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Review

Bovine Colostrum Applications in Sick and Healthy People: A Systematic Review

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Research and EBP Unit, Health Professions Department, Azienda USL-IRCCS di Reggio Emilia, Via Amendola, 2-42122 Reggio Emilia, Italy
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Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via di Montpellier, 1-00133 Rome, Italy
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Hematology Unit, Azienda USL-IRCCS di Reggio Emilia, Via Amendola, 2-42122 Reggio Emilia, Italy
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ASST-Azienda Socio-Sanitaria Territoriale di Mantova, Strada Lago Paiolo, 10-46100 Mantova, Italy
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Unit of Food Science and Nutrition, Department of Science and Technology for Humans and the Environment, University Campus Bio-Medico of Rome, Via Alvaro del Portillo, 21-00128 Rome, Italy
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Research Unit Nursing Science, University Campus Bio-Medico of Rome, Via Alvaro del Portillo, 21-00128 Rome, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Raymond Playford
Nutrients 2021, 13(7), 2194; https://doi.org/10.3390/nu13072194
Received: 26 May 2021 / Revised: 16 June 2021 / Accepted: 22 June 2021 / Published: 25 June 2021
(This article belongs to the Special Issue The Use of Bovine Colostrum in Medical Practice and Human Health)
Colostrum is the first secretion of mammalian glands during the early period after birth giving. Its components are biologically active and have beneficial effects on new-born growth and well-being. Bovine colostrum has the highest concentration of these substances and its supplementation or application may provide health benefits. This systematic review was conducted to update current knowledge on bovine colostrum effects including all administration routes on healthy and sick subjects. Full texts or abstracts of twenty-eight papers as reports of systematic reviews, randomized controlled trials, observational studies and case series were included after searches in Medline, Embase, Cochrane Library and Cinahl databases. The full texts of selected studies were assessed for quality using validated tools and their results were summarized in different categories. Studies were highly heterogeneous as regards to population, intervention, outcome and risk of bias. Bovine colostrum topical application was shown effective on vaginal dryness related symptoms limitation. Its use as food supplement showed interesting effects preventing upper respiratory illness in sportsmen, modulating immune system response and reducing intestinal permeability in healthy and sick subjects. Conflicting results were provided in pediatric population and little evidence is available on its use with older adults. Further studies are mandatory to better understand all factors influencing its activity. View Full-Text
Keywords: bovine colostrum; whey; milk; food supplementation; health improvement; physical performance; immune system; systematic review bovine colostrum; whey; milk; food supplementation; health improvement; physical performance; immune system; systematic review
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MDPI and ACS Style

Guberti, M.; Botti, S.; Capuzzo, M.T.; Nardozi, S.; Fusco, A.; Cera, A.; Dugo, L.; Piredda, M.; De Marinis, M.G. Bovine Colostrum Applications in Sick and Healthy People: A Systematic Review. Nutrients 2021, 13, 2194. https://doi.org/10.3390/nu13072194

AMA Style

Guberti M, Botti S, Capuzzo MT, Nardozi S, Fusco A, Cera A, Dugo L, Piredda M, De Marinis MG. Bovine Colostrum Applications in Sick and Healthy People: A Systematic Review. Nutrients. 2021; 13(7):2194. https://doi.org/10.3390/nu13072194

Chicago/Turabian Style

Guberti, Monica, Stefano Botti, Maria T. Capuzzo, Sara Nardozi, Andrea Fusco, Andrea Cera, Laura Dugo, Michela Piredda, and Maria G. De Marinis 2021. "Bovine Colostrum Applications in Sick and Healthy People: A Systematic Review" Nutrients 13, no. 7: 2194. https://doi.org/10.3390/nu13072194

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