Next Article in Journal
Exercise Attenuates the Transition from Fatty Liver to Steatohepatitis and Reduces Tumor Formation in Mice
Previous Article in Journal
Neuronal Repressor REST Controls Ewing Sarcoma Growth and Metastasis by Affecting Vascular Pericyte Coverage and Vessel Perfusion
 
Search for Articles:
Title / Keyword
Author / Affiliation
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
Journals
Cancers
Volume 12
Issue 6
10.3390/cancers12061406
cancers-logo
Submit to this Journal Review for this Journal Edit a Special Issue
► Article Menu

Article Menu

share announcement question_answer thumb_up
...
textsms
...
Review

The Role of the Gut Microbiome in Colorectal Cancer Development and Therapy Response

by
Lidia Sánchez-Alcoholado
1,†,
Bruno Ramos-Molina
2,†,
Ana Otero
3,
Aurora Laborda-Illanes
1,
Rafael Ordóñez
3,
José Antonio Medina
3,
Jaime Gómez-Millán
3,* and
María Isabel Queipo-Ortuño
1
1
Unidad de Gestión Clínica Intercentros de Oncología Médica, Hospitales Universitarios Regional y Virgen de la Victoria. Instituto de Investigación Biomédica de Málaga (IBIMA)-CIMES-UMA, 29010 Málaga, Spain
2
Departamento de Cirugía Digestiva, Endocrina y Transplante de Órganos Abdominales, Instituto Murciano de Investigación Biosanitária (IMIB-Arrixaca), 30120 Murcia, Spain
3
Unidad de Gestión Clínica de Oncología Radioterápica, Hospital Universitario Virgen de la Victoria. Instituto de Investigación Biomédica de Málaga (IBIMA), 29010 Málaga, Spain
*
Author to whom correspondence should be addressed.
†
These authors contributed equally.
Cancers 2020, 12(6), 1406; https://doi.org/10.3390/cancers12061406
Received: 22 April 2020 / Revised: 24 May 2020 / Accepted: 28 May 2020 / Published: 29 May 2020
(This article belongs to the Section Systematic Review or Meta-Analysis in Cancer Research)
View Full-Text Download PDF
Browse Figures
Review Reports

Abstract

Colorectal cancer (CRC) is the third most common cancer worldwide and the leading cause of cancer-related deaths. Recently, several studies have demonstrated that gut microbiota can alter CRC susceptibility and progression by modulating mechanisms such as inflammation and DNA damage, and by producing metabolites involved in tumor progression or suppression. Dysbiosis of gut microbiota has been observed in patients with CRC, with a decrease in commensal bacterial species (butyrate-producing bacteria) and an enrichment of detrimental bacterial populations (pro-inflammatory opportunistic pathogens). CRC is characterized by altered production of bacterial metabolites directly involved in cancer metabolism including short-chain fatty acids and polyamines. Emerging evidence suggests that diet has an important impact on the risk of CRC development. The intake of high-fiber diets and the supplementation of diet with polyunsaturated fatty acids, polyphenols and probiotics, which are known to regulate gut microbiota, could be not only a potential mechanism for the reduction of CRC risk in a primary prevention setting, but may also be important to enhance the response to cancer therapy when used as adjuvant to conventional treatment for CRC. Therefore, a personalized modulation of the pattern of gut microbiome by diet may be a promising approach to prevent the development and progression of CRC and to improve the efficacy of antitumoral therapy. View Full-Text
Keywords: colorectal cancer; gut microbiota; dysbiosis; inflammation; short-chain fatty acids; polyamines; dietary fiber; polyunsaturated fatty acids; polyphenols; probiotics colorectal cancer; gut microbiota; dysbiosis; inflammation; short-chain fatty acids; polyamines; dietary fiber; polyunsaturated fatty acids; polyphenols; probiotics
►▼ Show Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
SciFeed

Share and Cite

MDPI and ACS Style

Sánchez-Alcoholado, L.; Ramos-Molina, B.; Otero, A.; Laborda-Illanes, A.; Ordóñez, R.; Medina, J.A.; Gómez-Millán, J.; Queipo-Ortuño, M.I. The Role of the Gut Microbiome in Colorectal Cancer Development and Therapy Response. Cancers 2020, 12, 1406. https://doi.org/10.3390/cancers12061406

AMA Style

Sánchez-Alcoholado L, Ramos-Molina B, Otero A, Laborda-Illanes A, Ordóñez R, Medina JA, Gómez-Millán J, Queipo-Ortuño MI. The Role of the Gut Microbiome in Colorectal Cancer Development and Therapy Response. Cancers. 2020; 12(6):1406. https://doi.org/10.3390/cancers12061406

Chicago/Turabian Style

Sánchez-Alcoholado, Lidia, Bruno Ramos-Molina, Ana Otero, Aurora Laborda-Illanes, Rafael Ordóñez, José A. Medina, Jaime Gómez-Millán, and María I. Queipo-Ortuño. 2020. "The Role of the Gut Microbiome in Colorectal Cancer Development and Therapy Response" Cancers 12, no. 6: 1406. https://doi.org/10.3390/cancers12061406

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Map by Country/Region

1
Back to TopTop