Association between Serum Zinc Levels and Clinical Index or the Body Composition in Incident Hemodialysis Patients

Toida, Tatsunori; Toida, Reiko; Ebihara, Shou; Takahashi, Risa; Komatsu, Hiroyuki; Uezono, Shigehiro; Sato, Yuji; Fujimoto, Shouichi

doi:10.3390/nu12103187

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Association between Serum Zinc Levels and Clinical Index or the Body Composition in Incident Hemodialysis Patients

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Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan

Department of Internal Medicine, Miyazaki Prefectural Nobeoka Hospital, Nobeoka 882-0835, Japan

Department of Internal Medicine, Chiyoda Hospital, Hyuga 883-0064, Japan

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Division of Circulatory and Body Fluid Regulation, Department of Internal Medicine, University of Miyazaki, Miyazaki 889-1692, Japan

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Center for Medical Education and Career Development, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan

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Division of Nephrology, Department of Internal Medicine, National Health Insurance Takachiho Town Hospital, Takachiho 882-1101, Japan

Author to whom correspondence should be addressed.

Nutrients 2020, 12(10), 3187; https://doi.org/10.3390/nu12103187

Received: 12 September 2020 / Revised: 14 October 2020 / Accepted: 15 October 2020 / Published: 19 October 2020

(This article belongs to the Special Issue Zinc and Copper Levels in the Body and Human Health)

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Abstract

Background: The relationships between serum zinc levels and body composition or clinical outcomes of incident hemodialysis (HD) patients remain unclear. Methods: This prospective observational study examined the relationships between serum zinc levels and clinical indexes, including body composition, in 142 incident HD patients using a bioelectrical impedance analysis. Patients were divided into three groups according to baseline serum zinc levels: tertile, <45, 45–59, and ≥60 µg/dL. The reference group was set as ≥60 µg/dL. Cox’s regression analysis was performed to investigate the relationships between serum zinc categories and cardiovascular events and all-cause mortality after adjustments for potential confounders. Results: Serum zinc levels positively correlated with the nutritional index and negatively correlated with fluid volume markers. In a mean follow-up of 2.5 years, there were 20 cases of cardiovascular events and 15 of all-cause mortality. In the Cox’s regression analysis for cardiovascular events and all-cause mortality, the hazard ratio increased with a decrease in serum zinc levels, but was not significant. Conclusion: Serum zinc levels were associated with nutritional and fluid volume markers in incident HD patients. To clarify the relationship between serum zinc levels and cardiovascular events or mortality, further studies with a larger number of cases will be necessary. View Full-Text

Keywords: serum zinc levels; hemodialysis; nutritional status

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MDPI and ACS Style

Toida, T.; Toida, R.; Ebihara, S.; Takahashi, R.; Komatsu, H.; Uezono, S.; Sato, Y.; Fujimoto, S. Association between Serum Zinc Levels and Clinical Index or the Body Composition in Incident Hemodialysis Patients. Nutrients 2020, 12, 3187. https://doi.org/10.3390/nu12103187

AMA Style

Toida T, Toida R, Ebihara S, Takahashi R, Komatsu H, Uezono S, Sato Y, Fujimoto S. Association between Serum Zinc Levels and Clinical Index or the Body Composition in Incident Hemodialysis Patients. Nutrients. 2020; 12(10):3187. https://doi.org/10.3390/nu12103187

Chicago/Turabian Style

Toida, Tatsunori, Reiko Toida, Shou Ebihara, Risa Takahashi, Hiroyuki Komatsu, Shigehiro Uezono, Yuji Sato, and Shouichi Fujimoto. 2020. "Association between Serum Zinc Levels and Clinical Index or the Body Composition in Incident Hemodialysis Patients" Nutrients 12, no. 10: 3187. https://doi.org/10.3390/nu12103187

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Association between Serum Zinc Levels and Clinical Index or the Body Composition in Incident Hemodialysis Patients

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