The Patient’s Point of View: COVID-19 and Neuroendocrine Tumor Disease

Simple Summary Since neuroendocrine tumor patients require a highly specialized and interdisciplinary infrastructure for diagnostic and therapy, medical care has been very challenging during the COVID-19 pandemic. In cooperation with the patient organization NETZWERK NeT we were able to distribute a comprehensive survey, which has profoundly investigated the healthcare structure and patient-specific concerns during the crisis. In addition to regular medical care, there is a considerable need to measure patient-reported outcomes such as social and emotional distress in a structured way to optimize individual therapy for NET patients. Abstract The assessment of cancer patient care during the COVID-19 pandemic has been mainly reported from a physician’s perspective. Patients with rare tumor entities such as neuroendocrine tumors (NET), which require a complex and specialized care infrastructure, were highly affected by the COVID-19 crisis. Using a structured questionnaire consisting of a general section on the disease and a special COVID-19 section to record medical care, vaccination behavior as well as social and psycho-emotional parameters were collected from NET patients. The survey was distributed via direct medical contact and via the patient organization NETZWERK NeT. A total of 684 patients participated in the survey and 79.2% (n = 542) of the participants answered the questionnaire completely (54 questions). Patient characteristics were comparable to those in large NET registries. The majority of participants were patients with pancreatic and small bowel NET on somatostatin analogue (SSA) therapy. Medical care under COVID-19 was adequate and appointment cancellations and postponements were not common. Nevertheless, the majority of patients were worried about adequate treatment for their tumor disease during the crisis. Most of the participants considered themselves to be at risk of severe COVID-19 infection and were therefore very concerned. This was accompanied by an extremely high vaccination readiness rate of 90%. Increased distress in the social and psycho-emotional domains in the course of the crisis reflected a need for optimization in the medical care of NET patients, although the rate of COVID-19 positive participants was low (3.7%). Therefore, patient-reported measurements are required to identify and address all areas of medical care. Overall, our survey provides an essential contribution to the care of NET patients during the COVID-19 pandemic from the patient’s perspective.


Introduction
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2-COVID- 19) has been a global health emergency since January 2020. Although vaccination is now widely available, infection numbers are rising again. Apart from the severe economic consequences of the pandemic, various aspects of human coexistence, traditions and habits have changed dramatically. Due to the pandemic, global health care systems have been challenged as never before [1,2]. The number of COVID-19 positive cases is still increasing and currently surpasses 200 million worldwide, with the highest numbers in America and Europe. Over four million deaths have been directly related to COVID-19, with the number of unreported cases being significantly higher (WHO dashboard).
Patients with cancer were particularly affected during the pandemic. There are many different explanations for this phenomenon, including worse survival rates of cancer patients suffering from COVID-19 infections, deterioration of medical care through prioritization and resource limitations for both in-and outpatients and a delay in initial cancer diagnosis due to COVID-19 fear [3][4][5].
The European Society of Medical Oncology (ESMO) offered recommendations for cancer care in general and guidance for diagnostics and therapy in the COVID-19 era for some tumor entities. Independently, practical recommendations for patients with neuroendocrine neoplasms (NEN) were provided [6]. In these rare neoplasms with a very heterogeneous spectrum ranging from very slow-growing neuroendocrine tumors to aggressive neuroendocrine carcinomas, highly individualized and complex medical care is required. Factors to be considered include functionality (clinically relevant hormone secretion), primary tumor localization, Ki-67 proliferation index and somatostatin receptor status. Highly specialized centers, including centers of excellence with multidisciplinary teams and tumor boards (MDT), are urgently required for the optimal treatment of this disease. In the context of the pandemic, we have observed strong regional differences. The Italian Association for Neuroendocrine Tumors (It.a.net) indicated a significant influence of the COVID-19 pandemic on the number of newly diagnosed NEN patients, surgical procedures for these patients, nuclear medicine therapies (PRRT) and MDT activities [7]. In contrast, data from Germany, Austria, and Switzerland demonstrated only a minority of postponed or canceled diagnostic and therapeutic procedures. In addition, there was a significant difference in the assessment of how COVID-19 impacted patient care between physicians in a university and a non-university setting [8].
However, all assessments were presented from a physician's perspective. A structured survey from the patient's perspective has not been reported yet. In collaboration with the patient organization NETZWERK NeT (Netzwerk Neuroendokrine Tumoren (NeT) e.V.; https://www.netzwerk-net.de, accessed on 30 November 2021), we conducted in a structured manner a comprehensive analysis of the management of NEN patients during the COVID-19 pandemic, including psychological parameters such as worries and fears of these patients as well as their vaccination behavior.

Methods
Ethical approval was obtained from the local ethical review committee of the Martin Luther University Halle-Wittenberg (number: 2021-015; January 2021). A total of 54 questions was developed, including 19 general questions about characteristics of the underlying NET disease, disease history, actual treatment status, symptoms and 35 specific questions about the impact of the COVID-19 pandemic on tumor treatment and disease care. Multiple choice or yes/no answers and optional text answers were available in the survey. Except for the optional text boxes, all questions were mandatory. Participants were able to temporarily save the questionnaire before completion and complete it at a later time.
The survey was performed between March 19th and June 19th 2021 in the following three German-speaking countries: Austria, Switzerland and Germany (flow chart Supplementary Figure S1). The survey was open to patients with NET disease undergoing therapy (including watch and wait) or follow-up. The survey was circulated via the patient organization NETZwerk NET e.V. as well as via personal contact with the attending NET specialist. The full survey is provided in the Supplemental Materials.
LimeSurvey software (LimeSurvey GmbH, Hamburg, Germany) was used to conduct the online survey. Descriptive statistics were calculated using Office Excel 2016 (Microsoft Corporation, Redmond, DC, USA) and GraphPad Prism 5 (GraphPad Software, San Diego, CA, USA). The association between two variables was performed based on Chi-square and Fisher's exact tests, as appropriate.

Anxieties and Concerns of Patients during COVID-19
Regardless of whether receiving systemic therapy or being on follow-up, 78.6% (n = 426) of participants considered themselves to be at risk of a severe COVID-19 infection. Of the participants, 26.9% (n = 146) discussed their personal risk of severe COVID-19 infection with their NET specialist. In this context, 16.2% (n = 88) of the respondents (60.3% of 146 patients) mentioned that they had been informed about interventions to reduce the risk of exposure to COVID-19. The vast majority of participants (86.7%, n = 470) reported wearing FFP2 masks for self-protection; a surgical mask was used by only 9.8% (n = 53) of participants. In addition, many patients applied self-testing once or several times for COVID-19 (60.3%, n = 382). Some participants (4.2%, n = 23) reported that they would have preferred a COVID-19 test. Reasons for the lack of implementation were not recorded.
Of the participants, 45.9% (n = 249) and 36.3% (n = 197) were hesitant to visit the NET centers for outpatient or inpatient treatment as a result of the COVID-19 situation ( Figure 2). In subgroup analyses, baseline characteristics such as tumor-specific symptoms, age, hormone secretion and therapy status were assessed as factors relevant for the avoidance of health-care facilities. Among outpatients (baseline fear 45.9%), symptoms (48.8%), age over 60 (46.6%) and recent follow-up (47.9%) tended to be associated with greater fear of COVID-19 infection ( Figure 3A). For the inpatients (baseline fear 36.3%), this was the case for symptoms (40.2%), functional activity (37.8%) and therapy (37.7%) ( Figure 3B). Outpatient or inpatient follow-up consultations were canceled by patients themselves in 10.5% (n = 57) and 1.9% (n = 10) of cases, respectively, due to fear of COVID-19 infection.

Anxieties and Concerns of Patients during COVID-19
Regardless of whether receiving systemic therapy or being on follow-up, 78.6% (n = 426) of participants considered themselves to be at risk of a severe COVID-19 infection. Of the participants, 26.9% (n = 146) discussed their personal risk of severe COVID-19 infection with their NET specialist. In this context, 16.2% (n = 88) of the respondents (60.3% of 146 patients) mentioned that they had been informed about interventions to reduce the risk of exposure to COVID-19. The vast majority of participants (86.7%, n = 470) reported wearing FFP2 masks for self-protection; a surgical mask was used by only 9.8% (n = 53) of participants. In addition, many patients applied self-testing once or several times for COVID-19 (60.3%, n = 382). Some participants (4.2%, n = 23) reported that they would have preferred a COVID-19 test. Reasons for the lack of implementation were not recorded.
Of the participants, 45.9% (n = 249) and 36.3% (n = 197) were hesitant to visit the NET centers for outpatient or inpatient treatment as a result of the COVID-19 situation ( Figure  2). In subgroup analyses, baseline characteristics such as tumor-specific symptoms, age, hormone secretion and therapy status were assessed as factors relevant for the avoidance of health-care facilities. Among outpatients (baseline fear 45.9%), symptoms (48.8%), age over 60 (46.6%) and recent follow-up (47.9%) tended to be associated with greater fear of COVID-19 infection ( Figure 3A). For the inpatients (baseline fear 36.3%), this was the case for symptoms (40.2%), functional activity (37.8%) and therapy (37.7%) ( Figure 3B). Outpatient or inpatient follow-up consultations were canceled by patients themselves in 10.5% (n = 57) and 1.9% (n = 10) of cases, respectively, due to fear of COVID-19 infection.  Overall, 34.9% (n = 162) of the participants feared worsening of their NET disease during the COVID-19 pandemic. In 1.3% (n = 7) of the patients, a severe/very severe deterioration had already occurred, while a minor deterioration was reported in 13.1% (n = 71) of the patients (Figure 4).
Regarding the handling of private and/or family meetings by the patients during the pandemic, 14.9% (n = 81) answered that all meetings and 47.2% (n = 256) that many meetings had been canceled. Only 9.9% (n = 54) of the participants reported that no appointments had been canceled. Of the participants, 61.3% (n = 333) had regularly attended in-person Overall, 34.9% (n = 162) of the participants feared worsening of their NET disease during the COVID-19 pandemic. In 1.3% (n = 7) of the patients, a severe/very severe deterioration had already occurred, while a minor deterioration was reported in 13.1% (n = 71) of the patients (Figure 4).   Overall, 34.9% (n = 162) of the participants feared worsening of their NET disea during the COVID-19 pandemic. In 1.3% (n = 7) of the patients, a severe/very severe de rioration had already occurred, while a minor deterioration was reported in 13.1% (n = 7 of the patients (Figure 4).

Psychological Impact of the COVID-19 Pandemic for NET Patients
As already mentioned, 89.7% (n = 485) of the participants expressed anxieties related to the pandemic, 54.2% (n = 294) had minor anxieties, 35.2% (n = 191) had major anxieties) and 78.6% (n = 426) of the participants regarded themselves as a risk group for severe COVID-19 disease.

COVID-19 Positive Patients and Their Characteristics
Within the survey, 20 participants (3.7%) reported that they experienced a COVID-19 infection. We examined this subgroup in detail and stratified it in patients in active therapy (n = 11) or patients under follow-up (n = 9) ( Table 2). Half of the patients with COVID-19 infection had a pancreatic primary tumor, which was treated in 11 patients at time of COVID-19 diagnosis as follows: SSA in 5 patients, PRRT in 2 patients, TKI in 1 patient, chemotherapy in 1 patient, and watch-and-wait strategy in 2 patients. The most common comorbidities included hypertension, diabetes, lung disease, chronic renal failure and liver cirrhosis (see Table 2). In two patients no relevant comorbidities were mentioned. Interestingly, preexisting lung disease was exclusively reported in four patients under active systemic treatment. A total of 15 of the 20 patients had classified themselves as being at risk for severe COVID-19 infection. Based on self-assessment, 9 infections were mild, 10 were moderate and 1 was severe, requiring intensive care. The latter was ob- Overall, 58.1% (n = 315) of the respondents felt more socially isolated due to the COVID-19 situation (from least to most affected). As before, the surveillance group achieved the highest values in the subgroup analyses (53.2%) ( Figure 5D). Strategies to overcome social isolation were as follows: support from family (49.6%, n = 269), support from friends (13.5%, n = 73) and support from neighbors (6.1%, n = 33).
Psychiatric comorbidities such as depression, anxiety disorders or unstable emotional personality disorders were reported by 20.7% of all participants (n = 112). Within the distinct treatment groups, there was a significant difference between the surveillance group and the therapy plus watch-and-wait cohort (30.1% vs. 11.9% and 13.2%) ( Figure 5E). In the context of the COVID-19 crisis, these comorbidities worsened severely or very severely in 11.6% (n = 63) of cases. Forty-seven participants reported no or only minor negative effects.
In a panel of five questions, we asked about a number of items associated with emotional state. The answer options for these questions ranged from: yes, completely or rather agree; partly agree; no, rather disagree; or not at all. Lack of happiness, loss of interest, depressed mood and reduced motivation were observed in 56.6% (n = 307) of all participants. In relation to the different treatment groups, there was no difference concerning this item ( Figure 5F). Furthermore, insomnia in 54.8% (n = 297), loneliness in 55.2% (n = 299), alterations of the body feeling/sensation in 46.5% (n = 252) and loss of hobbies in 76.8% (n = 416) of participants were frequently recorded for the entire study population.

COVID-19 Positive Patients and Their Characteristics
Within the survey, 20 participants (3.7%) reported that they experienced a COVID-19 infection. We examined this subgroup in detail and stratified it in patients in active therapy (n = 11) or patients under follow-up (n = 9) ( Table 2). Half of the patients with COVID-19 infection had a pancreatic primary tumor, which was treated in 11 patients at time of COVID-19 diagnosis as follows: SSA in 5 patients, PRRT in 2 patients, TKI in 1 patient, chemotherapy in 1 patient, and watch-and-wait strategy in 2 patients. The most common comorbidities included hypertension, diabetes, lung disease, chronic renal failure and liver cirrhosis (see Table 2). In two patients no relevant comorbidities were mentioned. Interestingly, preexisting lung disease was exclusively reported in four patients under active systemic treatment. A total of 15 of the 20 patients had classified themselves as being at risk for severe COVID-19 infection. Based on self-assessment, 9 infections were mild, 10 were moderate and 1 was severe, requiring intensive care. The latter was observed under PRRT in a patient with small bowel NET. Subsequent symptoms of the COVID-19 infection were reported by those affected as follows: fatigue (45%, n = 9), impaired concentration (35%, n = 7), impaired olfactory/gustatory sense (20%, n = 4), insomnia (10%, n = 2), and headaches (10%, n = 2). A total of 5 participants (25%) reported no symptoms. At the time of the survey, 17 participants in the COVID-recovered group were planning to get subsequently vaccinated against COVID-19 and 3 were still undecided.

Opinions on Vaccination
In addition to the 20 patients who had recovered from COVID-19 at time of the survey, a total of 29.5% (n = 160) of the participants reported COVID-19 positive individuals in their close environment. The willingness to get vaccinated was 89.3% (n = 484) at the time of the survey (72.4% of the participants received an influenza vaccination within the last 5 years). We compared our data (published by our group at the beginning of the year 2021 [9]) with data obtained by similar online surveys on healthy control persons (n = 410) and patients with inflammatory bowel disease (IBD; n = 1032). Interestingly, the willingness to get vaccinated for either influenza or COVID-19 was significantly lower in these other two patient cohorts (controls: 45.3% and 55.6%; IBD patients: 65.1% and 58.5%) ( Figure 6). Of the participants in our NET cohort, 7.0% (n = 38) were still undecided and 3.7% (n = 20) refused vaccination. Notably, the vaccination refusal rate in the NET cohort was significantly lower compared to the independently reported cohorts of healthy control subjects (13.2%, n = 54) and IBD patients (11.1%, n = 114). Fourteen NET patients (2.6%) were in doubt about COVID-vaccination due to a lack of long-term data and insufficient safety aspects. Two patients were concerned that the vaccination would interfere with current therapy and might worsen therapy efficacy. One patient was discouraged from getting vaccinated by a physician's advice due to poor general condition and another patient described a known allergy to vaccination.

Opinions on Vaccination
In addition to the 20 patients who had recovered from COVID-19 at time of the vey, a total of 29.5% (n = 160) of the participants reported COVID-19 positive individ in their close environment. The willingness to get vaccinated was 89.3% (n = 484) at time of the survey (72.4% of the participants received an influenza vaccination within last 5 years). We compared our data (published by our group at the beginning of the y 2021 [9]) with data obtained by similar online surveys on healthy control persons (n = and patients with inflammatory bowel disease (IBD; n = 1032). Interestingly, the will ness to get vaccinated for either influenza or COVID-19 was significantly lower in th other two patient cohorts (controls: 45.3% and 55.6%; IBD patients: 65.1% and 58.5%) ( ure 6). Of the participants in our NET cohort, 7.0% (n = 38) were still undecided and 3 (n = 20) refused vaccination. Notably, the vaccination refusal rate in the NET cohort significantly lower compared to the independently reported cohorts of healthy con subjects (13.2%, n = 54) and IBD patients (11.1%, n = 114). Fourteen NET patients (2. were in doubt about COVID-vaccination due to a lack of long-term data and insuffic safety aspects. Two patients were concerned that the vaccination would interfere w current therapy and might worsen therapy efficacy. One patient was discouraged f getting vaccinated by a physician's advice due to poor general condition and another tient described a known allergy to vaccination.

Discussion
Taking care of patients with neuroendocrine neoplasms represents a major challe in the COVID-19 era. In this respect, studies have observed considerable regional dif ences in the care of patients, both in the outpatient and inpatient sectors [6][7][8]. Howe all published empirical data so far have been based exclusively on physicians' ass ments. This study investigated the impact of the COVID-19 pandemic from the patie perspective in a structured setting. Our data show that many NET patients conside themselves at risk for a severe course of COVID-19 infection and were therefore very c cerned. Medical accessibility during and education about the pandemic by the attend physician was usually provided. However, NET patients displayed a high level of p chological stress and anxiety, which had not been adequately addressed. Compared to

Discussion
Taking care of patients with neuroendocrine neoplasms represents a major challenge in the COVID-19 era. In this respect, studies have observed considerable regional differences in the care of patients, both in the outpatient and inpatient sectors [6][7][8]. However, all published empirical data so far have been based exclusively on physicians' assessments. This study investigated the impact of the COVID-19 pandemic from the patient's perspective in a structured setting. Our data show that many NET patients considered themselves at risk for a severe course of COVID-19 infection and were therefore very concerned. Medical accessibility during and education about the pandemic by the attending physician was usually provided. However, NET patients displayed a high level of psychological stress and anxiety, which had not been adequately addressed. Compared to the general popula-tion, there was a very high willingness to get vaccinated, despite the fact that the risk for COVID-19 infection is not higher in this group of patients than in other chronic diseases.
The participants of this survey can be considered as representative of NEN patients in general in central Europe. Although this survey addressed a specific population of NEN patients organized through a patient organization and treated mainly in university hospitals and ENETS centers, it displays a similar age distribution and primary tumor localization compared to the German NET registry [10]. Compared to these registry data, a slightly higher proportion of patients with small intestine (duodenal and ileum) NEN participated in our survey and, additionally, patients with lung NEN were included. However, compared to the data of Niederle et al., there were significantly fewer participants with stomach, appendix and rectum NEN [11]. Due to the mostly favorable long-term prognosis of localized stages of these entities, these patients are usually followed-up in a less structured way [1]. Interestingly, about half of the participants reported having a functional disease, mainly the carcinoid syndrome (CS). Within all NENs, the functionality is significantly less frequent than reported in this survey [12]. The higher rate of functional tumors observed in our cohort is in line with the more favorable short diagnostic latency between symptom onset and diagnosis reported in our cohort compared to international surveys, in which estimated median latencies of more than 50 months were observed [13,14].
NEN patients require a multidisciplinary team with an appropriate armamentarium of diagnostic and therapeutic approaches. Therefore, most patients are treated in university hospitals or dedicated NET centers. During the COVID-19 pandemic, these specialized hospitals were and still are highly affected by governmental regulations prioritizing COVID-19 positive patients. Interestingly, patients reported that only a minority of outpatient or inpatient appointments had to be postponed [8]. One reason for the continuity of medical care was certainly the implementation of telephone or video consultations, which was used by one-third of the participants during the COVID-19 period. This approach is supported by the current ESMO guidelines aiming to avoid personal visits [15]. Furthermore, patients who required only follow-up investigations or patients who received somatostatin analogues or watch-and-wait strategies within our survey were more flexible and did not rely on frequent control visits or inpatient treatment at centers. Still, a substantial proportion of patients on active treatment requiring regular inpatient and outpatient contacts (e.g., PRRT, chemotherapy) reported changes in the treatment schedule. This might have contributed to the fear of disease worsening during the COVID pandemic.
The survey included 20 patients with SARS-CoV-2 infection, one of whom required intensive care. Thus, the overall rate of COVID-19 positive participants was 3.7%. This is significantly higher than the infection rate of 0.68% evaluated in patients with active cancer therapy in Italy [16]. However, our survey covered the period from the start of the COVID-19 pandemic in Europe to June 2021, and thus recorded a long observational phase, which may explain the higher rate of COVID-19 infections. When compared to the infection rate of the entire population of Germany at this time (3,728,141 cases on 1 June 2021) of approximately 4.5%, there is no apparent difference [5]. In our view, the impact of severe and lethal COVID-19 infections is not well reflected by this survey. However, based on the results of the INTENSIVE study, which collected COVID-19 positive GEP-NEN patients worldwide, it is estimated that this ratio is low in GEP-NEN patients [17]. In the INTENSIVE study, 89 COVID-19 positive NEN patients were collected worldwide. Overall, only few severe courses of the infection were observed: 7 patients (7.8%) died due to COVID-19, while 80% of the patients completely recovered without long-term side effects [17]. The latter is not reflected in our study by the COVID-19 recovered participants. The vast majority of participants, 75%, reported long-term impairments such as fatigue, impaired concentration and senses, insomnia and headaches. It is apparent that patientreported outcomes provide a different, possibly more accurate reflection in comparison to medical records. Altogether, our data indicate that NEN patients have no increased susceptibility for SARS-CoV-2 infections or a severe course of the disease compared to the general population.
Early vaccination is recommended because patients with regular out-and inpatient appointments, active cancer treatment and frequent contacts with health care workers are at risk for COVID-19 [18]. Only little information is available on the acceptance and willingness to get vaccinated in the entire population and particularly among cancer patients. In an analysis performed in the United States, 69% of adult participants wanted to be vaccinated [19]. Similar results were observed in Germany, where 65.1% of healthy adults planned to get vaccinated as soon as possible [9]. A recently published nationwide multicenter survey in Korea resulted in a vaccination readiness of 61.8% in cancer patients, higher than other reports from France and Poland (53.7 and 60.3%), but lower compared to the general population data [2,20,21]. In our study, the acceptance and willingness to vaccinate was 89.3% and thus much higher compared to other cancer patient cohorts. Possible reasons include a generally increased willingness to get vaccinated (see also influenza vaccination readiness), adequate medical education and the self-assessment to be at risk for a severe COVID-19 infection and solicitude about the pandemic. Most likely, the most influential factor to convince undecided patients is the physician's advice [20].
The measurement of health-related quality of life (HRQoL) in patients with cancer is essential for the correct assessment of symptoms related to tumor burden and therapy. In NEN, further characteristics have to be taken into account: hormone secretion and its concomitant symptoms, long/chronic course of the disease, possibly a hereditary trait with familial predisposition, as well as a broad spectrum of therapies with various side effects. Therefore, the assessment of HRQoL is particularly challenging. Previous work has demonstrated that depression and anxiety are very relevant in NEN patients regardless of hormone secretion [22,23]. In our study, a great fear of acquiring a COVID-19 infection and the worsening of NEN disease in the course of the COVID-19 pandemic were detected. Given the reduced availability of contacts to the NET center and the treating physician, these worries might not have been adequately addressed. Compared to a study prior to the COVID-19 pandemic, which reported a 25% rate of anxiety in advanced NEN stages, we observed a significant increase in the COVID-19 pandemic [23]. In parallel, major symptoms of depression were reported in 50-75% of patients in our survey. Since most participants were on surveillance or SSA treatment, the therapy modality is most likely not a major influencing factor. Rather, we believe that the self-assessment of being at increased risk resulting in anxiety and subsequent psycho-emotional distress is a specific pattern for NEN patients during the course of the COVID-19 crisis. Interestingly, the prevalence of anxiety and depression also seems to increase over the course of the pandemic waves. In an Italian study by Lauricella, this effect was shown within the 1st and 2nd pandemic waves for NET patients [24]. Since our survey was conducted during the 3rd wave, the higher rates of psycho-emotional distress can be better explained.
In addition to disease-focused medical care, the structured use of psycho-oncological support such as video or telephone consultations can help alleviate patients' concerns. Patient-reported outcome measurements of physical, social, and emotional distress should therefore be regularly recorded, evaluated in a structured way and addressed in order to be able to offer NEN patients a comprehensive and individualized therapy.

Conclusions
The most important finding of our survey is the increased anxiety reported by NEN patients. This includes fear of the disease worsening as well as fear of acquiring a severe COVID-19 infection. This fear may explain the high rate of willingness to get vaccinated. These highly relevant patient concerns are frequently not adequately addressed by physicians. Thus, we conclude that actively addressing the patients' anxieties during the consultation is eminently important. Providing adequate, individualized information about the risk of severe COVID-19 disease and ensuring access to optimal cancer care will greatly benefit patients' well-being.