Responsiveness of Urinary and Plasma Alkylresorcinol Metabolites to Rye Intake in Finnish Women
Folkhälsan Research Center, Institute for Preventive Medicine, Nutrition and Cancer, and Division of Clinical Chemistry, University of Helsinki, Haartmaninkatu 8, P.O. Box 63, FI-00014, Finland
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Cancers 2010, 2(2), 513-522; https://doi.org/10.3390/cancers2020513
Received: 9 April 2010
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Revised: 12 April 2010
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Accepted: 12 April 2010
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Published: 14 April 2010
(This article belongs to the Special Issue Biomarkers: Oncology Studies)
Alkylresorcinols [ARs] have been proposed for use as biomarkers of whole-grain intake. The aim here was to examine the responsiveness of AR metabolites to rye intake. Sixty women were divided into three groups according to their rye consumption. We observed significant differences between groups in plasma 3-[3,5-dihydroxyphenyl]-1-propanoic acid [DHPPA] and in urinary DHPPA and 3,5-dihydroxybenzoic acid [DHBA]. In addition, these AR metabolites increased proportionally to rye fiber intake. We conclude that these ARs metabolites are accurate and useful biomarkers of rye fiber intake. Further studies are needed to confirm our results in larger and different populations.
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Keywords:
whole-grain cereals; rye; alkylresorcinol metabolites; responsiveness
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MDPI and ACS Style
Aubertin-Leheudre, M.; Koskela, A.; Samaletdin, A.; Adlercreutz, H. Responsiveness of Urinary and Plasma Alkylresorcinol Metabolites to Rye Intake in Finnish Women. Cancers 2010, 2, 513-522. https://doi.org/10.3390/cancers2020513
AMA Style
Aubertin-Leheudre M, Koskela A, Samaletdin A, Adlercreutz H. Responsiveness of Urinary and Plasma Alkylresorcinol Metabolites to Rye Intake in Finnish Women. Cancers. 2010; 2(2):513-522. https://doi.org/10.3390/cancers2020513
Chicago/Turabian StyleAubertin-Leheudre, Mylène, Anja Koskela, Adile Samaletdin, and Herman Adlercreutz. 2010. "Responsiveness of Urinary and Plasma Alkylresorcinol Metabolites to Rye Intake in Finnish Women" Cancers 2, no. 2: 513-522. https://doi.org/10.3390/cancers2020513
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