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Open AccessArticle

Fermented Brown Rice and Rice Bran with Aspergillus oryzae (FBRA) Prevents Inflammation-Related Carcinogenesis in Mice, through Inhibition of Inflammatory Cell Infiltration

1
Division of Pathological Biochemistry, Tottori University Faculty of Medicine, Tottori 683-8503, Japan
2
Japanese Red Cross Society, Minato-ku, Tokyo 105-8521, Japan
3
School of Nursing and Social Services, Health Sciences University of Hokkaido, 1757 Kanazawa, Ishikari-Tobetsu, Hokkaido 061-0293, Japan
4
Chromosome Engineering Research Center, Tottori University, Tottori 683-8503, Japan
5
Genmai Koso Co., Ltd., Sapporo, Hokkaido 001-0012, Japan
6
Sapporo Cancer Seminar Foundation, Sapporo, Hokkaido 001-0012, Japan
*
Author to whom correspondence should be addressed.
Nutrients 2015, 7(12), 10237-10250; https://doi.org/10.3390/nu7125531
Received: 27 October 2015 / Revised: 13 November 2015 / Accepted: 26 November 2015 / Published: 8 December 2015
(This article belongs to the Special Issue Cereal Grains for Human Health)
We have established an inflammation-related carcinogenesis model in mouse, in which regressive QR-32 cells subcutaneously co-implanted with a foreign body—gelatin sponge—convert themselves into lethal tumors due to massive infiltration of inflammatory cells into the sponge. Animals were fed with a diet containing 5% or 10% fermented brown rice and rice bran with Aspergillus oryzae (FBRA). In 5% and 10% FBRA diet groups, tumor incidences were lower (35% and 20%, respectively) than in the non-treated group (70%). We found that FBRA reduced the number of inflammatory cells infiltrating into the sponge. FBRA administration did not cause myelosuppression, which indicated that the anti-inflammatory effects of FBRA took place at the inflammatory lesion. FBRA did not have antitumor effects on the implanted QRsP-11 tumor cells, which is a tumorigenic cell line established from a tumor arisen after co-implantation of QR-32 cells with sponge. FBRA did not reduce formation of 8-hydroxy-2′-deoxyguanine adducts, a marker of oxidative DNA damage in the inflammatory lesion; however, it reduced expression of inflammation-related genes such as TNF-α, Mac-1, CCL3 and CXCL2. These results suggest that FBRA will be an effective chemopreventive agent against inflammation-related carcinogenesis that acts by inhibiting inflammatory cell infiltration into inflammatory lesions. View Full-Text
Keywords: fermented brown rice and rice bran with Aspergillus oryzae (FBRA); inflammation-related carcinogenesis; inflammation fermented brown rice and rice bran with Aspergillus oryzae (FBRA); inflammation-related carcinogenesis; inflammation
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Onuma, K.; Kanda, Y.; Suzuki Ikeda, S.; Sakaki, R.; Nonomura, T.; Kobayashi, M.; Osaki, M.; Shikanai, M.; Kobayashi, H.; Okada, F. Fermented Brown Rice and Rice Bran with Aspergillus oryzae (FBRA) Prevents Inflammation-Related Carcinogenesis in Mice, through Inhibition of Inflammatory Cell Infiltration. Nutrients 2015, 7, 10237-10250.

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