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Article

Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults

1
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
2
Baltimore County Health Department, Baltimore, MD 21212, USA
3
Ohio State University Comprehensive Cancer Center, Columbus, OH 43202, USA
*
Author to whom correspondence should be addressed.
Cancers 2014, 6(3), 1691-1704; https://doi.org/10.3390/cancers6031691
Received: 20 June 2014 / Revised: 24 July 2014 / Accepted: 6 August 2014 / Published: 14 August 2014
(This article belongs to the Special Issue DNA Viruses in Human Cancer)
Oral HPV infection, the cause of most oropharyngeal cancer in the U.S., is not well studied among high-risk young adults. Men (n = 340) and women (n = 270) aged 18–25 years attending Baltimore County STD clinics were recruited if they declined HPV vaccination. Each participant had a 30-second oral rinse and gargle sample tested for 37 types of HPV DNA, and a risk-factor survey. Factors associated with prevalent infection were explored using log binomial regression. Men had higher prevalence of any oral HPV (15.3% vs. 7.8%, p = 0.004) and vaccine-type oral HPV (i.e., HPV16/18/6/11: 5.0% vs. 1.1%, p = 0.007) infection than women. In multivariate analysis, male gender (aPR = 1.93, 95% CI = 1.10–3.39), number of recent oral sex partners (p-trend = 0.013) and having ever performed oral sex on a woman (aPR = 1.73, 95% CI = 1.06–2.82) were associated with increased oral HPV prevalence. Performing oral sex on a woman may confer higher risk of oral HPV acquisition than performing oral sex on a man. View Full-Text
Keywords: oral HPV; young adults; STD clinic; gender oral HPV; young adults; STD clinic; gender
MDPI and ACS Style

D'Souza, G.; Kluz, N.; Wentz, A.; Youngfellow, R.M.; Griffioen, A.; Stammer, E.; Guo, Y.; Xiao, W.; Gillison, M.L. Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults. Cancers 2014, 6, 1691-1704. https://doi.org/10.3390/cancers6031691

AMA Style

D'Souza G, Kluz N, Wentz A, Youngfellow RM, Griffioen A, Stammer E, Guo Y, Xiao W, Gillison ML. Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults. Cancers. 2014; 6(3):1691-1704. https://doi.org/10.3390/cancers6031691

Chicago/Turabian Style

D'Souza, Gypsyamber, Nicole Kluz, Alicia Wentz, Renee M. Youngfellow, Anne Griffioen, Emily Stammer, Yingshi Guo, Weihong Xiao, and Maura L. Gillison. 2014. "Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults" Cancers 6, no. 3: 1691-1704. https://doi.org/10.3390/cancers6031691

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