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Article

The TOTUM-63 Supplement and High-Intensity Interval Training Combination Limits Weight Gain, Improves Glycemic Control, and Influences the Composition of Gut Mucosa-Associated Bacteria in Rats on a High Fat Diet

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Laboratoire des Adaptations Métaboliques à l’Exercice en conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne, CRNH Auvergne, 63000 Clermont-Ferrand, France
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Valbiotis R&D, Riom Center, 63200 Riom, France
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Inserm U1016, Team “Mucosal Microbiota in Chronic Inflammatory Diseases”, Université de Paris, CNRS UMR 8104, 75014 Paris, France
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Laboratoire Microorganismes: Génome et Environnement (LMGE), Université Clermont Auvergne, CNRS, 63000 Clermont-Ferrand, France
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Microbes, Intestin, Inflammation et Susceptibilité de l’Hôte (M2iSH), UMR 1071 Inserm, USC-INRAE 2018, Université Clermont Auvergne, CRNH Auvergne, 63000 Clermont-Ferrand, France
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Laboratoire Interuniversitaire de la Biologie et de la Motricité (LIBM), Université Claude Bernard Lyon 1, EA 7424, 69266 Villeurbane, France
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UMR 7266 CNRS-ULR, LIENSs, Equipe BCBS, La Rochelle Université, 17042 La Rochelle, France
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Valbiotis R&D, La Rochelle Center, 17000 La Rochelle, France
*
Author to whom correspondence should be addressed.
Academic Editor: Antonio Brunetti
Nutrients 2021, 13(5), 1569; https://doi.org/10.3390/nu13051569
Received: 7 April 2021 / Revised: 30 April 2021 / Accepted: 2 May 2021 / Published: 7 May 2021
(This article belongs to the Special Issue Exercise, Microbiota, Health and Performance)
Obesity and prediabetes are the two strongest risk factors of type 2 diabetes. It has been reported that TOTUM-63, a polyphenol-rich plant extract, has beneficial effects on body weight (BW) and insulin resistance in mice fed a high fat diet (HFD). The study aim was to determine whether high-intensity interval training (HIIT) and/or TOTUM-63 supplementation improved body composition and glycemic control and gut microbiota composition in a Western diet-induced obesity rat model. Wistar rats received a standard diet (CTRL; control; n = 12) or HFD (HFD; n = 48) for 16 weeks. Then, HFD rats were divided in four groups: HFD, HFD + TOTUM-63 (T63), HFD + HIIT (HIIT), and HFD + HIIT +T63 (HIIT + T63). Training was performed 4 days/week for 12 weeks. TOTUM-63 was included in diet composition (2%). The HIIT + T63 combination significantly limited BW gain, without any energy intake modulation, and improved glycemic control. BW variation was correlated with increased α-diversity of the colon mucosa microbiota in the HIIT + T63 group. Moreover, the relative abundance of Anaeroplasma, Christensenellaceae and Oscillospira was higher in the HIIT + T63 group. Altogether, these results suggest that the HIIT and TOTUM-63 combination could be proposed for the management of obesity and prediabetes. View Full-Text
Keywords: high-intensity interval training; plant extract supplementation; glycemic control; body composition; microbiota high-intensity interval training; plant extract supplementation; glycemic control; body composition; microbiota
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MDPI and ACS Style

Dupuit, M.; Chavanelle, V.; Chassaing, B.; Perriere, F.; Etienne, M.; Plissonneau, C.; Boscaro, A.; Barnich, N.; Pialoux, V.; Maugard, T.; Le Joubioux, F.; Peltier, S.; Sirvent, P.; Otero, Y.F.; Boisseau, N. The TOTUM-63 Supplement and High-Intensity Interval Training Combination Limits Weight Gain, Improves Glycemic Control, and Influences the Composition of Gut Mucosa-Associated Bacteria in Rats on a High Fat Diet. Nutrients 2021, 13, 1569. https://doi.org/10.3390/nu13051569

AMA Style

Dupuit M, Chavanelle V, Chassaing B, Perriere F, Etienne M, Plissonneau C, Boscaro A, Barnich N, Pialoux V, Maugard T, Le Joubioux F, Peltier S, Sirvent P, Otero YF, Boisseau N. The TOTUM-63 Supplement and High-Intensity Interval Training Combination Limits Weight Gain, Improves Glycemic Control, and Influences the Composition of Gut Mucosa-Associated Bacteria in Rats on a High Fat Diet. Nutrients. 2021; 13(5):1569. https://doi.org/10.3390/nu13051569

Chicago/Turabian Style

Dupuit, Marine, Vivien Chavanelle, Benoit Chassaing, Fanny Perriere, Monique Etienne, Claire Plissonneau, Audrey Boscaro, Nicolas Barnich, Vincent Pialoux, Thierry Maugard, Florian Le Joubioux, Sébastien Peltier, Pascal Sirvent, Yolanda F. Otero, and Nathalie Boisseau. 2021. "The TOTUM-63 Supplement and High-Intensity Interval Training Combination Limits Weight Gain, Improves Glycemic Control, and Influences the Composition of Gut Mucosa-Associated Bacteria in Rats on a High Fat Diet" Nutrients 13, no. 5: 1569. https://doi.org/10.3390/nu13051569

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