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Live Longer with Vitamin D?

Academy for Micronutrient Medicine, Zweigertstr, 55, 45130 Essen, Germany
Department of Dermatology, The Saarland University Hospital, 66421 Homburg/Saar, Germany
Boston University Medical Center, 85 East Newton Street M-1013, Boston, MA 02118, USA
Author to whom correspondence should be addressed.
Nutrients 2015, 7(3), 1871-1880;
Received: 17 December 2014 / Revised: 25 February 2015 / Accepted: 3 March 2015 / Published: 12 March 2015
(This article belongs to the Special Issue Immune Regulation by Vitamin D)
PDF [177 KB, uploaded 12 March 2015]


The global burden of vitamin D deficiency or insufficiency is of great concern for public health. According to recent studies, vitamin D deficiency is an important etiological factor in the pathogenesis of many chronic diseases. Whether or not there is a connection between 25-hydoxyvitamin D (25(OH)D) status and overall mortality is a matter of considerable debate. A new meta-analysis confirmed that low 25(OH)D levels were associated with a significant increased risk for all-cause mortality. Individuals with severe vitamin D deficiency have almost twice the mortality rate as those with 25(OH)D level ≥ 30 ng/mL, (≥75 nmol/L). Unlike previous meta-analyses which suggested that serum 25(OH)D > 50 ng/mL was associated with increased mortality, this new analysis found that there was no increased risk even when 25(OH)D levels were ≥70 ng/mL. In general, closer attention should be paid to vitamin D deficiency in medical and pharmaceutical practice than has been the case hitherto. The results of these studies are consistent with the recommendation to improve the general vitamin D status in children and adults by means of a healthy approach to sunlight exposure, consumption of foods containing vitamin D and supplementation with vitamin D preparations. View Full-Text
Keywords: vitamin D; 25-hydroxyvitamin D; vitamin D deficiency; breast cancer; cancer; overall mortality vitamin D; 25-hydroxyvitamin D; vitamin D deficiency; breast cancer; cancer; overall mortality

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Gröber, U.; Reichrath, J.; Holick, M.F. Live Longer with Vitamin D? Nutrients 2015, 7, 1871-1880.

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