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Thalassemia Reports, Volume 12, Issue 1

March 2022 - 5 articles

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Articles (5)

  • Article
  • Open Access
3 Citations
3,357 Views
10 Pages

Random Forest Clustering Identifies Three Subgroups of β-Thalassemia with Distinct Clinical Severity

  • Angela Vitrano,
  • Khaled M. Musallam,
  • Antonella Meloni,
  • Sebastiano Addario Pollina,
  • Mehran Karimi,
  • Amal El-Beshlawy,
  • Mahmoud Hajipour,
  • Vito Di Marco,
  • Saqib Hussain Ansari and
  • Aldo Filosa
  • + 15 authors

18 February 2022

In this work, we aimed to establish subgroups of clinical severity in a global cohort of β-thalassemia through unsupervised random forest (RF) clustering. We used a large global dataset of 7910 β-thalassemia patients and evaluated 19 indica...

  • Article
  • Open Access
3,542 Views
10 Pages

15 December 2021

Background: The progressive renal function inadequacy results in altered hepcidin metabolism due to a shifting of its renal elimination, which consequently affects enteric iron absorption and iron stores’ availability. This study aimed to inves...