Next Article in Journal
Nanobody Technology for Mycotoxin Detection: Current Status and Prospects
Next Article in Special Issue
Current Status of Mycotoxin Contamination of Food Commodities in Zimbabwe
Previous Article in Journal
Development of an Analytical Method for Simultaneous Determination of the Modified Forms of 4,15-Diacetoxyscirpenol and their Occurrence in Japanese Retail Food
Previous Article in Special Issue
Variation in the Microbiome, Trichothecenes, and Aflatoxins in Stored Wheat Grains in Wuhan, China
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessArticle
Toxins 2018, 10(5), 179; https://doi.org/10.3390/toxins10050179

Comparison of Anorectic Potencies of Type A Trichothecenes T-2 Toxin, HT-2 Toxin, Diacetoxyscirpenol, and Neosolaniol

1
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China
2
Shandong Lonct Enzymes Co., Ltd., Linyi 276000, China
*
Authors to whom correspondence should be addressed.
Received: 1 April 2018 / Revised: 25 April 2018 / Accepted: 26 April 2018 / Published: 29 April 2018
(This article belongs to the Collection Understanding Mycotoxin Occurrence in Food and Feed Chains)
Full-Text   |   PDF [14175 KB, uploaded 3 May 2018]   |  

Abstract

Trichothecene mycotoxins are common contaminants in cereal grains and negatively impact human and animal health. Although anorexia is a common hallmark of type B trichothecenes-induced toxicity, less is known about the anorectic potencies of type A trichothecenes. The purpose of this study was to compare the anorectic potencies of four type A trichothecenes (T-2 toxin (T-2), HT-2 toxin (HT-2), diacetoxyscirpenol (DAS), and neosolaniol (NEO)) in mice. Following oral exposure to T-2, HT-2, DAS, and NEO, the no observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs) were 0.01, 0.01, 0.1, and 0.01 mg/kg body weight (BW), and 0.1, 0.1, 0.5, and 0.1 mg/kg BW, respectively. Following intraperitoneal (IP) exposure to T-2, HT-2, DAS, and NEO, the NOAELs were 0.01 mg/kg BW, except for DAS (less than 0.01 mg/kg BW), and the LOAELs were 0.1, 0.1, 0.01, and 0.1 mg/kg BW, respectively. Taken together, the results suggest that (1) type A trichothecenes could dose-dependently elicit anorectic responses following both oral gavage and IP exposure in mice; (2) the anorectic responses follow an approximate rank order of T-2 = HT-2 = NEO > DAS for oral exposure, and DAS > T-2 = HT-2 = NEO for IP administration; (3) IP exposure to T-2, HT-2, DAS, and NEO evoked stronger anorectic effects than oral exposure. From a public health perspective, comparative anorectic potency data should be useful for establishing toxic equivalency factors for type A trichothecenes. View Full-Text
Keywords: trichothecene; anorexia; T-2 toxin; HT-2 toxin; diacetoxyscirpenol; neosolaniol trichothecene; anorexia; T-2 toxin; HT-2 toxin; diacetoxyscirpenol; neosolaniol
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Zhang, J.; Zhang, H.; Liu, S.; Wu, W.; Zhang, H. Comparison of Anorectic Potencies of Type A Trichothecenes T-2 Toxin, HT-2 Toxin, Diacetoxyscirpenol, and Neosolaniol. Toxins 2018, 10, 179.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top