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The Role of Necroptosis in ROS-Mediated Cancer Therapies and Its Promising Applications

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Department of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan
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Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan
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Department of Surgery, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
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Division of General and Digestive Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
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Center for Cancer Research, Kaohsiung Medical University, Kaohsiung 807, Taiwan
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Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
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Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
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Department of Chemistry, National Institute of Technology Tiruchirappalli, Tiruchirappalli 620015, Tamilnadu, India
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Department of Ophthalmology, Kaohsiung Municipal Hsiaokang Hospital, Kaohsiung 812, Taiwan
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Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
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Department of Biological Sciences and Technology, National University of Tainan, Tainan 700, Taiwan
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Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan
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Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
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The Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
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Authors to whom correspondence should be addressed.
Cancers 2020, 12(8), 2185; https://doi.org/10.3390/cancers12082185
Received: 21 July 2020 / Accepted: 30 July 2020 / Published: 5 August 2020
Over the past decades, promising therapies targeting different signaling pathways have emerged. Among these pathways, apoptosis has been well investigated and targeted to design diverse chemotherapies. However, some patients are chemoresistant to these therapies due to compromised apoptotic cell death. Hence, exploring alternative treatments aimed at different mechanisms of cell death seems to be a potential strategy for bypassing impaired apoptotic cell death. Emerging evidence has shown that necroptosis, a caspase-independent form of cell death with features between apoptosis and necrosis, can overcome the predicament of drug resistance. Furthermore, previous studies have also indicated that there is a close correlation between necroptosis and reactive oxygen species (ROS); both necroptosis and ROS play significant roles both under human physiological conditions such as the regulation of inflammation and in cancer biology. Several small molecules used in experiments and clinical practice eliminate cancer cells via the modulation of ROS and necroptosis. The molecular mechanisms of these promising therapies are discussed in detail in this review. View Full-Text
Keywords: necroptosis; reactive oxygen species; cancer; chemotherapy necroptosis; reactive oxygen species; cancer; chemotherapy
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MDPI and ACS Style

Hsu, S.-K.; Chang, W.-T.; Lin, I.-L.; Chen, Y.-F.; Padalwar, N.B.; Cheng, K.-C.; Teng, Y.-N.; Wang, C.-H.; Chiu, C.-C. The Role of Necroptosis in ROS-Mediated Cancer Therapies and Its Promising Applications. Cancers 2020, 12, 2185.

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