Mild and Efficient Tunable Brønsted Acidic Ionic Liquid Catalyzed O -Acetylation and O -Trimethylsilylation with Trimethylsilyl Acetate (TMSOAc) and Hexamethyldisilazane (HMDS)

: This report discloses a mild and efﬁcient O -acetylation using easily accessible TMSOAc as a novel acetyl reagent and O -trimethylsilylation using HMDS for various alcohols catalyzed by tunable Brønsted acidic ionic liquids (TBAILs). Imidazolium-based TBAILs were prepared by a two-step atom-economic reaction and acidities measured by using UV-visible spectroscopy. Both protections for alcohols were accomplished at room temperature with good to excellent yields, while the products and TBAILs were separated by simple work-up for O -silylation and column chromatography for O -acetylation. Notably, with the simple post-process, TBAILs catalyst in this solvent free method easily recovered and recycled several times without signiﬁcant degradation. donor and silylation using HMDS in the presence of a recyclable tunable Brønsted acidic ionic liquid. Our investigation suggested that TBAIL catalyzed acetylation using TMSOAc proceeds through silylation intermediate. Both transformations were proceeded at room temperature and provided mild to excellent yields. The use of TBAIL for diverse alcohols presents a simple alternative to costly and toxic catalysts. This method may be more useful in the future for extensive study of acetylation and silylation of different alcohols, and for the synthesis of natural products and small molecules TBAIL was recycled and reused at least 5 times, which provided another eco-friendly method in the ﬁeld of alcohol protection.


Introduction
The development of protections for synthesizing natural and unnatural products containing multiple functional groups is a foundational part of organic chemistry that is still being used today. Therefore, functional group protection is a fundamental reaction very commonly used in organic chemistry to perform selective reactions [1]. Among the other functional groups, alcoholic and phenolic moieties are the most common functional groups. One of the most fundamental and common transformations in organic chemistry is the acetylation of hydroxyl groups [2], which is achieved through acid halides and corresponding anhydrides [3,4]. The poor hydroxyl nucleophilicity, especially for phenols, demands the catalysts to activate anhydrides, such as protic acids, Lewis acids, and pyridine derivatives [5]. Recently, metal triflates and other metal salts [5][6][7][8][9] and ionic liquids [10][11][12][13] have also been discovered to be potential alternative catalysts. However, these catalysts have gripped grave disadvantages for acetylation in terms of its cost, longer reaction times, and toxicity. Hence, improvement of clean, cost-effective, versatile, and an eco-friendly procedure is continually being sought.
The use of silyl-based reagents has gained much more attention nowadays. Silyl carboxylates (acyloxysilane) were first studied by Yur'ev and Belyakova in 1960 [14]. Previous reports suggested that the reaction of nucleophiles with silyl carboxylates followed two possible pathways, where alcohol attacks silicon or the carbonyl group in Scheme 1 [14][15][16][17][18].
In 1970, Olah and co-workers reported that an iodotrimethylsilane mediated transesterification reaction would proceed through acyloxysilane as an intermediate state at a strictly neutral condition [19]. This method, acyloxysilane (trimethylsilyl acetate) with alcohols efficiently catalyzed by tunable Brønsted acidic ionic liquids (TBAILs), for the formation of a challenging acetylated product, was observed. To the best of our knowledge, TBAILs have never been used with trimethylsilyl acetate (TMSOAc) for acetylation reaction. Usually, trimethylsilyl acetate has been used for the preparation of by-product free oligosiloxane [20], α-silyl carboxylic acid [21], and silyl ketene acetals [22]. Recently, our lab reported that trimethylsilyl acetate was used for the silylation of sugars in the presence of a base [23]. Due to ease of handling, room temperature stability, and commercial availability, these reagents have much interest in organic transformation.
Ionic liquids (ILs) because of their excellent properties and green solvent have gained widespread application in numerous fields. ILs are salts that are made up of the constituents of organic cations and organic or inorganic anions. Organic cations, for example, imidazolium, ammonium, phosphonium, and pyridinium ions, can be combined with a variety of anions, for example, BF4 − , triflates, halides, (CF3SO2)2N − , or PF6 − which give rise to Scheme 1. Possible pathways for O-nucleophile attack (O-acetylation) [14][15][16][17][18].
In 1970, Olah and co-workers reported that an iodotrimethylsilane mediated transesterification reaction would proceed through acyloxysilane as an intermediate state at a strictly neutral condition [19]. This method, acyloxysilane (trimethylsilyl acetate) with alcohols efficiently catalyzed by tunable Brønsted acidic ionic liquids (TBAILs), for the formation of a challenging acetylated product, was observed. To the best of our knowledge, TBAILs have never been used with trimethylsilyl acetate (TMSOAc) for acetylation reaction. Usually, trimethylsilyl acetate has been used for the preparation of by-product free oligosiloxane [20], α-silyl carboxylic acid [21], and silyl ketene acetals [22]. Recently, our lab reported that trimethylsilyl acetate was used for the silylation of sugars in the presence of a base [23]. Due to ease of handling, room temperature stability, and commercial availability, these reagents have much interest in organic transformation.
Ionic liquids (ILs) because of their excellent properties and green solvent have gained widespread application in numerous fields. ILs are salts that are made up of the constituents of organic cations and organic or inorganic anions. Organic cations, for example, imidazolium, ammonium, phosphonium, and pyridinium ions, can be combined with a variety of anions, for example, BF 4 − , triflates, halides, (CF 3 SO 2 ) 2 N − , or PF 6 − which give rise to various possible sequences. The physicochemical properties of ILs are perhaps tuned by switching the combinations of cation and anion [49]. In 2002, Cole and co-workers first reported the Brønsted-acidic ionic liquids (BAILs). Because of their excellent properties such as thermal stability, non-toxicity, high acidic character, ease of separation, and inertness towards air and water, they have gained considerable attention [50,51]. Since then, they have been utilized in a broad range of organic transformations. The use of green solvents results in a great decrease in the effects of global warming caused due to the use of conventional hazardous solvents. Since halide ions are generally non-favorable for the green chemistry [49]. Our previously synthesized ionic liquids were effectively utilized for applications in various organic transformations such as Friedel-Crafts acylation using acyl chloride and thioesterification [52], per-O-acetylation using acetic anhydride, and benzylidene ring-opening [53], and fatty acids esterification [54], based on our earlier experience in the area of ionic liquids and its utility. In this protocol, we aimed to provide an easy and eco-friendly method for the protection of alcohol. Thus, we reported TBAILs as our green catalysts for acetylation using TMSOAc as a novel reagent, and silylation using HMDS without metal and solvent.

Results and Discussion
Tunable Brønsted acidic ionic liquids were prepared according to the reported method [52][53][54] by using a two-step atom-economic reaction in which aryl imidazole was synthesized by using Ullmann type coupling followed by treatment with an acid, as shown in Figure 1. Newly prepared TBAILs (1a-1f) are white and yellow solids in nature without any noticeable fumes or evident degree of vapor pressure. The Brønsted acidity functions were measured with UV-visible spectroscopy using crystal violet dye as an indicator [54]. The synthesized TBAILs are completely soluble in water and willingly soluble in organic polar solvents such as methanol, ethanol, and acetone. The solubility order for catalysts 1a-1f is as follows 1a > 1b > 1c > 1d > 1e > 1f [54]. With increasing interest toward a greener method for the protection of alcohol, efficient, safe, and cost-effective TBAILs were employed for the O-acetylation using TMSOAc, and O-silylation using HMDS were studied.
an easy and eco-friendly method for the protection of alcohol. Thus, we reported TBAILs as our green catalysts for acetylation using TMSOAc as a novel reagent, and silylation using HMDS without metal and solvent.

Results and Discussion
Tunable Brønsted acidic ionic liquids were prepared according to the reported method [52][53][54] by using a two-step atom-economic reaction in which aryl imidazole was synthesized by using Ullmann type coupling followed by treatment with an acid, as shown in Figure 1. Newly prepared TBAILs (1a-1f) are white and yellow solids in nature without any noticeable fumes or evident degree of vapor pressure. The Brønsted acidity functions were measured with UV-visible spectroscopy using crystal violet dye as an indicator [54]. The synthesized TBAILs are completely soluble in water and willingly soluble in organic polar solvents such as methanol, ethanol, and acetone. The solubility order for catalysts 1a-1f is as follows 1a > 1b > 1c > 1d > 1e > 1f [54]. With increasing interest toward a greener method for the protection of alcohol, efficient, safe, and cost-effective TBAILs were employed for the O-acetylation using TMSOAc, and O-silylation using HMDS were studied.

Acetylation of Alcohols Using TMSOAc
With the series of designed ionic liquid catalysts in hand, it is possible to study the condition for acetylation reaction by using TMSOAc as a reagent and the results are reported in Table 1. The initially step of our study was to define the best reaction conditions for the catalyst and reagent. These experiments were performed on undecanol 2a as a model substrate and TMSOAc 3 as a reagent to resolve the optimization condition. Firstly, we studied a series of experiments with various TBAILs, 1a-1f, where it was recommended that 1a was the finest catalyst for the acetylation providing the desired product 4a in excellent yield (95%, Table 1, entry 1). Ionic liquids 1b-1f showed less activity as compared to 1a, most expected due to weaker acidity [54] (Table 1, entries 2-6). Even low or high catalyst loadings (Table 1, entries 7 and 8) were not very influenced on reaction yields. We have observed that the reaction gives silylation intermediate, which was finally converted to an acetylated product. The next step was to study the amount of reagent used in the reaction for the conversion of the starting material. Lowering the reagent (Table 1, entry 9) further slightly lowers the reaction yield and increasing the reagent (Table 1, entry 10) does not affect the reaction yield. Ionic liquids 1b-1f showed less activity as compared to 1a, most expected due to weaker acidity [54] (Table 1, entries 2-6).
1a (0.05) 2.5 4 95% a Notes: All reactions were performed using 2a (1 mmol), at room temperature. b Isolated yield. The reactions crude were purified by column chromatography and identified by 1 H-NMR.
Concerning the reaction rate and productivity, it was shown that 1a was the finest catalyst for acetylation reaction. Acetylation reactions were operated under different equivalents of catalyst 1a from 0.03 to 0.07 (Table 1, entries 7-8) and the different equivalents of TMSOAc 3 from 1.5 to 2.5 at room temperature (Table 1, entries 9-10). Taking into account its good reactivity, 1a was selected as the best TBAIL for acetylation of alcohols.
Various structurally diverse alcohols underwent acetylation using previously optimized reaction conditions to provide the corresponding acetates in moderate to excellent yields. The results are reported in Scheme 2. The bromoundecyl alcohol 2b in TMSOAc 3 was transformed to bromoundecyl acetate 4b in 96% excellent yield by using the 0.05 equivalent of ionic liquid 1a. Using the same reaction condition, other primary alcohols also resulted in good yields. Acetylation of hindered secondary alcohol 4i, which is often considered difficult, is also accomplished in reasonably good to moderate yields.
1a (0.05) 2.5 4 95% a Notes: All reactions were performed using 2a (1 mmol), at room temperature. b Isolated yield. The reactions were purified by column chromatography and identified by 1 H-NMR.
Concerning the reaction rate and productivity, it was shown that 1a was the finest catalyst for acetylation reaction. Acetylation reactions were operated under different equivalents of catalyst 1a from 0.03 to 0.07 (Table 1, entries 7-8) and the different equivalents of TMSOAc 3 from 1.5 to 2.5 at room temperature (Table 1, entries 9-10). Taking into account its good reactivity, 1a was selected as the best TBAIL for acetylation of alcohols.
Various structurally diverse alcohols underwent acetylation using previously optimized reaction conditions to provide the corresponding acetates in moderate to excellent yields. The results are reported in Scheme 2. The bromoundecyl alcohol 2b in TMSOAc 3 was transformed to bromoundecyl acetate 4b in 96% excellent yield by using the 0.05 equivalent of ionic liquid 1a. Using the same reaction condition, other primary alcohols also resulted in good yields. Acetylation of hindered secondary alcohol 4i, which is often considered difficult, is also accomplished in reasonably good to moderate yields.
The reactions of sp 2 -hybridized carbon attached -OH, for example, o-cresol and pcresol remained intact at standard reaction conditions. It is a good indication for obtaining the selective acetylation consisting of various alcohols. To further explore the universality of the acetylation reaction, a substrate containing sp 2 -hybridized carbon holding -OH and primary alcohol was examined using standard reaction conditions. We observed that only sp 3 -carbon holding -OH was selectively acetylated 2j with 60% yield after 24 h, as shown in Scheme 3. The poor hydroxyl nucleophilicity of sp 2 carbon-holding hydroxy group, especially for phenols, did not proceed acetylation at ambient conditions. Thus, the good nucleophilic character of primary alcohols leads to acetylation predominantly over phenol. The acetylation of alcohols is a well-known process, but usually using either expensive metal salts or metal triflate, acid, or toxic base pyridine [4], with environmentally harmful solvents such as DCM or ACN [5][6][7][8][9]. Thus, there is space for improvement for a green method for acetylation. Table 2 shows the reported methods for acetylation in the presence of ionic liquids. However, some of these reported methods experience limitations in the reuse procedure and using acetic anhydride as the acylating agent cannot achieve selectivity for primary alcohol over phenolic -OH. Our present work using TMSOAc for acetylation showed some advantages in terms of selectivity and advantages such as room temperature reaction, solvent-free, and metal-free protocol.  3 (a,b) . a Notes: All reactions were performed using 2b-2j (1 mmol), 1a (0.05 mmol), and TMSOAc 3 (2 mmol) for 4 h at room temperature. b Isolated yield. The reaction crudes were purified by column chromatography and identified by 1 H-NMR.
The reactions of sp 2 -hybridized carbon attached -OH, for example, o-cresol and pcresol remained intact at standard reaction conditions. It is a good indication for obtaining the selective acetylation consisting of various alcohols. To further explore the universality of the acetylation reaction, a substrate containing sp 2 -hybridized carbon holding -OH and primary alcohol was examined using standard reaction conditions. We observed that only sp 3 -carbon holding -OH was selectively acetylated 2j with 60% yield after 24 h, as shown in Scheme 3. The poor hydroxyl nucleophilicity of sp 2 carbon-holding hydroxy group, especially for phenols, did not proceed acetylation at ambient conditions. Thus, the good nucleophilic character of primary alcohols leads to acetylation predominantly over phenol. The acetylation of alcohols are a well-known process, but usually using either expensive metal salts or metal triflate, acid, or toxic base pyridine [4], with environmentally harmful solvents such as DCM or ACN [5][6][7][8][9]. Thus, there is space for improvement for a green method for acetylation. Table 2 shows the reported methods for acetylation in the presence of ionic liquids. However, some of these reported methods experience limitations in the reuse procedure and using acetic anhydride as the acylating agent cannot achieve selectivity for primary alcohol over phenolic -OH. Our present work using TMSOAc for acetylation showed some advantages in terms of selectivity and advantages such as room temperature reaction, solvent-free, and metal-free protocol. Scheme 2. Ionic liquid 1a catalyzed acetylation of different alcohols using TMSOAc 3 (a,b) . a Notes: All reactions were performed using 2b-2j (1 mmol), 1a (0.05 mmol), and TMSOAc 3 (2 mmol) for 4 h at room temperature. b Isolated yield. The reaction crudes were purified by column chromatography and identified by 1 H-NMR. 3 (a,b) . a Notes: All reactions were performed using 2b-2j (1 mmol), 1a (0.05 mmol), and TMSOAc 3 (2 mmol) for 4 h at room temperature. b Isolated yield. The reaction crudes were purified by column chromatography and identified by 1 H-NMR.

Scheme 2. Ionic liquid 1a catalyzed acetylation of different alcohols using TMSOAc
The reactions of sp 2 -hybridized carbon attached -OH, for example, o-cresol and pcresol remained intact at standard reaction conditions. It is a good indication for obtaining the selective acetylation consisting of various alcohols. To further explore the universality of the acetylation reaction, a substrate containing sp 2 -hybridized carbon holding -OH and primary alcohol was examined using standard reaction conditions. We observed that only sp 3 -carbon holding -OH was selectively acetylated 2j with 60% yield after 24 h, as shown in Scheme 3. The poor hydroxyl nucleophilicity of sp 2 carbon-holding hydroxy group, especially for phenols, did not proceed acetylation at ambient conditions. Thus, the good nucleophilic character of primary alcohols leads to acetylation predominantly over phenol. The acetylation of alcohols are a well-known process, but usually using either expensive metal salts or metal triflate, acid, or toxic base pyridine [4], with environmentally harmful solvents such as DCM or ACN [5][6][7][8][9]. Thus, there is space for improvement for a green method for acetylation. Table 2 shows the reported methods for acetylation in the presence of ionic liquids. However, some of these reported methods experience limitations in the reuse procedure and using acetic anhydride as the acylating agent cannot achieve selectivity for primary alcohol over phenolic -OH. Our present work using TMSOAc for acetylation showed some advantages in terms of selectivity and advantages such as room temperature reaction, solvent-free, and metal-free protocol.

Silylation of Alcohol Using HMDS
Previously synthesized TBAILs were also tested for the silylation of alcohols. Undecanol 2a (1.0 equiv.) was selected as the model substrate and HMDS 5 (1.0 equiv.) was selected as the reagent; the results are reported in Table 3. Initially, our aim was to study the best reaction conditions for catalyst selection and equivalents. This reaction proceeded without a catalyst but remained unfinished even after 96 h ( Table 3, entry 1). Subsequently, the same reaction was performed using 1a as the catalyst (0.05 eq.) and stirred at room temperature for 1 h, to afford product 6a with an excellent yield of 98% (Table 3, entry 2). Inspired by these results, various TBAILs 1b-1f were examined. Among all these TBAILs 1a-1f with the same amount of loading (5 mol%), 1a was given excellent yield at room temperature for 1 h.

Silylation of Alcohol Using HMDS
Previously synthesized TBAILs were also tested for the silylation of alcohols. Undecanol 2a (1.0 equiv.) was selected as the model substrate and HMDS 5 (1.0 equiv.) was selected as the reagent; the results are reported in Table 3. Initially, our aim was to study the best reaction conditions for catalyst selection and equivalents. This reaction proceeded without a catalyst but remained unfinished even after 96 h ( Table 3, entry 1). Subsequently, the same reaction was performed using 1a as the catalyst (0.05 eq.) and stirred at room temperature for 1 h, to afford product 6a with an excellent yield of 98% (Table 3, entry 2). Inspired by these results, various TBAILs 1b-1f were examined. Among all these TBAILs 1a-1f with the same amount of loading (5 mol%), 1a was given excellent yield at room temperature for 1 h. 1a (0.07) 1.0 1 h 92% a Notes: All reactions were performed using 2a (1 mmol). b The products were confirmed by using 1 H-NMR.
As expected, the nature of the ionic liquid 1a played a pivotal role in the reaction, because ionic liquids 1b-1f resulted in relatively lower yields (Table 3, entries 3-7). Lowering the concentration of 1a to 0.03 equivalent led to a lower yield (93%, Table 3, entry 8), while increasing it to a 0.07 equivalent also reduced the reaction yield (92%, Table 3, entry 9). Finally, with the optimized reaction condition in hand, the scope of the method was explored. Various aliphatic and aromatic alcohol substrates were studied to evaluate the generality and effectiveness of the developed protocol (Scheme 4). Table 3 shows the silylation of long-chain 2a isolated with a 98% yield in 1 h. 1a (0.07) 1.0 1 92% a Notes: All reactions were performed using 2a (1 mmol). b The products were confirmed by using 1 H-NMR.
As expected, the nature of the ionic liquid 1a played a pivotal role in the reaction, because ionic liquids 1b-1f resulted in relatively lower yields (Table 3, entries 3-7). Lowering the concentration of 1a to 0.03 equivalent led to a lower yield (93%, Table 3, entry 8), while increasing it to a 0.07 equivalent also reduced the reaction yield (92%, Table 3, entry 9). Finally, with the optimized reaction condition in hand, the scope of the method was explored. Various aliphatic and aromatic alcohol substrates were studied to evaluate the generality and effectiveness of the developed protocol (Scheme 4). Table 3 shows the silylation of long-chain 2a isolated with a 98% yield in 1 h. Under the same condition, Bromo-substituted long-chain alcohols 2b was consumed in 2 h with a very good yield of 97%. Compounds 2c and 2d were formed the desired products 6c and 6d in high yield. The reaction proceeded very smoothly with benzyl alcohol derivatives containing a halogen group afforded the corresponding products with Under the same condition, Bromo-substituted long-chain alcohols 2b was consumed in 2 h with a very good yield of 97%. Compounds 2c and 2d were formed the desired products 6c and 6d in high yield. The reaction proceeded very smoothly with benzyl alcohol derivatives containing a halogen group afforded the corresponding products with 6e in 95%, 6f in 95%, and 6g in 96% and 6h in 95% yields, respectively. Similarly, the silylation reaction of secondary alcohols such as hindered benzhydrol delivered the corresponding silylating product 6i in 97% yield.
The comparison of present catalyst TBAIL 1a with earlier reports for silylation with HMDS reveals that the present work exhibits some utility, as shown in Table 4. The salient features of TBAIL 1a as a catalyst for O-silylation are short reaction times, reaction proceeds at room temperature, two-step atom economy for the preparation of the catalyst, ease for separation of a catalyst, and product from the reaction mixture. In addition, the catalyst recovered easily without loss in its activity.

Reuse of TBAIL 1a for Silylation and Acetylation of Alcohols
Ionic liquid 1a was recovered from the reaction mixture and reuse for acetylation of 2a using TMSOAc 3 without any considerable loss in reaction yield (run 1-95%, run 2-93%, run 3-90%, run 4-89%, run 5-88%), as shown in Figure 2. Notably, failure to cut out volatile from recovered IL can be a decrease in the yields of the consecutive reactions. TBAIL 1a could be reused several times with low cross-contamination.  After completion, the reaction mixture was added ether and then extracted with water. TBAIL 1a was recovered from the water layer and dried over the high vacuum without a significant loss in catalytic activity. Indeed, the reaction still afforded 91% after five cycles ( Figure 2). Experimental data showed that 1a can be recycled and reused for several cycles. 19 F NMR was performed for fresh, recovered catalyst 1a and the obtained results are shown in Figure 3. These results suggested no significant changes in the catalyst and triflate anion remains in the aqueous phase-−80.083 ppm, as shown by 19 F NMR [53]. The prospect of ionic liquid as a green solvent and catalyst on broad proportion applications, the recovery of the catalyst to help reduce cost and diminish their impact on the environment. The recycling of TBAIL 1a for silylation was tested between the reactions of 2a and 5, as shown in Figure 2.
After completion, the reaction mixture was added ether and then extracted with water. TBAIL 1a was recovered from the water layer and dried over the high vacuum without a Catalysts 2021, 11, 825 8 of 13 significant loss in catalytic activity. Indeed, the reaction still afforded 91% after five cycles ( Figure 2). Experimental data showed that 1a can be recycled and reused for several cycles. 19 F NMR was performed for fresh, recovered catalyst 1a and the obtained results are shown in Figure 3. These results suggested no significant changes in the catalyst and triflate anion remains in the aqueous phase-−80.083 ppm, as shown by 19 F NMR [53]. After completion, the reaction mixture was added ether and then extracted with water. TBAIL 1a was recovered from the water layer and dried over the high vacuum without a significant loss in catalytic activity. Indeed, the reaction still afforded 91% after five cycles ( Figure 2). Experimental data showed that 1a can be recycled and reused for several cycles. 19 F NMR was performed for fresh, recovered catalyst 1a and the obtained results are shown in Figure 3. These results suggested no significant changes in the catalyst and triflate anion remains in the aqueous phase-−80.083 ppm, as shown by 19 F NMR [53].   19 F HNMR for recycled TBAIL 1a reprinted with permission from [53]. Copyright 2020, MDPI.

General Information
The reactions were conducted in glassware (sealed tube), under the nitrogen atmosphere. All reagents were purchased from Aldrich and Across and utilized without further purification unless otherwise mentioned. Silica Gel 60 was used for flash column chromatography. TLC was performed on pre-coated Aluminium plate of Silica Gel 60 F254. Detection was executed by spraying with a solution of Ce(NH4)2(NO3)6 (0.8 g), (NH4)6Mo7O24 (20.0 g) and 10% H2SO4 (400 mL) and subsequent heating on a hot plate. 1 H, 13 C NMR, DEPT, 1 H-13 C HSQC, NOESY, and 1 H-1 H COSY spectra were recorded using (Varian, Inc., Palo Alto, CA, USA) and (JEOL Ltd. Tokyo, Japan) 400 MHz instruments. Chemical shifts are in ppm from Me4Si generated from the CDCl3 lock signal at δ 7.26 ppm for 1 HNMR and δ 77.0 ppm for 13 C NMR. Mass spectra were analyzed on orbitrap instrument with an ESI source and FAB.

General Information
The reactions were conducted in glassware (sealed tube), under the nitrogen atmosphere. All reagents were purchased from Aldrich and Across and utilized without further purification unless otherwise mentioned. Silica Gel 60 was used for flash column chromatography. TLC was performed on pre-coated Aluminium plate of Silica Gel 60 F 254. Detection was executed by spraying with a solution of Ce(NH 4 ) 2 (NO 3 ) 6 (0.8 g), (NH 4 ) 6 Mo 7 O 24 (20.0 g) and 10% H 2 SO 4 (400 mL) and subsequent heating on a hot plate. 1 H, 13 C NMR, DEPT, 1 H-13 C HSQC, NOESY, and 1 H-1 H COSY spectra were recorded using (Varian, Inc., Palo Alto, CA, USA) and (JEOL Ltd. Tokyo, Japan) 400 MHz instruments. Chemical shifts are in ppm from Me 4 Si generated from the CDCl 3 lock signal at δ 7.26 ppm for 1 HNMR and δ 77.0 ppm for 13 C NMR. Mass spectra were analyzed on orbitrap instrument with an ESI source and FAB.

General Procedure for Preparation of TBAILs
Tunable Brønsted acidic ionic liquids (TBAILs) were prepared and characterized with different techniques such as 1 HNMR, 13 C NMR, Brønsted acidity using UV-visible spectroscopy and mass spectroscopy, as described in previously reported reference procedures [52][53][54].

General Procedure for O-Acetylation Reaction (A)
A sealed tube furnished with magnetic stirrer bar was charged with 2a-2i (1.0 equiv.), these were added trimethylsilyl acetate (2.0 equiv. for 2a-2i) and ionic liquids (0.05 equiv. for 2a-2i) at room temperature, and stirred for reaction time (4 h for 2a-2i, 24 h for 2j). After completion, the reaction mixture was concentrated. The crude products were purified by using column chromatography on silica gel to give the desired products 4a-4j. 1 [47].

Conclusions
A mild and efficient method has been established for acetylation using novel TMSOAc as an acetyl donor and silylation using HMDS in the presence of a recyclable tunable Brønsted acidic ionic liquid. Our investigation suggested that TBAIL catalyzed acetylation using TMSOAc proceeds through silylation intermediate. Both transformations were proceeded at room temperature and provided mild to excellent yields. The use of TBAIL for diverse alcohols presents a simple alternative to costly and toxic catalysts. This method may be more useful in the future for extensive study of acetylation and silylation of different alcohols, and for the synthesis of natural products and small molecules TBAIL was recycled and reused at least 5 times, which provided another eco-friendly method in the field of alcohol protection.