for acrylate substrates in order to avoid the hydrolysis of primary and secondary alkyl acrylates; in our system, β,β-diarylation was active for both n-butyl and cyclohexyl acrylates, without any hydrolysis of ester functions, but was inert for tert-butyl acrylate.expected, 1d-1g reacted very efficiently with 2b to provide high yields in the initial, as well as the reuse, runs (Entries 4-7); 4h was obtained in yields between 34% and 47%, in the initial and reuse runs, when 1h was employed (Entry 8).Unfortunately, a β,β-diarylated product was unable to be obtained when tert-butyl acrylate was employed.In this case, only a quantitative yield of monoarylated product was observed.This result was in contrast with a report from Nájera's group [48,49].They achieved a β,β-diarylated reaction in water with only tert-butyl acrylate for acrylate substrates in order to avoid the hydrolysis of primary and secondary alkyl acrylates; in our system, β,β-diarylation was active for both n-butyl and cyclohexyl acrylates, without any hydrolysis of ester functions, but was inert for tert-butyl acrylate.expected, 1d-1g reacted very efficiently with 2b to provide high yields in the initial, as well as the reuse, runs (Entries 4-7); 4h was obtained in yields between 34% and 47%, in the initial and reuse runs, when 1h was employed (Entry 8).Unfortunately, a β,β-diarylated product was unable to be obtained when tert-butyl acrylate was employed.In this case, only a quantitative yield of monoarylated product was observed.This result was in contrast with a report from Nájera's group [48,49].They achieved a β,β-diarylated reaction in water with only tert-butyl acrylate for acrylate substrates in order to avoid the hydrolysis of primary and secondary alkyl acrylates; in our system, β,β-diarylation was active for both n-butyl and cyclohexyl acrylates, without any hydrolysis of ester functions, but was inert for tert-butyl acrylate.expected, 1d-1g reacted very efficiently with 2b to provide high yields in the initial, as well as the reuse, runs (Entries 4-7); 4h was obtained in yields between 34% and 47%, in the initial and reuse runs, when 1h was employed (Entry 8).Unfortunately, a β,β-diarylated product was unable to be obtained when tert-butyl acrylate was employed.In this case, only a quantitative yield of monoarylated product was observed.This result was in contrast with a report from Nájera's group [48,49].They achieved a β,β-diarylated reaction in water with only tert-butyl acrylate for acrylate substrates in order to avoid the hydrolysis of primary and secondary alkyl acrylates; in our system, β,β-diarylation was active for both n-butyl and cyclohexyl acrylates, without any hydrolysis of ester functions, but was inert for tert-butyl acrylate.expected, 1d-1g reacted very efficiently with 2b to provide high yields in the initial, as well as the reuse, runs (Entries 4-7); 4h was obtained in yields between 34% and 47%, in the initial and reuse runs, when 1h was employed (Entry 8).Unfortunately, a β,β-diarylated product was unable to be obtained when tert-butyl acrylate was employed.In this case, only a quantitative yield of monoarylated product was observed.This result was in contrast with a report from Nájera's group [48,49].They achieved a β,β-diarylated reaction in water with only tert-butyl acrylate for acrylate substrates in order to avoid the hydrolysis of primary and secondary alkyl acrylates; in our system, β,β-diarylation was active for both n-butyl and cyclohexyl acrylates, without any hydrolysis of ester functions, but was inert for tert-butyl acrylate.expected, 1d-1g reacted very efficiently with 2b to provide high yields in the initial, as well as the reuse, runs (Entries 4-7); 4h was obtained in yields between 34% and 47%, in the initial and reuse runs, when 1h was employed (Entry 8).Unfortunately, a β,β-diarylated product was unable to be obtained when tert-butyl acrylate was employed.In this case, only a quantitative yield of monoarylated product was observed.This result was in contrast with a report from Nájera's group [48,49].They achieved a β,β-diarylated reaction in water with only tert-butyl acrylate for acrylate substrates in order to avoid the hydrolysis of primary and secondary alkyl acrylates; in our system, β,β-diarylation was active for both n-butyl and cyclohexyl acrylates, without any hydrolysis of ester functions, but was inert for tert-butyl acrylate.expected, 1d-1g reacted very efficiently with 2b to provide high yields in the initial, as well as the reuse, runs (Entries 4-7); 4h was obtained in yields between 34% and 47%, in the initial and reuse runs, when 1h was employed (Entry 8).Unfortunately, a β,β-diarylated product was unable to be obtained when tert-butyl acrylate was employed.In this case, only a quantitative yield of monoarylated product was observed.This result was in contrast with a report from Nájera's group [48,49].They achieved a β,β-diarylated reaction in water with only tert-butyl acrylate for acrylate substrates in order to avoid the hydrolysis of primary and secondary alkyl acrylates; in our system, β,β-diarylation was active for both n-butyl and cyclohexyl acrylates, without any hydrolysis of ester functions, but was inert for tert-butyl acrylate.With N,N-diethylacrylamide, 2c, β,β-diarylacrylamides, 5, could also be obtained using the double Mizoroki-Heck reaction.As illustrated in Table 3, 1a coupled with 2c at 140 • C gave yields of 5a at 50% and 60% when the reaction times were 24 h and 36 h, respectively (Entries 1 and 2).Further prolonging the reaction time to 48 h furnished 5a in a 79% yield, and, thus, 69% and 63% yields were achieved in the subsequent reuse runs (Entry 3).Hence, by extending the reaction time to 48 h, β,β-diarylation of 1 onto 2c provided an efficient method to furnish the desired products in high yields (Entries 3 and 4, and 6-9), with the exception of the electron-poor 1c and the sterically-congested 1h (Entries 5 and 10).With N,N-diethylacrylamide, 2c, β,β-diarylacrylamides, 5, could also be obtained using the double Mizoroki-Heck reaction.As illustrated in Table 3, 1a coupled with 2c at 140 °C gave yields of 5a at 50% and 60% when the reaction times were 24 h and 36 h, respectively (Entries 1 and 2).Further prolonging the reaction time to 48 h furnished 5a in a 79% yield, and, thus, 69% and 63% yields were achieved in the subsequent reuse runs (Entry 3).Hence, by extending the reaction time to 48 h, β,βdiarylation of 1 onto 2c provided an efficient method to furnish the desired products in high yields (Entries 3 and 4, and 6-9), with the exception of the electron-poor 1c and the sterically-congested 1h (Entries 5 and 10).With N,N-diethylacrylamide, 2c, β,β-diarylacrylamides, 5, could also be obtained using the double Mizoroki-Heck reaction.As illustrated in Table 3, 1a coupled with 2c at 140 °C gave yields of 5a at 50% and 60% when the reaction times were 24 h and 36 h, respectively (Entries 1 and 2).Further prolonging the reaction time to 48 h furnished 5a in a 79% yield, and, thus, 69% and 63% yields were achieved in the subsequent reuse runs (Entry 3).Hence, by extending the reaction time to 48 h, β,βdiarylation of 1 onto 2c provided an efficient method to furnish the desired products in high yields (Entries 3 and 4, and 6-9), with the exception of the electron-poor 1c and the sterically-congested 1h (Entries 5 and 10).With N,N-diethylacrylamide, 2c, β,β-diarylacrylamides, 5, could also be obtained using the double Mizoroki-Heck reaction.As illustrated in Table 3, 1a coupled with 2c at 140 °C gave yields of 5a at 50% and 60% when the reaction times were 24 h and 36 h, respectively (Entries 1 and 2).Further prolonging the reaction time to 48 h furnished 5a in a 79% yield, and, thus, 69% and 63% yields were achieved in the subsequent reuse runs (Entry 3).Hence, by extending the reaction time to 48 h, β,βdiarylation of 1 onto 2c provided an efficient method to furnish the desired products in high yields (Entries 3 and 4, and 6-9), with the exception of the electron-poor 1c and the sterically-congested 1h (Entries 5 and 10).With N,N-diethylacrylamide, 2c, β,β-diarylacrylamides, 5, could also be obtained using the double Mizoroki-Heck reaction.As illustrated in Table 3, 1a coupled with 2c at 140 °C gave yields of 5a at 50% and 60% when the reaction times were 24 h and 36 h, respectively (Entries 1 and 2).Further prolonging the reaction time to 48 h furnished 5a in a 79% yield, and, thus, 69% and 63% yields were achieved in the subsequent reuse runs (Entry 3).Hence, by extending the reaction time to 48 h, β,βdiarylation of 1 onto 2c provided an efficient method to furnish the desired products in high yields (Entries 3 and 4, and 6-9), with the exception of the electron-poor 1c and the sterically-congested 1h (Entries 5 and 10).With N,N-diethylacrylamide, 2c, β,β-diarylacrylamides, 5, could also be obtained using the double Mizoroki-Heck reaction.As illustrated in Table 3, 1a coupled with 2c at 140 °C gave yields of 5a at 50% and 60% when the reaction times were 24 h and 36 h, respectively (Entries 1 and 2).Further prolonging the reaction time to 48 h furnished 5a in a 79% yield, and, thus, 69% and 63% yields were achieved in the subsequent reuse runs (Entry 3).Hence, by extending the reaction time to 48 h, β,βdiarylation of 1 onto 2c provided an efficient method to furnish the desired products in high yields (Entries 3 and 4, and 6-9), with the exception of the electron-poor 1c and the sterically-congested 1h (Entries 5 and 10).With N,N-diethylacrylamide, 2c, β,β-diarylacrylamides, 5, could also be obtained using the double Mizoroki-Heck reaction.As illustrated in Table 3, 1a coupled with 2c at 140 °C gave yields of 5a at 50% and 60% when the reaction times were 24 h and 36 h, respectively (Entries 1 and 2).Further prolonging the reaction time to 48 h furnished 5a in a 79% yield, and, thus, 69% and 63% yields were achieved in the subsequent reuse runs (Entry 3).Hence, by extending the reaction time to 48 h, β,βdiarylation of 1 onto 2c provided an efficient method to furnish the desired products in high yields (Entries 3 and 4, and 6-9), with the exception of the electron-poor 1c and the sterically-congested 1h (Entries 5 and 10).With N,N-diethylacrylamide, 2c, β,β-diarylacrylamides, 5, could also be obtained using the double Mizoroki-Heck reaction.As illustrated in Table 3, 1a coupled with 2c at 140 °C gave yields of 5a at 50% and 60% when the reaction times were 24 h and 36 h, respectively (Entries 1 and 2).Further prolonging the reaction time to 48 h furnished 5a in a 79% yield, and, thus, 69% and 63% yields were achieved in the subsequent reuse runs (Entry 3).Hence, by extending the reaction time to 48 h, β,βdiarylation of 1 onto 2c provided an efficient method to furnish the desired products in high yields (Entries 3 and 4, and 6-9), with the exception of the electron-poor 1c and the sterically-congested 1h (Entries 5 and 10).With N,N-diethylacrylamide, 2c, β,β-diarylacrylamides, 5, could also be obtained using the double Mizoroki-Heck reaction.As illustrated in Table 3, 1a coupled with 2c at 140 °C gave yields of 5a at 50% and 60% when the reaction times were 24 h and 36 h, respectively (Entries 1 and 2).Further prolonging the reaction time to 48 h furnished 5a in a 79% yield, and, thus, 69% and 63% yields were achieved in the subsequent reuse runs (Entry 3).Hence, by extending the reaction time to 48 h, β,βdiarylation of 1 onto 2c provided an efficient method to furnish the desired products in high yields (Entries 3 and 4, and 6-9), with the exception of the electron-poor 1c and the sterically-congested 1h (Entries 5 and 10).With N,N-diethylacrylamide, 2c, β,β-diarylacrylamides, 5, could also be obtained using the double Mizoroki-Heck reaction.As illustrated in Table 3, 1a coupled with 2c at 140 °C gave yields of 5a at 50% and 60% when the reaction times were 24 h and 36 h, respectively (Entries 1 and 2).Further prolonging the reaction time to 48 h furnished 5a in a 79% yield, and, thus, 69% and 63% yields were achieved in the subsequent reuse runs (Entry 3).Hence, by extending the reaction time to 48 h, β,βdiarylation of 1 onto 2c provided an efficient method to furnish the desired products in high yields (Entries 3 and 4, and 6-9), with the exception of the electron-poor 1c and the sterically-congested 1h (Entries 5 and 10).With N,N-diethylacrylamide, 2c, β,β-diarylacrylamides, 5, could also be obtained using the double Mizoroki-Heck reaction.As illustrated in Table 3, 1a coupled with 2c at 140 °C gave yields of 5a at 50% and 60% when the reaction times were 24 h and 36 h, respectively (Entries 1 and 2).Further prolonging the reaction time to 48 h furnished 5a in a 79% yield, and, thus, 69% and 63% yields were achieved in the subsequent reuse runs (Entry 3).Hence, by extending the reaction time to 48 h, β,βdiarylation of 1 onto 2c provided an efficient method to furnish the desired products in high yields (Entries 3 and 4, and 6-9), with the exception of the electron-poor 1c and the sterically-congested 1h (Entries 5 and 10).With N,N-diethylacrylamide, 2c, β,β-diarylacrylamides, 5, could also be obtained using the double Mizoroki-Heck reaction.As illustrated in Table 3, 1a coupled with 2c at 140 °C gave yields of 5a at 50% and 60% when the reaction times were 24 h and 36 h, respectively (Entries 1 and 2).Further prolonging the reaction time to 48 h furnished 5a in a 79% yield, and, thus, 69% and 63% yields were achieved in the subsequent reuse runs (Entry 3).Hence, by extending the reaction time to 48 h, β,βdiarylation of 1 onto 2c provided an efficient method to furnish the desired products in high yields (Entries 3 and 4, and 6-9), with the exception of the electron-poor 1c and the sterically-congested 1h (Entries 5 and 10).With N,N-diethylacrylamide, 2c, β,β-diarylacrylamides, 5, could also be obtained using the double Mizoroki-Heck reaction.As illustrated in Table 3, 1a coupled with 2c at 140 °C gave yields of 5a at 50% and 60% when the reaction times were 24 h and 36 h, respectively (Entries 1 and 2).Further prolonging the reaction time to 48 h furnished 5a in a 79% yield, and, thus, 69% and 63% yields were achieved in the subsequent reuse runs (Entry 3).Hence, by extending the reaction time to 48 h, β,βdiarylation of 1 onto 2c provided an efficient method to furnish the desired products in high yields (Entries 3 and 4, and 6-9), with the exception of the electron-poor 1c and the sterically-congested 1h (Entries 5 and 10).With N,N-diethylacrylamide, 2c, β,β-diarylacrylamides, 5, could also be obtained using the double Mizoroki-Heck reaction.As illustrated in Table 3, 1a coupled with 2c at 140 °C gave yields of 5a at 50% and 60% when the reaction times were 24 h and 36 h, respectively (Entries 1 and 2).Further prolonging the reaction time to 48 h furnished 5a in a 79% yield, and, thus, 69% and 63% yields were achieved in the subsequent reuse runs (Entry 3).Hence, by extending the reaction time to 48 h, β,βdiarylation of 1 onto 2c provided an efficient method to furnish the desired products in high yields (Entries 3 and 4, and 6-9), with the exception of the electron-poor 1c and the sterically-congested 1h (Entries 5 and 10).With N,N-diethylacrylamide, 2c, β,β-diarylacrylamides, 5, could also be obtained using the double Mizoroki-Heck reaction.As illustrated in Table 3, 1a coupled with 2c at 140 °C gave yields of 5a at 50% and 60% when the reaction times were 24 h and 36 h, respectively (Entries 1 and 2).Further prolonging the reaction time to 48 h furnished 5a in a 79% yield, and, thus, 69% and 63% yields were achieved in the subsequent reuse runs (Entry 3).Hence, by extending the reaction time to 48 h, β,βdiarylation of 1 onto 2c provided an efficient method to furnish the desired products in high yields (Entries 3 and 4, and 6-9), with the exception of the electron-poor 1c and the sterically-congested 1h (Entries 5 and 10).Aryl iodides were also able to be double arylated onto low-boiling-point acrylonitrile, 2d, and the results are shown in Table 4.All of the double Mizoroki-Heck reactions efficiently provided the corresponding β,β-diarylated products, with reuses of the catalytic system showing only slight decreases to activities (Entries 1-10).Aryl iodides were also able to be double arylated onto low-boiling-point acrylonitrile, 2d, and the results are shown in Table 4.All of the double Mizoroki-Heck reactions efficiently provided the corresponding β,β-diarylated products, with reuses of the catalytic system showing only slight decreases to activities (Entries 1-10).Aryl iodides were also able to be double arylated onto low-boiling-point acrylonitrile, 2d, and the results are shown in Table 4.All of the double Mizoroki-Heck reactions efficiently provided the corresponding β,β-diarylated products, with reuses of the catalytic system showing only slight decreases to activities (Entries 1-10).Aryl iodides were also able to be double arylated onto low-boiling-point acrylonitrile, 2d, and the results are shown in Table 4.All of the double Mizoroki-Heck reactions efficiently provided the corresponding β,β-diarylated products, with reuses of the catalytic system showing only slight decreases to activities (Entries 1-10).Aryl iodides were also able to be double arylated onto low-boiling-point acrylonitrile, 2d, and the results are shown in Table 4.All of the double Mizoroki-Heck reactions efficiently provided the corresponding β,β-diarylated products, with reuses of the catalytic system showing only slight decreases to activities (Entries 1-10).Aryl iodides were also able to be double arylated onto low-boiling-point acrylonitrile, 2d, and the results are shown in Table 4.All of the double Mizoroki-Heck reactions efficiently provided the corresponding β,β-diarylated products, with reuses of the catalytic system showing only slight decreases to activities (Entries 1-10).Aryl iodides were also able to be double arylated onto low-boiling-point acrylonitrile, 2d, and the results are shown in Table 4.All of the double Mizoroki-Heck reactions efficiently provided the corresponding β,β-diarylated products, with reuses of the catalytic system showing only slight decreases to activities (Entries 1-10).Aryl iodides were also able to be double arylated onto low-boiling-point acrylonitrile, 2d, and the results are shown in Table 4.All of the double Mizoroki-Heck reactions efficiently provided the corresponding β,β-diarylated products, with reuses of the catalytic system showing only slight decreases to activities (Entries 1-10).Aryl iodides were also able to be double arylated onto low-boiling-point acrylonitrile, 2d, and the results are shown in Table 4.All of the double Mizoroki-Heck reactions efficiently provided the corresponding β,β-diarylated products, with reuses of the catalytic system showing only slight decreases to activities (Entries 1-10).Aryl iodides were also able to be double arylated onto low-boiling-point acrylonitrile, 2d, and the results are shown in Table 4.All of the double Mizoroki-Heck reactions efficiently provided the corresponding β,β-diarylated products, with reuses of the catalytic system showing only slight decreases to activities (Entries 1-10).Aryl iodides were also able to be double arylated onto low-boiling-point acrylonitrile, 2d, and the results are shown in Table 4.All of the double Mizoroki-Heck reactions efficiently provided the corresponding β,β-diarylated products, with reuses of the catalytic system showing only slight decreases to activities (Entries 1-10).Aryl iodides were also able to be double arylated onto low-boiling-point acrylonitrile, 2d, and the results are shown in Table 4.All of the double Mizoroki-Heck reactions efficiently provided the corresponding β,β-diarylated products, with reuses of the catalytic system showing only slight decreases to activities (Entries 1-10).Aryl iodides were also able to be double arylated onto low-boiling-point acrylonitrile, 2d, and the results are shown in Table 4.All of the double Mizoroki-Heck reactions efficiently provided the corresponding β,β-diarylated products, with reuses of the catalytic system showing only slight decreases to activities (Entries 1-10).Aryl iodides were also able to be double arylated onto low-boiling-point acrylonitrile, 2d, and the results are shown in Table 4.All of the double Mizoroki-Heck reactions efficiently provided the corresponding β,β-diarylated products, with reuses of the catalytic system showing only slight decreases to activities (Entries 1-10).Aryl iodides were also able to be double arylated onto low-boiling-point acrylonitrile, 2d, and the results are shown in Table 4.All of the double Mizoroki-Heck reactions efficiently provided the corresponding β,β-diarylated products, with reuses of the catalytic system showing only slight decreases to activities (Entries 1-10).Aryl iodides were also able to be double arylated onto low-boiling-point acrylonitrile, 2d, and the results are shown in Table 4.All of the double Mizoroki-Heck reactions efficiently provided the corresponding β,β-diarylated products, with reuses of the catalytic system showing only slight decreases to activities (Entries 1-10).Aryl iodides were also able to be double arylated onto low-boiling-point acrylonitrile, 2d, and the results are shown in Table 4.All of the double Mizoroki-Heck reactions efficiently provided the corresponding β,β-diarylated products, with reuses of the catalytic system showing only slight decreases to activities (Entries 1-10).Aryl iodides were also able to be double arylated onto low-boiling-point acrylonitrile, 2d, and the results are shown in Table 4.All of the double Mizoroki-Heck reactions efficiently provided the corresponding β,β-diarylated products, with reuses of the catalytic system showing only slight decreases to activities (Entries 1-10).Aryl iodides were also able to be double arylated onto low-boiling-point acrylonitrile, 2d, and the results are shown in Table 4.All of the double Mizoroki-Heck reactions efficiently provided the corresponding β,β-diarylated products, with reuses of the catalytic system showing only slight decreases to activities (Entries 1-10).Next, we moved on to the synthesis of unsymmetrical β,β-diarylated alkenes using the Mizoroki-Heck coupling of aryl iodides with aryl-substituted alkenes (Table 5).The coupling of 1e or 1h with 7, giving a mixture of E/Z isomers, in high to excellent yields, with only a slight steric effect, was observed (Entries 1-8).It is interesting to note that the anticancer drug 8ej, known as CC-5079 [10], could also be synthesized in excellent yields using this simple protocol (Entries 9 and 10).The stereochemistry of 8ej can be controlled by the introduction of different aryl iodides, thus that, when 1j was employed as the aryl iodide source, Z isomer was obtained as the major product; in contrast, E isomer predominated over the Z form, as 1k was the aryl halide partner.Next, we moved on to the synthesis of unsymmetrical β,β-diarylated alkenes using the Mizoroki-Heck coupling of aryl iodides with aryl-substituted alkenes (Table 5).The coupling of 1e or 1h with 7, giving a mixture of E/Z isomers, in high to excellent yields, with only a slight steric effect, was observed (Entries 1-8).It is interesting to note that the anticancer drug 8ej, known as CC-5079 [10], could also be synthesized in excellent yields using this simple protocol (Entries 9 and 10).The stereochemistry of 8ej can be controlled by the introduction of different aryl iodides, thus that, when 1j was employed as the aryl iodide source, Z isomer was obtained as the major product; in contrast, E isomer predominated over the Z form, as 1k was the aryl halide partner.Next, we moved on to the synthesis of unsymmetrical β,β-diarylated alkenes using the Mizoroki-Heck coupling of aryl iodides with aryl-substituted alkenes (Table 5).The coupling of 1e or 1h with 7, giving a mixture of E/Z isomers, in high to excellent yields, with only a slight steric effect, was observed (Entries 1-8).It is interesting to note that the anticancer drug 8ej, known as CC-5079 [10], could also be synthesized in excellent yields using this simple protocol (Entries 9 and 10).The stereochemistry of 8ej can be controlled by the introduction of different aryl iodides, thus that, when 1j was employed as the aryl iodide source, Z isomer was obtained as the major product; in Next, we moved on to the synthesis of unsymmetrical β,β-diarylated alkenes using the Mizoroki-Heck coupling of aryl iodides with aryl-substituted alkenes (Table 5).The coupling of 1e or 1h with 7, giving a mixture of E/Z isomers, in high to excellent yields, with only a slight steric effect, was observed (Entries 1-8).It is interesting to note that the anticancer drug 8ej, known as CC-5079 [10], could also be synthesized in excellent yields using this simple protocol (Entries 9 and 10).The stereochemistry of 8ej can be controlled by the introduction of different aryl iodides, thus that, when 1j was employed as the aryl iodide source, Z isomer was obtained as the major product; in Next, we moved on to the synthesis of unsymmetrical β,β-diarylated alkenes using the Mizoroki-Heck coupling of aryl iodides with aryl-substituted alkenes (Table 5).The coupling of 1e or 1h with 7, giving a mixture of E/Z isomers, in high to excellent yields, with only a slight steric effect, was observed (Entries 1-8).It is interesting to note that the anticancer drug 8ej, known as CC-5079 [10], could also be synthesized in excellent yields using this simple protocol (Entries 9 and 10).The stereochemistry of 8ej can be controlled by the introduction of different aryl iodides, thus that, when 1j was employed as the aryl iodide source, Z isomer was obtained as the major product; in contrast, E isomer predominated over the Z form, as 1k was the aryl halide partner.Next, we moved on to the synthesis of unsymmetrical β,β-diarylated alkenes using the Mizoroki-Heck coupling of aryl iodides with aryl-substituted alkenes (Table 5).The coupling of 1e or 1h with 7, giving a mixture of E/Z isomers, in high to excellent yields, with only a slight steric effect, was observed (Entries 1-8).It is interesting to note that the anticancer drug 8ej, known as CC-5079 [10], could also be synthesized in excellent yields using this simple protocol (Entries 9 and 10).The stereochemistry of 8ej can be controlled by the introduction of different aryl iodides, thus that, when 1j was employed as the aryl iodide source, Z isomer was obtained as the major product; in contrast, E isomer predominated over the Z form, as 1k was the aryl halide partner.Next, we moved on to the synthesis of unsymmetrical β,β-diarylated alkenes using the Mizoroki-Heck coupling of aryl iodides with aryl-substituted alkenes (Table 5).The coupling of 1e or 1h with 7, giving a mixture of E/Z isomers, in high to excellent yields, with only a slight steric effect, was observed (Entries 1-8).It is interesting to note that the anticancer drug 8ej, known as CC-5079 [10], could also be synthesized in excellent yields using this simple protocol (Entries 9 and 10).The stereochemistry of 8ej can be controlled by the introduction of different aryl iodides, thus that, when 1j was employed as the aryl iodide source, Z isomer was obtained as the major product; in contrast, E isomer predominated over the Z form, as 1k was the aryl halide partner.Next, we moved on to the synthesis of unsymmetrical β,β-diarylated alkenes using the Mizoroki-Heck coupling of aryl iodides with aryl-substituted alkenes (Table 5).The coupling of 1e or 1h with 7, giving a mixture of E/Z isomers, in high to excellent yields, with only a slight steric effect, was observed (Entries 1-8).It is interesting to note that the anticancer drug 8ej, known as CC-5079 [10], could also be synthesized in excellent yields using this simple protocol (Entries 9 and 10).The stereochemistry of 8ej can be controlled by the introduction of different aryl iodides, thus that, when 1j was employed as the aryl iodide source, Z isomer was obtained as the major product; in contrast, E isomer predominated over the Z form, as 1k was the aryl halide partner.Next, we moved on to the synthesis of unsymmetrical β,β-diarylated alkenes using the Mizoroki-Heck coupling of aryl iodides with aryl-substituted alkenes (Table 5).The coupling of 1e or 1h with 7, giving a mixture of E/Z isomers, in high to excellent yields, with only a slight steric effect, was observed (Entries 1-8).It is interesting to note that the anticancer drug 8ej, known as CC-5079 [10], could also be synthesized in excellent yields using this simple protocol (Entries 9 and 10).The stereochemistry of 8ej can be controlled by the introduction of different aryl iodides, thus that, when 1j was employed as the aryl iodide source, Z isomer was obtained as the major product; in contrast, E isomer predominated over the Z form, as 1k was the aryl halide partner.Next, we moved on to the synthesis of unsymmetrical β,β-diarylated alkenes using the Mizoroki-Heck coupling of aryl iodides with aryl-substituted alkenes (Table 5).The coupling of 1e or 1h with 7, giving a mixture of E/Z isomers, in high to excellent yields, with only a slight steric effect, was observed (Entries 1-8).It is interesting to note that the anticancer drug 8ej, known as CC-5079 [10], could also be synthesized in excellent yields using this simple protocol (Entries 9 and 10).The stereochemistry of 8ej can be controlled by the introduction of different aryl iodides, thus that, when 1j was employed as the aryl iodide source, Z isomer was obtained as the major product; in contrast, E isomer predominated over the Z form, as 1k was the aryl halide partner.Next, we moved on to the synthesis of unsymmetrical β,β-diarylated alkenes using the Mizoroki-Heck coupling of aryl iodides with aryl-substituted alkenes (Table 5).The coupling of 1e or 1h with 7, giving a mixture of E/Z isomers, in high to excellent yields, with only a slight steric effect, was observed (Entries 1-8).It is interesting to note that the anticancer drug 8ej, known as CC-5079 [10], could also be synthesized in excellent yields using this simple protocol (Entries 9 and 10).The stereochemistry of 8ej can be controlled by the introduction of different aryl iodides, thus that, when 1j was employed as the aryl iodide source, Z isomer was obtained as the major product; in contrast, E isomer predominated over the Z form, as 1k was the aryl halide partner.Next, we moved on to the synthesis of unsymmetrical β,β-diarylated alkenes using the Mizoroki-Heck coupling of aryl iodides with aryl-substituted alkenes (Table 5).The coupling of 1e or 1h with 7, giving a mixture of E/Z isomers, in high to excellent yields, with only a slight steric effect, was observed (Entries 1-8).It is interesting to note that the anticancer drug 8ej, known as CC-5079 [10], could also be synthesized in excellent yields using this simple protocol (Entries 9 and 10).The stereochemistry of 8ej can be controlled by the introduction of different aryl iodides, thus that, when 1j was employed as the aryl iodide source, Z isomer was obtained as the major product; in contrast, E isomer predominated over the Z form, as 1k was the aryl halide partner.Next, we moved on to the synthesis of unsymmetrical β,β-diarylated alkenes using the Mizoroki-Heck coupling of aryl iodides with aryl-substituted alkenes (Table 5).The coupling of 1e or 1h with 7, giving a mixture of E/Z isomers, in high to excellent yields, with only a slight steric effect, was observed (Entries 1-8).It is interesting to note that the anticancer drug 8ej, known as CC-5079 [10], could also be synthesized in excellent yields using this simple protocol (Entries 9 and 10).The stereochemistry of 8ej can be controlled by the introduction of different aryl iodides, thus that, when 1j was employed as the aryl iodide source, Z isomer was obtained as the major product; in contrast, E isomer predominated over the Z form, as 1k was the aryl halide partner.Next, we moved on to the synthesis of unsymmetrical β,β-diarylated alkenes using the Mizoroki-Heck coupling of aryl iodides with aryl-substituted alkenes (Table 5).The coupling of 1e or 1h with 7, giving a mixture of E/Z isomers, in high to excellent yields, with only a slight steric effect, was observed (Entries 1-8).It is interesting to note that the anticancer drug 8ej, known as CC-5079 [10], could also be synthesized in excellent yields using this simple protocol (Entries 9 and 10).The stereochemistry of 8ej can be controlled by the introduction of different aryl iodides, thus that, when 1j was employed as the aryl iodide source, Z isomer was obtained as the major product; in contrast, E isomer predominated over the Z form, as 1k was the aryl halide partner.Next, we moved on to the synthesis of unsymmetrical β,β-diarylated alkenes using the Mizoroki-Heck coupling of aryl iodides with aryl-substituted alkenes (Table 5).The coupling of 1e or 1h with 7, giving a mixture of E/Z isomers, in high to excellent yields, with only a slight steric effect, was observed (Entries 1-8).It is interesting to note that the anticancer drug 8ej, known as CC-5079 [10], could also be synthesized in excellent yields using this simple protocol (Entries 9 and 10).The stereochemistry of 8ej can be controlled by the introduction of different aryl iodides, thus that, when 1j was employed as the aryl iodide source, Z isomer was obtained as the major product; in contrast, E isomer predominated over the Z form, as 1k was the aryl halide partner.Next, we moved on to the synthesis of unsymmetrical β,β-diarylated alkenes using the Mizoroki-Heck coupling of aryl iodides with aryl-substituted alkenes (Table 5).The coupling of 1e or 1h with 7, giving a mixture of E/Z isomers, in high to excellent yields, with only a slight steric effect, was observed (Entries 1-8).It is interesting to note that the anticancer drug 8ej, known as CC-5079 [10], could also be synthesized in excellent yields using this simple protocol (Entries 9 and 10).The stereochemistry of 8ej can be controlled by the introduction of different aryl iodides, thus that, when 1j was employed as the aryl iodide source, Z isomer was obtained as the major product; in contrast, E isomer predominated over the Z form, as 1k was the aryl halide partner.Next, we moved on to the synthesis of unsymmetrical β,β-diarylated alkenes using the Mizoroki-Heck coupling of aryl iodides with aryl-substituted alkenes (Table 5).The coupling of 1e or 1h with 7, giving a mixture of E/Z isomers, in high to excellent yields, with only a slight steric effect, was observed (Entries 1-8).It is interesting to note that the anticancer drug 8ej, known as CC-5079 [10], could also be synthesized in excellent yields using this simple protocol (Entries 9 and 10).The stereochemistry of 8ej can be controlled by the introduction of different aryl iodides, thus that, when 1j was employed as the aryl iodide source, Z isomer was obtained as the major product; in contrast, E isomer predominated over the Z form, as 1k was the aryl halide partner.Next, we moved on to the synthesis of unsymmetrical β,β-diarylated alkenes using the Mizoroki-Heck coupling of aryl iodides with aryl-substituted alkenes (Table 5).The coupling of 1e or 1h with 7, giving a mixture of E/Z isomers, in high to excellent yields, with only a slight steric effect, was observed (Entries 1-8).It is interesting to note that the anticancer drug 8ej, known as CC-5079 [10], could also be synthesized in excellent yields using this simple protocol (Entries 9 and 10).The stereochemistry of 8ej can be controlled by the introduction of different aryl iodides, thus that, when 1j was employed as the aryl iodide source, Z isomer was obtained as the major product; in contrast, E isomer predominated over the Z form, as 1k was the aryl halide partner.

General Methods
Chemicals were used as received from commercial suppliers.The cationic 2,2 -bipyridyl ligand [51,52], 7a-c [50], 7e [53] and 7f [54] were synthesized according to known procedures. 1 H-and 13 C-NMR spectra were acquired for the CDCl 3 solution at 25 • C on a Bruker Biospin AG 300 NMR spectrometer (Bruker Co., Faellanden, Switzerland), in which the chemical shifts (δ in ppm) were determined with respect to the non-deuterated chloroform, which was used as a reference ( 1 H-NMR: CHCl 3 at 7.24; 13 C-NMR: CDCl 3 at 77.0 ppm).The melting points for the solid products were measured using an automated melting point apparatus.High-resolution mass spectra (HRMS) of the new compounds were recorded at the Instrument Center Service of National Central University, the Ministry of Science and Technology of Taiwan.The known double Mizoroki-Heck coupling products, and their physical data, are consistent with those reported in published papers (see Supplementary Materials for the spectral data of all double Mizoroki-Heck products, and copies of 1 H-and 13 C-NMR spectra, for unknown and unsymmetrical β,β-diarylated products).

Typical Procedure for the Double Mizoroki-Heck Reaction
Aryl iodide (2.5 mmol), alkene (1.0 mmol), Bu 3 N (2.5 mmol), and H 2 O (1 mL) was added to a 25-mL, sealable tube, equipped with a stirring bar.After the addition of PdCl 2 (NH 3 ) 2 /cationic 2,2 -bipyridyl aqueous solution (1 mL, 0.01 mmol in 1 mL H 2 O), the tube was sealed using a Teflon-coated screw cap under air, and this tube was then stirred in an oil bath at 140 • C for 24 h (in the case of Table 3, the reaction time was 48 h).After cooling the reaction to room temperature, the resultant solution was extracted with hexane/EtOAc (1/1, 3 × 3 mL), the combined organic layers were dried over anhydrous MgSO 4 , and the solvent was then evaporated under reduced pressure.Flash chromatography on silica gel provided the double Mizoroki-Heck product.

Typical Procedure for the Reuse of Catalytic Aqueous Solution for the Double Mizoroki-Heck Reaction
The reaction was performed following the procedure in Section 3.2 After the initial reaction was extracted with hexane/EtOAc (1/1, 3 × 3 mL), the double Mizoroki-Heck product was purified from the combined organic layers, according to the previously-described method (Section 3.2).The residual aqueous layer was then recharged with aryl iodide, alkene, and Bu 3 N for the reuse run.

Typical Procedure for the Synthesis of Unsymmetrical β,β-diarylated Alkenes
Aryl iodide (1.5 mmol), aryl substituted alkene (1.0 mmol), Bu 3 N (1.5 mmol), and H 2 O (1 mL) was added to a 25 mL sealable tube, equipped with a stirring bar.After the addition of PdCl 2 (NH 3 ) 2 /cationic 2,2 -bipyridyl solution (1 mL, 0.01 mmol in 1 mL H 2 O), the tube was sealed using a Teflon-coated screw cap under air, and stirred in an oil bath at 140 • C for 24 h (in the cases of Entries 5 and 6 of Table 5, the reaction time was 48 h).After cooling to room temperature, the aqueous reaction mixture was extracted with hexane/EtOAc (1/1, 3 × 3 mL), the combined organic phase was dried over anhydrous MgSO 4 , and the solvent was removed under reduced pressure.Flash chromatography on silica gel gave the desired product.

Conclusions
In conclusion, we have proven that water-soluble PdCl 2 (NH 3 ) 2 /cationic 2,2 -bipyridyl is an efficient catalytic system to catalyze the double Mizoroki-Heck reaction of aryl iodides onto activated alkenes, using water as the reaction medium.After being separated from the organic phase by extracting with hexane/EtOAc, the residual aqueous layer is able to be reused for the next run, which makes this procedure greener and reduces the waste of precious metals.Polyarylation of aryl halides onto other alkenes is presently under investigation.
b Isolated yields.c The initial run.d The first reuse run.e The second reuse run.
b Isolated yields.c The initial run.d The first reuse run.e The second reuse run.
b Isolated yields.c The initial run.d The first reuse run.e The second reuse run.
b Isolated yields.c The initial run.d The first reuse run.e The second reuse run.
b Isolated yields.cTheinitial run.dThefirst reuse run.e The second reuse run.

Table 4 .
Palladium-catalyzed β,β-diarylation of acrylonitrile (2d) in water a .Isolated yields.c Reaction time was 24 h.d Reaction time was 36 h.e The initial run.f The first reuse run.g The second reuse run. b
Isolated yields.c Reaction time was 24 h.d Reaction time was 36 h.e The initial run.f The first reuse run.g The second reuse run. b
Isolated yields.c Reaction time was 24 h.d Reaction time was 36 h.e The initial run.f The first reuse run.g The second reuse run. b
Isolated yields.c Reaction time was 24 h.d Reaction time was 36 h.e The initial run.f The first reuse run.g The second reuse run. b
Isolated yields.c Reaction time was 24 h.d Reaction time was 36 h.e The initial run.f The first reuse run.g The second reuse run. b
Isolated yields.c Reaction time was 24 h.d Reaction time was 36 h.e The initial run.f The first reuse run.g The second reuse run. b
Isolated yields.c Reaction time was 24 h.d Reaction time was 36 h.e The initial run.f The first reuse run.g The second reuse run. b
Isolated yields.c Reaction time was 24 h.d Reaction time was 36 h.e The initial run.f The first reuse run.g The second reuse run. b
) at 140 °C for 48 h.b Isolated yields.c Reaction time was 24 h.d Reaction time was 36 h.e The initial run.f The first reuse run.g The second reuse run.
) at 140 °C for 48 h.b Isolated yields.c Reaction time was 24 h.d Reaction time was 36 h.e The initial run.f The first reuse run.g The second reuse run.
) at 140 °C for 48 h.b Isolated yields.c Reaction time was 24 h.d Reaction time was 36 h.e The initial run.f The first reuse run.g The second reuse run.
) at 140 °C for 48 h.b Isolated yields.c Reaction time was 24 h.d Reaction time was 36 h.e The initial run.f The first reuse run.g The second reuse run.
) at 140 °C for 48 h.b Isolated yields.c Reaction time was 24 h.d Reaction time was 36 h.e The initial run.f The first reuse run.g The second reuse run.
) at 140 °C for 48 h.b Isolated yields.c Reaction time was 24 h.d Reaction time was 36 h.e The initial run.f The first reuse run.g The second reuse run.
) at 140 °C for 48 h.b Isolated yields.c Reaction time was 24 h.d Reaction time was 36 h.e The initial run.f The first reuse run.g The second reuse run.
) at 140 °C for 48 h.b Isolated yields.c Reaction time was 24 h.d Reaction time was 36 h.e The initial run.f The first reuse run.g The second reuse run.