The Role of Activator Protein-1 (AP-1) Family Members in CD30-Positive Lymphomas
AbstractThe Activator Protein-1 (AP-1) transcription factor (TF) family, composed of a variety of members including c-JUN, c-FOS and ATF, is involved in mediating many biological processes such as proliferation, differentiation and cell death. Since their discovery, the role of AP-1 TFs in cancer development has been extensively analysed. Multiple in vitro and in vivo studies have highlighted the complexity of these TFs, mainly due to their cell-type specific homo- or hetero-dimerization resulting in diverse transcriptional response profiles. However, as a result of the increasing knowledge of the role of AP-1 TFs in disease, these TFs are being recognized as promising therapeutic targets for various malignancies. In this review, we focus on the impact of deregulated expression of AP-1 TFs in CD30-positive lymphomas including Classical Hodgkin Lymphoma and Anaplastic Large Cell Lymphoma. View Full-Text
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Garces de los Fayos Alonso, I.; Liang, H.-C.; Turner, S.D.; Lagger, S.; Merkel, O.; Kenner, L. The Role of Activator Protein-1 (AP-1) Family Members in CD30-Positive Lymphomas. Cancers 2018, 10, 93.
Garces de los Fayos Alonso I, Liang H-C, Turner SD, Lagger S, Merkel O, Kenner L. The Role of Activator Protein-1 (AP-1) Family Members in CD30-Positive Lymphomas. Cancers. 2018; 10(4):93.Chicago/Turabian Style
Garces de los Fayos Alonso, Ines; Liang, Huan-Chang; Turner, Suzanne D.; Lagger, Sabine; Merkel, Olaf; Kenner, Lukas. 2018. "The Role of Activator Protein-1 (AP-1) Family Members in CD30-Positive Lymphomas." Cancers 10, no. 4: 93.
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