Direct Cross-Coupling of Alcohols with O -Nucleophiles Mediated by N -Iodosuccinimide as a Precatalyst under Mild Reaction Conditions

: We report N -iodosuccinimide as the most efficient and selective precatalyst among the N -halosuccinimides for dehydrative O -alkylation reactions between various alcohols under high-substrate concentration reaction conditions. The protocol is non-metal, one-pot, selective, and easily scalable, with excellent yields; enhancing the green chemical profiles of these transfor-mations.


Results and Discussion
We began our investigations by using diphenylmethanol 1 with NIS as the precatalyst under solvent-free reaction conditions (SFRC), where the dimerization process was observed, resulting in the formation of symmetric ether 2 (entry 1, Table 1). For the transformation of diphenylmethanol 1 without NIS, in the presence of MeOH 3 under HCRC, no conversion of the starting material was observed [15]. The effect of NIS loading for the reaction of diphenylmethanol 1 in the absence of a nucleophile source under SFRC was examined, and the results are presented in Table 1, and in Supplementary Materials To increase the yield of the product, different concentrations of the precatalyst were used. Employing 0.5 mol% of the precatalyst, the formation of the corresponding product 2 with good yield was observed, accompanied by a trace of oxidized alcohol (entry 1). By increasing the precatalyst loading to 1 mol%, we observed the high conversion of the starting material 1 into the corresponding product 2, accompanied by a trace of oxidized alcohol (entry 2). We found that for the quantitative conversion of the starting material 1 to the dimeric ether 2, 2 mol% of the precatalyst was effective (entry 3).
In searching for the optimal reaction conditions, different parameters, such as loading of the NIS as the mediator and temperature for the reaction of diphenylmethanol 1 with MeOH 3 under HCRC, were first examined, and the results are presented in the Tables 2 and 3 and in Supplementary Materials. To determine the effectiveness of the NIS as the mediator, different concentrations of the precatalyst were employed. In the reaction of diphenylmethanol 1 with MeOH 3 using 0.5 mol% of the precatalyst, the formation of the corresponding product 4 in good yield and accompanied by a small amount of symmetric ether 2 was observed (entry 1). By increasing the precatalyst loading to 1 mol%, quantitative conversion of the starting material 1 into the corresponding product 4 was noticed, accompanied by a small amount of dimeric ether 2 (entry 2). Similar results were achieved when the precatalyst loading was increased up to 2 mol% (entry 3). An improvement of 100% yield, without forming the dimeric ether was attained by increasing the precatalyst loading up to 3 mol% (entry 4).  The effect of temperature on the course of the reaction was examined by the reaction of diphenylmethanol 1 with MeOH 3 mediated by NIS under HCRC. When the reaction was carried out at room temperature, no transformation took place (entry 1). When the reaction was performed at 40-45 °C, the desired product 4 in low yield and a small amount of dimeric ether 2 were obtained (entry 2). An increase of reaction temperature up to 50-55 °C provided the corresponding product 4 in moderate yield, accompanied by a small amount of symmetric ether 2 (entry 3). Further optimization revealed that the reaction could be performed smoothly by raising the temperature to 60-65 °C. An improvement by 100% yield without forming the symmetric ether was attained by increasing the reaction temperature to 70-75 °C.
Screening on precatalyst loading and reaction temperature showed that 3 mol% NIS, 70-75 °C, and 6 h were the best conditions ensuring complete conversion of 1 into the corresponding ether 4 (Scheme 1).

Scheme 1.
Optimal reaction conditions for the conversion of diphenylmethanol 1 into the (methoxymethylene)dibenzene 4 mediated by NIS under HCRC.
Encouraged by these promising results, we applied the obtained optimal reaction conditions to direct dehydrative O-alkylation reactions between different alcohols mediated by NIS under HCRC, and the results are collected in Table 4. Table 4. Transformation of benzyl and tertiary alkyl alcohols with alkyl alcohols mediated by NIS under SFRC, under HCRC or in solution a . Effective transformation with MeOH 3, mediated by NIS, was observed in the reaction with additional derivatives of diphenylmethanol bearing EDG or EWG on the aro-matic rings affording the corresponding products in excellent yields. We checked the reaction of phenyl(p-tolyl)methanol 5 with NIS as the mediator, in the absence or in the presence of MeOH, wherein in both cases we established the quantitative formation of the dimeric ether 6 (entry 3, Table 4) or the corresponding ether 7 (entry 4, Table 4). Etherification of (4-chlorophenyl)(phenyl)methanol 8 with MeOH 3, mediated by NIS under HCRC, provided the corresponding product 9 in excellent yield (entry 5, Table 4).
Furthermore, we performed the reaction of diphenylmethanol 1 catalyzed by NIS, in the presence of EtOH 10, under HCRC, which efficiently and successfully resulted in the formation of the corresponding ether 11, accompanied by a small amount of dimeric ether 2 and oxidized alcohol (entry 6, Table 4). The transformation of diphenylmethanol 1 catalyzed by NIS in isopropyl solution (i-PrOH) 12, provided the corresponding ether 13 in high yield, accompanied by a small amount of oxidized alcohol (entry 7, Table 4).
The effective and selective transformation was observed in the reaction with tertiary benzyl and alkyl alcohols. 2-Phenylpropan-2-ol 16 was readily mediated by NIS under HCRC to afford quantitative yields of target ether 17 in methanol solution [15] (entry 9, Table 4). α,α-dimethylbenzenepropanol 18 catalyzed by NIS, in the presence of MeOH 3 under HCRC was successfully converted into their corresponding ether 19 [15] (entry 10, Table 4).
In the case of 1,1-diphenylethanol in the presence of a substoichiometric amount of NIS (0.5 mol% NIS, 70-75 °C, 24 h) under SFRC, 1,1-diphenylethene in the quantitative yield was observed, while in the presence of MeOH, EtOH, and i-PrOH increasing the amount of NIS up to 5 mol%, under HCRC, the formation of the corresponding alkene in high yield, accompanied by the formation of benzophenone (12-30%) was observed. We further investigated reactions of primary benzyl alcohols bearing EWG and EDG on the aromatic ring with MeOH under HCRC. In the case of primary unsubstituted benzyl alcohol 20, in the presence of MeOH, mediated by NIS, and under HCRC, only a trace amount of benzaldehyde was observed [15] (entry 11, Table 4). The transformation of 4-methylbenzyl alcohol 22 catalyzed by NIS in the absence of MeOH, under SFRC, was efficiently and selectively converted into the dimeric ether 23 (entry 12, Table 4). Etherification of 4-methylbenzyl alcohol 22 with MeOH under HCRC or in solution, using NIS as the precatalyst was not efficient (entry 13, Table 4). 4-chlorobenzyl alcohol 25 in the presence of MeOH, mediated by NIS was unable to undergo conversion (entry 14, Table  4).
Furthermore, we performed the reaction of phenyl(p-tolyl)methanol 5 with NIS as the mediator in the presence of ethoxytrimethylsilane (TMSOEt) 26 as the nucleophile source, where the ethoxy functional group was introduced efficiently into the organic molecule 27 [15], (entry 15, Table 4).
Additionally, to verify the synthetic value of the reported procedure, synthesis of (methoxymethylene)dibenzene 4 was accomplished at 10 mmol scale with high yield.
It was reported that the I-N bond of NIS as a precatalyst was activated by its reaction with the addition of alcohol. Consequently, it seems possible that transient halogen bonding could be necessary for the catalytic activity of NIS. Based on all the presented results, a potential explanation indicates the formation of HOI from the decomposition of NIS as the precatalyst by its reaction with the addition of alcohol [20][21][22][23]. The halogen bonding adducts are not the activated species. Instead, halonium (X + ) transfer will generate the intermediate resulting succinimide anion and HOI, promoting the etherification reaction.
HOI decomposes, forming I2 and HIO3. Iodine is well known for forming HOI and HI in aqueous reaction media, providing the regeneration of HOI for further activity as a catalyst. It could be seen that the formation of water through the etherification reaction as the only by-product of the reaction could accelerate the reaction. The assumption that NIS was a precatalyst providing HOI, I2, and protons during the system, which could correspond to nucleophilic substitution acceleration, was indicated to be reasonable [15,18]. To get insight into the precatalyst's thermal stability, thermal gravimetric analysis (TGA) on the NIS was accomplished. It was observed that degradation of the NIS did not occur at 25-200 °C [15].
To further extend this etherification protocol's scope, we studied the impact of NIS as the precatalyst for direct etherification of diphenylmethanol 1 with primary benzyl alcohols bearing an electron-withdrawing, as well as electron-donating, substituent on the aromatic ring under SFRC. The results are collected in Table 5. Direct etherification of diphenylmethanol 1 with unsubstituted benzyl alcohol 20 was carried out using NIS as the precatalyst under SFRC, leading to the corresponding ether 29 in high yield. In contrast, a small amount of oxidized alcohol and aldehyde were detected as side products (entry 1, Table 5). In the case of the reaction of diphenylmethanol 1 with 4-methylbenzyl alcohol 22 using NIS as the precatalyst under SFRC, the formation of the corresponding ether 30 in good yield, with a small amount of oxidized alcohol and dimeric ether 2 as side products (entry 2, Table 5), was detected. In the case of the reaction of diphenylmethanol 1 with 4-chlorobenzyl alcohol 25, mediated by NIS under SFRC, we observed the quantitative conversion of the starting material 1 into the corresponding ether 31, accompanied by a small amount of oxidized alcohol (entry 3, Table 5). We previously presented the stereochemical pathway of the etherification between (S)-(-)-1-phenylethanol 14 and MeOH 3, mediated by NIS, affording the corresponding ether 15 in moderate yield (entry 8, Table 4) and accompanied by a small amount of oxidized alcohol. The specific rotation of pure product 15 provided the value [α] = +15°, disclosing that we are not dealing with totally SN1 or SN2 cases but with the combination of both. It could be seen that the dimerization process is the SN1 and the final etherification is the SN2 mechanism, (Scheme 2). Scheme 2. Plausible reaction mechanism.
General procedure for etherification of alcohols mediated by NIS on half mmol scale: A mixture of benzyl alcohol (0.5 mmol), and N-iodosuccinimide as a mediator (3-10 mol%), which had been powdered in a mortar in the case of solid-state reactants, was placed in a 4 mL screw-capped vial, followed by adding liquid component alkyl alcohol (1 mmol-1 mL) and heated to 70-75 °C for 6 h-24 h. TLC detected the progress of the reaction mixture. After cooling down to room temperature the mixture was diluted with ethyl acetate (15 mL), washed thoroughly with Na2S2O3 (2 × 3 mL), NaHCO3 (2 × 3 mL), and distilled water (2 × 5 mL), and dried over anhydrous Na2SO4. The solvent was evaporated under reduced pressure, and the crude reaction mixture obtained was determined by 1 H NMR.
The scale-up procedure for the synthesis of (Methoxymethylene)dibenzene 4 with MeOH 3, mediated by NIS: A mixture of diphenylmethanol 1 (10 mmol, 2.2425 g), 3 mol% NIS (67.5 mg, 0.3 mol), which had been previously powdered in a mortar, was transferred to a 20 mL screw-capped glass scintillation vial, MeOH 3 (20 mmol, (800 μL) was added, and heated at 70-75 °C for 6 h. TLC followed the progress of the reaction mixture. Upon completion of the reaction, the mixture was cooled to room temperature. Finally, the crude reaction mixture was purified by column chromatography to obtain a pure product in excellent yield (colorless oil, 2.1725 g, and 90%).

Conclusions
In conclusion, we have presented an efficient, selective, one-pot, metal-free methodology for direct C-O bond formation from readily available alcohols, using NIS as a metal-free and easy-to-handle precatalyst under HCRC. In the case of 1,1-diphenylethanol mediated by NIS under SFRC, dehydration resulting in 1,1-diphenylethene was observed, while phenyl-substituted primary and secondary alcohols under the same conditions gave dimeric ethers. Phenyl-substituted primary, secondary, and tertiary alcohols under HCRC gave alkyl ethers, while under the same conditions 1,1-diphenylethanol gave 1,1-diphenylethene. The large scale synthesis of methoxymethylene)dibenzene 4 was performed, with excellent yield. Moreover, etherification could also be achieved by cross coupling two different benzyl alcohols and mediated by NIS as the precatalyst under SFRC.

Supplementary
Materials: The following are available online at www.mdpi.com/article/10.3390/catal11070858/s1, General Information, Optimisation of Reaction Conditions, Figure S1: The effect of loading of NIS on the conversion of diphenylmethanol 1 under SFRC, Figure S2