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Open AccessReview

Biomaterials Meet Microfluidics: From Synthesis Technologies to Biological Applications

by Jingyun Ma 1,2, Yachen Wang 1,2 and Jing Liu 1,2,*
1
Regenerative Medicine Center, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China
2
Stem Cell Clinical Research Center, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China
*
Author to whom correspondence should be addressed.
Micromachines 2017, 8(8), 255; https://doi.org/10.3390/mi8080255
Received: 7 July 2017 / Revised: 28 July 2017 / Accepted: 14 August 2017 / Published: 19 August 2017
(This article belongs to the Special Issue Biomedical Microfluidic Devices)
Microfluidics is characterized by laminar flow at micro-scale dimension, high surface to volume ratio, and markedly improved heat/mass transfer. In addition, together with advantages of large-scale integration and flexible manipulation, microfluidic technology has been rapidly developed as one of the most important platforms in the field of functional biomaterial synthesis. Compared to biomaterials assisted by conventional strategies, functional biomaterials synthesized by microfluidics are with superior properties and performances, due to their controllable morphology and composition, which have shown great advantages and potential in the field of biomedicine, biosensing, and tissue engineering. Take the significance of microfluidic engineered biomaterials into consideration; this review highlights the microfluidic synthesis technologies and biomedical applications of materials. We divide microfluidic based biomaterials into four kinds. According to the material dimensionality, it includes: 0D (particulate materials), 1D (fibrous materials), 2D (sheet materials), and 3D (construct forms of materials). In particular, micro/nano-particles and micro/nano-fibers are introduced respectively. This classification standard could include all of the microfluidic biomaterials, and we envision introducing a comprehensive and overall evaluation and presentation of microfluidic based biomaterials and their applications. View Full-Text
Keywords: functional biomaterials; microfluidics; controllable synthesis; biological applications functional biomaterials; microfluidics; controllable synthesis; biological applications
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Ma, J.; Wang, Y.; Liu, J. Biomaterials Meet Microfluidics: From Synthesis Technologies to Biological Applications. Micromachines 2017, 8, 255.

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