Integration of a Droplet-Based Microfluidic System and Silicon Nanoribbon FET Sensor

Afrasiabi, Roodabeh; Soderberg, Lovisa M.; Joensson, Haakan N.; Björk, Per; Andersson Svahn, Helene; Linnros, Jan

doi:10.3390/mi7080134

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Integration of a Droplet-Based Microfluidic System and Silicon Nanoribbon FET Sensor

^1,†,

^2,†

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Helene Andersson Svahn

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Jan Linnros

Materials and Nano Physics, School of Information and Communication Technology, KTH Royal Institute of Technology, SE-164 40 Kista, Sweden

Division of Proteomics and Nanobiotechnology, Science for Life Laboratory, KTH Royal Institute of Technology, SE-171 65 Solna, Sweden

Acreo Swedish ICT AB, SE-164 40 Kista, Sweden

Author to whom correspondence should be addressed.

^†

These authors contributed equally to the work.

Academic Editors: Andrew J. deMello and Xavier Casadevall i Solvas

Micromachines 2016, 7(8), 134; https://doi.org/10.3390/mi7080134

Received: 5 July 2016 / Revised: 27 July 2016 / Accepted: 29 July 2016 / Published: 5 August 2016

(This article belongs to the Special Issue Droplet Microfluidics: Techniques and Technologies, Volume II)

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Abstract

We present a novel microfluidic system that integrates droplet microfluidics with a silicon nanoribbon field-effect transistor (SiNR FET), and utilize this integrated system to sense differences in pH. The device allows for selective droplet transfer to a continuous water phase, actuated by dielectrophoresis, and subsequent detection of the pH level in the retrieved droplets by SiNR FETs on an electrical sensor chip. The integrated microfluidic system demonstrates a label-free detection method for droplet microfluidics, presenting an alternative to optical fluorescence detection. In this work, we were able to differentiate between droplet trains of one pH-unit difference. The pH-based detection method in our integrated system has the potential to be utilized in the detection of biochemical reactions that induce a pH-shift in the droplets. View Full-Text

Keywords: NanoFET; silicon nanoribbon; droplet microfluidics; pH measurement

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

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MDPI and ACS Style

Afrasiabi, R.; Soderberg, L.M.; Joensson, H.N.; Björk, P.; Andersson Svahn, H.; Linnros, J. Integration of a Droplet-Based Microfluidic System and Silicon Nanoribbon FET Sensor. Micromachines 2016, 7, 134. https://doi.org/10.3390/mi7080134

AMA Style

Afrasiabi R, Soderberg LM, Joensson HN, Björk P, Andersson Svahn H, Linnros J. Integration of a Droplet-Based Microfluidic System and Silicon Nanoribbon FET Sensor. Micromachines. 2016; 7(8):134. https://doi.org/10.3390/mi7080134

Chicago/Turabian Style

Afrasiabi, Roodabeh, Lovisa M. Soderberg, Haakan N. Joensson, Per Björk, Helene Andersson Svahn, and Jan Linnros. 2016. "Integration of a Droplet-Based Microfluidic System and Silicon Nanoribbon FET Sensor" Micromachines 7, no. 8: 134. https://doi.org/10.3390/mi7080134

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