catalysts

: Herein, to the best of our knowledge, the ﬁrst heterobimetallic Y/Eu porous metal–organic framework (MOF), based on 3-amino-4-hydroxybenzoic acid (H 2 L) ligand, with the following formulae {[Y 3.5 Eu 1.5 L 6 (OH) 3 (H 2 O) 3 ] · 12DMF} n (in advance, namely Y/Eu-MOF ), is described. The three-dimensional structure has been synthesized by solvothermal routes and thoroughly characterized, by means of single crystal X-ray diffraction, powder X-ray diffraction, electronic microscopy, ICP-AES, electrophoretic mobility, and FTIR spectra. Intriguingly, the porous nature allows for coordinated solvent molecules displacement, yielding unsaturated metal centers, which can act as a Lewis acid catalyst. This novel supramolecular entity has been tested in cyanosilylation and hydroboration reactions on carbonyl substrates of a diverse nature, exhibiting an extraordinary activity.


Introduction
Metal-organic frameworks are multifunctional, inorganic-organic systems composed of organic ligands and metallic nodes and, since the 1990s, have emerged as promising materials for infinite applications, among them heterogeneous catalysis [1,2].
Their intrinsic porosity, along with easy tunability and functionalization, are some of the appealing characteristics to be employed in heterogeneous catalysis [3].The structural porosity provides a confined space to which substrates have access and catalysis can take place.Furthermore, the MOF's robustness provides stable skeletons, where unsaturated metallic centers can act as a Lewis acid catalyst, subsequent displacement of coordinated solvent molecules could occur, and the further activation of the substrates already accessed through the channels might help the catalysis evolve [4].
In this context, cyanosilylation and hydroboration reactions catalyzed by heterogeneous catalysts, such as MOFs, are presented as interesting approaches for the formation of cyanohydrins and alcohols [5,6].The cyanosilylation reaction is an important synthetic tool for C-C bond formation in organic systems, since it gives access to key intermediates of great interest in the field of pesticides and medical application, among which α-hydroxy acids, α-hydroxy ketones, α-amino acids, and β-amino alcohols can be mentioned [7,8].
The heterobimetallic Y/Eu-MOF presented herein was designed when looking for a synergy and enhanced catalytic activity, with respect to their isostructural pristine counterparts, which were able to exhibit activity for seven cycles, with very low catalytic loading of 0.5 mol%, no catalyst leaking, TOF values of 106 h −1 and 1031 h −1 , and preferred suitability towards aldehydic and ketonic substrates for Y-MOF [15] and Eu-MOF, respectively.
Taking all into consideration, our interest lies in exploring the catalytic activity of this novel heterobimetallic MOF, based on 3-amino-4-hydroxybenzoic acid polytopic ligand, in the cyanosilylation and hydroboration reactions of aldehydes and ketones of diverse nature under solvent-free and environmentally friendly conditions, in order to eventually conclude whether catalytic activity enhances, with respect to initial counterparts.

Preparation of the Catalyst
The solvothermal reaction between 3-amino-4-hydroxybenzoic acid (H 2 L) ligand and Y-Eu metal mixture in a basic media yields a three-dimensional, porous, metal-organic framework that crystallizes in hexagonal P63/m space group.The asymmetric unit of this supramolecular entity is composed of a deprotonated ligand molecule, two metal atoms with special positions (in addition to a coordinated water molecule), and a hydroxyl bridge, which acts as connector among neighboring metallic centers.Note that, taking into consideration that metals are randomly distributed within the crystal structure, a tentative formula is presented, which is corroborated by bulk properties of the material (see ICP-AES results in Table S2 or SEM-EDX results in Figure S3).
Therefore, regarding the metal environment, two surroundings are described: nine coordinated MN 3 O 6 and eight coordinated MO 8 environments, which, according to continuous shape measurements, confirm the spherical capped square antiprism (TCTPR-9) and triangular dodecahedron (TDD-8) polyhedra, respectively.The former coordination environment is composed of three hydroxyl oxygens and amino atoms from L in addition to three additional oxygen atoms belonging to ligand hydroxyl group.The latter metallic nucleus is composed of the coordination of a water solvent molecule, an oxygen belonging to a hydroxyl bridge, along with six oxygen atoms, corresponding to two ligand hydroxyl and two carboxylate moieties.
As aforementioned, hydroxyl bridges µ 3 -OH − join metallic centers constructing M 5 (OH) 3 secondary building units in the structure, being the ligand connector, among different sbu.Regarding the connectivity of the supramolecular entity, from the topological point of view, six-connected nodes are described, which, according to TOPOS software [31] examination, the framework disposed of the acs network with the (4 9 •6 6 ) point symbol.Intrinsic porosity, characterized by three dimensional micropores of 10.1 × 13.3 Å of Y/Eu-MOF (according to PLATON-v1.18[32] cavities, corresponds to 19% of the volume of the structure) and enables solvent crystallization molecules to be trapped, whiting the pores; concretely, DMF molecules have been demonstrated to be located in the microchannels (Figure 1).
of Y/Eu-MOF (according to PLATON-v1.18[32] cavities, corresponds to 19% of the volume of the structure) and enables solvent crystallization molecules to be trapped, whiting the pores; concretely, DMF molecules have been demonstrated to be located in the microchannels (Figure 1).

Chemical Composition
Single-crystal X-ray diffraction allowed for proposing an approximated formula of the heterobimetallic catalyst, which was further confirmed by FT-IR, ICP-AES, PXRD, and SEM-EDX.For a detailed explanation of PXRD and FT-IR, please check supporting information, Figures S1 and S2, respectively.
ICP-AES analysis, conducted in the heterobimetallic compound Y/Eu-MOF, exhibited an yttrium content of 1672 mg/L (corresponding to 18.8 mM of Y 3+ ) and europium content of 1268 mg/L (8.34 mM Eu 3+ ).The calculated Y to Eu relationship gives 2.25, which is very much in line with the proposed formula, where a proportion of 2.33 is expected.Additionally, SEM-EDX mapping confirms that both metals are present in single crystal.However, the mapping spectrum, performed in one single crystal, showed relatively higher Y 3+ to Eu 3+ proportions; for the crystal in which spectrum was collected, a relationship of 3.25, regarding to Y to Eu, was calculated.This is due to the uneven distribution of metals throughout the catalyst structure.Nonetheless, the proposed formula, which is derived by single crystal X-ray diffraction, powder X-ray diffraction, SEM-EDX, and ICP-

Chemical Composition
Single-crystal X-ray diffraction allowed for proposing an approximated formula of the heterobimetallic catalyst, which was further confirmed by FT-IR, ICP-AES, PXRD, and SEM-EDX.For a detailed explanation of PXRD and FT-IR, please check supporting information, Figures S1 and S2, respectively.
ICP-AES analysis, conducted in the heterobimetallic compound Y/Eu-MOF, exhibited an yttrium content of 1672 mg/L (corresponding to 18.8 mM of Y 3+ ) and europium content of 1268 mg/L (8.34 mM Eu 3+ ).The calculated Y to Eu relationship gives 2.25, which is very much in line with the proposed formula, where a proportion of 2.33 is expected.Additionally, SEM-EDX mapping confirms that both metals are present in single crystal.However, the mapping spectrum, performed in one single crystal, showed relatively higher Y 3+ to Eu 3+ proportions; for the crystal in which spectrum was collected, a relationship of 3.25, regarding to Y to Eu, was calculated.This is due to the uneven distribution of metals throughout the catalyst structure.Nonetheless, the proposed formula, which is derived by single crystal X-ray diffraction, powder X-ray diffraction, SEM-EDX, and ICP-AES, is consistent and summarizes the best approximation for data obtained in the aforementioned techniques.

Chemical Stability and Electrophoretic Behavior
ζ-potential is one of the fundamental parameters normally used to measure the magnitude of the electrostatic (or charge) repulsion or attraction between particles, being an indirect estimate of the surface charge density of the systems and helping to determine the repulsive interactions between colloidal particles, as well as the tendency of aggregation.Systems with high ζ-potential ( − / + ) are considered electrically stable, whereas colloids with low ζ-potential ( − / + ) are usually referred to as systems that tend to aggregate and further precipitate.In this study, measurements were always conducted at a fixed conductivity of 330 µS/cm, which is equivalent to a concentration of about 3.7 mM NaCl (Figure S7).The highest negative value of the ζ-potential, obtained with Y/Eu-MOF, was reached at pH 10 (−35.8 ± 0.5 mV, electrophoretic mobility of −2.252 ± 0.035 µmcm/Vs), suggesting that: (i) the dissociation of external acidic groups have occurred, conferring the overall negative charge (Figures S8 and S9, Table S7); (ii) the MOF particles will tend to repel each other, and there will be no tendency for the particles to come together at this basic pH, due to this large value of ζ-potential.However, when reducing the pH of the solutions, the ζ-potentials values started to increase, evidencing an isoelectric point between pH 4 and 5. Similar results were previously reported by our group.The Eu-MOF catalyst, with the highest negative value of ζ-potential, was also obtained at pH 10 (−25.0 ± 0.6 mV); however, in this case, the isoelectric point was obtained between pH 8 and 9 (Figure 2).From an electrophoretic behavior point of view, the mixed nature of MOF confers both a higher stability, as a function of pH, and less tendency to aggregate.
AES, is consistent and summarizes the best approximation for data obtained in the aforementioned techniques.

Chemical Stability and Electrophoretic Behavior
ζ-potential is one of the fundamental parameters normally used to measure the magnitude of the electrostatic (or charge) repulsion or attraction between particles, being an indirect estimate of the surface charge density of the systems and helping to determine the repulsive interactions between colloidal particles, as well as the tendency of aggregation.Systems with high ζ-potential ( − / + ) are considered electrically stable, whereas colloids with low ζ-potential ( − / + ) are usually referred to as systems that tend to aggregate and further precipitate.In this study, measurements were always conducted at a fixed conductivity of 330 µS/cm, which is equivalent to a concentration of about 3.7 mM NaCl (Figure S7).The highest negative value of the ζ-potential, obtained with Y/Eu-MOF, was reached at pH 10 (−35.8 ± 0.5 mV, electrophoretic mobility of −2.252 ± 0.035 µmcm/Vs), suggesting that: (i) the dissociation of external acidic groups have occurred, conferring the overall negative charge (Figures S8 and S9, Table S7); (ii) the MOF particles will tend to repel each other, and there will be no tendency for the particles to come together at this basic pH, due to this large value of ζ-potential.However, when reducing the pH of the solutions, the ζ-potentials values started to increase, evidencing an isoelectric point between pH 4 and 5. Similar results were previously reported by our group.The Eu-MOF catalyst, with the highest negative value of ζ-potential, was also obtained at pH 10 (−25.0 ± 0.6 mV); however, in this case, the isoelectric point was obtained between pH 8 and 9 (Figure 2).From an electrophoretic behavior point of view, the mixed nature of MOF confers both a higher stability, as a function of pH, and less tendency to aggregate.In order to determine the particle size distribution of the catalyst in the suspended and deposited fraction, optical microscope images were assayed (Figures S4 and S5).The catalyst was suspended in distilled water; the suspension was shaken vigorously and subsequently left for sedimentation for 5 min, and the suspended fraction separated.The deposited fraction was composed of 68% of the total amount of catalyst initially weighted, having an average particle size distribution of 12 ± 6 µm (Figure S4).The suspended fraction showed an average particle size of 8 ± 4 µm (Figure S5).Obtained values are relatively similar to SEM images, in which single crystals and larger aggregates are appreciated.In order to determine the particle size distribution of the catalyst in the suspended and deposited fraction, optical microscope images were assayed (Figures S4 and S5).The catalyst was suspended in distilled water; the suspension was shaken vigorously and subsequently left for sedimentation for 5 min, and the suspended fraction separated.The deposited fraction was composed of 68% of the total amount of catalyst initially weighted, having an average particle size distribution of 12 ± 6 µm (Figure S4).The suspended fraction showed an average particle size of 8 ± 4 µm (Figure S5).Obtained values are relatively similar to SEM images, in which single crystals and larger aggregates are appreciated.Taking into consideration the average particle size distribution in the suspension, it is suggested that single-crystals remain relatively well-suspended, and aggregates of superior size tend to deposit.

Study of the Catalytic Activity
The catalytic activity of Y/Eu-MOF (0.5 mol%) was initially evaluated in the cyanosilylation reaction of carbonyl compounds (Y/Eu-MOF) using TMSCN as the nucleophile, solvent free reaction conditions, room temperature, and N 2 atmosphere.These conditions have been already reported in our previous works, with monometallic Y or Eu MOF synthetized with the same ligand H 2 L (3-amino-4-hydroxybenzoic acid) [15], obtaining only 8% conversion after 14 h when the blank reaction was tested.
The scope of the reaction was evaluated with five highly reactive aldehydes of different natures, such as aromatic, heteroaromatic, and aliphatic, demonstrating that independently of the nature of the substituent, the reaction takes place with very good to excellent conversions (89-99%), after only 24 h (Scheme 1).Later on, less reactive and sterically demanding ketones were tested, observing a significant decrease in conversion (74-77%), when electron-donating or -withdrawing substituents were located at the para-position, whereas, again, excellent conversion were achieved with aromatic, heteroaromatic, and aliphatic substrates (91-99%) (Scheme 1).These results overpass the ones published, until the moment for other groups [21][22][23], and have similar catalytic behaviour with our pristine Eu-MOF.
suggested that single-crystals remain relatively well-suspended, and aggregates of superior size tend to deposit.

Study of the Catalytic Activity
The catalytic activity of Y/Eu-MOF (0.5 mol%) was initially evaluated in the cyanosilylation reaction of carbonyl compounds (Y/Eu-MOF) using TMSCN as the nucleophile, solvent free reaction conditions, room temperature, and N2 atmosphere.These conditions have been already reported in our previous works, with monometallic Y or Eu MOF synthetized with the same ligand H2L (3-amino-4-hydroxybenzoic acid) [15], obtaining only 8% conversion after 14 h when the blank reaction was tested.
The scope of the reaction was evaluated with five highly reactive aldehydes of different natures, such as aromatic, heteroaromatic, and aliphatic, demonstrating that independently of the nature of the substituent, the reaction takes place with very good to excellent conversions (89-99%), after only 24 h (Scheme 1).Later on, less reactive and sterically demanding ketones were tested, observing a significant decrease in conversion (74-77%), when electron-donating or -withdrawing substituents were located at the para-position, whereas, again, excellent conversion were achieved with aromatic, heteroaromatic, and aliphatic substrates (91-99%) (Scheme 1).These results overpass the ones published, until the moment for other groups [21][22][23], and have similar catalytic behaviour with our pristine Eu-MOF.Scheme 1. Scope of the cyanosilylation reaction using aldehydes and ketones.
As a continuation of the study of the catalytic activity of Y/Eu-MOF, we decided to go one step forward and test, for the first time, the hydroboration reaction of carbonyl compounds with a lanthanide based-MOF catalyst.For that, the optimization of the reaction conditions was carried out (Table S8).First of all, the reaction was tested with solvents of different natures, as well as without solvent (entries 1-5), obtaining the best result in the absence of solvent (entry 1, Table S8).Finally, the amount of catalyst was also tested (entries 6-8), observing that, with a slight increase from 0.35 to 0.5 mol%, the reaction took place with full conversion (entry 6).
With the optimal reaction conditions in hand, the scope of the reaction was evaluated again, using a broad range of different ketones (Scheme 2).The use of electron-donating Scheme 1. Scope of the cyanosilylation reaction using aldehydes and ketones.
As a continuation of the study of the catalytic activity of Y/Eu-MOF, we decided to go one step forward and test, for the first time, the hydroboration reaction of carbonyl compounds with a lanthanide based-MOF catalyst.For that, the optimization of the reaction conditions was carried out (Table S8).First of all, the reaction was tested with solvents of different natures, as well as without solvent (entries 1-5), obtaining the best result in the absence of solvent (entry 1, Table S8).Finally, the amount of catalyst was also tested (entries 6-8), observing that, with a slight increase from 0.35 to 0.5 mol%, the reaction took place with full conversion (entry 6).
With the optimal reaction conditions in hand, the scope of the reaction was evaluated again, using a broad range of different ketones (Scheme 2).The use of electron-donating groups in the para-position of the aromatic ring negatively influenced the catalytic reaction, causing the reaction time to increase from 24 to 48 or even 120 h, in order to obtain moderate conversions (45-67%).This influence on the increase in reaction time did not take place when electron-withdrawing substituents were used, observing that, regardless of the position of the aromatic ring in which the substituents were found, yields were good (71-90%).Furthermore, heteroaromatic ketones reached good results in only 24 h of reaction (88%).The steric hindrance of ketones, such as 1j and 1p, needed superior reaction times of 48 and 120 h, respectively, in order to achieve full conversion.Aliphatic ketones, with different natures, were tested and provided good results (95-99%).Then, we decided to test cyclic ketones, which are usually less employed, obtaining moderate results (61-63%).Finally, the chemoselectivity of the reaction was pursued by employing ketones bearing double bonds and ester groups, achieving, in both cases, the specific reduction of the carbonyls; although, in the latter, the conversion was lower than 5%, due to the poor solubility of the substrate in HBpin.Another important issue that needed to be addressed was if our catalysis was the object of hidden boron catalysis [33].To distinguish between "true" catalysis and BH 3 catalysis, for reactions using HBpin, we performed two complementary experiments.With the help of 1 H and 11 B NMR, we pursued the possible MOF-promoted BH 3 formation by monitoring the mixture of our MOF catalyst and HBpin under catalytic conditions.The lack of BH 3 signals was evidenced during the whole experiment, proving that our MOF catalyst does not promote formation of BH 3 .In addition, we performed the hydroboration of acetophenone with BH 3 •THF, instead of with HBpin, showing no substrate conversion and, therefore, further verifying that, under our catalytic conditions, hidden boron catalysis does not exist.

Recyclability and Leaching Studies of the Catalyst
Recyclability tests were also investigated, in order to study the heterogeneous nature of the catalyst.After standard reaction conditions, using acetophenone as substrate (Schemes S1 and S2), the catalyst was isolated from the reaction mixture via centrifugation and washed several times with dichloromethane.The catalyst was dried under vacuum and then charged with a new set of reagents, in order to evaluate its recyclability.The corresponding products were obtained in a 28% and 61% for cyanosilylation and hydroboration, respectively, and, in another consecutive cycle, 0% and 15% of conversion, respectively, was achieved (Figure S10).A leaching test was also carried out, in the case of the hydroboration reaction (Scheme S3).For that, after the first and second reaction of recyclability test, the catalyst was removed by centrifugation and supernatant was filtered through a plug of celite and dried under vacuum.Then, 1-(pyridin-2-yl)ethan-1-one (1i) and HBpin were added to the crude of the corresponding reaction cycle, and the reaction was stirred under inert N 2 atmosphere at room temperature for 24 h.After that time, an aliquot was analysed by 1 H NMR, obtaining, in the first cycle, a 38% of conversion and, in the second cycle, a 13% of product, corroborating the leaching of Y or Eu.

Green Chemistry Metrics
Green chemistry metrics such as atomic economy (AE), mass intensity (MI), reaction mass efficiency (RME), and carbon efficiency (CE) were calculated for both reactions studied (Table S9), in order to evaluate if the reactions are eco-friendly and can overcome environmental and health problems.The obtained values for cyanosilylation reaction were 100% of AE, 1.127 for MI, 95.7% for RME, and 96.8% for CE.These results are comparable to those described previously for related lanthanide-based MOFs [15,16,19,20].In the case of the hydroboration reaction, these values decreased considerably, down to 49.1%, 2.406, 46.8%, and 52.1% for AE, MI, RME, and CE, respectively, due to the final hydrolysis and consequent loss of atoms in the final product (Table S9).

Materials
All experiments involving moisture-sensitive compounds were performed under an inert atmosphere of N 2 using standard techniques.Unless otherwise indicated, reagents and substrates were purchased from commercial sources and used as received.Metallic precursors, such as europium (III) nitrate pentahydrate (99.9%,Alfa Aesar), and yttrium (III) nitrate hexahydrate (99.9% of purity, Fluorochem), were used as received, as well as 3amino-4-hydroxybenzoic acid ligand (H 2 L, C 7 H 7 NO 3 , 97% of purity), which was purchased from Fluorochem.Solvents not required to be dry were purchased as technical grade and used as received.Conversion values relative to the limiting reagent were calculated from the 1 H NMR spectra of the reaction crudes.Isolated products of cyanosilylation reaction were obtained after centrifugation (12,300 rpm, 5 min, 20 • C) and washed with dichloromethane (2 × 0.5 mL), in order to remove the catalyst or column chromatography in silica gel using hexane as eluent.For the hydroboration reaction, first of all the hydrolysis of the product was carried out adding NaOH (0.1 M, 0.5 mL) and Et 2 O (0.5 mL) and stirring the mixture overnight; after that, the catalyst was removed via centrifugation (12,300 rpm, 5 min, 20 • C) and washed with dichloromethane (2 × 0.5 mL).

Synthesis of {[Y 3.5 Eu 1.5 L 6 (OH) 3 (H 2 O) 3 ]•12DMF} n , namely Y/Eu-MOF:
The 3-amino-4-hydroxybenzoic acid (0.010 g, 0.0625 mmol) was dissolved in 0.2 mL of DMF containing 10 µL of Et 3 N (0.072 mmol).In a separate vial, Eu(NO 3 ) 3 •5H 2 O (0.006 g, 0.0145 mmol) and Y(NO 3 ) 3 •6H 2 O (0.011 g, 0.0289 mmol) salts were dissolved into a 0.8 mL of distilled water.After dissolution, 0.2 mL of DMF and 0.8 mL of H 2 O were added to the metal and ligand solutions, respectively.Finally, the metal solution was added dropwise and under continuous agitation to the ligand solution.The obtained brown solution was introduced to the oven at 100 • C for 2 h in a screw-capped vial (6 mL) to yield hexagonal single crystals.For the reaction scaling up synthetic procedure, consult the supporting material.
General procedure for the cyanosilylation reaction: In a 1 mL vial, with a septum screw capped, equipped with a stirring bar, Y/Eu-MOF catalyst (0.5 mol%) was weighed.Subsequently, the corresponding amount of carbonylic compound 1 (0.25 mmol) was added, followed by trimethylsilyl cyanide (TMSCN) (34 µL, 0.275 mmol, 1.1 equiv.), and the reaction was stirred under inert N 2 atmosphere at room temperature for 24 h.Once the reaction was finished, the catalyst was removed by centrifugation (12,300 rpm, 5 min) and washed with DCM (2 × 0.5 mL), obtaining the corresponding pure products 2 and 3, after removal of the solvent with rotary evaporator.When not full conversion was reached, the product was purified by column chromatography using hexane as eluent.
General procedure for the hydroboration reaction: In a 1 mL vial, with a septum screw capped, equipped with a stirring bar, Y/Eu-MOF catalyst (0.5 mol%) was weighed.Subsequently, the corresponding amount of carbonylic compound 1 (0.25 mmol) was added, followed by pinacolborane (HBpin) (40 µL, 0.275 mmol, 1.1 equiv.), and the reaction was stirred under inert N 2 atmosphere at room temperature for the corresponding time, as indicated on the table.After that time, the hydrolysis of the final product was carried out adding NaOH (0.1 M, 0.5 mL) and Et 2 O (0.5 mL), and the mixture was stirred overnight.Once the reaction was finished, the catalyst was removed by centrifugation (12,300 rpm, 5 min) and washed with DCM (2 × 0.5 mL), obtaining the corresponding product 4 after removal of the solvent with rotary evaporator.When not full conversion was reached the product was purified by column chromatography.

Conclusions
All in all, to the best of our knowledge, we report the first mixed heterobimetallic Y/Eu-MOF, based on a 3-amino-4-hydroxylbenzoic acid ligand, with impressive catalytic efficiency in the cyanosilylation and hydroboration reaction of carbonyl compounds, but reduced recyclability, compared to the related MOFs.The catalyst has been thoroughly characterized by means of X-ray crystallography, FTIR, ICP-AES, and PXRD; its electrophoretic behavior, as a function of pH, has been also assayed, showing a negative surface charge with a very low tendency to aggregate.

Supplementary Materials:
The following supporting information can be downloaded at: https: //www.mdpi.com/article/10.3390/catal12030299/s1.Table S1: Elemental analysis of compounds Y/Eu-MOF.Table S2: ICP-AES results of compound Y/Eu-MOF.Table S3: Crystallographic data and structure refinement details of compound Y/Eu-MOF.Table S4: Selected bond lengths (Å) and angles ( • ) for compound Y/Eu-MOF.Table S5 S7: Electrophoretic mobility and ζ-potential dependence, with the pH of the Y/Eu-MOFs particles dispersed in water.Conductivity fixed at 330 µS/cm.Table S8: Optimization of the reaction conditions in the hydroboration reaction.Table S9: Green metrics calculated for Y/Eu-MOF catalyst.Table S10: Catalytic cyanosilylation of benzaldehyde performances of Ln-MOFs, as reported in the literature.

Figure 1 .
Figure 1.Perspective view of the (a) metal coordination environments found in heterobimetallic compound Y/Eu-MOF.(b) View of the pentametallic nodous, where M5(OH)3 sbu are appreciable.(c) View for the formation of the 1 D channels; (d) the cavities present in the structure along the a axis.Color code: Y (green), Eu (purple), C (grey), O (red), N (blue), and H (white).Note that, due to the altering and randomly oriented disposition metals, an approximated representation has been performed, taking into consideration proposed formula of {[Y3.5Eu1.5L6(OH)3(H2O)3]•12DMF}n.

Figure 1 .
Figure 1.Perspective view of the (a) metal coordination environments found in heterobimetallic compound Y/Eu-MOF.(b) View of the pentametallic nodous, where M 5 (OH) 3 sbu are appreciable.(c) View for the formation of the 1 D channels; (d) the cavities present in the structure along the a axis.Color code: Y (green), Eu (purple), C (grey), O (red), N (blue), and H (white).Note that, due to the altering and randomly oriented disposition metals, an approximated representation has been performed, taking into consideration proposed formula of {[Y 3.5 Eu 1.5 L 6 (OH) 3 (H 2 O) 3 ]•12DMF} n .

Figure 2 .
Figure 2. Comparison of ζ-potential behavior, as a function of pH, obtained with Y/Eu-MOF and Eu-MOF.All the measurements were performed with a constant conductivity of 330 µS/cm.

Figure 2 .
Figure 2. Comparison of ζ-potential behavior, as a function of pH, obtained with Y/Eu-MOF and Eu-MOF.All the measurements were performed with a constant conductivity of 330 µS/cm.

1 Scheme 2 .
Scheme 2. Scope of the hydroboration reaction of ketones.Reaction carried out for 24 h. a Reaction carried out during 24 h; b Reaction carried out during 48 h; c Reaction carried out during 120 h.
Figure S1: Figure of the pattern matching analysis and experimental PXRD for Y/Eu-MOF.Figure S2: Figure of the infrared spectra of the ligand and Y/Eu-MOF.
Figure S3: SEM and EDS mapping of bulk material of Y/Eu-MOF.

Figure S4 :
Images and particle size distribution (an overall of 250 particles) in the deposited fraction of Y/Eu-MOF catalyst non-suspended in water (about a 68% of the total amount), determined from optical microscope images.
Figure S5: Images and particle size distribution (an overall of 250 particles) of Y/Eu-MOF crystals in the fraction steadily suspended in water (about a 32% of the total amount), determined from optical microscope images.
Figure S6: Comparation of the particle size distribution of Y/Eu-MOF in the fraction steadily suspended in water and the non-suspended, determined from optical microscope images.
Figure S8: ζ-potential (mV) dependence with the pH of the Y/Eu-MOF.All the measurements were performed with constant conductivity of 330 µS/cm.
Figure S9: Electrophoretic mobility (µm•cm/V•s) dependence with the pH of the Y/Eu-MOF.All the measurements were performed with constant conductivity of 330 µS/cm.
Figure S10: Study of the recyclability of Y/Eu-MOF (0.5 mol%) catalyst on the cyanosilylation and hydroboration reaction of acetophenone as carbonyl substrate.
Figure S11:Analysis of the TOF (h −1 ) obtained in the cyanosilylation reaction of acetophenone at different times of reaction with Y/Eu-MOF (0.5 mol%), with the optimized reaction conditions.FigureS12: Analysis of the TOF (h −1 ) obtained in the hydroboration reaction acetophenone at different times of reaction with Y/Eu-MOF (0.5 mol%), with the optimized reaction conditions.Scheme S1: Reaction conditions : Table of the continuous Shape Measurements for the MN 3 O 6 coordination environment.Table S6: Table of the continuous Shape Measurements for the MO 8 coordination environment.Table