PK model diagnostic Plots for combined study
1 Model diagnostic plot list:
- Observations vs. population predicted value (PRED) in both linear and log scales with a line of identity and a regression line
- Observations vs. individual PRED in both linear and log scales with a line of identity and a regression line
- Individual WRES vs. individual PRED
- Individual WRES vs. time or time after dose
- Histogram and/or QQ plot of IWRES
- Assessment of shrinkage of ETA
- Observations (or dependent variable), individual PRED, and PRED concentrations vs. time (overlaid and/or side by side)
- VPCs
Byon et al. 2013: “Establishing Best Practices and Guidance in Population Modeling: An Experience With an Internal Population Pharmacokinetic Analysis Guidance”
2 VRC01
Figure 2.1: Observations vs Predictions; scatterplot of the residuals; QQ plot of the residuals; distribution of the random effects
Figure 2.2: Individual fits
Figure 2.3: Individual fits
Figure 2.4: Individual fits
Figure 2.5: Individual fits
Figure 2.6: Individual fits
Figure 2.7: Individual fits
Figure 2.8: Individual fits
Figure 2.9: Individual fits
Figure 2.10: Individual fits
Figure 2.11: Individual fits
Figure 2.12: Individual fits
Figure 2.13: Individual fits
Figure 2.14: VPC
3 VRC01LS
Figure 3.1: Observations vs Predictions; scatterplot of the residuals; QQ plot of the residuals; distribution of the random effects
Figure 3.2: Individual fits
Figure 3.3: Individual fits
Figure 3.4: Individual fits
Figure 3.5: Individual fits
Figure 3.6: VPC
4 VRC07.523LS
Figure 4.1: Observations vs Predictions; scatterplot of the residuals; QQ plot of the residuals; distribution of the random effects
Figure 4.2: Individual fits
Figure 4.3: Individual fits
Figure 4.4: Individual fits
Figure 4.5: Individual fits
Figure 4.6: Individual fits
Figure 4.7: Individual fits
Figure 4.8: Individual fits
Figure 4.9: Individual fits
Figure 4.10: Individual fits
Figure 4.11: Individual fits
Figure 4.12: Individual fits
Figure 4.13: Individual fits
Figure 4.14: VPC
5 PGT121
Figure 5.1: Observations vs Predictions; scatterplot of the residuals; QQ plot of the residuals; distribution of the random effects
Figure 5.2: Individual fits
Figure 5.3: Individual fits
Figure 5.4: Individual fits
Figure 5.5: VPC
6 PGT121LS
Figure 6.1: Observations vs Predictions; scatterplot of the residuals; QQ plot of the residuals; distribution of the random effects
Figure 6.2: Individual fits
Figure 6.3: Individual fits
Figure 6.4: Individual fits
Figure 6.5: VPC
7 PGDM1400
Figure 7.1: Observations vs Predictions; scatterplot of the residuals; QQ plot of the residuals; distribution of the random effects
Figure 7.2: Individual fits
Figure 7.3: Individual fits
Figure 7.4: Individual fits
Figure 7.5: VPC
8 PGDM1400LS
Figure 8.1: Observations vs Predictions; scatterplot of the residuals; QQ plot of the residuals; distribution of the random effects
Figure 8.2: Individual fits
Figure 8.3: VPC
9 3BNC117
Figure 9.1: Observations vs Predictions; scatterplot of the residuals; QQ plot of the residuals; distribution of the random effects
Figure 9.2: Individual fits
Figure 9.3: Individual fits
Figure 9.4: Individual fits
Figure 9.5: VPC
10 3BNC117LS
Figure 10.1: Observations vs Predictions; scatterplot of the residuals; QQ plot of the residuals; distribution of the random effects
Figure 10.2: Individual fits
Figure 10.3: Individual fits
Figure 10.4: Individual fits
Figure 10.5: Individual fits
Figure 10.6: VPC
11 10-1074
Figure 11.1: Observations vs Predictions; scatterplot of the residuals; QQ plot of the residuals; distribution of the random effects
Figure 11.2: Individual fits
Figure 11.3: Individual fits
Figure 11.4: Individual fits
Figure 11.5: VPC
12 10-1074LS
Figure 12.1: Observations vs Predictions; scatterplot of the residuals; QQ plot of the residuals; distribution of the random effects
Figure 12.2: Individual fits
Figure 12.3: Individual fits
Figure 12.4: Individual fits
Figure 12.5: Individual fits
Figure 12.6: VPC