Amperometric Monitoring of Dissolution of pH-Responsive EUDRAGIT® Polymer Film Coatings
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Stichting Imec Nederland within OnePlanet Research Center, Bronland 10, 6708 WH Wageningen, The Netherlands
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School of Chemistry, University College Cork, Kane Building, T12 YN60 Cork, Ireland
*
Authors to whom correspondence should be addressed.
Academic Editor: Aiqun Liu
Micromachines 2022, 13(3), 362; https://doi.org/10.3390/mi13030362
Received: 31 January 2022
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Revised: 23 February 2022
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Accepted: 24 February 2022
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Published: 25 February 2022
(This article belongs to the Special Issue Thin Film Devices for Healthcare and Environmental Sensing)
Electrochemical sensors are powerful tools for the detection and real-time monitoring of a wide variety of analytes. However, the long-term operation of Faradaic sensors in complex media is challenging due to fouling. The protection of the electrode surface during in vivo operation is a key element for improving the monitoring of analytes. Here, we study different EUDRAGIT® controlled release acrylate copolymers for protecting electrode surfaces. The dissolution of these polymers—namely EUDRAGIT® L 30 D-55 and EUDRAGIT® FS 30 D—is triggered by a change in pH of the environment, and it is electrochemically monitored by detecting electrode access by means of a redox probe. The full dissolution of the polymer is achieved within 30 min and the electrode response indicates a complete recovery of the original electrochemical performance. We demonstrate that amperometric sensing is a practical and straightforward technique for real-time and in situ sensing of EUDRAGIT® dissolution profiles. It will find future applications in determining the protection of polymer electrode coating in real matrices and in vivo applications.
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Keywords:
EUDRAGIT®; protective polymers; sensor protection; electroanalysis; fouling; polymer characterization
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MDPI and ACS Style
Mestres, J.; Leonardi, F.; Mathwig, K. Amperometric Monitoring of Dissolution of pH-Responsive EUDRAGIT® Polymer Film Coatings. Micromachines 2022, 13, 362. https://doi.org/10.3390/mi13030362
AMA Style
Mestres J, Leonardi F, Mathwig K. Amperometric Monitoring of Dissolution of pH-Responsive EUDRAGIT® Polymer Film Coatings. Micromachines. 2022; 13(3):362. https://doi.org/10.3390/mi13030362
Chicago/Turabian StyleMestres, Júlia, Francesca Leonardi, and Klaus Mathwig. 2022. "Amperometric Monitoring of Dissolution of pH-Responsive EUDRAGIT® Polymer Film Coatings" Micromachines 13, no. 3: 362. https://doi.org/10.3390/mi13030362
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