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Nutrients
Volume 12
Issue 4
10.3390/nu12041172
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Article

Furbellow (Brown Algae) Extract Increases Lifespan in Drosophila by Interfering with TOR-Signaling

by
Yang Li
1,2,
Renja Romey-Glüsing
1,
Navid Tahan Zadeh
1,
Jakob von Frieling
1,
Julia Hoffmann
1,
Patricia Huebbe
3,
Iris Bruchhaus
4,
Gerald Rimbach
3,
Christine Fink
1,5 and
Thomas Roeder
1,5,*
1
Department of Molecular Physiology, Kiel University, D-24098 Kiel, Germany
2
College of Life Sciences, Qingdao University, Qingdao 266071, China
3
Department of Food Sciences, Kiel University, 24098 Kiel, Germany
4
Bernhard-Nocht-Institute for Tropical Medicine, D-20359 Hamburg, Germany
5
DZL, German Center for Lung Research, ARCN, D-24098 Kiel, Germany
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(4), 1172; https://doi.org/10.3390/nu12041172
Received: 30 March 2020 / Revised: 17 April 2020 / Accepted: 21 April 2020 / Published: 22 April 2020
(This article belongs to the Special Issue Dietary Restriction and Lifespan)
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Abstract

Algal products are well known for their health promoting effects. Nonetheless, an in depth understanding of the underlying molecular mechanisms is still only fragmentary. Here, we show that aqueous furbelow extracts (brown algae, Saccorhiza polyschides) lengthen the life of both sexes of the fruit fly Drosophila melanogaster substantially, if used as nutritional additives to conventional food. This life prolonging effect became even more pronounced in the presence of stressors, such as high-fat dieting of living under drought conditions. Application of the extracts did not change food intake, excretion, or other major physiological parameters. Nevertheless, effects on the intestinal microbiota were observed, leading to an increased species richness, which is usually associated with healthy conditions. Lifespan extension was not observed in target of rapamycin (TOR)-deficient animals, implying that functional TOR signaling is necessary to unfold the positive effects of brown algae extract (BAE) on this important trait. The lack of life lengthening in animals with deregulated TOR signaling exclusively targeted to body fat showed that this major energy storage organ is instrumental for transmitting these effects. In addition, expression of Imaginal morphogenesis protein-Late 2 (Imp-L2), an effective inhibitor of insulin signaling implies that BAE exerts their positive effects through interaction with the tightly interwoven TOR- and insulin-signaling systems, although insulin levels were not directly affected by this intervention. View Full-Text
Keywords: Saccorhiza polyschides; brown algae; TOR signaling; Drosophila melanogaster; Imp-L2; insulin signaling; lifespan Saccorhiza polyschides; brown algae; TOR signaling; Drosophila melanogaster; Imp-L2; insulin signaling; lifespan
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MDPI and ACS Style

Li, Y.; Romey-Glüsing, R.; Tahan Zadeh, N.; von Frieling, J.; Hoffmann, J.; Huebbe, P.; Bruchhaus, I.; Rimbach, G.; Fink, C.; Roeder, T. Furbellow (Brown Algae) Extract Increases Lifespan in Drosophila by Interfering with TOR-Signaling. Nutrients 2020, 12, 1172. https://doi.org/10.3390/nu12041172

AMA Style

Li Y, Romey-Glüsing R, Tahan Zadeh N, von Frieling J, Hoffmann J, Huebbe P, Bruchhaus I, Rimbach G, Fink C, Roeder T. Furbellow (Brown Algae) Extract Increases Lifespan in Drosophila by Interfering with TOR-Signaling. Nutrients. 2020; 12(4):1172. https://doi.org/10.3390/nu12041172

Chicago/Turabian Style

Li, Yang, Renja Romey-Glüsing, Navid Tahan Zadeh, Jakob von Frieling, Julia Hoffmann, Patricia Huebbe, Iris Bruchhaus, Gerald Rimbach, Christine Fink, and Thomas Roeder. 2020. "Furbellow (Brown Algae) Extract Increases Lifespan in Drosophila by Interfering with TOR-Signaling" Nutrients 12, no. 4: 1172. https://doi.org/10.3390/nu12041172

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