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Open AccessArticle

Glucose Homeostasis Variables in Pregnancy versus Maternal and Infant Body Composition

1
Department of Clinical and Experimental Medicine, Linköping University, Linköping SE 581 85, Sweden
2
Department of Biosciences and Nutrition, Karolinska Institute, NOVUM, Huddinge SE 141 83, Sweden
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Author to whom correspondence should be addressed.
Nutrients 2015, 7(7), 5615-5627; https://doi.org/10.3390/nu7075243
Received: 21 May 2015 / Revised: 24 June 2015 / Accepted: 2 July 2015 / Published: 10 July 2015
Intrauterine factors influence infant size and body composition but the mechanisms involved are to a large extent unknown. We studied relationships between the body composition of pregnant women and variables related to their glucose homeostasis, i.e., glucose, HOMA-IR (homeostasis model assessment-insulin resistance), hemoglobin A1c and IGFBP-1 (insulin-like growth factor binding protein-1), and related these variables to the body composition of their infants. Body composition of 209 women in gestational week 32 and of their healthy, singleton and full-term one-week-old infants was measured using air displacement plethysmography. Glucose homeostasis variables were assessed in gestational week 32. HOMA-IR was positively related to fat mass index and fat mass (r2 = 0.32, p < 0.001) of the women. Maternal glucose and HOMA-IR values were positively (p ≤ 0.006) associated, while IGFBP-1was negatively (p = 0.001) associated, with infant fat mass. HOMA-IR was positively associated with fat mass of daughters (p < 0.001), but not of sons (p = 0.65) (Sex-interaction: p = 0.042). In conclusion, glucose homeostasis variables of pregnant women are related to their own body composition and to that of their infants. The results suggest that a previously identified relationship between fat mass of mothers and daughters is mediated by maternal insulin resistance. View Full-Text
Keywords: body composition; infant; insulin resistance; pregnancy; sex difference body composition; infant; insulin resistance; pregnancy; sex difference
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Henriksson, P.; Löf, M.; Forsum, E. Glucose Homeostasis Variables in Pregnancy versus Maternal and Infant Body Composition. Nutrients 2015, 7, 5615-5627.

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