Next Article in Journal
Lactobacillus Acidophilus/Bifidobacterium Infantis Probiotics Are Beneficial to Extremely Low Gestational Age Infants Fed Human Milk
Next Article in Special Issue
Estradiol Replacement Improves High-Fat Diet-Induced Obesity by Suppressing the Action of Ghrelin in Ovariectomized Rats
Previous Article in Journal
Histidine in Health and Disease: Metabolism, Physiological Importance, and Use as a Supplement
Previous Article in Special Issue
Pituitary Glycoprotein Hormones in Human Milk before and after Pasteurization or Refrigeration
Open AccessArticle

Fluoxetine Mimics the Anorectic Action of Estrogen and Its Regulation of Circadian Feeding in Ovariectomized Female Rats

1
Department of Environmental Health, Nara Women’s University, Kitauoya Nishimachi, Nara 630-8506, Japan
2
Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(3), 849; https://doi.org/10.3390/nu12030849
Received: 17 February 2020 / Revised: 17 March 2020 / Accepted: 19 March 2020 / Published: 22 March 2020
(This article belongs to the Special Issue The Relationship between Diet and Hormones)
Our previous study demonstrated that chronic estrogen replacement in ovariectomized rats reduces food intake and augments c-Fos expression in the suprachiasmatic nucleus (SCN), specifically during the light phase. Here, we hypothesized that serotonergic neurons in the central nervous system (CNS), which have anorectic action and play a role in regulating circadian rhythm, mediate the light phase-specific anorectic action of estrogen, and that selective serotonin reuptake inhibitors (SSRIs) mimic the hypophagic action of estrogen. Female Wistar rats were ovariectomized and treated with estradiol (E2) or cholesterol by subcutaneously implanting a silicon capsule containing E2 or cholesterol. Then, half of the cholesterol-treated rats were injected with the SSRI fluoxetine (5 mg/kg) (FLX group), while the remaining rats in the cholesterol-treated group (CON group) and all those in the E2 group were injected with saline subcutaneously twice daily at the onsets of the light and dark phases. Both E2 and FLX reduced food intake during the light phase but not the dark phase, and reduced body weight gain. In addition, both E2 and FLX augmented the c-Fos expression in the SCN, specifically during the light phase. These data indicate that FLX exerts estrogen-like antiobesity and hypophagic actions by modifying circadian feeding patterns, and suggest that estrogen regulates circadian feeding rhythm via serotonergic neurons in the CNS. View Full-Text
Keywords: estradiol; selective serotonin reuptake inhibitor; hypophagia; circadian feeding rhythm; suprachiasmatic nucleus estradiol; selective serotonin reuptake inhibitor; hypophagia; circadian feeding rhythm; suprachiasmatic nucleus
Show Figures

Figure 1

MDPI and ACS Style

Nishimura, Y.; Mabuchi, K.; Omura, N.; Igarashi, A.; Miura, M.; Mima, N.; Negishi, H.; Morimoto, K.; Takamata, A. Fluoxetine Mimics the Anorectic Action of Estrogen and Its Regulation of Circadian Feeding in Ovariectomized Female Rats. Nutrients 2020, 12, 849.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop