Estimating 24-Hour Sodium Excretion from Spot Urine Samples in Chinese Adults: Can Spot Urine Substitute 24-Hour Urine Samples?

National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China

Shandong Center for Disease Control and Prevention, Jinan 250014, China

Author to whom correspondence should be addressed.

Nutrients 2020, 12(3), 798; https://doi.org/10.3390/nu12030798

Received: 24 February 2020 / Revised: 13 March 2020 / Accepted: 17 March 2020 / Published: 18 March 2020

(This article belongs to the Section Nutrition and Public Health)

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Abstract

Several estimating equations for predicting 24-h urinary sodium (24-hUNa) excretion using spot urine (SU) samples have been developed, but have not been readily available to Chinese populations. We aimed to compare and validate the six existing methods at population level and individual level. We extracted 1671 adults eligible for both 24-h urine and SU sample collection. Mean biases (95% CI) of predicting 24-hUNa excretion using six formulas were 58.6 (54.7, 62.5) mmol for Kawasaki, −2.7 (−6.2, 0.9) mmol for Tanaka, −24.5 (−28.0, −21.0) mmol for the International Cooperative Study on Salt, Other Factors, and Blood Pressure (INTERSALT) with potassium, –26.8 (−30.1, −23.3) mmol for INTERSALT without potassium, 5.9 (2.3, 9.6) mmol for Toft, and −24.2 (−27.7, −20.6) mmol for Whitton. The proportions of relative difference >40% with the six methods were nearly a third, and the proportions of absolute difference >51.3 mmol/24-h (3 g/day salt) were more than 40%. The misclassification rate were all >55% for the six methods at the individual level. Although the Tanaka method could offer a plausible estimation for surveillance of the population sodium excretion in Shandong province, caution remains when using the Tanaka formula for other provincial populations in China. However, these predictive methods were inadequate to evaluate individual sodium excretion. View Full-Text

Keywords: 24-hour urine; spot urine; urinary sodium excretion

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MDPI and ACS Style

Xu, J.; Zhang, J.; Liu, M.; Bai, Y.; Guo, X.; Dong, J.; Xu, A.; Wu, J. Estimating 24-Hour Sodium Excretion from Spot Urine Samples in Chinese Adults: Can Spot Urine Substitute 24-Hour Urine Samples? Nutrients 2020, 12, 798. https://doi.org/10.3390/nu12030798

AMA Style

Xu J, Zhang J, Liu M, Bai Y, Guo X, Dong J, Xu A, Wu J. Estimating 24-Hour Sodium Excretion from Spot Urine Samples in Chinese Adults: Can Spot Urine Substitute 24-Hour Urine Samples? Nutrients. 2020; 12(3):798. https://doi.org/10.3390/nu12030798

Chicago/Turabian Style

Xu, Jianwei, Jiyu Zhang, Min Liu, Yamin Bai, Xiaolei Guo, Jing Dong, Aiqiang Xu, and Jing Wu. 2020. "Estimating 24-Hour Sodium Excretion from Spot Urine Samples in Chinese Adults: Can Spot Urine Substitute 24-Hour Urine Samples?" Nutrients 12, no. 3: 798. https://doi.org/10.3390/nu12030798

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