Molecular Mechanisms Underlying Cancer Prevention and Intervention with Bioactive Food Components

Cancer is the second-leading cause of death in the world, and it represents a major health challenge [...].

sion. Their findings demonstrate that a gnetin C-supplemented diet effectively suppresses metastasis-associated protein 1-promoted tumor progression in high-risk premalignant prostate cancer transgenic mouse model. This study underscores the potential of gnetin C as a novel nutritional agent for prostate cancer prevention.
The study by Raina et al. [6] focused on elucidating the "stage-specific" efficacy of the bioactive food component inositol hexaphosphate (IP6, also known as phytic acid) against prostate cancer initiation, growth, and progression in a transgenic adenocarcinoma of the mouse prostate (TRAMP) model. Results indicated that IP6 feeding during the initial stages of cancer development prevents the progression of prostatic intraepithelial neoplasia lesions to adenocarcinoma, and IP6 feeding during the late stage of the disease reduces tumor growth and prevents its progression to the advanced stage of the disease. It has also been indicated that the anti-prostate cancer effects of IP6 are associated with its potential to eradicate the prostate cancer stem cell pool in the TRAMP model. Accordingly, IP6 intervention could have a therapeutic benefit during all stages of prostate tumorigenesis.
In this Special Issue, three review articles capture recent developments regarding research, elucidating the role of dietary phytochemicals on gastrointestinal tract cancers. Kang et al. [7] summarized the potential therapeutic effects of bioactive food components on the prevention and treatment of gastric cancer, with special focus on molecular mechanisms of action, bioavailability, and safety aspects. De et al. [8] reviewed the literature on phenolic phytocompounds endowed with anti-colorectal cancer activities, which are based on animal and human studies, to understand the impact of these results on the prevention and treatment of this cancer, which represents a significant cause of death worldwide. Dacrema et al. [9] presented an overview of the reciprocal interactions between spice-derived bioactive compounds and the gut microbiota to understand the role of dietary spices in the prevention of colorectal cancer.
There are two reviews dedicated to the impact of food-derived phytochemicals on hormone-related neoplasms. Prajapati and colleagues [10] dissected the concept of targeting luminal A-derived breast cancer stem cells with dietary phytocompounds by summarizing the signaling pathways implicated in therapy resistance. In their review, Kumar et al. [11] discussed the role of green tea catechins in the prevention of prostate cancer, presented evidence on the associations of microbiomes with prostate cancer, and evaluated the concept of utilizing the microbiome to identify biomarkers for the efficacy of green tea-derived constituents.
Nelumbo nucifera Gaertn., also known as the lotus, sacred lotus, Indian lotus, or Chinese water lily, is a recognized dietary and medicinal plant. Bishayee and colleagues [12] critically evaluated the potential of N. nucifera-derived products and phytoconstituents in cancer prevention and intervention with in-depth understanding of cellular and molecular mechanisms of action. Sulforaphane represents a metabolite of the phytochemical glucoraphanin, which is present in cruciferous vegetables, such as broccoli, Brussels sprouts, cabbage, and watercress. A review by Kaiser et al. [13] evaluated the recent state of knowledge on the efficacy of sulforaphane in preventing or reversing a variety of neoplasms based on preclinical and clinical studies. The authors also discussed the current limitations and challenges associated with sulforaphane research, and they suggested future research directions.
Finally, the work of Bouyahya et al. [14] focuses on recent advances in using dietary phenolic phytocompounds to sensitize various cancer cells towards chemotherapeutic agents and their values, in combination therapy, along with conventional anticancer drugs. Several phenolics, including caffeic acid, curcumin, gallic acid, resveratrol, rosmarinic acid, and sinapic acid, exhibit encouraging anticancer activities through sub-cellular, cellular, and molecular mechanisms, and they can increase the effectiveness of the approved cancer chemotherapeutic agents.
In conclusion, it is my hope that this Special Issue, featuring high-quality articles written by recognized leaders in the field, as well as young investigators from all over the world, would accelerate the translational impact of mechanism-based cancer prevention and inter-vention using multi-targeted dietary phytocompounds, identify current knowledge gaps, challenges, and pitfalls, as well as galvanize future research.

Conflicts of Interest:
The authors declare no conflict of interest.