Prehabilitation to Improve Outcomes of Patients with Gynaecological Cancer: A New Window of Opportunity?

Simple Summary Surgery is an important mainstay in the treatment of gynaecological cancers but is associated with operative complications, especially for those with poor physical and mental health. Prehabilitation is a new and upcoming strategy to optimise patients’ functional capacity, nutritional status and psychosocial wellbeing in order to reduce complications and enhance recovery. In this review, we assessed the evidence on prehabilitation programmes for patients with gynaecological cancer. The limited evidence shows that prehabilitation may reduce length of hospital stay for ovarian cancer patients, and may result in significant weight loss in patients with endometrial and cervical cancer. Comparative prospective studies are required to determine the effectiveness of prehabilitation on reducing operative complications and improving quality of life, and to further specify the content of such a programme for patients with gynaecological cancer. Abstract The literature evaluating the effect of prehabilitation programmes on postoperative outcomes and quality of life of patients with gynaecological cancer undergoing surgery was reviewed. Databases including Pubmed, Medline, EMBASE (Ovid) and PsycINFO were systematically searched to identify studies evaluating the effect of prehabilitation programmes on patients with gynaecological cancer. Both unimodal and multimodal prehabilitation programmes were included encompassing physical exercise and nutritional and psychological support. Primary outcomes were surgical complications and quality of life. Secondary outcomes were anthropometric changes and adherence to the prehabilitation programme. Seven studies fulfilled the inclusion criteria, comprising 580 patients. Included studies were nonrandomised prospective studies (n = 4), retrospective studies (n = 2) and one case report. Unimodal programmes and multimodal programmes were included. In patients with ovarian cancer, multimodal prehabilitation resulted in significantly reduced hospital stay and time to chemotherapy. In patients with endometrial and cervical cancer, prehabilitation was associated with significant weight loss, but had no significant effects on surgical complications or mortality. No adverse events of the programmes were reported. Evidence on the effect of prehabilitation for patients with gynaecological cancer is limited. Future studies are needed to determine the effects on postoperative complications and quality of life.


Introduction
Gynaecological malignancies account for approximately 13% of all new cancer diagnoses in women in Europe [1]. Surgery is an important mainstay of treatment for these women. However, surgery is associated with significant risks on both intraoperative (4.7%) and postoperative complications (25.9%) [2]. The majority of the gynaecological cancer population, especially endometrial and vulvar cancer patients, are characterised by advanced age, obesity and a sedentary lifestyle. Endometrial cancer has the strongest association with obesity among all cancers in women. Ovarian cancer patients are further characterised by malnourishment due to tumour growth and decreased intake [3][4][5][6][7][8][9]. Consequently, gynaecological cancer patients are often high-risk surgical patients.
Surgical complications significantly impede recovery and negatively impact quality of life of patients. Furthermore, they may delay adjuvant therapies, with a subsequent detrimental effect on survival [10][11][12]. Current approaches to reduce surgical complications have focused mainly on postoperative care. The widely adopted Enhanced Recovery After Surgery (ERAS) protocol has been shown to significantly reduce surgical complication rates and hospital stay [13][14][15]. However, this approach fails to address modifiable preoperative risk factors such as physical fitness, nutritional status and smoking. Prehabilitation programmes have been shown to improve operative outcomes and quality of life through optimisation of patients prior to surgery [16]. Several prehabilitation programmes are well established for orthopaedic and cardiac surgery and have recently been introduced in colorectal and abdominal cancer surgery [17][18][19][20][21].
Following similarities in risk factors targeted by prehabilitation among different cancer sites, prehabilitation has the potential to improve outcomes for patients with gynaecological cancer. A systematic search and narrative review were therefore performed to assess the effectiveness of prehabilitation programmes on surgical complications, mortality and quality of life of gynaecological cancer patients undergoing surgical treatment.

Criteria for Considering Studies for This Review
This review was performed according to Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines [22]. Studies evaluating the effectiveness of prehabilitation programmes on postoperative and quality of life outcomes in patients with gynaecological cancer were identified. Both unimodal and multimodal interventions consisting of physical exercise, nutritional support, smoking cessation, reduction in alcohol consumption or psychological support were included. Eligible study designs included randomised controlled trials (RCTs), cohort studies, pilot studies, feasibility studies and case reports. Studies were excluded if there was no full-text availability or they were not available in the English language. In addition, studies evaluating a prehabilitation programme with a duration of less than 3 days were excluded. Reviews were assessed for eligible studies. Primary outcomes were defined as surgical complications and mortality. Complications included intraoperative complications such as injuries, blood loss and conversion rates, and postoperative complications including infection, pain, haemorrhage, wound problems, pulmonary complications, venous-thromboembolism and hospital stay. Secondary outcomes were defined as time from surgery to starting adjuvant treatment, quality of life and anthropometric changes.

Study Selection
A total of 1026 articles were identified. Following title and abstract review, 31 articles were retrieved in full text, of which five met the inclusion criteria. A search of reference lists identified a further 13 articles, of which two were eligible for inclusion. This resulted in the inclusion of seven unique articles ( Figure 1). Studies were grouped according to type of cancer included.

Included Studies
Four of the included studies were nonrandomised prospective studies [25][26][27][28], two were retrospective studies [29,30] and one was a case report [31]. All studies were singleinstitution designs, with five studies being comparative studies, comparing prehabilitation to standard care [25][26][27][28]30]. The study by Diaz-Feijoo et al. was included as a preliminary report prior to their later publication in 2022 [28,32]. Five hundred eighty patients with gynaecological cancer were included in the studies, of which 212 participated in a prehabilitation programme. The number of patients per study ranged from 34 to 294 patients. Characteristics of included studies are illustrated per cancer group in Table 1 (ovarian cancer) and Table 2 (endometrial and cervical cancer). Four studies reported predominantly on ovarian cancer patients [26][27][28]30]. Mean age of this population varied between 55 and 70 years [26,28]. BMI was reported in one study, with a median of 24 kg/m 2 , and severity of comorbidities reported was moderate (Charlson comorbidity index 4, ASA 2-3) [26,28]. The three other studies mainly included endometrial or cervical cancer patients [25,29,31]. Mean age of study populations varied between 54 and 58 years [25,29]. Comorbidities reported were hypertension and diabetes, and were prevalent in the majority of patients in the study of Aubrey et al., with a median BMI of 48 kg/m 2 [29]. Two studies assessed multimodal prehabilitation programmes [27,28], and the remaining studies assessed unimodal programmes [25,26,29,30], with types of interventions shown in Tables 1 and 2. Three studies evaluate preoperative programmes only, while one study continued the intervention postoperatively [26]. Finally, the case report described an individualised programme for an endometrial cancer patient [31].

Included Studies
Four of the included studies were nonrandomised prospective studies [25][26][27][28], two were retrospective studies [29,30] and one was a case report [31]. All studies were singleinstitution designs, with five studies being comparative studies, comparing prehabilitation to standard care [25][26][27][28]30]. The study by Diaz-Feijoo et al. was included as a preliminary report prior to their later publication in 2022 [28,32]. Five hundred eighty patients with gynaecological cancer were included in the studies, of which 212 participated in a prehabilitation programme. The number of patients per study ranged from 34 to 294 patients. Characteristics of included studies are illustrated per cancer group in Table 1 (ovarian cancer) and Table 2 (endometrial and cervical cancer). Four studies reported predominantly on ovarian cancer patients [26][27][28]30]. Mean age of this population varied between 55 and 70 years [26,28]. BMI was reported in one study, with a median of 24 kg/m 2 , and severity of comorbidities reported was moderate (Charlson comorbidity index 4, ASA 2-3) [26,28]. The three other studies mainly included endometrial or cervical cancer patients [25,29,31]. Mean age of study populations varied between 54 and 58 years [25,29]. Comorbidities reported were hypertension and diabetes, and were prevalent in the majority of patients in the study of Aubrey et al., with a median BMI of 48 kg/m 2 [29]. Two studies assessed multimodal prehabilitation programmes [27,28], and the remaining studies assessed unimodal programmes [25,26,29,30], with types of interventions shown in Tables  1 and 2. Three studies evaluate preoperative programmes only, while one study continued

Ovarian Cancer Prehabilitation Programmes
Four studies reported on a prehabilitation programme in patients with ovarian cancer, including a total of 428 patients, the vast majority of whom underwent surgery for confirmed or suspected cancer (Table 1) [26][27][28]30]. Two studies reported on multimodal programmes [27,28]. Diaz-Feijoo et al. (intervention group (IG) n = 15, control group (CG) n = 19) assessed a programme consisting of physical therapy, psychological support and nutritional optimisation. Physical therapy consisted of supervised three weekly exercises, consisting of endurance training on a cyclo-ergometer or treadmill and strength (resistance) training. In addition, patients underwent respiratory physiotherapy with a spirometer. Psychological support was delivered through group sessions to reduce anxiety and support appropriate coping. Nutritional optimisation included individualised diets, protein supplements and preoperative immunonutrition. Outcomes were defined as postoperative complications (up to 30 days), length of hospital stay, time until adjuvant chemotherapy and adherence to the programme [28]. Seibaek et al. (IG n = 55, CG n = 90) reported on a programme consisting of physical therapy, psychological support, nutritional supplementation and smoking cessation. Physical therapy consisted of early physiotherapy supporting respiration and circulation, but was not further specified. Psychological support was delivered through individual telephone coaching and the provision of written and visual information. Exact duration of the preoperative programme was not specified in weeks. Outcome measurements included quality of life (Short-Form 36 (SF-36)) and the life orientation (SOC; sense of coherence) questionnaire preoperatively and eight weeks postoperatively. Women with suspected ovarian cancer and ascites were allocated to the intervention, with the control group being women with suspected ovarian cancer without ascites [27]. Two other studies evaluated a unimodal programme of nutritional optimisation with immunonutrition supplements in comparison with a control group with a normal varied diet [26,30]. Fernández-Candela et al. (IG n = 48, CG n = 59) administered immunonutrition (Atempero R ; containing L-arginine, omega-3 fatty acids and nucleotides) twice daily for seven days preoperatively. The intervention group differed from the control group with more extensive visceral resections, more often chemotherapy and less frequent administration of hyperthermic intraperitoneal chemotherapy (HIPEC). The effect of nutritional support was evaluated through length of hospital stay, postoperative complications, biochemical parameters (serum albumin and CRP), and adherence [30]. Hertlein et al. assessed immunonutrition (Impact R ; containing arginine, nucleotides and omega-3 fatty acids with a high-calorie formula) given three times daily for five days pre-and postoperatively in malnourished patients (IG n = 28, CG n = 19). Outcome measures included length of stay, postoperative complications and compliance [26].

Effectiveness of Prehabilitation Programmes
Diaz-Feijoo et al. reported a significantly shorter length of stay of 2 days in the intervention group, and also a significantly shorter time until start of chemotherapy (10 days; IG 25 days and CG 35 days). There was no significant difference in major complications, defined as Clavien-Dindo ≥ 3 (respectively, 40% in IG and 63% in CG), and no major adverse events occurred [28]. Seibaek et al. assessed quality of life and showed a significantly higher physical functioning In the control group compared to the intervention group after completion of the programme (mean difference of 10.88 points on physical functioning using Short-Form 36 (SF-36), scale 0-100). Other quality of life domains did not show significant differences between groups. However, groups were not comparable in terms of age and diagnosis, nor was baseline functioning assessed prior to starting the programme. Postoperatively, physical functioning did not retain its statistical difference. A difference in complications between the intervention and control group was not assessed [27]. Fernández-Candela et al. found immunonutrition not to be associated with reduced operative complications, assessed by the Clavien-Dindo classification. However, a multivariate subgroup analysis showed that immunonutrition was associated with a reduction in major complications (Clavien-Dindo III-V) with an odds ratio of 0.247 (CI: 0.071-0.895). No other differences were found between immunonutrition and outcomes [30]. Hertlein et al. did not observe a significant effect of immunonutrition on any of the outcomes assessed, including postoperative complications and length of hospital stay [26]. Adherence to the programme was assessed by two studies. In the study by Diaz-Feijoo et al., overall adherence to the prehabilitation programme was deemed satisfactory in 80% of the participants [28]. Hertlein et al. assessed the compliance of immunonutrition intake preand postoperatively and found a satisfactory compliance (defined as 8-11 of 15 servings) of 78.6% preoperatively. Optimal compliance (defined as 12-15 servings) was 60.7% and 21.4%, respectively. Reasons for noncompliance were poor motivation and nausea and vomiting [26].

Endometrial Cancer and Cervical Cancer Prehabilitation Programmes
Two studies reported on a unimodal prehabilitation programme for gynaecological cancer patients (nutrition and psychological therapy). Aubrey et al. assessed mostly patients with endometrial cancer patients (63%) but also included endometrial hyperplasia and patients with adnexal masses [25,29] (Table 2). A study by Arnaboldi et al. included a majority of patients with (recurrent or progressive) cervical (59.2%) and endometrial (14.3%) cancer undergoing pelvic exenteration (Table 2). An additional case report evaluated the role of a multimodal prehabilitation programme, containing physical Cancers 2022, 14, 3448 7 of 13 therapy and nutritional optimisation [31] (Table 2). Aubrey et al. compared three types of weight loss interventions in 48 patients with a BMI > 40 kg/m 2 : a low-calorie liquid diet utilising Optifast 900 for up to 12 weeks; a structured low-calorie meal plan with or without concomitant antiobesity medication (AOM) (GLP-1 analogues or extended-release naltrexone-bupropion); or a six-month programme involving dietician-supported dietary change and AOM, followed by a low-calorie liquid diet. During weight loss interventions, medical management was initiated in 12/30 women (progesterone-containing intrauterine or an aromatase inhibitor) with either grade 1 endometrioid carcinoma or atypical endometrial hyperplasia. Outcome measures included weight loss (%), surgical time, estimated blood loss, conversion rates to laparotomy and hospital stay [29]. The unimodal study by Arnaboldi et al. assessed the introduction of a preoperative psychological intervention on postoperative pain (Visual Analogue Scale; VAS) and length of hospital stay. Gynaecological patients presenting with high levels of psychological distress (Psychological Distress Inventory (PDI) ≥ 30) were offered preoperative telephone counselling and face-to-face interviews throughout their hospital stay. Outcomes were compared to patients with lower levels of psychological distress who did not receive an intervention (PDI < 30) [25]. Finally, Carli et al. described an individualised 3-week home-based programme consisting of physical therapy and nutritional optimisation for an 88-year-old endometrial cancer patient. Physical therapy involved thrice weekly training which included strengthening exercises, abdominal breathing exercises and supervised walking. Nutritional support focused on increasing dietary intake of protein and calories. Outcome measures consisted of exercise tolerance (six-minute walk test), cognitive function (Repeatable Battery for the Assessment of Neuropsychological Status), quality of life (SF-36) and perioperative complications [31].

Effectiveness of Prehabilitation Programmes
Aubrey et al. found that weight loss interventions lead to a significant reduction in weight from initial consultation to end of the intervention (mean weight difference = 12.0 kg, 9.7%). However, they did not specify between the different interventions, with the majority of women receiving the low-calorie liquid diet up to 12 weeks (n = 39). Median number of weight loss clinic visits was 7 days. There was no significant association between BMI, weight loss and surgical outcomes. Arnaboldi et al. evaluated postoperative pain and length of hospitalisation between the intervention (PDI < 30) and control group (PDI ≥ 30). No significant difference in outcomes between the groups was observed. However, comparability of groups, besides PDI scores, was not reported [25]. Finally, the case report by Carli et al. reported that no perioperative complications occurred, and that individual improvements were seen in exercise tolerance, cognitive function and several components of quality of life following the programme [31].

Quality of the Studies
Six of the included studies were nonrandomised cohort studies [25][26][27][28][29][30]. An evaluation of bias using the ROBINS-I tool is illustrated in Table 3 for these studies [23]. All studies were considered to be at moderate risk of bias according to the ROBINS-I tool primarily due to their selection of participants and selection of reported results. In addition, three of the studies were found to be at serious risk of bias due to missing information used to determine which patients were offered interventions [25]; subjective methods used to measure outcomes, such as questionnaires [27]; and significant differences in standard care between intervention and control groups [30]. Several studies had a significant selection bias, with Arnaboldi et al. allocating patients to the intervention based on their preoperative psychological distress inventory (PDI) score and Seibaek et al. allocating patients to the intervention based on presence of ascites [25,27]. Fernández-Candela et al. reported significant differences in baseline characteristics between intervention and control groups [30]. All studies clearly described the prehabilitation interventions administered to patients. The case report was considered as being of low risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports [31]. Table 3. Risk of bias analysis (ROBINS-I).

Missing Data
Measurement of Outcomes

Selection of Reported Results
Arnaboldi [25] Candela et al. reported significant differences in baseline characteristics between intervention and control groups [30]. All studies clearly described the prehabilitation interventions administered to patients. The case report was considered as being of low risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports [31].

Discussion
This review summarises the existing literature on the effectiveness of prehabilitation programmes on postoperative complications and quality of life of patients with gynaecologic cancer. Although prehabilitation is shown to significantly improve postoperative outcomes of patients in other surgical fields, this review demonstrates that evidence of beneficial effects in gynaecological cancer is not completely clear.
A total of seven studies were identified evaluating a prehabilitation programme for gynaecological cancer patients in which considerable heterogeneity of interventions and outcome measures were observed. One study of relatively high methodological quality, with adequate handling of confounders and parity of interventions, reported significant improvements in time to adjuvant treatment and shorter hospital stays in ovarian cancer patients [28]. As chemotherapy is an integral part of ovarian cancer management, a delay in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result in a significantly poorer prognosis [29]. Other studies, however, failed to demonstrate such Candela et al. reported significant differences in baseline characteristics between intervention and control groups [30]. All studies clearly described the prehabilitation interventions administered to patients. The case report was considered as being of low risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports [31].

Discussion
This review summarises the existing literature on the effectiveness of prehabilitation programmes on postoperative complications and quality of life of patients with gynaecologic cancer. Although prehabilitation is shown to significantly improve postoperative outcomes of patients in other surgical fields, this review demonstrates that evidence of beneficial effects in gynaecological cancer is not completely clear.
A total of seven studies were identified evaluating a prehabilitation programme for gynaecological cancer patients in which considerable heterogeneity of interventions and outcome measures were observed. One study of relatively high methodological quality, with adequate handling of confounders and parity of interventions, reported significant improvements in time to adjuvant treatment and shorter hospital stays in ovarian cancer patients [28]. As chemotherapy is an integral part of ovarian cancer management, a delay in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result in a significantly poorer prognosis [29]. Other studies, however, failed to demonstrate such Candela et al. reported significant differences in baseline characteristics between intervention and control groups [30]. All studies clearly described the prehabilitation interventions administered to patients. The case report was considered as being of low risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports [31].

Discussion
This review summarises the existing literature on the effectiveness of prehabilitation programmes on postoperative complications and quality of life of patients with gynaecologic cancer. Although prehabilitation is shown to significantly improve postoperative outcomes of patients in other surgical fields, this review demonstrates that evidence of beneficial effects in gynaecological cancer is not completely clear.
A total of seven studies were identified evaluating a prehabilitation programme for gynaecological cancer patients in which considerable heterogeneity of interventions and outcome measures were observed. One study of relatively high methodological quality, with adequate handling of confounders and parity of interventions, reported significant improvements in time to adjuvant treatment and shorter hospital stays in ovarian cancer patients [28]. As chemotherapy is an integral part of ovarian cancer management, a delay in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result in a significantly poorer prognosis [29]. Other studies, however, failed to demonstrate such the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports [31].

Discussion
This review summarises the existing literature on the effectiveness of prehabilitation programmes on postoperative complications and quality of life of patients with gynaecologic cancer. Although prehabilitation is shown to significantly improve postoperative outcomes of patients in other surgical fields, this review demonstrates that evidence of beneficial effects in gynaecological cancer is not completely clear.
A total of seven studies were identified evaluating a prehabilitation programme for gynaecological cancer patients in which considerable heterogeneity of interventions and outcome measures were observed. One study of relatively high methodological quality, with adequate handling of confounders and parity of interventions, reported significant improvements in time to adjuvant treatment and shorter hospital stays in ovarian cancer patients [28]. As chemotherapy is an integral part of ovarian cancer management, a delay in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result in a significantly poorer prognosis [29]. Other studies, however, failed to demonstrate such improvements [26][27][28]30]. Whilst this may be related to differences in the outcome measures reported, it is also likely that bias related to confounding and selection impacted on the ability of these studies to accurately measure the true effectiveness of the interventions. Even despite the relatively large numbers of patients reported [27,30]. No serious adverse events of the programmes have been reported by the included studies [26,28,30,31]. To our knowledge, there has been one further study by Miralpeix et al. evaluating a prehabilitation programme after our search was performed. This pilot study also demonstrated the feasibility and safety of a multimodal prehabilitation programme before interval cytoreductive surgery in ovarian cancer patients, with significant improvement of nutritional parameters [33].
Prehabilitation programmes have already been extensively assessed in other cancer sites. In colorectal cancer, results are promising, with significant reductions of complication rates up to 51% and a significantly shortened length of stay [20,21,34]. The majority of these programmes are multimodal, comprising exercise therapy, nutritional guidance, psychological interventions and treatment of intoxications and anaemia, with exercise being one of the most important mainstays [21,34]. A recent systematic review and metaanalysis comprising 3962 patients undergoing abdominal cancer surgery found Candela et al. reported significant d intervention and control groups [30]. A interventions administered to patients. T risk of bias, using the Joanna Briggs Ins Reports [31]. Table 3. Risk of bias analysis (ROBINS-I).

Discussion
This review summarises the existing programmes on postoperative compli gynaecologic cancer. Although prehab postoperative outcomes of patients in oth evidence of beneficial effects in gynaecol A total of seven studies were identi gynaecological cancer patients in which outcome measures were observed. One s with adequate handling of confounders improvements in time to adjuvant treatm patients [28]. As chemotherapy is an inte in adjuvant treatment beyond 25 to 35 significantly poorer prognosis [29]. Othe Candela et al. reported significant d intervention and control groups [30]. A interventions administered to patients. risk of bias, using the Joanna Briggs Ins Reports [31]. Table 3. Risk of bias analysis (ROBINS-I).

Discussion
This review summarises the existin programmes on postoperative compl gynaecologic cancer. Although preha postoperative outcomes of patients in ot evidence of beneficial effects in gynaeco A total of seven studies were ident gynaecological cancer patients in which outcome measures were observed. One with adequate handling of confounders improvements in time to adjuvant treatm patients [28]. As chemotherapy is an inte in adjuvant treatment beyond 25 to 35 significantly poorer prognosis [29]. Oth Candela et al. reported intervention and control interventions administer risk of bias, using the Joa Reports [31].

Discussion
This review summar programmes on postop gynaecologic cancer. A postoperative outcomes o evidence of beneficial effe A total of seven stud gynaecological cancer pa outcome measures were with adequate handling improvements in time to patients [28]. As chemoth in adjuvant treatment be significantly poorer prog Aubrey [29] al. allocating patients to the intervention based on presence of ascites [25,27]. Fernández-Candela et al. reported significant differences in baseline characteristics between intervention and control groups [30]. All studies clearly described the prehabilitation interventions administered to patients. The case report was considered as being of low risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports [31]. Table 3. Risk of bias analysis (ROBINS-I).

Discussion
This review summarises the existing literature on the effectiveness of prehabilitation programmes on postoperative complications and quality of life of patients with gynaecologic cancer. Although prehabilitation is shown to significantly improve postoperative outcomes of patients in other surgical fields, this review demonstrates that evidence of beneficial effects in gynaecological cancer is not completely clear.
A total of seven studies were identified evaluating a prehabilitation programme for gynaecological cancer patients in which considerable heterogeneity of interventions and outcome measures were observed. One study of relatively high methodological quality, with adequate handling of confounders and parity of interventions, reported significant improvements in time to adjuvant treatment and shorter hospital stays in ovarian cancer patients [28]. As chemotherapy is an integral part of ovarian cancer management, a delay in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result in a significantly poorer prognosis [29]. Other studies, however, failed to demonstrate such al. allocating patients to the intervention based on presence of ascites [25,27]. Fernández-Candela et al. reported significant differences in baseline characteristics between intervention and control groups [30]. All studies clearly described the prehabilitation interventions administered to patients. The case report was considered as being of low risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports [31]. Table 3. Risk of bias analysis (ROBINS-I).

Discussion
This review summarises the existing literature on the effectiveness of prehabilitation programmes on postoperative complications and quality of life of patients with gynaecologic cancer. Although prehabilitation is shown to significantly improve postoperative outcomes of patients in other surgical fields, this review demonstrates that evidence of beneficial effects in gynaecological cancer is not completely clear.
A total of seven studies were identified evaluating a prehabilitation programme for gynaecological cancer patients in which considerable heterogeneity of interventions and outcome measures were observed. One study of relatively high methodological quality, with adequate handling of confounders and parity of interventions, reported significant improvements in time to adjuvant treatment and shorter hospital stays in ovarian cancer patients [28]. As chemotherapy is an integral part of ovarian cancer management, a delay in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result in a significantly poorer prognosis [29]. Other studies, however, failed to demonstrate such al. allocating patients to the intervention based on presence of ascites [25,27]. Fernández-Candela et al. reported significant differences in baseline characteristics between intervention and control groups [30]. All studies clearly described the prehabilitation interventions administered to patients. The case report was considered as being of low risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports [31]. Table 3. Risk of bias analysis (ROBINS-I).

Discussion
This review summarises the existing literature on the effectiveness of prehabilitation programmes on postoperative complications and quality of life of patients with gynaecologic cancer. Although prehabilitation is shown to significantly improve postoperative outcomes of patients in other surgical fields, this review demonstrates that evidence of beneficial effects in gynaecological cancer is not completely clear.
A total of seven studies were identified evaluating a prehabilitation programme for gynaecological cancer patients in which considerable heterogeneity of interventions and outcome measures were observed. One study of relatively high methodological quality, with adequate handling of confounders and parity of interventions, reported significant improvements in time to adjuvant treatment and shorter hospital stays in ovarian cancer patients [28]. As chemotherapy is an integral part of ovarian cancer management, a delay in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result in a significantly poorer prognosis [29]. Other studies, however, failed to demonstrate such al. allocating patients to the intervention based on presence of ascites [25,27]. Fernán Candela et al. reported significant differences in baseline characteristics betw intervention and control groups [30]. All studies clearly described the prehabilit interventions administered to patients. The case report was considered as being of risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Reports [31]. Table 3. Risk of bias analysis (ROBINS-I).

Discussion
This review summarises the existing literature on the effectiveness of prehabilit programmes on postoperative complications and quality of life of patients gynaecologic cancer. Although prehabilitation is shown to significantly imp postoperative outcomes of patients in other surgical fields, this review demonstrates evidence of beneficial effects in gynaecological cancer is not completely clear.
A total of seven studies were identified evaluating a prehabilitation programm gynaecological cancer patients in which considerable heterogeneity of interventions outcome measures were observed. One study of relatively high methodological qu with adequate handling of confounders and parity of interventions, reported signif improvements in time to adjuvant treatment and shorter hospital stays in ovarian ca patients [28]. As chemotherapy is an integral part of ovarian cancer management, a d in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result significantly poorer prognosis [29]. Other studies, however, failed to demonstrate al. allocating patients to the intervention based on pres Candela et al. reported significant differences in intervention and control groups [30]. All studies clea interventions administered to patients. The case repor risk of bias, using the Joanna Briggs Institute (JBI) Cri Reports [31]. Table 3. Risk of bias analysis (ROBINS-I).

Discussion
This review summarises the existing literature on programmes on postoperative complications and gynaecologic cancer. Although prehabilitation is s postoperative outcomes of patients in other surgical fie evidence of beneficial effects in gynaecological cancer i A total of seven studies were identified evaluating gynaecological cancer patients in which considerable h outcome measures were observed. One study of relati with adequate handling of confounders and parity of improvements in time to adjuvant treatment and short patients [28]. As chemotherapy is an integral part of ov in adjuvant treatment beyond 25 to 35 days due to s significantly poorer prognosis [29]. Other studies, how al. allocating patients to the intervention based on pre Candela et al. reported significant differences in intervention and control groups [30]. All studies cle interventions administered to patients. The case repo risk of bias, using the Joanna Briggs Institute (JBI) Cr Reports [31]. Table 3. Risk of bias analysis (ROBINS-I).

Discussion
This review summarises the existing literature on programmes on postoperative complications and gynaecologic cancer. Although prehabilitation is postoperative outcomes of patients in other surgical fie evidence of beneficial effects in gynaecological cancer A total of seven studies were identified evaluatin gynaecological cancer patients in which considerable outcome measures were observed. One study of relat with adequate handling of confounders and parity of improvements in time to adjuvant treatment and shor patients [28]. As chemotherapy is an integral part of ov in adjuvant treatment beyond 25 to 35 days due to s significantly poorer prognosis [29]. Other studies, ho al. allocating patients to t Candela et al. reported intervention and control interventions administer risk of bias, using the Joa Reports [31].

Discussion
This review summar programmes on postop gynaecologic cancer. A postoperative outcomes o evidence of beneficial effe A total of seven stud gynaecological cancer pa outcome measures were with adequate handling improvements in time to patients [28]. As chemoth in adjuvant treatment be significantly poorer prog Diaz-Feijoo [28] had a significant selection bias, with Arnaboldi et al. allocating patients to the intervention based on their preoperative psychological distress inventory (PDI) score and Seibaek et al. allocating patients to the intervention based on presence of ascites [25,27]. Fernández-Candela et al. reported significant differences in baseline characteristics between intervention and control groups [30]. All studies clearly described the prehabilitation interventions administered to patients. The case report was considered as being of low risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports [31].

Discussion
This review summarises the existing literature on the effectiveness of prehabilitation programmes on postoperative complications and quality of life of patients with gynaecologic cancer. Although prehabilitation is shown to significantly improve postoperative outcomes of patients in other surgical fields, this review demonstrates that evidence of beneficial effects in gynaecological cancer is not completely clear.
A total of seven studies were identified evaluating a prehabilitation programme for gynaecological cancer patients in which considerable heterogeneity of interventions and outcome measures were observed. One study of relatively high methodological quality, with adequate handling of confounders and parity of interventions, reported significant improvements in time to adjuvant treatment and shorter hospital stays in ovarian cancer patients [28]. As chemotherapy is an integral part of ovarian cancer management, a delay in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result in a significantly poorer prognosis [29]. Other studies, however, failed to demonstrate such had a significant selection bias, with Arnaboldi et al. allocating patients to the intervention based on their preoperative psychological distress inventory (PDI) score and Seibaek et al. allocating patients to the intervention based on presence of ascites [25,27]. Fernández-Candela et al. reported significant differences in baseline characteristics between intervention and control groups [30]. All studies clearly described the prehabilitation interventions administered to patients. The case report was considered as being of low risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports [31].

Discussion
This review summarises the existing literature on the effectiveness of prehabilitation programmes on postoperative complications and quality of life of patients with gynaecologic cancer. Although prehabilitation is shown to significantly improve postoperative outcomes of patients in other surgical fields, this review demonstrates that evidence of beneficial effects in gynaecological cancer is not completely clear.
A total of seven studies were identified evaluating a prehabilitation programme for gynaecological cancer patients in which considerable heterogeneity of interventions and outcome measures were observed. One study of relatively high methodological quality, with adequate handling of confounders and parity of interventions, reported significant improvements in time to adjuvant treatment and shorter hospital stays in ovarian cancer patients [28]. As chemotherapy is an integral part of ovarian cancer management, a delay in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result in a significantly poorer prognosis [29]. Other studies, however, failed to demonstrate such had a significant selection bias, with Arnaboldi et al. allocating patients to the intervention based on their preoperative psychological distress inventory (PDI) score and Seibaek et al. allocating patients to the intervention based on presence of ascites [25,27]. Fernández-Candela et al. reported significant differences in baseline characteristics between intervention and control groups [30]. All studies clearly described the prehabilitation interventions administered to patients. The case report was considered as being of low risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports [31].

Discussion
This review summarises the existing literature on the effectiveness of prehabilitation programmes on postoperative complications and quality of life of patients with gynaecologic cancer. Although prehabilitation is shown to significantly improve postoperative outcomes of patients in other surgical fields, this review demonstrates that evidence of beneficial effects in gynaecological cancer is not completely clear.
A total of seven studies were identified evaluating a prehabilitation programme for gynaecological cancer patients in which considerable heterogeneity of interventions and outcome measures were observed. One study of relatively high methodological quality, with adequate handling of confounders and parity of interventions, reported significant improvements in time to adjuvant treatment and shorter hospital stays in ovarian cancer patients [28]. As chemotherapy is an integral part of ovarian cancer management, a delay in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result in a significantly poorer prognosis [29]. Other studies, however, failed to demonstrate such had a significant selection bias, with Arnaboldi et al. allocating patients to the interve based on their preoperative psychological distress inventory (PDI) score and Seiba al. allocating patients to the intervention based on presence of ascites [25,27]. Fernán Candela et al. reported significant differences in baseline characteristics betw intervention and control groups [30]. All studies clearly described the prehabilit interventions administered to patients. The case report was considered as being of risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Reports [31].

Discussion
This review summarises the existing literature on the effectiveness of prehabilit programmes on postoperative complications and quality of life of patients gynaecologic cancer. Although prehabilitation is shown to significantly imp postoperative outcomes of patients in other surgical fields, this review demonstrates evidence of beneficial effects in gynaecological cancer is not completely clear.
A total of seven studies were identified evaluating a prehabilitation programm gynaecological cancer patients in which considerable heterogeneity of interventions outcome measures were observed. One study of relatively high methodological qu with adequate handling of confounders and parity of interventions, reported signif improvements in time to adjuvant treatment and shorter hospital stays in ovarian ca patients [28]. As chemotherapy is an integral part of ovarian cancer management, a d in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result significantly poorer prognosis [29]. Other studies, however, failed to demonstrate al. allocating patients to the intervention based on presence of ascites [25,27]. Fernández-Candela et al. reported significant differences in baseline characteristics between intervention and control groups [30]. All studies clearly described the prehabilitation interventions administered to patients. The case report was considered as being of low risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports [31]. Table 3. Risk of bias analysis (ROBINS-I).

Discussion
This review summarises the existing literature on the effectiveness of prehabilitation programmes on postoperative complications and quality of life of patients with gynaecologic cancer. Although prehabilitation is shown to significantly improve postoperative outcomes of patients in other surgical fields, this review demonstrates that evidence of beneficial effects in gynaecological cancer is not completely clear. A total of seven studies were identified evaluating a prehabilitation programme for gynaecological cancer patients in which considerable heterogeneity of interventions and outcome measures were observed. One study of relatively high methodological quality, with adequate handling of confounders and parity of interventions, reported significant improvements in time to adjuvant treatment and shorter hospital stays in ovarian cancer patients [28]. As chemotherapy is an integral part of ovarian cancer management, a delay in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result in a significantly poorer prognosis [29]. Other studies, however, failed to demonstrate such improvements [26][27][28]30]. Whilst this may be related to differences in the outcome measures reported, it is also likely that bias related to confounding and selection impacted on the ability of these studies to accurately measure the true effectiveness of the interventions. Even despite the relatively large numbers of patients reported [27,30]. No serious adverse events of the programmes have been reported by the included studies [26,28,30,31]. To our knowledge, there has been one further study by Miralpeix et al. evaluating a prehabilitation programme after our search was performed. This pilot study also demonstrated the feasibility and safety of a multimodal prehabilitation programme before interval cytoreductive surgery in ovarian cancer patients, with significant improvement of nutritional parameters [33].
Prehabilitation programmes have already been extensively assessed in other cancer sites. In colorectal cancer, results are promising, with significant reductions of complication rates up to 51% and a significantly shortened length of stay [20,21,34]. The majority of these programmes are multimodal, comprising exercise therapy, nutritional guidance, psychological interventions and treatment of intoxications and anaemia, with exercise being one of the most important mainstays [21,34]. A recent systematic review and metaanalysis comprising 3962 patients undergoing abdominal cancer surgery found had a significant selection bias, with Arnaboldi et al. all based on their preoperative psychological distress inv al. allocating patients to the intervention based on pre Candela et al. reported significant differences in intervention and control groups [30]. All studies cle interventions administered to patients. The case repo risk of bias, using the Joanna Briggs Institute (JBI) Cr Reports [31].

Discussion
This review summarises the existing literature on programmes on postoperative complications and gynaecologic cancer. Although prehabilitation is postoperative outcomes of patients in other surgical fie evidence of beneficial effects in gynaecological cancer A total of seven studies were identified evaluatin gynaecological cancer patients in which considerable outcome measures were observed. One study of relat with adequate handling of confounders and parity of improvements in time to adjuvant treatment and shor patients [28]. As chemotherapy is an integral part of ov in adjuvant treatment beyond 25 to 35 days due to s significantly poorer prognosis [29]. Other studies, ho had a significant selection based on their preoperat al. allocating patients to t Candela et al. reported intervention and control interventions administer risk of bias, using the Joa Reports [31].

Discussion
This review summar programmes on postop gynaecologic cancer. A postoperative outcomes o evidence of beneficial effe A total of seven stud gynaecological cancer pa outcome measures were with adequate handling improvements in time to patients [28]. As chemoth in adjuvant treatment be significantly poorer prog Fernández-Candea [30] methods used to measure outcomes, such as questionnaires [27]; and significant differences in standard care between intervention and control groups [30]. Several studies had a significant selection bias, with Arnaboldi et al. allocating patients to the intervention based on their preoperative psychological distress inventory (PDI) score and Seibaek et al. allocating patients to the intervention based on presence of ascites [25,27]. Fernández-Candela et al. reported significant differences in baseline characteristics between intervention and control groups [30]. All studies clearly described the prehabilitation interventions administered to patients. The case report was considered as being of low risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports [31].

Discussion
This review summarises the existing literature on the effectiveness of prehabilitation programmes on postoperative complications and quality of life of patients with gynaecologic cancer. Although prehabilitation is shown to significantly improve postoperative outcomes of patients in other surgical fields, this review demonstrates that evidence of beneficial effects in gynaecological cancer is not completely clear.
A total of seven studies were identified evaluating a prehabilitation programme for gynaecological cancer patients in which considerable heterogeneity of interventions and outcome measures were observed. One study of relatively high methodological quality, with adequate handling of confounders and parity of interventions, reported significant improvements in time to adjuvant treatment and shorter hospital stays in ovarian cancer patients [28]. As chemotherapy is an integral part of ovarian cancer management, a delay in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result in a significantly poorer prognosis [29]. Other studies, however, failed to demonstrate such methods used to measure outcomes, such as questionnaires [27]; and significant differences in standard care between intervention and control groups [30]. Several studies had a significant selection bias, with Arnaboldi et al. allocating patients to the intervention based on their preoperative psychological distress inventory (PDI) score and Seibaek et al. allocating patients to the intervention based on presence of ascites [25,27]. Fernández-Candela et al. reported significant differences in baseline characteristics between intervention and control groups [30]. All studies clearly described the prehabilitation interventions administered to patients. The case report was considered as being of low risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports [31]. Table 3. Risk of bias analysis (ROBINS-I).

Discussion
This review summarises the existing literature on the effectiveness of prehabilitation programmes on postoperative complications and quality of life of patients with gynaecologic cancer. Although prehabilitation is shown to significantly improve postoperative outcomes of patients in other surgical fields, this review demonstrates that evidence of beneficial effects in gynaecological cancer is not completely clear.
A total of seven studies were identified evaluating a prehabilitation programme for gynaecological cancer patients in which considerable heterogeneity of interventions and outcome measures were observed. One study of relatively high methodological quality, with adequate handling of confounders and parity of interventions, reported significant improvements in time to adjuvant treatment and shorter hospital stays in ovarian cancer patients [28]. As chemotherapy is an integral part of ovarian cancer management, a delay in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result in a significantly poorer prognosis [29]. Other studies, however, failed to demonstrate such methods used to measure outcomes, such as questionnaires [27]; and significant differences in standard care between intervention and control groups [30]. Several studies had a significant selection bias, with Arnaboldi et al. allocating patients to the intervention based on their preoperative psychological distress inventory (PDI) score and Seibaek et al. allocating patients to the intervention based on presence of ascites [25,27]. Fernández-Candela et al. reported significant differences in baseline characteristics between intervention and control groups [30]. All studies clearly described the prehabilitation interventions administered to patients. The case report was considered as being of low risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports [31]. Table 3. Risk of bias analysis (ROBINS-I).

Discussion
This review summarises the existing literature on the effectiveness of prehabilitation programmes on postoperative complications and quality of life of patients with gynaecologic cancer. Although prehabilitation is shown to significantly improve postoperative outcomes of patients in other surgical fields, this review demonstrates that evidence of beneficial effects in gynaecological cancer is not completely clear.
A total of seven studies were identified evaluating a prehabilitation programme for gynaecological cancer patients in which considerable heterogeneity of interventions and outcome measures were observed. One study of relatively high methodological quality, with adequate handling of confounders and parity of interventions, reported significant improvements in time to adjuvant treatment and shorter hospital stays in ovarian cancer patients [28]. As chemotherapy is an integral part of ovarian cancer management, a delay in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result in a significantly poorer prognosis [29]. Other studies, however, failed to demonstrate such methods used to measure outcomes, such as ques differences in standard care between intervention and co had a significant selection bias, with Arnaboldi et al. allo based on their preoperative psychological distress inve al. allocating patients to the intervention based on prese Candela et al. reported significant differences in b intervention and control groups [30]. All studies clea interventions administered to patients. The case report risk of bias, using the Joanna Briggs Institute (JBI) Crit Reports [31]. Table 3. Risk of bias analysis (ROBINS-I).

Discussion
This review summarises the existing literature on th programmes on postoperative complications and q gynaecologic cancer. Although prehabilitation is s postoperative outcomes of patients in other surgical fiel evidence of beneficial effects in gynaecological cancer is A total of seven studies were identified evaluating gynaecological cancer patients in which considerable h outcome measures were observed. One study of relativ with adequate handling of confounders and parity of in improvements in time to adjuvant treatment and shorte patients [28]. As chemotherapy is an integral part of ova in adjuvant treatment beyond 25 to 35 days due to su significantly poorer prognosis [29]. Other studies, how methods used to measure outcomes, such as questionnaires [2 differences in standard care between intervention and control groups had a significant selection bias, with Arnaboldi et al. allocating patient based on their preoperative psychological distress inventory (PDI) s al. allocating patients to the intervention based on presence of ascites Candela et al. reported significant differences in baseline char intervention and control groups [30]. All studies clearly described interventions administered to patients. The case report was conside risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisa Reports [31]. Table 3. Risk of bias analysis (ROBINS-I).

Discussion
This review summarises the existing literature on the effectivene programmes on postoperative complications and quality of life gynaecologic cancer. Although prehabilitation is shown to sig postoperative outcomes of patients in other surgical fields, this review evidence of beneficial effects in gynaecological cancer is not complete A total of seven studies were identified evaluating a prehabilita gynaecological cancer patients in which considerable heterogeneity o outcome measures were observed. One study of relatively high meth with adequate handling of confounders and parity of interventions, improvements in time to adjuvant treatment and shorter hospital sta patients [28]. As chemotherapy is an integral part of ovarian cancer m in adjuvant treatment beyond 25 to 35 days due to surgical morbid significantly poorer prognosis [29]. Other studies, however, failed t methods used to measure outcomes, such as que differences in standard care between intervention and had a significant selection bias, with Arnaboldi et al. all based on their preoperative psychological distress inv al. allocating patients to the intervention based on pre Candela et al. reported significant differences in intervention and control groups [30]. All studies cle interventions administered to patients. The case repo risk of bias, using the Joanna Briggs Institute (JBI) Cr Reports [31]. Table 3. Risk of bias analysis (ROBINS-I).

Discussion
This review summarises the existing literature on programmes on postoperative complications and gynaecologic cancer. Although prehabilitation is postoperative outcomes of patients in other surgical fie evidence of beneficial effects in gynaecological cancer A total of seven studies were identified evaluatin gynaecological cancer patients in which considerable outcome measures were observed. One study of relat with adequate handling of confounders and parity of improvements in time to adjuvant treatment and shor patients [28]. As chemotherapy is an integral part of ov in adjuvant treatment beyond 25 to 35 days due to s significantly poorer prognosis [29]. Other studies, ho methods used to meas differences in standard ca had a significant selection based on their preoperat al. allocating patients to t Candela et al. reported intervention and control interventions administer risk of bias, using the Joa Reports [31].

Discussion
This review summar programmes on postop gynaecologic cancer. A postoperative outcomes o evidence of beneficial effe A total of seven stud gynaecological cancer pa outcome measures were with adequate handling improvements in time to patients [28]. As chemoth in adjuvant treatment be significantly poorer prog Hertlein [26] methods used to measure outcomes, such as questionnaires [27]; and significant differences in standard care between intervention and control groups [30]. Several studies had a significant selection bias, with Arnaboldi et al. allocating patients to the intervention based on their preoperative psychological distress inventory (PDI) score and Seibaek et al. allocating patients to the intervention based on presence of ascites [25,27]. Fernández-Candela et al. reported significant differences in baseline characteristics between intervention and control groups [30]. All studies clearly described the prehabilitation interventions administered to patients. The case report was considered as being of low risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports [31]. Table 3. Risk of bias analysis (ROBINS-I).

Discussion
This review summarises the existing literature on the effectiveness of prehabilitation programmes on postoperative complications and quality of life of patients with gynaecologic cancer. Although prehabilitation is shown to significantly improve postoperative outcomes of patients in other surgical fields, this review demonstrates that evidence of beneficial effects in gynaecological cancer is not completely clear.
A total of seven studies were identified evaluating a prehabilitation programme for gynaecological cancer patients in which considerable heterogeneity of interventions and outcome measures were observed. One study of relatively high methodological quality, with adequate handling of confounders and parity of interventions, reported significant improvements in time to adjuvant treatment and shorter hospital stays in ovarian cancer patients [28]. As chemotherapy is an integral part of ovarian cancer management, a delay in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result in a significantly poorer prognosis [29]. Other studies, however, failed to demonstrate such methods used to measure outcomes, such as questionnaires [27]; and significant differences in standard care between intervention and control groups [30]. Several studies had a significant selection bias, with Arnaboldi et al. allocating patients to the intervention based on their preoperative psychological distress inventory (PDI) score and Seibaek et al. allocating patients to the intervention based on presence of ascites [25,27]. Fernández-Candela et al. reported significant differences in baseline characteristics between intervention and control groups [30]. All studies clearly described the prehabilitation interventions administered to patients. The case report was considered as being of low risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports [31]. Table 3. Risk of bias analysis (ROBINS-I).

Discussion
This review summarises the existing literature on the effectiveness of prehabilitation programmes on postoperative complications and quality of life of patients with gynaecologic cancer. Although prehabilitation is shown to significantly improve postoperative outcomes of patients in other surgical fields, this review demonstrates that evidence of beneficial effects in gynaecological cancer is not completely clear.
A total of seven studies were identified evaluating a prehabilitation programme for gynaecological cancer patients in which considerable heterogeneity of interventions and outcome measures were observed. One study of relatively high methodological quality, with adequate handling of confounders and parity of interventions, reported significant improvements in time to adjuvant treatment and shorter hospital stays in ovarian cancer patients [28]. As chemotherapy is an integral part of ovarian cancer management, a delay in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result in a significantly poorer prognosis [29]. Other studies, however, failed to demonstrate such methods used to measure outcomes, such as questionnaires [27]; and significant differences in standard care between intervention and control groups [30]. Several studies had a significant selection bias, with Arnaboldi et al. allocating patients to the intervention based on their preoperative psychological distress inventory (PDI) score and Seibaek et al. allocating patients to the intervention based on presence of ascites [25,27]. Fernández-Candela et al. reported significant differences in baseline characteristics between intervention and control groups [30]. All studies clearly described the prehabilitation interventions administered to patients. The case report was considered as being of low risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports [31]. Table 3. Risk of bias analysis (ROBINS-I).

Discussion
This review summarises the existing literature on the effectiveness of prehabilitation programmes on postoperative complications and quality of life of patients with gynaecologic cancer. Although prehabilitation is shown to significantly improve postoperative outcomes of patients in other surgical fields, this review demonstrates that evidence of beneficial effects in gynaecological cancer is not completely clear.
A total of seven studies were identified evaluating a prehabilitation programme for gynaecological cancer patients in which considerable heterogeneity of interventions and outcome measures were observed. One study of relatively high methodological quality, with adequate handling of confounders and parity of interventions, reported significant improvements in time to adjuvant treatment and shorter hospital stays in ovarian cancer patients [28]. As chemotherapy is an integral part of ovarian cancer management, a delay in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result in a significantly poorer prognosis [29]. Other studies, however, failed to demonstrate such methods used to measure outcomes, such as questionnaires [2 differences in standard care between intervention and control groups [ had a significant selection bias, with Arnaboldi et al. allocating patients based on their preoperative psychological distress inventory (PDI) sc al. allocating patients to the intervention based on presence of ascites Candela et al. reported significant differences in baseline chara intervention and control groups [30]. All studies clearly described interventions administered to patients. The case report was consider risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Reports [31]. Table 3. Risk of bias analysis (ROBINS-I).

Discussion
This review summarises the existing literature on the effectivenes programmes on postoperative complications and quality of life gynaecologic cancer. Although prehabilitation is shown to sig postoperative outcomes of patients in other surgical fields, this review evidence of beneficial effects in gynaecological cancer is not complete A total of seven studies were identified evaluating a prehabilitat gynaecological cancer patients in which considerable heterogeneity o outcome measures were observed. One study of relatively high meth with adequate handling of confounders and parity of interventions, r improvements in time to adjuvant treatment and shorter hospital stay patients [28]. As chemotherapy is an integral part of ovarian cancer m in adjuvant treatment beyond 25 to 35 days due to surgical morbid significantly poorer prognosis [29]. Other studies, however, failed to significant selection bias, with Arnaboldi et al. allocating patients to the intervention based on their preoperative psychological distress inventory (PDI) score and Seibaek et al. allocating patients to the intervention based on presence of ascites [25,27]. Fernández-Candela et al. reported significant differences in baseline characteristics between intervention and control groups [30]. All studies clearly described the prehabilitation interventions administered to patients. The case report was considered as being of low risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports [31]. Table 3. Risk of bias analysis (ROBINS-I).

Discussion
This review summarises the existing literature on the effectiveness of prehabilitation programmes on postoperative complications and quality of life of patients with gynaecologic cancer. Although prehabilitation is shown to significantly improve postoperative outcomes of patients in other surgical fields, this review demonstrates that evidence of beneficial effects in gynaecological cancer is not completely clear. A total of seven studies were identified evaluating a prehabilitation programme for gynaecological cancer patients in which considerable heterogeneity of interventions and outcome measures were observed. One study of relatively high methodological quality, with adequate handling of confounders and parity of interventions, reported significant improvements in time to adjuvant treatment and shorter hospital stays in ovarian cancer patients [28]. As chemotherapy is an integral part of ovarian cancer management, a delay in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result in a significantly poorer prognosis [29]. Other studies, however, failed to demonstrate such improvements [26][27][28]30]. Whilst this may be related to differences in the outcome measures reported, it is also likely that bias related to confounding and selection impacted on the ability of these studies to accurately measure the true effectiveness of the interventions. Even despite the relatively large numbers of patients reported [27,30]. No serious adverse events of the programmes have been reported by the included studies [26,28,30,31]. To our knowledge, there has been one further study by Miralpeix et al. evaluating a prehabilitation programme after our search was performed. This pilot study also demonstrated the feasibility and safety of a multimodal prehabilitation programme before interval cytoreductive surgery in ovarian cancer patients, with significant improvement of nutritional parameters [33].
Prehabilitation programmes have already been extensively assessed in other cancer sites. In colorectal cancer, results are promising, with significant reductions of complication rates up to 51% and a significantly shortened length of stay [20,21,34]. The majority of these programmes are multimodal, comprising exercise therapy, nutritional guidance, psychological interventions and treatment of intoxications and anaemia, with exercise being one of the most important mainstays [21,34]. A recent systematic review and metaanalysis comprising 3962 patients undergoing abdominal cancer surgery found methods used to measure outcomes, such as que differences in standard care between intervention and had a significant selection bias, with Arnaboldi et al. all based on their preoperative psychological distress inv al. allocating patients to the intervention based on pre Candela et al. reported significant differences in intervention and control groups [30]. All studies cle interventions administered to patients. The case repo risk of bias, using the Joanna Briggs Institute (JBI) Cr Reports [31]. Table 3. Risk of bias analysis (ROBINS-I).

Discussion
This review summarises the existing literature on programmes on postoperative complications and gynaecologic cancer. Although prehabilitation is postoperative outcomes of patients in other surgical fie evidence of beneficial effects in gynaecological cancer A total of seven studies were identified evaluatin gynaecological cancer patients in which considerable outcome measures were observed. One study of relat with adequate handling of confounders and parity of improvements in time to adjuvant treatment and shor patients [28]. As chemotherapy is an integral part of ov in adjuvant treatment beyond 25 to 35 days due to s significantly poorer prognosis [29]. Other studies, ho methods used to meas differences in standard ca had a significant selection based on their preoperat al. allocating patients to t Candela et al. reported intervention and control interventions administer risk of bias, using the Joa Reports [31].

Discussion
This review summar programmes on postop gynaecologic cancer. A postoperative outcomes o evidence of beneficial effe A total of seven stud gynaecological cancer pa outcome measures were with adequate handling improvements in time to patients [28]. As chemoth in adjuvant treatment be significantly poorer prog

Seibaek [27]
Cancers 2022, 14, x FOR PEER REVIEW 9 of 15 methods used to measure outcomes, such as questionnaires [27]; and significant differences in standard care between intervention and control groups [30]. Several studies had a significant selection bias, with Arnaboldi et al. allocating patients to the intervention based on their preoperative psychological distress inventory (PDI) score and Seibaek et al. allocating patients to the intervention based on presence of ascites [25,27]. Fernández-Candela et al. reported significant differences in baseline characteristics between intervention and control groups [30]. All studies clearly described the prehabilitation interventions administered to patients. The case report was considered as being of low risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports [31]. Table 3. Risk of bias analysis (ROBINS-I).

Discussion
This review summarises the existing literature on the effectiveness of prehabilitation programmes on postoperative complications and quality of life of patients with gynaecologic cancer. Although prehabilitation is shown to significantly improve postoperative outcomes of patients in other surgical fields, this review demonstrates that evidence of beneficial effects in gynaecological cancer is not completely clear.
A total of seven studies were identified evaluating a prehabilitation programme for gynaecological cancer patients in which considerable heterogeneity of interventions and outcome measures were observed. One study of relatively high methodological quality, with adequate handling of confounders and parity of interventions, reported significant improvements in time to adjuvant treatment and shorter hospital stays in ovarian cancer patients [28]. As chemotherapy is an integral part of ovarian cancer management, a delay in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result in a significantly poorer prognosis [29]. Other studies, however, failed to demonstrate such Cancers 2022, 14, x FOR PEER REVIEW 9 of 15 methods used to measure outcomes, such as questionnaires [27]; and significant differences in standard care between intervention and control groups [30]. Several studies had a significant selection bias, with Arnaboldi et al. allocating patients to the intervention based on their preoperative psychological distress inventory (PDI) score and Seibaek et al. allocating patients to the intervention based on presence of ascites [25,27]. Fernández-Candela et al. reported significant differences in baseline characteristics between intervention and control groups [30]. All studies clearly described the prehabilitation interventions administered to patients. The case report was considered as being of low risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports [31]. Table 3. Risk of bias analysis (ROBINS-I).

Discussion
This review summarises the existing literature on the effectiveness of prehabilitation programmes on postoperative complications and quality of life of patients with gynaecologic cancer. Although prehabilitation is shown to significantly improve postoperative outcomes of patients in other surgical fields, this review demonstrates that evidence of beneficial effects in gynaecological cancer is not completely clear.
A total of seven studies were identified evaluating a prehabilitation programme for gynaecological cancer patients in which considerable heterogeneity of interventions and outcome measures were observed. One study of relatively high methodological quality, with adequate handling of confounders and parity of interventions, reported significant improvements in time to adjuvant treatment and shorter hospital stays in ovarian cancer patients [28]. As chemotherapy is an integral part of ovarian cancer management, a delay in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result in a significantly poorer prognosis [29]. Other studies, however, failed to demonstrate such Cancers 2022, 14, x FOR PEER REVIEW 9 of 15 methods used to measure outcomes, such as questionnaires [27]; and significant differences in standard care between intervention and control groups [30]. Several studies had a significant selection bias, with Arnaboldi et al. allocating patients to the intervention based on their preoperative psychological distress inventory (PDI) score and Seibaek et al. allocating patients to the intervention based on presence of ascites [25,27]. Fernández-Candela et al. reported significant differences in baseline characteristics between intervention and control groups [30]. All studies clearly described the prehabilitation interventions administered to patients. The case report was considered as being of low risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports [31]. Table 3. Risk of bias analysis (ROBINS-I).

Discussion
This review summarises the existing literature on the effectiveness of prehabilitation programmes on postoperative complications and quality of life of patients with gynaecologic cancer. Although prehabilitation is shown to significantly improve postoperative outcomes of patients in other surgical fields, this review demonstrates that evidence of beneficial effects in gynaecological cancer is not completely clear.
A total of seven studies were identified evaluating a prehabilitation programme for gynaecological cancer patients in which considerable heterogeneity of interventions and outcome measures were observed. One study of relatively high methodological quality, with adequate handling of confounders and parity of interventions, reported significant improvements in time to adjuvant treatment and shorter hospital stays in ovarian cancer patients [28]. As chemotherapy is an integral part of ovarian cancer management, a delay in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result in a significantly poorer prognosis [29]. Other studies, however, failed to demonstrate such  [25,27]. Fernández-Candela et al. reported significant differences in baseline characteristics between intervention and control groups [30]. All studies clearly described the prehabilitation interventions administered to patients. The case report was considered as being of low risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports [31]. Table 3. Risk of bias analysis (ROBINS-I).

Discussion
This review summarises the existing literature on the effectiveness of prehabilitation programmes on postoperative complications and quality of life of patients with gynaecologic cancer. Although prehabilitation is shown to significantly improve postoperative outcomes of patients in other surgical fields, this review demonstrates that evidence of beneficial effects in gynaecological cancer is not completely clear. A total of seven studies were identified evaluating a prehabilitation programme for gynaecological cancer patients in which considerable heterogeneity of interventions and outcome measures were observed. One study of relatively high methodological quality, with adequate handling of confounders and parity of interventions, reported significant improvements in time to adjuvant treatment and shorter hospital stays in ovarian cancer patients [28]. As chemotherapy is an integral part of ovarian cancer management, a delay in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result in a significantly poorer prognosis [29]. Other studies, however, failed to demonstrate such improvements [26][27][28]30]. Whilst this may be related to differences in the outcome measures reported, it is also likely that bias related to confounding and selection impacted on the ability of these studies to accurately measure the true effectiveness of the interventions. Even despite the relatively large numbers of patients reported [27,30]. No serious adverse events of the programmes have been reported by the included studies [26,28,30,31]. To our knowledge, there has been one further study by Miralpeix et al. evaluating a prehabilitation programme after our search was performed. This pilot study also demonstrated the feasibility and safety of a multimodal prehabilitation programme before interval cytoreductive surgery in ovarian cancer patients, with significant improvement of nutritional parameters [33].
Prehabilitation programmes have already been extensively assessed in other cancer sites. In colorectal cancer, results are promising, with significant reductions of complication rates up to 51% and a significantly shortened length of stay [20,21,34]. The majority of these programmes are multimodal, comprising exercise therapy, nutritional guidance, psychological interventions and treatment of intoxications and anaemia, with exercise being one of the most important mainstays [21,34]. A recent systematic review and metaanalysis comprising 3962 patients undergoing abdominal cancer surgery found  [30]. All studies clea interventions administered to patients. The case repor risk of bias, using the Joanna Briggs Institute (JBI) Cri Reports [31]. Table 3. Risk of bias analysis (ROBINS-I).

Discussion
This review summarises the existing literature on programmes on postoperative complications and gynaecologic cancer. Although prehabilitation is s postoperative outcomes of patients in other surgical fie evidence of beneficial effects in gynaecological cancer i A total of seven studies were identified evaluating gynaecological cancer patients in which considerable h outcome measures were observed. One study of relati with adequate handling of confounders and parity of improvements in time to adjuvant treatment and short patients [28]. As chemotherapy is an integral part of ov in adjuvant treatment beyond 25 to 35 days due to s significantly poorer prognosis [29]. Other studies, how

Discussion
This review summari programmes on postope gynaecologic cancer. Al postoperative outcomes o evidence of beneficial effe A total of seven stud gynaecological cancer pat outcome measures were o with adequate handling o improvements in time to a patients [28]. As chemothe in adjuvant treatment bey significantly poorer progn

Discussion
This review summar programmes on postop gynaecologic cancer. A postoperative outcomes o evidence of beneficial effe A total of seven stud gynaecological cancer pa outcome measures were with adequate handling improvements in time to patients [28]. As chemoth in adjuvant treatment be significantly poorer prog Cancers 2022, 14, x FOR PEER REVIEW 9 of 15 methods used to measure outcomes, such as questionnaires [27]; and significant differences in standard care between intervention and control groups [30]. Several studies had a significant selection bias, with Arnaboldi et al. allocating patients to the intervention based on their preoperative psychological distress inventory (PDI) score and Seibaek et al. allocating patients to the intervention based on presence of ascites [25,27]. Fernández-Candela et al. reported significant differences in baseline characteristics between intervention and control groups [30]. All studies clearly described the prehabilitation interventions administered to patients. The case report was considered as being of low risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports [31]. Table 3. Risk of bias analysis (ROBINS-I).

Discussion
This review summarises the existing literature on the effectiveness of prehabilitation programmes on postoperative complications and quality of life of patients with gynaecologic cancer. Although prehabilitation is shown to significantly improve postoperative outcomes of patients in other surgical fields, this review demonstrates that evidence of beneficial effects in gynaecological cancer is not completely clear.
A total of seven studies were identified evaluating a prehabilitation programme for gynaecological cancer patients in which considerable heterogeneity of interventions and outcome measures were observed. One study of relatively high methodological quality, with adequate handling of confounders and parity of interventions, reported significant improvements in time to adjuvant treatment and shorter hospital stays in ovarian cancer patients [28]. As chemotherapy is an integral part of ovarian cancer management, a delay in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result in a significantly poorer prognosis [29]. Other studies, however, failed to demonstrate such Serious risk; Cancers 2022, 14, x FOR PEER REVIEW 9 of 15 methods used to measure outcomes, such as questionnaires [27]; and significant differences in standard care between intervention and control groups [30]. Several studies had a significant selection bias, with Arnaboldi et al. allocating patients to the intervention based on their preoperative psychological distress inventory (PDI) score and Seibaek et al. allocating patients to the intervention based on presence of ascites [25,27]. Fernández-Candela et al. reported significant differences in baseline characteristics between intervention and control groups [30]. All studies clearly described the prehabilitation interventions administered to patients. The case report was considered as being of low risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports [31].

Discussion
This review summarises the existing literature on the effectiveness of prehabilitation programmes on postoperative complications and quality of life of patients with gynaecologic cancer. Although prehabilitation is shown to significantly improve postoperative outcomes of patients in other surgical fields, this review demonstrates that evidence of beneficial effects in gynaecological cancer is not completely clear.
A total of seven studies were identified evaluating a prehabilitation programme for gynaecological cancer patients in which considerable heterogeneity of interventions and outcome measures were observed. One study of relatively high methodological quality, with adequate handling of confounders and parity of interventions, reported significant improvements in time to adjuvant treatment and shorter hospital stays in ovarian cancer patients [28]. As chemotherapy is an integral part of ovarian cancer management, a delay in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result in a significantly poorer prognosis [29]. Other studies, however, failed to demonstrate such Moderate risk; Cancers 2022, 14, x FOR PEER REVIEW 9 of 15 methods used to measure outcomes, such as questionnaires [27]; and significant differences in standard care between intervention and control groups [30]. Several studies had a significant selection bias, with Arnaboldi et al. allocating patients to the intervention based on their preoperative psychological distress inventory (PDI) score and Seibaek et al. allocating patients to the intervention based on presence of ascites [25,27]. Fernández-Candela et al. reported significant differences in baseline characteristics between intervention and control groups [30]. All studies clearly described the prehabilitation interventions administered to patients. The case report was considered as being of low risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports [31].

Discussion
This review summarises the existing literature on the effectiveness of prehabilitation programmes on postoperative complications and quality of life of patients with gynaecologic cancer. Although prehabilitation is shown to significantly improve postoperative outcomes of patients in other surgical fields, this review demonstrates that evidence of beneficial effects in gynaecological cancer is not completely clear.
A total of seven studies were identified evaluating a prehabilitation programme for gynaecological cancer patients in which considerable heterogeneity of interventions and outcome measures were observed. One study of relatively high methodological quality, with adequate handling of confounders and parity of interventions, reported significant improvements in time to adjuvant treatment and shorter hospital stays in ovarian cancer patients [28]. As chemotherapy is an integral part of ovarian cancer management, a delay in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result in a significantly poorer prognosis [29]. Other studies, however, failed to demonstrate such  [25,27]. Fernández-Candela et al. reported significant differences in baseline characteristics between intervention and control groups [30]. All studies clearly described the prehabilitation interventions administered to patients. The case report was considered as being of low risk of bias, using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports [31]. Table 3. Risk of bias analysis (ROBINS-I).

Discussion
This review summarises the existing literature on the effectiveness of prehabilitation programmes on postoperative complications and quality of life of patients with gynaecologic cancer. Although prehabilitation is shown to significantly improve postoperative outcomes of patients in other surgical fields, this review demonstrates that evidence of beneficial effects in gynaecological cancer is not completely clear. A total of seven studies were identified evaluating a prehabilitation programme for gynaecological cancer patients in which considerable heterogeneity of interventions and outcome measures were observed. One study of relatively high methodological quality, with adequate handling of confounders and parity of interventions, reported significant improvements in time to adjuvant treatment and shorter hospital stays in ovarian cancer patients [28]. As chemotherapy is an integral part of ovarian cancer management, a delay in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result in a significantly poorer prognosis [29]. Other studies, however, failed to demonstrate such improvements [26][27][28]30]. Whilst this may be related to differences in the outcome measures reported, it is also likely that bias related to confounding and selection impacted on the ability of these studies to accurately measure the true effectiveness of the interventions. Even despite the relatively large numbers of patients reported [27,30]. No serious adverse events of the programmes have been reported by the included studies [26,28,30,31]. To our knowledge, there has been one further study by Miralpeix et al. evaluating a prehabilitation programme after our search was performed. This pilot study also demonstrated the feasibility and safety of a multimodal prehabilitation programme before interval cytoreductive surgery in ovarian cancer patients, with significant improvement of nutritional parameters [33].
Prehabilitation programmes have already been extensively assessed in other cancer sites. In colorectal cancer, results are promising, with significant reductions of complication rates up to 51% and a significantly shortened length of stay [20,21,34]. The majority of these programmes are multimodal, comprising exercise therapy, nutritional guidance, psychological interventions and treatment of intoxications and anaemia, with exercise being one of the most important mainstays [21,34]. A recent systematic review and metaanalysis comprising 3962 patients undergoing abdominal cancer surgery found No information.

Discussion
This review summarises the existing literature on the effectiveness of prehabilitation programmes on postoperative complications and quality of life of patients with gynaecologic cancer. Although prehabilitation is shown to significantly improve postoperative outcomes of patients in other surgical fields, this review demonstrates that evidence of beneficial effects in gynaecological cancer is not completely clear.
A total of seven studies were identified evaluating a prehabilitation programme for gynaecological cancer patients in which considerable heterogeneity of interventions and outcome measures were observed. One study of relatively high methodological quality, with adequate handling of confounders and parity of interventions, reported significant improvements in time to adjuvant treatment and shorter hospital stays in ovarian cancer patients [28]. As chemotherapy is an integral part of ovarian cancer management, a delay in adjuvant treatment beyond 25 to 35 days due to surgical morbidity will result in a significantly poorer prognosis [29]. Other studies, however, failed to demonstrate such improvements [26][27][28]30]. Whilst this may be related to differences in the outcome measures reported, it is also likely that bias related to confounding and selection impacted on the ability of these studies to accurately measure the true effectiveness of the interventions. Even despite the relatively large numbers of patients reported [27,30]. No serious adverse events of the programmes have been reported by the included studies [26,28,30,31]. To our knowledge, there has been one further study by Miralpeix et al. evaluating a prehabilitation programme after our search was performed. This pilot study also demonstrated the feasibility and safety of a multimodal prehabilitation programme before interval cytoreductive surgery in ovarian cancer patients, with significant improvement of nutritional parameters [33].
Prehabilitation programmes have already been extensively assessed in other cancer sites. In colorectal cancer, results are promising, with significant reductions of complication rates up to 51% and a significantly shortened length of stay [20,21,34]. The majority of these programmes are multimodal, comprising exercise therapy, nutritional guidance, psychological interventions and treatment of intoxications and anaemia, with exercise being one of the most important mainstays [21,34]. A recent systematic review and meta-analysis comprising 3962 patients undergoing abdominal cancer surgery found significant reductions in complication rates and length of stay for unimodal (exercise or nutrition) and multimodal prehabilitation programmes [35]. In addition, a systematic review of prehabilitation in hepatobiliary, colorectal and upper gastrointestinal cancer surgery showed a reduced hospital stay of almost 2 days [17]. Similar results have been reported for bladder cancer, assessing both unimodal and multimodal prehabilitation programmes, with improvements found in complication rates, functional capacity and strength and quality of life [36][37][38][39].
The studies described above demonstrate the feasibility of introducing a prehabilitation programme in the preoperative period of gynaecological cancer patients, a patient group who may particularly benefit from prehabilitation. This cohort of women is characterised by modifiable risk factors that both predispose them to malignancy and increase the risk of postoperative morbidity and prolonged hospital stay [5,[40][41][42]. Most patients with endometrial and ovarian cancer are overweight or obese, with the majority engaging in sedentary lifestyles, failing to meet national recommendations for exercise and nutrition [7,43,44]. Consequently, these women have a high burden of obesity-related comorbidities, particularly cardiovascular disease [45][46][47]. Although not consistently reported, study populations in this review were characterised by the presence of moderate comorbidities and high BMI. Malnourishment is also a common problem among gynaecological cancer patients, with reported rates up to 67% of patients [6,41,48]. Finally, cancer diagnosis confers significant psychological distress to patients, with additional stressors of infertility, female organ removal and induced menopause in this patient group. The prevalence of anxiety and depression amongst gynaecological cancer patients has subsequently been reported up to 30% [49].
This systematic review is the most recent and comprehensive literature search to date evaluating prehabilitation for gynaecological cancer patients. The majority of studies in this review evaluated a combination of cancer types, of which ovarian, (recurrent) endometrial and cervical cancer were the most prevalent. The results of the review are, however, limited by the nonrandomised and retrospective design of studies and small study populations. There was often a difference in baseline characteristics between groups, and several studies included benign conditions and other cancer types, introducing further bias [25,[27][28][29][30]. Arnaboldi et al. assessed patients undergoing exenterative surgery, which is not standard primary treatment, prohibiting extrapolation of results to the general endometrial and cervical cancer population [25]. The variation in components of the programmes and the lack of detailed description of some interventions are also important limitations. In addition, differences in assessment of postoperative complications, quality of life, coping and cognitive functioning limit comparability of studies. Future studies should take this into account by including detailed descriptions of interventions and selecting outcome measures allowing comparability with other studies. Lastly, the study by Diaz-Feijoo et al. was included as a preliminary report prior to their later publication in 2022. After comparison with their published paper, we conclude no significant differences in methodology nor reported results [28,32].
Despite demonstrating the feasibility of prehabilitation, defining the essential components and attributes of a prehabilitation programme still poses a challenge. The exercise programmes assessed in this review generally included aerobic and resistance training, although not described in detail by all studies. This is in concurrence with the American College of Sports Medicine (ACSM) guidelines, recommending aerobic and resistance for cancer patients. However, the ACSM was unable to give recommendations for gynaecological cancer patients specifically due to limited data [50]. Following the variety of health impairments prevalent among gynaecological cancer patients, a prehabilitation programme should include both exercise and nutritional interventions, ideally in combination with psychological support and smoking cessation. Factors known to improve adherence and compliance include setting attainable goals and individualised guidance [51]. Possible strategies may include supervised individual or group exercise sessions and coaching sessions. Another challenge may be the limited time frame for prehabilitation in cancer patients, as it is dictated by the national and international recommendations on time between diagnosis and treatment [52,53]. Studies in this review implemented a programme varying from 5 days to over 6 months, with the multimodal programmes lasting around 2-3 weeks.
Prehabilitation may also provide an opportunity to introduce sustainable lifestyle changes, as current counselling on a healthy lifestyle is inadequate and incongruent with patients' needs [54]. Cancer patients are in a ''teachable moment", willingly to modify their lifestyle in hope of achieving better health [55]. Currently, endometrial cancer patients are still more likely to die of cardiovascular disease than endometrial cancer [56]. Sustainable lifestyle changes could positively influence long-term survival and recurrence of cancer patients [57,58]. Therefore, it is clear that there is a need for future prospective randomised studies to assess the short-term and long-term impact of prehabilitation for gynaecological cancer patients.

Conclusions
The results of this systematic review support the view that prehabilitation is feasible within patients with gynaecological cancer. Although further research is needed to further delineate the clear benefits and essential components of a prehabilitation programme in this specific group, preliminary studies have already shown potential benefits in terms of length of hospital stay, weight loss and decreasing time to adjuvant chemotherapy. In combination with the extrapolated outcomes from similar treatments in other cancers, this sets down a clear need for investment in future prospective randomised studies, preferably with carefully controlled outcome measures designed to assess the impact and benefits for both the patient populations and health systems alike. Funding: This research received no external funding.

Conflicts of Interest:
The authors declare no conflict of interest.