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Nutrients
Volume 12
Issue 12
10.3390/nu12123787
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Article

Dietary Cameroonian Plants Exhibit Anti-Inflammatory Activity in Human Gastric Epithelial Cells

by
Achille Parfait Atchan Nwakiban
1,2,
Marco Fumagalli
2,
Stefano Piazza
2,
Andrea Magnavacca
2,
Giulia Martinelli
2,
Giangiacomo Beretta
3,
Paolo Magni
2,4,
Armelle Deutou Tchamgoue
5,
Gabriel Agbor Agbor
5,
Jules-Roger Kuiaté
1,
Mario Dell’Agli
2,* and
Enrico Sangiovanni
2
1
Department of Biochemistry, Faculty of science, University of Dschang, P.O. Box 96 Dschang, Cameroon
2
Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy
3
Department of Environmental Science and Policy, Università degli Studi di Milano, 20133 Milan, Italy
4
IRCCS MultiMedica, Sesto San Giovanni, Via Milanese, 300, Sesto San Giovanni, 20099 Milan, Italy
5
Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies, 4124 Yaoundé, Cameroon
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(12), 3787; https://doi.org/10.3390/nu12123787
Received: 17 November 2020 / Revised: 8 December 2020 / Accepted: 8 December 2020 / Published: 10 December 2020
(This article belongs to the Special Issue New Research in Dietary Supplements and Healthy Foods)
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Abstract

In Cameroon, local plants are traditionally used as remedies for a variety of ailments. In this regard, several papers report health benefits of Cameroonian spices, which include antioxidant and anti-microbial properties, whereas gastric anti-inflammatory activities have never been previously considered. The present study investigates the antioxidant and anti-inflammatory activities of hydro-alcoholic extracts of eleven Cameroonian spices in gastric epithelial cells (AGS and GES-1 cells). The extracts showed antioxidant properties in a cell-free system and reduced H2O2-induced ROS generation in gastric epithelial cells. After preliminary screening on TNFα-induced NF-κB driven transcription, six extracts from Xylopia parviflora, Xylopia aethiopica, Tetrapleura tetraptera, Dichrostachys glomerata, Aframomum melegueta, and Aframomum citratum were selected for further studies focusing on the anti-inflammatory activity. The extracts reduced the expression of some NF-κB-dependent pro-inflammatory mediators strictly involved in the gastric inflammatory process, such as IL-8, IL-6, and enzymes such as PTGS2 (COX-2), without affecting PTGS1 (COX-1). In conclusion, the selected extracts decreased pro-inflammatory markers by inhibiting the NF-κB signaling in gastric cells, justifying, in part, the traditional use of these spices. Other molecular mechanisms cannot be excluded, and further studies are needed to better clarify their biological activities at the gastric level. View Full-Text
Keywords: gastric inflammation; ethnopharmacology; Cameroonian plants; interleukin 8; interleukin 6; NF-κB; COX-2; antioxidant gastric inflammation; ethnopharmacology; Cameroonian plants; interleukin 8; interleukin 6; NF-κB; COX-2; antioxidant
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

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MDPI and ACS Style

Nwakiban, A.P.A.; Fumagalli, M.; Piazza, S.; Magnavacca, A.; Martinelli, G.; Beretta, G.; Magni, P.; Tchamgoue, A.D.; Agbor, G.A.; Kuiaté, J.-R.; Dell’Agli, M.; Sangiovanni, E. Dietary Cameroonian Plants Exhibit Anti-Inflammatory Activity in Human Gastric Epithelial Cells. Nutrients 2020, 12, 3787. https://doi.org/10.3390/nu12123787

AMA Style

Nwakiban APA, Fumagalli M, Piazza S, Magnavacca A, Martinelli G, Beretta G, Magni P, Tchamgoue AD, Agbor GA, Kuiaté J-R, Dell’Agli M, Sangiovanni E. Dietary Cameroonian Plants Exhibit Anti-Inflammatory Activity in Human Gastric Epithelial Cells. Nutrients. 2020; 12(12):3787. https://doi.org/10.3390/nu12123787

Chicago/Turabian Style

Nwakiban, Achille P.A., Marco Fumagalli, Stefano Piazza, Andrea Magnavacca, Giulia Martinelli, Giangiacomo Beretta, Paolo Magni, Armelle D. Tchamgoue, Gabriel A. Agbor, Jules-Roger Kuiaté, Mario Dell’Agli, and Enrico Sangiovanni. 2020. "Dietary Cameroonian Plants Exhibit Anti-Inflammatory Activity in Human Gastric Epithelial Cells" Nutrients 12, no. 12: 3787. https://doi.org/10.3390/nu12123787

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